{"id":"https://openalex.org/W4200475737","doi":"https://doi.org/10.1016/j.sjbs.2021.11.061","title":"Therapeutic potential of induced iron depletion using iron chelators in Covid-19","display_name":"Therapeutic potential of induced iron depletion using iron chelators in Covid-19","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4200475737","doi":"https://doi.org/10.1016/j.sjbs.2021.11.061","pmid":"https://pubmed.ncbi.nlm.nih.gov/34924800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8666385"},"language":"en","primary_location":{"id":"doi:10.1016/j.sjbs.2021.11.061","doi":"https://doi.org/10.1016/j.sjbs.2021.11.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2021.11.061","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X21010275/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1319562X21010275/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107944114","display_name":"Punnoth Poonkuzhi Naseef","orcid":"https://orcid.org/0000-0001-9692-6323","observed_orcids":["https://orcid.org/0000-0001-9692-6323"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Punnoth Poonkuzhi Naseef","raw_affiliation_strings":["Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052399997","display_name":"Muhammed Elayadeth\u2010Meethal","orcid":"https://orcid.org/0000-0003-0044-0762","observed_orcids":["https://orcid.org/0000-0003-0044-0762"]},"institutions":[{"id":"https://openalex.org/I335685885","display_name":"Kerala Veterinary and Animal Sciences University","ror":"https://ror.org/00rf3br26","country_code":"IN","type":"education","lineage":["https://openalex.org/I335685885"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Muhammed Elayadeth-Meethal","raw_affiliation_strings":["Department of Animal Breeding and Genetics, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, 673576, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Breeding and Genetics, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, 673576, Kerala, India","institution_ids":["https://openalex.org/I335685885"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K.T. Mohammed Salim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.T. Mohammed Salim","raw_affiliation_strings":["Department of Pharmacy Practice, Al Shifa College of Pharmacy, Malappuram, 679325, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Al Shifa College of Pharmacy, Malappuram, 679325, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112956069","display_name":"A Anjana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Anjana","raw_affiliation_strings":["Department of Pharmacy Practice, Al Shifa College of Pharmacy, Malappuram, 679325, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Al Shifa College of Pharmacy, Malappuram, 679325, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064235319","display_name":"C. Muhas","orcid":"https://orcid.org/0000-0002-3151-6742","observed_orcids":["https://orcid.org/0000-0002-3151-6742"]},"institutions":[{"id":"https://openalex.org/I4405262993","display_name":"K.T.N College of Pharmacy","ror":"https://ror.org/012dtws03","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262993"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C Muhas","raw_affiliation_strings":["Department of Pharmacy Practice, KTN College of Pharmacy, Chalavara, Palakkad, 679505, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, KTN College of Pharmacy, Chalavara, Palakkad, 679505, Kerala, India","institution_ids":["https://openalex.org/I4405262993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059951287","display_name":"K. Abdul Vajid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Abdul Vajid","raw_affiliation_strings":["Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, Kerala, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066989709","display_name":"Mohamed Saheer Kuruniyan","orcid":"https://orcid.org/0000-0003-3341-0914","observed_orcids":["https://orcid.org/0000-0003-3341-0914"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed Saheer Kuruniyan","raw_affiliation_strings":["Department of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107944114"],"corresponding_institution_ids":[],"apc_list":{"value":1250,"currency":"USD","value_usd":1250},"apc_paid":{"value":1250,"currency":"USD","value_usd":1250},"fwci":0.955,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.69401177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"4","first_page":"1947","last_page":"1956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.17239999771118164,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9819999933242798},{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hyperferritinemia","display_name":"hyperferritinemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.9490000009536743},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/deferiprone","display_name":"deferiprone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.7639999985694885},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antifibrotic-activity","display_name":"antifibrotic activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.800000011920929},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2776517179","wikidata":"https://www.wikidata.org/wiki/Q749664","display_name":"Deferiprone","level":3,"score":0.9470254182815552},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.9110883474349976},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.8817882537841797},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.7454409003257751},{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.6445688605308533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5829358100891113},{"id":"https://openalex.org/C2777218474","wikidata":"https://www.wikidata.org/wiki/Q1069061","display_name":"Chelation therapy","level":3,"score":0.5368868112564087},{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.4834040701389313},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.4755037724971771},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46492600440979004},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4500657320022583},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4347570538520813},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4250103831291199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32350635528564453},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2931830883026123},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.2683991491794586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1923428177833557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15263304114341736},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sjbs.2021.11.061","doi":"https://doi.org/10.1016/j.sjbs.2021.11.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2021.11.061","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X21010275/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8666385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8666385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi J Biol Sci","raw_type":"Text"},{"id":"pmid:34924800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34924800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi journal of biological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.sjbs.2021.11.061","doi":"https://doi.org/10.1016/j.sjbs.2021.11.061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2021.11.061","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X21010275/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5931360519","display_name":null,"funder_award_id":"RGP 2/ 191/42","funder_id":"https://openalex.org/F4320322804","funder_display_name":"Deanship of Scientific Research, King Faisal University"},{"id":"https://openalex.org/G751302319","display_name":null,"funder_award_id":"RGP2/191/42","funder_id":"https://openalex.org/F4320324433","funder_display_name":"King Khalid University"}],"funders":[{"id":"https://openalex.org/F4320322804","display_name":"Deanship of Scientific Research, King Faisal University","ror":"https://ror.org/00dn43547"},{"id":"https://openalex.org/F4320324433","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200475737.pdf","grobid_xml":"https://content.openalex.org/works/W4200475737.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W2002176673","https://openalex.org/W2127264578","https://openalex.org/W2152599602","https://openalex.org/W2293829826","https://openalex.org/W2560708839","https://openalex.org/W2609085690","https://openalex.org/W2609202736","https://openalex.org/W2616610956","https://openalex.org/W2617504457","https://openalex.org/W2617626520","https://openalex.org/W2739185028","https://openalex.org/W2739573556","https://openalex.org/W2739735509","https://openalex.org/W2762087180","https://openalex.org/W2773662309","https://openalex.org/W2783561367","https://openalex.org/W2790659043","https://openalex.org/W2799420761","https://openalex.org/W2802240071","https://openalex.org/W2808936950","https://openalex.org/W2809698024","https://openalex.org/W2886498462","https://openalex.org/W2889143556","https://openalex.org/W2890744142","https://openalex.org/W2897222476","https://openalex.org/W2899413530","https://openalex.org/W2900070653","https://openalex.org/W2912452700","https://openalex.org/W2913489164","https://openalex.org/W2915373590","https://openalex.org/W2916265250","https://openalex.org/W2916290398","https://openalex.org/W2921859884","https://openalex.org/W2933563665","https://openalex.org/W2936231616","https://openalex.org/W2938391787","https://openalex.org/W2939322913","https://openalex.org/W2941074881","https://openalex.org/W2944731734","https://openalex.org/W2947401288","https://openalex.org/W2953307741","https://openalex.org/W2954656622","https://openalex.org/W2961268319","https://openalex.org/W2973124663","https://openalex.org/W2978585643","https://openalex.org/W2980918949","https://openalex.org/W2987433176","https://openalex.org/W3000292609","https://openalex.org/W3002108456","https://openalex.org/W3003540192","https://openalex.org/W3003582320","https://openalex.org/W3009314935","https://openalex.org/W3009885589