{"id":"https://openalex.org/W4200480555","doi":"https://doi.org/10.1093/geroni/igab046.623","title":"Genetic Variants Correlate With Better Processing Speed","display_name":"Genetic Variants Correlate With Better Processing Speed","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200480555","doi":"https://doi.org/10.1093/geroni/igab046.623"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igab046.623","doi":"https://doi.org/10.1093/geroni/igab046.623","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igab046.623","pdf_url":"https://academic.oup.com/innovateage/article-pdf/5/Supplement_1/162/43179187/igab046.623.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/5/Supplement_1/162/43179187/igab046.623.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020101661","display_name":"Zeyuan Song","orcid":"https://orcid.org/0000-0002-7352-4177","observed_orcids":["https://orcid.org/0000-0002-7352-4177"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeyuan Song","raw_affiliation_strings":["Boston University School of Public Health, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024778544","display_name":"Anastasia Gurinovich","orcid":"https://orcid.org/0000-0001-9808-9397","observed_orcids":["https://orcid.org/0000-0001-9808-9397"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia Gurinovich","raw_affiliation_strings":["Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019626205","display_name":"Kaare Christensen","orcid":"https://orcid.org/0000-0002-5429-5292","observed_orcids":["https://orcid.org/0000-0002-5429-5292"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kaare Christensen","raw_affiliation_strings":["Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052975905","display_name":"Marianne Nygaard","orcid":"https://orcid.org/0000-0003-0703-2665","observed_orcids":["https://orcid.org/0000-0003-0703-2665"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marianne Nygaard","raw_affiliation_strings":["Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017000677","display_name":"Jonas Mengel\u2010From","orcid":"https://orcid.org/0000-0003-1573-8908","observed_orcids":["https://orcid.org/0000-0003-1573-8908"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonas Mengel-From","raw_affiliation_strings":["Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102850471","display_name":"Stacy L. Andersen","orcid":"https://orcid.org/0000-0002-2442-6386","observed_orcids":["https://orcid.org/0000-0002-2442-6386"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy Andersen","raw_affiliation_strings":["Boston University School of Medicine, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University School of Medicine, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031579243","display_name":"Thomas T. Perls","orcid":"https://orcid.org/0000-0002-2492-4334","observed_orcids":["https://orcid.org/0000-0002-2492-4334","https://orcid.org/0000-0003-1545-1720"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Perls","raw_affiliation_strings":["Boston University, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003627453","display_name":"Paola Sebastiani B","orcid":"https://orcid.org/0000-0001-6419-1545","observed_orcids":["https://orcid.org/0000-0001-6419-1545"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Sebastiani","raw_affiliation_strings":["Tufts Medical Center, Physician Organization, BOSTON, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medical Center, Physician Organization, BOSTON, Massachusetts, United States","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3493,"currency":"USD","value_usd":3493},"apc_paid":{"value":3493,"currency":"USD","value_usd":3493},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Supplement_1","first_page":"162","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.9980000257492065},{"id":"https://openalex.org/keywords/digit-symbol-substitution-test","display_name":"Digit Symbol Substitution Test","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.8579999804496765},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7160000205039978},{"id":"https://openalex.org/keywords/long-life-family-study","display_name":"Long Life Family Study","score":0.8989999890327454},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.6779999732971191},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.8629999756813049},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-beta","display_name":"retinoic acid receptor beta","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cognitive-resilience","display_name":"cognitive resilience","score":0.5759999752044678},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6782728433609009},{"id":"https://openalex.org/C2777965283","wikidata":"https://www.wikidata.org/wiki/Q5275755","display_name":"Digit symbol substitution