{"id":"https://openalex.org/W4200524321","doi":"https://doi.org/10.1016/j.virusres.2021.198660","title":"High levels of soluble programmed death-1 are associated with virological response in chronic hepatitis B patients after antiviral treatment","display_name":"High levels of soluble programmed death-1 are associated with virological response in chronic hepatitis B patients after antiviral treatment","publication_year":2021,"publication_date":"2021-12-18","ids":{"openalex":"https://openalex.org/W4200524321","doi":"https://doi.org/10.1016/j.virusres.2021.198660","pmid":"https://pubmed.ncbi.nlm.nih.gov/34929214"},"language":"en","primary_location":{"id":"doi:10.1016/j.virusres.2021.198660","doi":"https://doi.org/10.1016/j.virusres.2021.198660","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virusres.2021.198660","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101714303","display_name":"Ning Tan","orcid":"https://orcid.org/0000-0001-9917-2192","observed_orcids":["https://orcid.org/0000-0001-9917-2192"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Tan","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005140056","display_name":"Hao Luo","orcid":"https://orcid.org/0000-0002-2067-7217","observed_orcids":["https://orcid.org/0000-0002-2067-7217"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Luo","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050463135","display_name":"Qian Kang","orcid":"https://orcid.org/0000-0001-5825-1660","observed_orcids":["https://orcid.org/0000-0001-5825-1660"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Kang","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050027379","display_name":"Jiali Pan","orcid":"https://orcid.org/0000-0002-3448-7430","observed_orcids":["https://orcid.org/0000-0002-3448-7430"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Pan","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102882662","display_name":"Ran Cheng","orcid":"https://orcid.org/0000-0001-6975-3498","observed_orcids":["https://orcid.org/0000-0001-6975-3498"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Cheng","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112414121","display_name":"Hongli Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongli Xi","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongyu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Chen","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yifan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Han","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012503019","display_name":"Yuqing Yang","orcid":"https://orcid.org/0000-0003-0409-2590","observed_orcids":["https://orcid.org/0000-0003-0409-2590"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Yang","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034168127","display_name":"Xiaoyuan Xu","orcid":"https://orcid.org/0000-0002-1759-4330","observed_orcids":["https://orcid.org/0000-0002-1759-4330"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyuan Xu","raw_affiliation_strings":["Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China","institution_ids":["https://openalex.org/I4210130930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034168127"],"corresponding_institution_ids":["https://openalex.org/I4210130930"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.5466,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63506706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"309","issue":null,"first_page":"198660","last_page":"198660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9340000152587891},{"id":"https://openalex.org/keywords/virological-response","display_name":"virological response","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogue-therapy","display_name":"nucleos(t)ide analogue therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hbv-dna","display_name":"HBV DNA","score":0.8970000147819519},{"id":"https://openalex.org/keywords/entecavir","display_name":"entecavir","score":0.7609999775886536},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/adefovir","display_name":"adefovir","score":0.8790000081062317},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5429999828338623},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.414000004529953},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.3569999933242798},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8782716393470764},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6500006914138794},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.547560453414917},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.44685229659080505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42569243907928467},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18776482343673706}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006513","descriptor_name":"Hepatitis B e Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.virusres.2021.198660","doi":"https://doi.org/10.1016/j.virusres.2021.198660","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virusres.2021.198660","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},{"id":"pmid:34929214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34929214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3864740999","display_name":null,"funder_award_id":"2017ZX10203202\\u2013003","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G397159331","display_name":null,"funder_award_id":"D161100002716003","funder_id":"https://openalex.org/F4320325902","funder_display_name":"Beijing Municipal Science and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320325902","display_name":"Beijing Municipal Science and Technology Commission","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1983251878","https://openalex.org/W2009474584","https://openalex.org/W2119896120","https://openalex.org/W2132205831","https://openalex.org/W2152095262","https://openalex.org/W2166849716","https://openalex.org/W2173855355","https://openalex.org/W2267571233","https://openalex.org/W2337204897","https://openalex.org/W2507136820","https://openalex.org/W2600057763","https://openalex.org/W2605785536","https://openalex.org/W2739640246","https://openalex.org/W2761099324","https://openalex.org/W2781766181","https://openalex.org/W2791839818","https://openalex.org/W2801167100","https://openalex.org/W2802499642","https://openalex.org/W2804297447","https://openalex.org/W2906267046","https://openalex.org/W3000082715","https://openalex.org/W3023526733"],"related_works":["https://openalex.org/W2069203268","https://openalex.org/W3200610425","https://openalex.org/W3023526733","https://openalex.org/W3119379728","https://openalex.org/W7043430228","https://openalex.org/W3187551290","https://openalex.org/W1995915978","https://openalex.org/W3030238475","https://openalex.org/W4205448607","https://openalex.org/W4220712125"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}