{"id":"https://openalex.org/W4200485141","doi":"https://doi.org/10.1038/s41598-021-03215-w","title":"Biological features between miRNAs and their targets are unveiled from deep learning models","display_name":"Biological features between miRNAs and their targets are unveiled from deep learning models","publication_year":2021,"publication_date":"2021-12-10","ids":{"openalex":"https://openalex.org/W4200485141","doi":"https://doi.org/10.1038/s41598-021-03215-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/34893648","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8664955"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-03215-w","doi":"https://doi.org/10.1038/s41598-021-03215-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-03215-w","pdf_url":"https://www.nature.com/articles/s41598-021-03215-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-03215-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078632663","display_name":"Tongjun Gu","orcid":"https://orcid.org/0000-0002-8379-0962","observed_orcids":["https://orcid.org/0000-0002-8379-0962"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tongjun Gu","raw_affiliation_strings":["Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA. tgu@ufl.edu","Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, 2033 Mowry Road, Gainesville, FL, 32610, USA. tgu@ufl.edu","Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, USA","Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA. tgu@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, 2033 Mowry Road, Gainesville, FL, 32610, USA. tgu@ufl.edu","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051515439","display_name":"Mingyi Xie","orcid":"https://orcid.org/0000-0001-7955-197X","observed_orcids":["https://orcid.org/0000-0001-7955-197X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyi Xie","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA","Genetics Institute, University of Florida, Gainesville, FL, USA","University of Florida Health Cancer Center, University of Florida, Gainesville, FL, USA","Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, USA","Genetics Institute, University of Florida, Gainesville, USA","University of Florida Health Cancer Center, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Genetics Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Health Cancer Center, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Genetics Institute, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Health Cancer Center, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020333008","display_name":"W. Brad Barbazuk","orcid":"https://orcid.org/0000-0002-0909-4563","observed_orcids":["https://orcid.org/0000-0002-0909-4563"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Brad Barbazuk","raw_affiliation_strings":["Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA","Department of Biology, University of Florida, Gainesville, FL, USA","Genetics Institute, University of Florida, Gainesville, FL, USA","Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, USA","Department of Biology, University of Florida, Gainesville, USA","Genetics Institute, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Biology, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Genetics Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Bioinformatics, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Biology, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Genetics Institute, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100413485","display_name":"Ji\u2010Hyun Lee","orcid":"https://orcid.org/0000-0001-6420-5150","observed_orcids":["https://orcid.org/0000-0001-6420-5150","https://orcid.org/0000-0003-0450-2879"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ji-Hyun Lee","raw_affiliation_strings":["Department of Biostatistics, University of Florida, Gainesville, FL, USA. jihyun.lee@ufl.edu","Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, 2033 Mowry Road, Gainesville, FL, 32610, USA. jihyun.lee@ufl.edu","Department of Biostatistics, University of Florida, Gainesville, USA","Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, Gainesville, FL, USA. jihyun.lee@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, 2033 Mowry Road, Gainesville, FL, 32610, USA. jihyun.lee@ufl.edu","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"Department of Biostatistics, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Division of Quantitative Sciences, University of Florida Health Cancer Center, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078632663","https://openalex.org/A5100413485"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":0.2608,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.42336017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"23825","last_page":"23825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mirna-target-prediction","display_name":"miRNA target prediction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mirna-target-interactions","display_name":"miRNA-target interactions","score":0.9509999752044678},{"id":"https://openalex.org/keywords/convolutional-neural-networks","display_name":"convolutional neural networks","score":0.8370000123977661},{"id":"https://openalex.org/keywords/recurrent-neural-networks","display_name":"recurrent neural networks","score":1.0},{"id":"https://openalex.org/keywords/hybrid-deep-learning","display_name":"hybrid deep learning model","score":0.7149999737739563},{"id":"https://openalex.org/keywords/seed-region","display_name":"seed region","score":0.9350000023841858},{"id":"https://openalex.org/keywords/free-energy","display_name":"free energy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/biological-characteristics","display_name":"biological characteristics","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.7990006804466248},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6800940036773682},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6597306728363037},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6499530076980591},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5492083430290222},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5401851534843445},{"id":"https://openalex.org/C147168706","wikidata":"https://www.wikidata.org/wiki/Q1457734","display_name":"Recurrent