test","level":4,"score":0.6746628284454346},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6566103100776672},{"id":"https://openalex.org/C164622146","wikidata":"https://www.wikidata.org/wiki/Q9035","display_name":"Danish","level":2,"score":0.6436513662338257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4921833574771881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43307602405548096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3500140309333801},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3156593441963196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1737225353717804},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12249293923377991},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/geroni/igab046.623","doi":"https://doi.org/10.1093/geroni/igab046.623","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igab046.623","pdf_url":"https://academic.oup.com/innovateage/article-pdf/5/Supplement_1/162/43179187/igab046.623.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8682555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8682555","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/6fde91be-0629-44c5-af2b-34a01b26f67c","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/6fde91be-0629-44c5-af2b-34a01b26f67c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gurinovich, A, Christensen, K, Nygaard, M, Mengel-From, J, Andersen, S L, Perls, T T, Sebastiani, P & Song, Z 2021, 'Genetic Variants Correlate With Better Processing Speed', Innovation in Aging, vol. 5, no. Suppl. 1, pp. 163-164. https://doi.org/10.1093/geroni/igab046.623","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1093/geroni/igab046.623","doi":"https://doi.org/10.1093/geroni/igab046.623","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igab046.623","pdf_url":"https://academic.oup.com/innovateage/article-pdf/5/Supplement_1/162/43179187/igab046.623.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200480555.pdf","grobid_xml":"https://content.openalex.org/works/W4200480555.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4318447245","https://openalex.org/W2199541209","https://openalex.org/W2539349626","https://openalex.org/W2051289128","https://openalex.org/W7169602409","https://openalex.org/W4200317110","https://openalex.org/W2056077634","https://openalex.org/W1945532630","https://openalex.org/W2019258139","https://openalex.org/W1977988147"],"abstract_inverted_index":{"Abstract":[0],"Some":[1],"cognitive":[2,214],"abilities,":[3],"such":[4,14],"as":[5,15,82],"vocabulary,":[6],"are":[7],"resilient":[8],"to":[9,53,111,129,213],"brain":[10],"aging,":[11],"while":[12],"others":[13],"conceptual":[16],"reasoning,":[17],"memory,":[18],"and":[19,25,73,85,121,146,209],"processing":[20,39,175,232],"speed,":[21],"decline":[22,29],"with":[23,60,91,118,173,177,230],"age":[24,84],"their":[26,74],"rate":[27],"of":[28,38,102,115,150,184],"is":[30],"genetically":[31],"regulated.":[32],"Despite":[33],"the":[34,43,112,123,130,141,147,195],"strong":[35],"genetic":[36,57,108,126,161,182,200],"heritability":[37],"speed":[40,176],"assessed":[41],"by":[42],"digit":[44],"symbol":[45],"substitution":[46],"test":[47],"(DSST),":[48],"previous":[49],"studies":[50],"have":[51,226],"failed":[52],"identify":[54],"robust":[55],"common":[56],"variants":[58,89,109,162,171,201,228],"associated":[59,90,172,229],"this":[61],"test.":[62],"The":[63,154,181],"Long":[64],"Life":[65],"Family":[66],"Study":[67,149],"(LLFS)":[68],"includes":[69],"long":[70],"lived":[71],"individuals":[72],"family":[75],"members":[76],"who":[77,86],"maintain":[78],"good":[79],"DSST":[80,103],"scores":[81],"they":[83],"may":[87],"carry":[88],"better":[92,174,231],"DSST.":[93],"We":[94],"therefore":[95],"conducted":[96],"a":[97],"genome-wide":[98,164],"association":[99],"study":[100],"(GWAS)":[101],"in":[104,156,189,194,219],"LLFS":[105,157,220],"using":[106,125],"~15M":[107],"imputed":[110,128],"HRC":[113],"panel":[114,136],"64,940":[116],"haplotypes":[117],"39,635,008":[119],"sites":[120],"replicated":[122,193],"findings":[124],"data":[127],"1000":[131],"Genomes":[132],"phase":[133],"3":[134,191],"reference":[135],"combining":[137],"two":[138,203,224],"Danish":[139,144,152,197],"cohorts:":[140],"Middle":[142],"Aged":[143],"Twins":[145],"Longitudinal":[148],"Aging":[151],"Twins.":[153],"GWAS":[155],"discovered":[158],"20":[159],"rare":[160],"reaching":[163],"significance":[165],"(p-value":[166],"<":[167],"5x10-8),":[168],"including":[169],"18":[170],"large":[178],"effect":[179],"size.":[180],"associations":[183],"rs7623455,":[185],"rs9821776,":[186],"rs9821587,":[187],"rs78704059":[188],"chromosome":[190],"were":[192],"combined":[196],"cohort.":[198],"These":[199],"tagged":[202],"hormone":[204],"receptor":[205],"related":[206,212],"genes,":[207],"THRB":[208],"RARB,":[210],"both":[211],"aging.":[215],"Further":[216],"gene-based":[217],"tests":[218],"confirmed":[221],"that":[222],"these":[223],"genes":[225],"protective":[227],"speed.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-12-31T00:00:00"}