{"id":"https://openalex.org/W4200517660","doi":"https://doi.org/10.1002/jbm.b.34992","title":"Alpha\u2010mangostin and resveratrol, dual\u2010drugs\u2010loaded mucoadhesive thiolated chitosan\u2010based nanoparticles for synergistic activity against colon cancer cells","display_name":"Alpha\u2010mangostin and resveratrol, dual\u2010drugs\u2010loaded mucoadhesive thiolated chitosan\u2010based nanoparticles for synergistic activity against colon cancer cells","publication_year":2021,"publication_date":"2021-12-16","ids":{"openalex":"https://openalex.org/W4200517660","doi":"https://doi.org/10.1002/jbm.b.34992","pmid":"https://pubmed.ncbi.nlm.nih.gov/34919783"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.b.34992","doi":"https://doi.org/10.1002/jbm.b.34992","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.b.34992","pdf_url":null,"source":{"id":"https://openalex.org/S198061209","display_name":"Journal of Biomedical Materials Research Part B Applied Biomaterials","issn_l":"1552-4973","issn":["1552-4973","1552-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part B: Applied Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039885513","display_name":"Wipada Samprasit","orcid":"https://orcid.org/0000-0001-9170-3438","observed_orcids":["https://orcid.org/0000-0001-9170-3438"]},"institutions":[{"id":"https://openalex.org/I89226531","display_name":"Rangsit University","ror":"https://ror.org/01cqcrc47","country_code":"TH","type":"education","lineage":["https://openalex.org/I89226531"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Wipada Samprasit","raw_affiliation_strings":["Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathum Thani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathum Thani, Thailand","institution_ids":["https://openalex.org/I89226531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011581277","display_name":"Praneet Opanasopit","orcid":"https://orcid.org/0000-0002-4878-2529","observed_orcids":["https://orcid.org/0000-0002-4878-2529"]},"institutions":[{"id":"https://openalex.org/I86677382","display_name":"Silpakorn University","ror":"https://ror.org/02d0tyt78","country_code":"TH","type":"education","lineage":["https://openalex.org/I86677382"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Praneet Opanasopit","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand","institution_ids":["https://openalex.org/I86677382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019693450","display_name":"Benchawan Chamsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89226531","display_name":"Rangsit University","ror":"https://ror.org/01cqcrc47","country_code":"TH","type":"education","lineage":["https://openalex.org/I89226531"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Benchawan Chamsai","raw_affiliation_strings":["Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathum Thani, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathum Thani, Thailand","institution_ids":["https://openalex.org/I89226531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039885513"],"corresponding_institution_ids":["https://openalex.org/I89226531"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.7211,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80312955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"110","issue":"6","first_page":"1221","last_page":"1233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-mangostin","display_name":"\u03b1-mangostin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mucoadhesion","display_name":"mucoadhesion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/eudragit-s100-coating","display_name":"Eudragit S100 coating","score":0.9660000205039978},{"id":"https://openalex.org/keywords/colon-specific-drug-delivery","display_name":"colon-targeted drug delivery","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dual-drug-loading","display_name":"dual drug loading","score":0.7749999761581421},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ionic-gelation","display_name":"ionic gelation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/targeted-nanomedicine","display_name":"targeted nanomedicine","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.8472646474838257},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.8038054704666138},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7174540162086487},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.5720696449279785},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.5304082632064819},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4958542287349701},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4743551015853882},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3395559787750244},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.33838215470314026},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3287103772163391},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.26108303666114807},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24131736159324646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1906844675540924},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15586557984352112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0978182852268219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.b.34992","doi":"https://doi.org/10.1002/jbm.b.34992","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.b.34992","pdf_url":null,"source":{"id":"https://openalex.org/S198061209","display_name":"Journal