{"id":"https://openalex.org/W4200525866","doi":"https://doi.org/10.3390/ijms222413538","title":"Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis","display_name":"Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis","publication_year":2021,"publication_date":"2021-12-17","ids":{"openalex":"https://openalex.org/W4200525866","doi":"https://doi.org/10.3390/ijms222413538","pmid":"https://pubmed.ncbi.nlm.nih.gov/34948335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8704603"},"language":"en","primary_location":{"id":"doi:10.3390/ijms222413538","doi":"https://doi.org/10.3390/ijms222413538","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413538","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13538/pdf?version=1639727014","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/24/13538/pdf?version=1639727014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086179187","display_name":"Erina Shiraishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Erina Shiraishi","raw_affiliation_strings":["Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan","Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan","institution_ids":["https://openalex.org/I205924995"]},{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086199075","display_name":"Keishi Ishida","orcid":"https://orcid.org/0000-0003-0206-9215","observed_orcids":["https://orcid.org/0000-0003-0206-9215"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keishi Ishida","raw_affiliation_strings":["Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0206-9215","affiliations":[{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064075415","display_name":"Daisuke Matsumaru","orcid":"https://orcid.org/0000-0002-1832-624X","observed_orcids":["https://orcid.org/0000-0002-1832-624X"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Matsumaru","raw_affiliation_strings":["Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1832-624X","affiliations":[{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026456093","display_name":"Akiko Ido","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I40502580","display_name":"Gifu University of Medical Science","ror":"https://ror.org/04tcj6w24","country_code":"JP","type":"education","lineage":["https://openalex.org/I40502580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Ido","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani 509-0293, Gifu, Japan","Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani 509-0293, Gifu, Japan","institution_ids":["https://openalex.org/I40502580"]},{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062431954","display_name":"Youhei Hiromori","orcid":"https://orcid.org/0009-0007-4381-6201","observed_orcids":["https://orcid.org/0009-0007-4381-6201"]},"institutions":[{"id":"https://openalex.org/I171559596","display_name":"Suzuka University of Medical Science","ror":"https://ror.org/00tq7xg10","country_code":"JP","type":"education","lineage":["https://openalex.org/I171559596"]},{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youhei Hiromori","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science 3500-3, Minamitamagaki, Suzuka 513-8670, Mie, Japan","Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science 3500-3, Minamitamagaki, Suzuka 513-8670, Mie, Japan","institution_ids":["https://openalex.org/I171559596"]},{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037934016","display_name":"Hisamitsu Nagase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I40502580","display_name":"Gifu University of Medical Science","ror":"https://ror.org/04tcj6w24","country_code":"JP","type":"education","lineage":["https://openalex.org/I40502580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisamitsu Nagase","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani 509-0293, Gifu, Japan","Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani 509-0293, Gifu, Japan","institution_ids":["https://openalex.org/I40502580"]},{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101739606","display_name":"Tsuyoshi Nakanishi","orcid":"https://orcid.org/0000-0002-2683-0075","observed_orcids":["https://orcid.org/0000-0002-2683-0075"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsuyoshi Nakanishi","raw_affiliation_strings":["Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2683-0075","affiliations":[{"raw_affiliation_string":"Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Gifu, Japan","institution_ids":["https://openalex.org/I173865709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101739606"],"corresponding_institution_ids":["https://openalex.org/I173865709"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.4511,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6460041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"24","first_page":"13538","last_page":"13538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14297","display_name":"Plant-Derived Bioactive Compounds","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brazilian-green-propolis","display_name":"Brazilian green propolis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.9810000061988831},{"id":"https://openalex.org/keywords/allergenicity","display_name":"allergenicity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/local-lymph-node-assay","display_name":"local lymph node assay","score":0.8629999756813049},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.824999988079071},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":1.0},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dc2-4-cells","display_name":"DC2.4 cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bee-propolis","display_name":"bee propolis","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.93824303150177},{"id":"https://openalex.org/C2780614586","wikidata":"https://www.wikidata.org/wiki/Q6664446","display_name":"Local lymph node assay","level":4,"score":0.9138898849487305},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.6798719167709351},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6120476722717285},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.606067955493927},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5586935877799988},{"id":"https://openalex.org/C3018346242","wikidata":"https://www.wikidata.org/wiki/Q4826986","display_name":"Skin