{"id":"https://openalex.org/W4200520645","doi":"https://doi.org/10.5281/zenodo.5774328","title":"GEN\u00c9TICA DEL HUESPED Y EVIDENCIAS FUNCIONALES DE LA SEVERIDAD DE LA ENFERMEDAD DEL DENGUE","display_name":"GEN\u00c9TICA DEL HUESPED Y EVIDENCIAS FUNCIONALES DE LA SEVERIDAD DE LA ENFERMEDAD DEL DENGUE","publication_year":2021,"publication_date":"2021-12-11","ids":{"openalex":"https://openalex.org/W4200520645","doi":"https://doi.org/10.5281/zenodo.5774328"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:5774329","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5774329","pdf_url":"https://zenodo.org/record/5774329","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/workingPaper"},"volume":null,"type":"report","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/5774329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017088447","display_name":"Yerly M. Useche","orcid":"https://orcid.org/0000-0003-3912-0707","observed_orcids":["https://orcid.org/0000-0003-3912-0707"]},"institutions":[{"id":"https://openalex.org/I4405253109","display_name":"Sociedad de Doctores e Investigadores de Colombia","ror":"https://ror.org/00ascas35","country_code":"CO","type":"nonprofit","lineage":["https://openalex.org/I4405253109"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Useche, Yerly","raw_affiliation_strings":["Grupo de Investigaci\u00f3n y Desarrollo en Ciencia, Tecnolog\u00eda e Innovaci\u00f3n \u2013 BioGRID, Sociedad de Doctores e Investigadores de Colombia - SoPhiC"],"raw_orcid":"https://orcid.org/0000-0003-3912-0707","affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n y Desarrollo en Ciencia, Tecnolog\u00eda e Innovaci\u00f3n \u2013 BioGRID, Sociedad de Doctores e Investigadores de Colombia - SoPhiC","institution_ids":["https://openalex.org/I4405253109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112380149","display_name":"Bertha Nelly Restrepo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105720","display_name":"Instituto Colombiano de Medicina Tropical","ror":"https://ror.org/01gpc7s59","country_code":"CO","type":"nonprofit","lineage":["https://openalex.org/I4210105720"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Restrepo, Bertha-Nelly","raw_affiliation_strings":["Instituto Colombiano de Medicina Tropical ICMT, Universidad CES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Colombiano de Medicina Tropical ICMT, Universidad CES","institution_ids":["https://openalex.org/I4210105720"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.8960000276565552},{"id":"https://openalex.org/keywords/host-genetics","display_name":"host genetics","score":0.9269999861717224},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7279999852180481},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7110000252723694},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.8930000066757202},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.6660000085830688},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.41735661029815674},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3072676658630371}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:zenodo.org:5774329","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5774329","pdf_url":"https://zenodo.org/record/5774329","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/workingPaper"},{"id":"doi:10.5281/zenodo.5774328","doi":"https://doi.org/10.5281/zenodo.5774328","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5774328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.5774329","doi":"https://doi.org/10.5281/zenodo.5774329","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5774329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:5774329","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5774329","pdf_url":"https://zenodo.org/record/5774329","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/workingPaper"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200520645.pdf","grobid_xml":"https://content.openalex.org/works/W4200520645.