{"id":"https://openalex.org/W4200515425","doi":"https://doi.org/10.1093/jjco/hyab187","title":"Management of bladder cancer in older patients","display_name":"Management of bladder cancer in older patients","publication_year":2021,"publication_date":"2021-11-27","ids":{"openalex":"https://openalex.org/W4200515425","doi":"https://doi.org/10.1093/jjco/hyab187","pmid":"https://pubmed.ncbi.nlm.nih.gov/34905776"},"language":"en","primary_location":{"id":"doi:10.1093/jjco/hyab187","doi":"https://doi.org/10.1093/jjco/hyab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jjco/hyab187","pdf_url":"https://academic.oup.com/jjco/article-pdf/52/3/203/42688189/hyab187.pdf","source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jjco/article-pdf/52/3/203/42688189/hyab187.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011348912","display_name":"Shingo Hatakeyama","orcid":"https://orcid.org/0000-0002-0026-4079","observed_orcids":["https://orcid.org/0000-0002-0026-4079"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shingo Hatakeyama","raw_affiliation_strings":["Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0026-4079","affiliations":[{"raw_affiliation_string":"Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047951647","display_name":"Shintaro Narita","orcid":"https://orcid.org/0000-0003-2988-1860","observed_orcids":["https://orcid.org/0000-0003-2988-1860"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro Narita","raw_affiliation_strings":["Department of Urology, Akita University Graduate School of Medicine, Akita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Akita University Graduate School of Medicine, Akita, Japan","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112753941","display_name":"Kazutaka Okita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutaka Okita","raw_affiliation_strings":["Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044499778","display_name":"Takuma Narita","orcid":"https://orcid.org/0000-0003-2572-3590","observed_orcids":["https://orcid.org/0000-0003-2572-3590"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuma Narita","raw_affiliation_strings":["Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000448586","display_name":"Hiromichi Iwamura","orcid":"https://orcid.org/0000-0003-0304-4650","observed_orcids":["https://orcid.org/0000-0003-0304-4650"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Iwamura","raw_affiliation_strings":["Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034118045","display_name":"Naoki Fujita","orcid":"https://orcid.org/0000-0001-8284-9582","observed_orcids":["https://orcid.org/0000-0001-8284-9582","https://orcid.org/0009-0002-1035-6660"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Fujita","raw_affiliation_strings":["Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044851719","display_name":"Junichi Inokuchi","orcid":"https://orcid.org/0000-0002-6791-905X","observed_orcids":["https://orcid.org/0000-0002-6791-905X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Inokuchi","raw_affiliation_strings":["Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030468520","display_name":"Yoshiyuki Matsui","orcid":"https://orcid.org/0000-0002-2953-7085","observed_orcids":["https://orcid.org/0000-0002-2953-7085"]},"institutions":[{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Matsui","raw_affiliation_strings":["Department of Urology, National Cancer Center Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943302","display_name":"Hiroshi Kitamura","orcid":"https://orcid.org/0000-0002-1592-931X","observed_orcids":["https://orcid.org/0000-0002-1592-931X","https://orcid.org/0000-0002-7678-6113"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kitamura","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076273759","display_name":"Chikara \u039fhyama","orcid":"https://orcid.org/0000-0003-1550-8379","observed_orcids":["https://orcid.org/0000-0003-1550-8379"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikara Ohyama","raw_affiliation_strings":["Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011348912"],"corresponding_institution_ids":["https://openalex.org/I146516829"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":null,"fwci":2.2618,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.87181691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"3","first_page":"203","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8399999737739563},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.902999997138977},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7820000052452087},{"id":"https://openalex.org/keywords/muscle-invasive-bladder-cancer","display_name":"muscle-invasive