neural network","level":3,"score":0.5353876352310181},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4343724846839905},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42686256766319275},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.4168529808521271},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3775247633457184},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.32878005504608154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24600884318351746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19161760807037354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06023260951042175},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-021-03215-w","doi":"https://doi.org/10.1038/s41598-021-03215-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-03215-w","pdf_url":"https://www.nature.com/articles/s41598-021-03215-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-797646/v1","doi":"https://doi.org/10.21203/rs.3.rs-797646/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-797646/v1","pdf_url":"https://www.researchsquare.com/article/rs-797646/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8664955","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8664955","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:34893648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34893648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:32a017c1741243c2b76b316994c64cd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32a017c1741243c2b76b316994c64cd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-03215-w","doi":"https://doi.org/10.1038/s41598-021-03215-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-03215-w","pdf_url":"https://www.nature.com/articles/s41598-021-03215-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5162587204","display_name":null,"funder_award_id":"21L03","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"},{"id":"https://openalex.org/G9000920957","display_name":"Molecular mechanisms for regulating microRNA levels in metazoans","funder_award_id":"R35GM128753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200485141.pdf","grobid_xml":"https://content.openalex.org/works/W4200485141.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1583837637","https://openalex.org/W1744683414","https://openalex.org/W1974254202","https://openalex.org/W1989493946","https://openalex.org/W2001508508","https://openalex.org/W2059073003","https://openalex.org/W2120456037","https://openalex.org/W2163199119","https://openalex.org/W2170446948","https://openalex.org/W2198606573","https://openalex.org/W2605409611","https://openalex.org/W2657631929","https://openalex.org/W2765950793","https://openalex.org/W2806518291","https://openalex.org/W2809363952","https://openalex.org/W2884170967","https://openalex.org/W2888358121","https://openalex.org/W2893880892","https://openalex.org/W2896829849","https://openalex.org/W2919115771","https://openalex.org/W2932585799","https://openalex.org/W2962928958","https://openalex.org/W3116286104","https://openalex.org/W3135697420","https://openalex.org/W3146360245","https://openalex.org/W4211064852","https://openalex.org/W6604578553"],"related_works":["https://openalex.org/W3135697420","https://openalex.org/W2884170967","https://openalex.org/W3206717311","https://openalex.org/W2806518291","https://openalex.org/W4405917718","https://openalex.org/W4404328723","https://openalex.org/W2949901326","https://openalex.org/W7139982964","https://openalex.org/W2344280239","https://openalex.org/W4412823215"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,33,172],"~":[3],"22":[4],"nucleotide":[5],"ubiquitous":[6],"gene":[7],"regulators.":[8],"They":[9],"modulate":[10],"a":[11,44],"broad":[12],"range":[13],"of":[14,70,110,133,199],"essential":[15],"cellular":[16],"processes":[17],"linked":[18],"to":[19,196],"human":[20],"health":[21],"and":[22,28,78,113,130],"diseases.":[23,39],"Consequently,":[24],"identifying":[25],"miRNA":[26,37,54],"targets":[27],"understanding":[29,198],"how":[30],"they":[31],"function":[32],"critical":[34],"for":[35,52],"treating":[36],"associated":[38],"In":[40,96],"our":[41,176],"earlier":[42],"work,":[43],"hybrid":[45],"deep":[46,71,169,189],"learning-based":[47],"approach":[48,65],"(miTAR)":[49],"was":[50],"developed":[51],"predicting":[53],"targets.":[55],"It":[56],"performs":[57],"substantially":[58],"better":[59],"than":[60],"the":[61,84,97,108,114,124,128,134,140,144,154,158,166,180,197,200],"existing":[62],"methods.":[63],"The":[64],"integrates":[66],"two":[67],"major":[68],"types":[69],"learning":[72,170,190],"algorithms:":[73],"convolutional":[74],"neural":[75,80],"networks":[76,81],"(CNNs)":[77],"recurrent":[79],"(RNNs).":[82],"However,":[83],"features":[85,182],"in":[86,123,146,183,202],"miRNA:target":[87,125,184,203],"interactions":[88],"learned":[89],"by":[90],"miTAR":[91,103],"have":[92],"not":[93],"been":[94],"investigated.":[95],"current":[98],"study,":[99],"we":[100],"demonstrated":[101],"that":[102,179],"captures":[104],"known":[105],"features,":[106,122],"including":[107],"involvement":[109],"seed":[111],"region":[112],"free":[115,141],"energy,":[116],"as":[117,119],"well":[118],"multiple":[120],"novel":[121],"interactions.":[126,204],"Interestingly,":[127],"CNN":[129,159],"RNN":[131,147],"layers":[132],"model":[135],"perform":[136],"differently":[137],"at":[138,152,164],"capturing":[139,153,165],"energy":[142],"feature:":[143],"units":[145],"layer":[148,160],"is":[149,161],"more":[150,162],"unique":[151],"feature":[155],"but":[156],"collectively":[157],"efficient":[163],"feature.":[167],"Although":[168],"models":[171],"commonly":[173],"thought":[174],"\"black-boxes\",":[175],"discoveries":[177],"support":[178],"biological":[181],"can":[185],"be":[186,194],"unveiled":[187],"from":[188],"models,":[191],"which":[192],"will":[193],"beneficial":[195],"mechanisms":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-12-31T00:00:00"}