of Biomedical Materials Research Part B Applied Biomaterials","issn_l":"1552-4973","issn":["1552-4973","1552-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part B: Applied Biomaterials","raw_type":"journal-article"},{"id":"pmid:34919783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34919783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part B, Applied biomaterials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3359972237","display_name":null,"funder_award_id":"RTA6180003","funder_id":"https://openalex.org/F4320329659","funder_display_name":"Thailand Science Research and Innovation"}],"funders":[{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":"https://ror.org/000025p04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1515624972","https://openalex.org/W1967901280","https://openalex.org/W1986348792","https://openalex.org/W1986879910","https://openalex.org/W2007981754","https://openalex.org/W2009805582","https://openalex.org/W2012247389","https://openalex.org/W2020935675","https://openalex.org/W2025409677","https://openalex.org/W2031626731","https://openalex.org/W2037510773","https://openalex.org/W2041480715","https://openalex.org/W2052080571","https://openalex.org/W2071215562","https://openalex.org/W2073002994","https://openalex.org/W2077945404","https://openalex.org/W2084003710","https://openalex.org/W2089407496","https://openalex.org/W2091044173","https://openalex.org/W2092346081","https://openalex.org/W2095249623","https://openalex.org/W2095457605","https://openalex.org/W2096563333","https://openalex.org/W2123179625","https://openalex.org/W2136528478","https://openalex.org/W2137889809","https://openalex.org/W2158325944","https://openalex.org/W2165453779","https://openalex.org/W2171467827","https://openalex.org/W2211969327","https://openalex.org/W2408595588","https://openalex.org/W2416924784","https://openalex.org/W2479137001","https://openalex.org/W2547063904","https://openalex.org/W2581095595","https://openalex.org/W2762997972","https://openalex.org/W2793304002","https://openalex.org/W2804425744","https://openalex.org/W2896165936","https://openalex.org/W2896261211","https://openalex.org/W3003605960","https://openalex.org/W3010498689","https://openalex.org/W4242516986"],"related_works":["https://openalex.org/W3118258733","https://openalex.org/W1801904186","https://openalex.org/W3197192305","https://openalex.org/W2978981344","https://openalex.org/W3159307586","https://openalex.org/W1983198703","https://openalex.org/W3154302066","https://openalex.org/W1974073285","https://openalex.org/W2333750700","https://openalex.org/W184469848"],"abstract_inverted_index":{"Alpha-mangostin":[0],"(M)":[1],"and":[2,21,37,44,50,59,82,91,105,132,137,145,148,168,174,195,214,231],"resveratrol":[3],"(R),":[4],"dual-drugs-loaded":[5],"mucoadhesive":[6,63],"thiolated":[7,160],"chitosan-based":[8],"nanoparticles":[9],"(NPs)":[10],"coated":[11,38],"by":[12,32],"Eudragit\u00ae":[13],"S100":[14],"(S)":[15],"were":[16,30,55,70,84,95,197],"developed":[17],"for":[18,86,244],"colon-specific":[19],"delivery":[20],"synergistic":[22,88,221,233],"activity":[23,74,207],"against":[24,75,208],"colon":[25,76,173,180,209,248],"cancer":[26,77,181,210],"cells.":[27,182,211],"The":[28,41,57,111,183,223],"NPs":[29,48,83,93,189,227],"prepared":[31],"the":[33,52,73,141,151,163,172,179,201,245],"ionotropic":[34],"gelation":[35],"method":[36],"with":[39,99],"S.":[40],"particle":[42,118],"size":[43],"zeta":[45,106,123],"potential":[46,107],"of":[47,79,101,108,114,188,247],"before":[49],"after":[51],"coating":[53,113],"process":[54],"observed.":[56],"M":[58,90,131,136,147,167,194,213],"R":[60,133,138,149,169,196,215],"loading":[61,216],"efficiency,":[62],"properties,":[64],"as":[65,67],"well":[66],"release":[68,139],"patterns":[69],"examined.":[71],"Moreover,":[72,212],"cells":[78],"M,":[80],"R,":[81],"studied":[85],"their":[87],"activity.":[89],"R-loaded":[92],"(MR-TNPs)":[94],"spherical":[96],"in":[97,130,166,171,240],"shape":[98],"sizes":[100,119],"around":[102],"540":[103],"nm":[104],"+39":[109],"mV.":[110],"S":[112,153],"MR-TNPs":[115],"provided":[116],"larger":[117],"which":[120,203],"offered":[121],"lower":[122],"potential.":[124],"However,":[125],"it":[126],"created":[127],"an":[128],"increase":[129],"loading,":[134],"prevented":[135],"at":[140,155,217],"upper":[142],"gastrointestinal":[143],"tract,":[144],"enhanced":[146],"reaching":[150],"colon.":[152],"dissolved":[154],"pH":[156],">":[157],"7.0":[158],"while":[159],"chitosan":[161],"formed":[162],"mucoadhesion,":[164],"resulting":[165],"remaining":[170],"allowing":[175],"them":[176],"to":[177],"enter":[178],"half-maximal":[184],"inhibitory":[185],"concentration":[186],"values":[187],"was":[190],"dramatically":[191],"decreased":[192],"when":[193],"dually":[198],"loaded":[199,229],"into":[200],"NPs,":[202],"indicated":[204],"significantly":[205],"higher":[206],"this":[218],"ratio":[219],"applied":[220],"efficiency.":[222,234],"results":[224],"illustrated":[225],"that":[226],"successfully":[228],"drugs":[230],"achieved":[232],"This":[235],"system":[236],"could":[237],"be":[238],"promising":[239],"facilitating":[241],"targeted":[242],"nanomedicines":[243],"treatment":[246],"cancer.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