","https://openalex.org/W3010604545","https://openalex.org/W3012195391","https://openalex.org/W3012730855","https://openalex.org/W3014003872","https://openalex.org/W3014852814","https://openalex.org/W3015730757","https://openalex.org/W3016122671","https://openalex.org/W3016629198","https://openalex.org/W3016689661","https://openalex.org/W3017384966","https://openalex.org/W3018313805","https://openalex.org/W3019579920","https://openalex.org/W3022721402","https://openalex.org/W3023982717","https://openalex.org/W3026978282","https://openalex.org/W3029748790","https://openalex.org/W3032427039","https://openalex.org/W3033285830","https://openalex.org/W3035618713","https://openalex.org/W3036770059","https://openalex.org/W3037867966","https://openalex.org/W3042270788","https://openalex.org/W3043991886","https://openalex.org/W3045102697","https://openalex.org/W3045185192","https://openalex.org/W3084154531","https://openalex.org/W3087016145","https://openalex.org/W3091519160","https://openalex.org/W3106043047","https://openalex.org/W3108493784","https://openalex.org/W3108754299","https://openalex.org/W3112856787","https://openalex.org/W3114118983","https://openalex.org/W3120486688","https://openalex.org/W3121425062","https://openalex.org/W3123922203","https://openalex.org/W3126443531","https://openalex.org/W3134043178","https://openalex.org/W3153696101","https://openalex.org/W3158244175","https://openalex.org/W3158625303","https://openalex.org/W3159520268","https://openalex.org/W3165455377","https://openalex.org/W3165734168","https://openalex.org/W3169767588","https://openalex.org/W3170276420","https://openalex.org/W3176073834","https://openalex.org/W3179283620","https://openalex.org/W3183937587","https://openalex.org/W3185330418","https://openalex.org/W3185488876","https://openalex.org/W3186637638","https://openalex.org/W3196832642","https://openalex.org/W3201837432","https://openalex.org/W3203260835","https://openalex.org/W3203592520","https://openalex.org/W4234459037","https://openalex.org/W6697156131","https://openalex.org/W6752940142","https://openalex.org/W6774707739","https://openalex.org/W6775753634","https://openalex.org/W6778363829","https://openalex.org/W6786612724","https://openalex.org/W6789498443","https://openalex.org/W6795037018","https://openalex.org/W6796565850","https://openalex.org/W6801936360"],"related_works":["https://openalex.org/W3049632045","https://openalex.org/W3042676445","https://openalex.org/W3082388475","https://openalex.org/W3119520299","https://openalex.org/W3081924239","https://openalex.org/W3022379979","https://openalex.org/W3029018410","https://openalex.org/W3017384966","https://openalex.org/W4207022674","https://openalex.org/W3215174877"],"abstract_inverted_index":{"Ferritin,":[0],"which":[1],"includes":[2],"twenty-four":[3],"light":[4],"and":[5,29,34,37,50,57,79,92,148,166],"heavy":[6],"chains":[7],"in":[8,11,32,40],"varying":[9],"proportions":[10],"different":[12],"tissues,":[13],"is":[14,26,43,68],"primarily":[15],"responsible":[16],"for":[17,156,183],"maintaining":[18],"the":[19,46,66,164],"body's":[20],"iron":[21,87,112,152,170,174],"metabolism.":[22],"Its":[23],"normal":[24],"value":[25],"between":[27,35],"10":[28],"200":[30],"ngmL\u22121":[31,39],"men":[33],"30":[36],"300":[38],"women.":[41],"Iron":[42,73],"delivered":[44],"to":[45,85,100,136,150],"tissue":[47],"via":[48],"them,":[49],"they":[51],"act":[52],"as":[53,70,76,121,123,177],"immunomodulators,":[54],"signaling":[55],"molecules,":[56],"inflammatory":[58],"markers.":[59],"When":[60],"ferritin":[61,102],"level":[62],"exceeds":[63],"1000":[64,127],"\u00b5gL-1,":[65],"patient":[67],"categorized":[69],"having":[71],"hyperferritinemia.":[72],"chelators":[74],"such":[75],"deferiprone,":[77],"deferirox,":[78],"deferoxamine":[80,125],"are":[81],"currently":[82],"FDA":[83],"approved":[84],"treat":[86],"overload.":[88],"The":[89],"inflammation":[90],"cascade":[91],"poor":[93],"prognosis":[94],"of":[95,169],"COVID-19":[96,157],"may":[97],"be":[98,141],"attributed":[99],"high":[101],"levels.":[103],"Critically":[104],"ill":[105],"patients":[106],"can":[107,140],"benefit":[108],"from":[109],"deferasirox,":[110],"an":[111],"chelator":[113],"administered":[114],"orally":[115],"at":[116,126],"20\u201340":[117],"mgkg\u22121":[118],"once":[119],"daily,":[120],"well":[122],"intravenous":[124],"mg":[128,133],"initially":[129],"followed":[130],"by":[131],"500":[132],"every":[134],"4":[135],"12":[137],"h.":[138],"It":[139],"combined":[142],"with":[143],"monoclonal":[144],"antibodies,":[145],"antioxidants,":[146],"corticosteroids,":[147],"lactoferrin":[149],"make":[151],"chelation":[153],"therapy":[154,176],"effective":[155],"victims.":[158],"In":[159],"this":[160],"article,":[161],"we":[162],"analyze":[163],"antiviral":[165],"antifibrotic":[167],"activity":[168],"chelators,":[171],"thereby":[172],"promoting":[173],"depletion":[175],"a":[178],"potentially":[179],"innovative":[180],"treatment":[181],"strategy":[182],"COVID-19.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-12-31T00:00:00"}