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W402779438","https://openalex.org/W1459224120","https://openalex.org/W1487642335","https://openalex.org/W1490925550","https://openalex.org/W1521002481","https://openalex.org/W1576694462","https://openalex.org/W1605375047","https://openalex.org/W1830783338","https://openalex.org/W1963731169","https://openalex.org/W1964682102","https://openalex.org/W1972593866","https://openalex.org/W1979641877","https://openalex.org/W1985739089","https://openalex.org/W1986689553","https://openalex.org/W1989929800","https://openalex.org/W1991647854","https://openalex.org/W1993008069","https://openalex.org/W1993879113","https://openalex.org/W1995848438","https://openalex.org/W1996820257","https://openalex.org/W1999473428","https://openalex.org/W1999543219","https://openalex.org/W2001548698","https://openalex.org/W2003112798","https://openalex.org/W2005286637","https://openalex.org/W2009259519","https://openalex.org/W2010992972","https://openalex.org/W2013337497","https://openalex.org/W2014692496","https://openalex.org/W2018537438","https://openalex.org/W2019272952","https://openalex.org/W2024248471","https://openalex.org/W2025149858","https://openalex.org/W2027335054","https://openalex.org/W2030214040","https://openalex.org/W2030704316","https://openalex.org/W2033091820","https://openalex.org/W2035430418","https://openalex.org/W2040300434","https://openalex.org/W2041683666","https://openalex.org/W2049967772","https://openalex.org/W2052099967","https://openalex.org/W2052570922","https://openalex.org/W2054785404","https://openalex.org/W2058295392","https://openalex.org/W2059952139","https://openalex.org/W2062347251","https://openalex.org/W2064507864","https://openalex.org/W2069197869","https://openalex.org/W2069268727","https://openalex.org/W2071131149","https://openalex.org/W2072999191","https://openalex.org/W2075755743","https://openalex.org/W2078417023","https://openalex.org/W2078956320","https://openalex.org/W2080395015","https://openalex.org/W2081800156","https://openalex.org/W2085069667","https://openalex.org/W2087786861","https://openalex.org/W2093658547","https://openalex.org/W2094150986","https://openalex.org/W2095118237","https://openalex.org/W2101423063","https://openalex.org/W2105181802","https://openalex.org/W2107182434","https://openalex.org/W2111070769","https://openalex.org/W2118092365","https://openalex.org/W2127769359","https://openalex.org/W2132951127","https://openalex.org/W2136294948","https://openalex.org/W2141988882","https://openalex.org/W2145748818","https://openalex.org/W2146200442","https://openalex.org/W2154994234","https://openalex.org/W2155302550","https://openalex.org/W2155518363","https://openalex.org/W2156065397","https://openalex.org/W2157142807","https://openalex.org/W2159226284","https://openalex.org/W2165338511","https://openalex.org/W2166006345","https://openalex.org/W2233529118","https://openalex.org/W2281455831","https://openalex.org/W2290480250","https://openalex.org/W2295259402","https://openalex.org/W2397100899","https://openalex.org/W2464082433","https://openalex.org/W2591879108","https://openalex.org/W2891104551","https://openalex.org/W2897387482","https://openalex.org/W3209945426"],"related_works":["https://openalex.org/W1012520831","https://openalex.org/W1989929800","https://openalex.org/W4414046504","https://openalex.org/W2885480877","https://openalex.org/W7098817013","https://openalex.org/W4413355077","https://openalex.org/W2020007229","https://openalex.org/W2070554900","https://openalex.org/W4415990170","https://openalex.org/W2518154824"],"abstract_inverted_index":{"Among":[0],"the":[1,16,21,28,34,42,53,60,70,89],"main":[2,90],"characteristics":[3],"of":[4,18,31,36,56,62,73,92],"most":[5],"human":[6],"infections":[7],"is":[8,105],"their":[9],"great":[10,29],"phenotypic":[11],"variability,":[12],"partly":[13],"due":[14,108],"to":[15,45,51,109],"diversity":[17,30],"mechanisms":[19,87],"that":[20,85,102],"immune":[22,43],"response":[23,44,75],"sets":[24],"in":[25,41,59,76,79,94],"motion":[26],"against":[27],"pathogens.":[32],"Recently,":[33],"discovery":[35],"new":[37],"genetic":[38,71],"variants":[39],"involved":[40],"various":[46],"pathogens":[47],"makes":[48],"it":[49],"possible":[50],"highlight":[52],"shared":[54],"role":[55],"signaling":[57],"pathways":[58],"pathogenesis":[61],"infectious":[63],"diseases,":[64],"which":[65],"provide":[66],"important":[67],"insights":[68],"into":[69],"regulation":[72],"said":[74],"humans.":[77],"Especially":[78],"dengue":[80],"disease,":[81],"numerous":[82],"data":[83],"show":[84],"immunopathological":[86],"are":[88],"determinants":[91],"variation":[93],"disease":[95,103],"outcomes.":[96],"In":[97],"fact,":[98],"recent":[99],"research":[100],"suggests":[101],"progression":[104],"more":[106],"likely":[107],"host":[110],"factors":[111],"than":[112],"viral":[113],"factors.":[114]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}