sensitization","level":3,"score":0.4983859062194824},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45994704961776733},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4569360315799713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.449550986289978},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35720109939575195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32813847064971924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2999832332134247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2977049946784973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24975517392158508},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.18607312440872192},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.15856537222862244},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.15434810519218445},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.1495521366596222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12455394864082336}],"mesh":[{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023441","descriptor_name":"Local Lymph Node Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms222413538","doi":"https://doi.org/10.3390/ijms222413538","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413538","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13538/pdf?version=1639727014","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8704603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8704603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:34948335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34948335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:88278d8efdc94b5ba65ccb2aef0ac535","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88278d8efdc94b5ba65ccb2aef0ac535","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 13538, p 13538 (2021)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01402:0005240256","doi":null,"is_oa":true,"landing_page_url":"https://gifu-pu.repo.nii.ac.jp/records/14550","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/ijms222413538","doi":"https://doi.org/10.3390/ijms222413538","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222413538","pdf_url":"https://www.mdpi.com/1422-0067/22/24/13538/pdf?version=1639727014","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2206181088","display_name":null,"funder_award_id":"21KD1004","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2838278034","display_name":"The effects of stress response system in the ovary: KEAP1-NRF2 system and female infertility","funder_award_id":"19K07361","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4110845141","display_name":"Analysis of reproductive toxicity and nonlinear reaction mechanism of bisphenol A analogues in food containers","funder_award_id":"18H03381","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G585482166","display_name":"\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u63a5\u89e6\u76ae\u819a\u708e\u306b\u304a\u3051\u308b\u611f\u4f5c\u6027\u7269\u8cea\u306e\u65b0\u898f\u6297\u539f\u6027\u7372\u5f97\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76","funder_award_id":"18J23393","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8603893332","display_name":"Novel skin sensitization assay using luciferase-expressing transgenic mice.","funder_award_id":"19K19413","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200525866.pdf","grobid_xml":"https://content.openalex.org/works/W4200525866.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W114119115","https://openalex.org/W1557338163","https://openalex.org/W1611001525","https://openalex.org/W1901657789","https://openalex.org/W1915147666","https://openalex.org/W1971515255","https://openalex.org/W1978984623","https://openalex.org/W1984237320","https://openalex.org/W1984590224","https://openalex.org/W2004762947","https://openalex.org/W2008286007","https://openalex.org/W2018760199","https://openalex.org/W2038108406","https://openalex.org/W2040270316","https://openalex.org/W2053228091","https://openalex.org/W2053760636","https://openalex.org/W2063854853","https://openalex.org/W2067317852","https://openalex.org/W2078891015","https://openalex.org/W2092879809","https://openalex.org/W2103762352","https://openalex.org/W2114417128","https://openalex.org/W2137137814","https://openalex.org/W2149439215","https://openalex.org/W2157974264","https://openalex.org/W2170098987","https://openalex.org/W2327925091","https://openalex.org/W2403419742","https://openalex.org/W2577182316","https://openalex.org/W2594685865","https://openalex.org/W2626769094","https://openalex.org/W2902199551","https://openalex.org/W2910994134","https://openalex.org/W2972149158","https://openalex.org/W2998019058","https://openalex.org/W3006793671","https://openalex.org/W3087668340","https://openalex.org/W3135061141"],"related_works":["https://openalex.org/W2734503862","https://openalex.org/W2103762352","https://openalex.org/W6910822231","https://openalex.org/W4245284618","https://openalex.org/W3026088199","https://openalex.org/W4210768271","https://openalex.org/W2348578185","https://openalex.org/W7042850237","https://openalex.org/W7156852900","https://openalex.org/W1754504979"],"abstract_inverted_index":{"Propolis":[0,23],"is":[1,155],"a":[2,126,141,156],"resinous":[3],"mixture":[4],"produced":[5],"by":[6,78],"bees":[7],"from":[8],"their":[9],"secretions":[10],"and":[11,84,97,154,176],"plant":[12],"material,":[13],"so":[14],"its":[15,20,29],"composition":[16],"varies":[17],"depending":[18],"on":[19,66,95,109,118,182],"botanical":[21],"origin.":[22],"has":[24,47],"several":[25],"beneficial":[26],"bioactivities,":[27],"but":[28,112],"skin":[30,39,127,152],"sensitization":[31,40,153],"properties":[32],"have":[33,172],"long":[34],"been":[35,49,173],"suspected.":[36],"Nevertheless,":[37],"the":[38,67,80,90,104,114,165,178,183],"potency":[41],"of":[42,82,89,92,106,116,164,167,186],"Brazilian":[43],"green":[44],"propolis":[45],"(BGP)":[46],"not":[48,102],"scientifically":[50,55],"evaluated.":[51],"Here,":[52],"we":[53,130],"used":[54,174],"reliable":[56],"tests":[57],"to":[58],"evaluate":[59],"it.":[60],"In":[61],"vitro":[62],"antigenicity":[63,91],"test":[64,72,93],"based":[65],"human":[68],"cell":[69],"line":[70],"activation":[71],"(OECD":[73],"TG":[74,138],"442E)":[75],"was":[76],"performed":[77,131],"measuring":[79],"expression":[81,105,115],"CD54":[83],"CD86,":[85],"which":[86,171],"are":[87],"indicators":[88],"substances,":[94],"THP-1":[96,110],"DC2.4":[98,119],"cells.":[99],"BGP":[100,123,150],"did":[101],"affect":[103],"either":[107],"marker":[108],"cells,":[111,120],"upregulated":[113],"CD86":[117],"suggesting":[121],"that":[122,148],"may":[124],"be":[125],"sensitizer.":[128],"Then,":[129],"local":[132],"lymph":[133],"node":[134],"assay":[135],"(LLNA,":[136],"OECD":[137],"429)":[139],"as":[140],"definitive":[142],"in":[143],"vivo":[144],"test.":[145],"LLNA":[146],"showed":[147],"1.70%":[149],"primed":[151],"\"moderate":[157],"sensitizer\".":[158],"Our":[159],"results":[160],"indicate":[161],"scientific":[162,180],"proof":[163],"validity":[166],"arbitrary":[168],"concentrations":[169],"(1-2%),":[170],"empirically,":[175],"provide":[177],"first":[179],"information":[181],"safe":[184],"use":[185],"BGP.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