bladder cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/radical-cystectomy","display_name":"radical cystectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trimodality-therapy","display_name":"trimodality therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cisplatin-based-chemotherapy","display_name":"cisplatin-based chemotherapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/geriatric-assessment","display_name":"geriatric assessment","score":0.8880000114440918},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.8830000162124634},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.946715235710144},{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.8922591805458069},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8226356506347656},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5031642317771912},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.49925780296325684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47240370512008667},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.4450942277908325},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.43626269698143005},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4273267090320587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.374573290348053},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3535352349281311},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27579936385154724},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.08725830912590027}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015653","descriptor_name":"Cystectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jjco/hyab187","doi":"https://doi.org/10.1093/jjco/hyab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jjco/hyab187","pdf_url":"https://academic.oup.com/jjco/article-pdf/52/3/203/42688189/hyab187.pdf","source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:34905776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34905776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jjco/hyab187","doi":"https://doi.org/10.1093/jjco/hyab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jjco/hyab187","pdf_url":"https://academic.oup.com/jjco/article-pdf/52/3/203/42688189/hyab187.pdf","source":{"id":"https://openalex.org/S149902429","display_name":"Japanese Journal of Clinical Oncology","issn_l":"0368-2811","issn":["0368-2811","1465-3621"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1977551817","display_name":"Development of a novel diagnostic method for urothelial carcinoma targeting urinary activated protein kinase C-alpha","funder_award_id":"19K09692","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G313206198","display_name":"\u65e2\u5b58\u816b\u760d\u30de\u30fc\u30ab\u30fc\u3092\u51cc\u99d5\u3059\u308b\u7cd6\u9396\u6027\u7cbe\u5de3\u816b\u760d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a","funder_award_id":"20K18130","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5795922988","display_name":null,"funder_award_id":"19H05556","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8362266089","display_name":null,"funder_award_id":"20K09517","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200515425.pdf","grobid_xml":"https://content.openalex.org/works/W4200515425.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1526147649","https://openalex.org/W1785081313","https://openalex.org/W1800122197","https://openalex.org/W1966304386","https://openalex.org/W1999472020","https://openalex.org/W2000269490","https://openalex.org/W2029172571","https://openalex.org/W2029790306","https://openalex.org/W2035993858","https://openalex.org/W2039011810","https://openalex.org/W2044941273","https://openalex.org/W2045154422","https://openalex.org/W2050103286","https://openalex.org/W2085826031","https://openalex.org/W2100115521","https://openalex.org/W2105092978","https://openalex.org/W2120955645","https://openalex.org/W2130930958","https://openalex.org/W2137405016","https://openalex.org/W2152189242","https://openalex.org/W2152762320","https://openalex.org/W2164059021","https://openalex.org/W2215839952","https://openalex.org/W2276379184","https://openalex.org/W2285811057","https://openalex.org/W2338667772","https://openalex.org/W2498336860","https://openalex.org/W2507525628","https://openalex.org/W2559804019","https://openalex.org/W2560843041","https://openalex.org/W2570312348","https://openalex.org/W2582671354","https://openalex.org/W2604619953","https://openalex.org/W2605794623","https://openalex.org/W2608995078","https://openalex.org/W2647663291","https