{"id":"https://openalex.org/W4200520949","doi":"https://doi.org/10.1016/j.bbrc.2021.12.031","title":"Aprepitant is a novel, selective activator of the K2P channel TRAAK","display_name":"Aprepitant is a novel, selective activator of the K2P channel TRAAK","publication_year":2021,"publication_date":"2021-12-14","ids":{"openalex":"https://openalex.org/W4200520949","doi":"https://doi.org/10.1016/j.bbrc.2021.12.031","pmid":"https://pubmed.ncbi.nlm.nih.gov/34942533"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2021.12.031","doi":"https://doi.org/10.1016/j.bbrc.2021.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.12.031","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X21016661/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0006291X21016661/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070396172","display_name":"David McCoull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D. McCoull","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK. Electronic address: david.mccoull@lifearc.org","LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK. Electronic address: david.mccoull@lifearc.org","institution_ids":["https://openalex.org/I109541847"]},{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059405759","display_name":"Emma L. Veale","orcid":"https://orcid.org/0000-0002-6778-9929","observed_orcids":["https://orcid.org/0000-0002-6778-9929"]},"institutions":[{"id":"https://openalex.org/I167056439","display_name":"Medway School of Pharmacy","ror":"https://ror.org/00fa9v295","country_code":"GB","type":"education","lineage":["https://openalex.org/I167056439"]},{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]},{"id":"https://openalex.org/I55060895","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71","country_code":"GB","type":"education","lineage":["https://openalex.org/I55060895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E.L. Veale","raw_affiliation_strings":["Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK","institution_ids":["https://openalex.org/I167056439","https://openalex.org/I20581793","https://openalex.org/I55060895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041152471","display_name":"Yvonne Walsh","orcid":"https://orcid.org/0000-0001-6136-3604","observed_orcids":["https://orcid.org/0000-0001-6136-3604"]},"institutions":[{"id":"https://openalex.org/I167056439","display_name":"Medway School of Pharmacy","ror":"https://ror.org/00fa9v295","country_code":"GB","type":"education","lineage":["https://openalex.org/I167056439"]},{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]},{"id":"https://openalex.org/I55060895","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71","country_code":"GB","type":"education","lineage":["https://openalex.org/I55060895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y. Walsh","raw_affiliation_strings":["Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK","institution_ids":["https://openalex.org/I167056439","https://openalex.org/I20581793","https://openalex.org/I55060895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092921447","display_name":"Lewis Byrom","orcid":"https://orcid.org/0000-0002-2261-7568","observed_orcids":["https://orcid.org/0000-0002-2261-7568"]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Byrom","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037541443","display_name":"T. Avkiran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Avkiran","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001403675","display_name":"Jonathan M. Large","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.M. Large","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039566914","display_name":"Egle Vaitone","orcid":"https://orcid.org/0000-0001-6514-6228","observed_orcids":["https://orcid.org/0000-0001-6514-6228"]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. Vaitone","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004527208","display_name":"Finbar Gaffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Gaffey","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110000680","display_name":"Jeffrey C. Jerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Jerman","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014692107","display_name":"Alistair A. Mathie","orcid":"https://orcid.org/0000-0001-6094-2890","observed_orcids":["https://orcid.org/0000-0001-6094-2890"]},"institutions":[{"id":"https://openalex.org/I127165138","display_name":"University of Suffolk","ror":"https://ror.org/01cy0sz82","country_code":"GB","type":"education","lineage":["https://openalex.org/I127165138"]},{"id":"https://openalex.org/I167056439","display_name":"Medway School of Pharmacy","ror":"https://ror.org/00fa9v295","country_code":"GB","type":"education","lineage":["https://openalex.org/I167056439"]},{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]},{"id":"https://openalex.org/I55060895","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71","country_code":"GB","type":"education","lineage":["https://openalex.org/I55060895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Mathie","raw_affiliation_strings":["Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK; School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK","Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK","School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK; School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK","institution_ids":["https://openalex.org/I127165138","https://openalex.org/I167056439","https://openalex.org/I20581793","https://openalex.org/I55060895"]},{"raw_affiliation_string":"Medway School of Pharmacy, University of Greenwich and University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK","institution_ids":["https://openalex.org/I167056439","https://openalex.org/I20581793","https://openalex.org/I55060895"]},{"raw_affiliation_string":"School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK","institution_ids":["https://openalex.org/I127165138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083695971","display_name":"Paul D. Wright","orcid":"https://orcid.org/0000-0001-8367-5529","observed_orcids":["https://orcid.org/0000-0001-8367-5529"]},"institutions":[{"id":"https://openalex.org/I109541847","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I109541847"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.D. Wright","raw_affiliation_strings":["LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK","institution_ids":["https://openalex.org/I109541847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070396172"],"corresponding_institution_ids":["https://openalex.org/I109541847"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.5593,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56183664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"588","issue":null,"first_page":"41","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aprepitant","display_name":"aprepitant","score":0.9670000076293945},{"id":"https://openalex.org/keywords/traak","display_name":"TRAAK","score":0.9950000047683716},{"id":"https://openalex.org/keywords/two-pore-domain-potassium-channels","display_name":"two-pore domain potassium channels","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.9100000262260437},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.6579999923706055},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2780574406","wikidata":"https://www.wikidata.org/wiki/Q621834","display_name":"Aprepitant","level":4,"score":0.9444220066070557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5267364978790283},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5183026194572449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3378814458847046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3149986267089844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2617722749710083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.214124858379364},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.1894553005695343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13190588355064392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11072281002998352},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077608","descriptor_name":"Aprepitant","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013793","descriptor_name":"Thallium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064729","descriptor_name":"Neurokinin-1 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbrc.2021.12.031","doi":"https://doi.org/10.1016/j.bbrc.2021.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.12.031","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X21016661/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:34942533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34942533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:kar.kent.ac.uk:92477","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.12.031>)","pdf_url":"https://kar.kent.ac.uk/92477/1/McCoull%20et%20al%202022.pdf","source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:westminsterresearch.westminster.ac.uk:w9525","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.12.031","pdf_url":null,"source":{"id":"https://openalex.org/S4306400277","display_name":"WestminsterResearch (University of Westminster)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94951947","host_organization_name":"University of Westminster","host_organization_lineage":["https://openalex.org/I94951947"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrc.2021.12.031","doi":"https://doi.org/10.1016/j.bbrc.2021.12.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.12.031","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X21016661/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200520949.pdf","grobid_xml":"https://content.openalex.org/works/W4200520949.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1480614936","https://openalex.org/W1482320560","https://openalex.org/W1962105746","https://openalex.org/W1963768700","https://openalex.org/W1980802466","https://openalex.org/W2018048919","https://openalex.org/W2041345208","https://openalex.org/W2043862101","https://openalex.org/W2049268718","https://openalex.org/W2075693545","https://openalex.org/W2079480529","https://openalex.org/W2083818620","https://openalex.org/W2098872371","https://openalex.org/W2114776119","https://openalex.org/W2116616972","https://openalex.org/W2126387799","https://openalex.org/W2155881793","https://openalex.org/W2157250445","https://openalex.org/W2160117096","https://openalex.org/W2753331910","https://openalex.org/W2800001093","https://openalex.org/W2902389585","https://openalex.org/W2925478418","https://openalex.org/W2977241603","https://openalex.org/W2980100759","https://openalex.org/W2980975640","https://openalex.org/W2983910499","https://openalex.org/W3011033216","https://openalex.org/W3090336390","https://openalex.org/W3094718656","https://openalex.org/W3115084304","https://openalex.org/W3154397480","https://openalex.org/W3194401742"],"related_works":["https://openalex.org/W3011033216","https://openalex.org/W2977241603","https://openalex.org/W2800001093","https://openalex.org/W2549018051","https://openalex.org/W3136365301","https://openalex.org/W4407808641","https://openalex.org/W2313541118","https://openalex.org/W2568125552","https://openalex.org/W2084078146","https://openalex.org/W4285773544"],"abstract_inverted_index":{"TRAAK":[0,62,93,199,209,229],"(KCNK4,":[1],"K2P4.1)":[2],"is":[3,55,114,174],"a":[4,26,46,56,76,96,107,130,192,215],"mechanosensitive":[5],"two-pore":[6],"domain":[7],"potassium":[8],"(K2P)":[9],"channel.":[10],"Due":[11],"to":[12,21,80,119,151,196,223],"its":[13],"expression":[14],"within":[15],"sensory":[16],"neurons":[17],"and":[18,87,122,129,146,163,176,201,204],"genetic":[19],"link":[20],"neuropathic":[22],"pain":[23],"it":[24],"represents":[25],"promising":[27],"potential":[28,198],"target":[29],"for":[30,61,140,148],"novel":[31,92,208],"analgesics.":[32],"In":[33],"common":[34],"with":[35],"many":[36],"other":[37,65,180],"channels":[38],"in":[39],"the":[40,64,68,89,161,183,189,207,226],"wider":[41],"K2P":[42,72,184,230],"sub-family,":[43],"there":[44,54],"remains":[45],"paucity":[47],"of":[48,58,67,71,85,91,98,111,127,132,167,182,191,206,228],"small":[49,108],"molecule":[50,109],"pharmacological":[51],"tools.":[52],"Specifically,":[53],"lack":[57],"molecules":[59,102],"selective":[60,175],"over":[63],"members":[66,181],"TREK":[69],"subfamily":[70],"channels.":[73,231],"We":[74,169],"developed":[75],"thallium":[77],"flux":[78],"assay":[79,195],"allow":[81],"high":[82,193],"throughput":[83,194],"screening":[84],"compounds":[86],"facilitate":[88],"identification":[90,203],"activators.":[94],"Using":[95],"library":[97],"\u223c1200":[99],"drug":[100],"like":[101],"we":[103],"identified":[104],"Aprepitant":[105,113,128,158,173],"as":[106],"activator":[110,210],"TRAAK.":[112,153,168],"an":[115],"NK-1":[116,133],"antagonist":[117],"used":[118,222],"treat":[120],"nausea":[121],"vomiting.":[123],"Close":[124],"structural":[125],"analogues":[126],"range":[131],"antagonists":[134],"were":[135],"also":[136,170],"selected":[137],"or":[138,142],"designed":[139],"purchase":[141],"brief":[143],"chemical":[144],"synthesis":[145],"screened":[147],"their":[149],"ability":[150],"activate":[152,179],"Electrophysiology":[154],"experiments":[155],"confirmed":[156],"that":[157,172],"activates":[159],"both":[160],"'long'":[162],"'short'":[164],"transcript":[165],"variants":[166],"demonstrated":[171],"does":[177],"not":[178],"superfamily.":[185],"This":[186,212],"work":[187],"describes":[188],"development":[190],"identify":[197],"activators":[200],"subsequent":[202],"confirmation":[205],"Aprepitant.":[211],"discovery":[213],"identifies":[214],"useful":[216],"tool":[217],"compound":[218],"which":[219],"can":[220],"be":[221],"further":[224],"probe":[225],"function":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}