://openalex.org/W2726527838","https://openalex.org/W2737546054","https://openalex.org/W2748705437","https://openalex.org/W2756189317","https://openalex.org/W2781043244","https://openalex.org/W2792709784","https://openalex.org/W2796060832","https://openalex.org/W2796194038","https://openalex.org/W2810144280","https://openalex.org/W2901549429","https://openalex.org/W2903843329","https://openalex.org/W2905500595","https://openalex.org/W2914575742","https://openalex.org/W2941090869","https://openalex.org/W2943108118","https://openalex.org/W2944413955","https://openalex.org/W2968353979","https://openalex.org/W2973223476","https://openalex.org/W2978508348","https://openalex.org/W2995340453","https://openalex.org/W3005057004","https://openalex.org/W3023288864","https://openalex.org/W3024501020","https://openalex.org/W3030624469","https://openalex.org/W3033617360","https://openalex.org/W3033960264","https://openalex.org/W3034032493","https://openalex.org/W3035827764","https://openalex.org/W3036701611","https://openalex.org/W3045981731","https://openalex.org/W3083253328","https://openalex.org/W3087466624","https://openalex.org/W3113007489","https://openalex.org/W3118434887","https://openalex.org/W3120770925","https://openalex.org/W3124827128","https://openalex.org/W3134072224","https://openalex.org/W3134079634","https://openalex.org/W3148869077","https://openalex.org/W3156045803","https://openalex.org/W3159611165","https://openalex.org/W3165120554","https://openalex.org/W3169202067","https://openalex.org/W3182456480","https://openalex.org/W3198699950","https://openalex.org/W3200773128","https://openalex.org/W3201595862","https://openalex.org/W3202867176","https://openalex.org/W4242669880"],"related_works":["https://openalex.org/W4401304446","https://openalex.org/W851976164","https://openalex.org/W6921369929","https://openalex.org/W3190736399","https://openalex.org/W2344911612","https://openalex.org/W2991316870","https://openalex.org/W2072143254","https://openalex.org/W4211215397","https://openalex.org/W1785081313","https://openalex.org/W2004065537"],"abstract_inverted_index":{"Evidence":[0],"has":[1,46,117],"shown":[2],"that":[3,22,101,180],"patients":[4,30,58,89,173,194,210],"with":[5,16,18,31,90,174,211],"bladder":[6,33,68,79,94,212],"cancer":[7,213],"are":[8,26,36],"diagnosed":[9],"at":[10],"a":[11,184],"much":[12],"older":[13,29,87,158,209],"age":[14],"compared":[15],"those":[17,57],"other":[19],"cancers.":[20],"Given":[21],"co-morbidities":[23],"and":[24,154,159,204],"frailty":[25,181,203],"prevalent":[27],"in":[28,66,156,172,187],"advanced":[32,142],"cancer,":[34,80],"they":[35],"easily":[37],"excluded":[38],"from":[39],"randomized":[40],"controlled":[41],"trials.":[42],"As":[43],"little":[44],"evidence":[45,178],"been":[47,118,137],"available":[48],"regarding":[49],"assessment":[50,218],"tools":[51],"for":[52,78,107,129,141,198,219],"frailty,":[53],"the":[54,74,125,138,188],"management":[55],"of":[56,76,86,190],"remains":[59],"challenging.":[60],"This":[61],"weakness":[62],"is":[63,73,82,98,104],"strongly":[64],"manifested":[65],"muscle-invasive":[67,93],"cancer.":[69,95],"Despite":[70],"radical":[71,102],"cystectomy":[72,103],"standard":[75,199],"care":[77],"there":[81],"an":[83,121],"extensive":[84],"undertreatment":[85],"adult":[88],"potentially":[91],"curative":[92],"However,":[96],"it":[97],"also":[99],"true":[100],"often":[105],"unsuitable":[106],"vulnerable":[108],"or":[109,164],"frail":[110],"patients.":[111,146,161],"Bladder":[112],"preservation":[113],"using":[114],"trimodality":[115,130],"therapy":[116,131],"utilized":[119],"as":[120],"alternative":[122],"option,":[123],"but":[124],"appropriate":[126],"selection":[127,189],"criteria":[128],"remain":[132],"unclear.":[133],"Cisplatin-based":[134],"regimens":[135],"have":[136,151],"first":[139],"choice":[140],"disease":[143],"among":[144],"eligible":[145],"Moreover,":[147,208],"immunotherapy":[148],"appears":[149],"to":[150,168,215],"similar":[152],"benefits":[153],"tolerability":[155],"both":[157],"younger":[160],"Furthermore,":[162],"palliative":[163],"supportive":[165],"interventions":[166],"need":[167,214],"be":[169,196],"initiated":[170],"earlier":[171],"metastatic":[175],"disease.":[176],"Accumulating":[177],"suggests":[179],"may":[182],"play":[183],"key":[185],"role":[186],"treatment":[191,200],"modalities.":[192],"Older":[193],"should":[195],"considered":[197],"based":[201],"on":[202],"not":[205],"chronological":[206],"age.":[207],"undergo":[216],"geriatric":[217],"proper":[220],"decision-making.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-12-31T00:00:00"}
