{"id":"https://openalex.org/W4200467167","doi":"https://doi.org/10.1093/ofid/ofab466.870","title":"673. Unbiased Microbial Cell-free DNA Next-Generation Sequencing Resolves HHV6 Variant Specificity and Demonstrates a Predominance of HHV6B over HHV6A in Real-World Clinical Experience","display_name":"673. Unbiased Microbial Cell-free DNA Next-Generation Sequencing Resolves HHV6 Variant Specificity and Demonstrates a Predominance of HHV6B over HHV6A in Real-World Clinical Experience","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200467167","doi":"https://doi.org/10.1093/ofid/ofab466.870"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofab466.870","doi":"https://doi.org/10.1093/ofid/ofab466.870","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.870","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4200467167"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofab466.870","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044938300","display_name":"Jose Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Alexander","raw_affiliation_strings":["Karius, Inc., Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc., Orlando, Florida","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037474512","display_name":"Sivan Bercovici","orcid":"https://orcid.org/0000-0002-4310-4868","observed_orcids":["https://orcid.org/0000-0002-4310-4868"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sivan Bercovici","raw_affiliation_strings":["Karius, Redwood City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Redwood City, California","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003676684","display_name":"Nicholas R. Degner","orcid":"https://orcid.org/0000-0003-4578-3726","observed_orcids":["https://orcid.org/0000-0003-4578-3726"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas R Degner","raw_affiliation_strings":["Karius Inc., San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius Inc., San Francisco, California","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017283910","display_name":"Ricardo Castillo-Galvan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Castillo-Galvan","raw_affiliation_strings":["Karius, Inc., Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc., Orlando, Florida","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057669149","display_name":"Aparna Arun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Arun","raw_affiliation_strings":["Karius, Inc., Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc., Orlando, Florida","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011693820","display_name":"Christiaan R. de Vries","orcid":"https://orcid.org/0000-0002-4667-5973","observed_orcids":["https://orcid.org/0000-0002-4667-5973"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christiaan R de Vries","raw_affiliation_strings":["Karius, Redwood City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Redwood City, California","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035980169","display_name":"Ann T. MacIntyre","orcid":"https://orcid.org/0000-0003-4410-113X","observed_orcids":["https://orcid.org/0000-0003-4410-113X"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Macintyre","raw_affiliation_strings":["Karius, Redwood City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Redwood City, California","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051228915","display_name":"Bradley A. Perkins","orcid":"https://orcid.org/0009-0003-4542-2805","observed_orcids":["https://orcid.org/0009-0003-4542-2805"]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley Perkins","raw_affiliation_strings":["Karius, Inc., Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc., Orlando, Florida","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107118866","display_name":"Asim A. Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asim A Ahmed","raw_affiliation_strings":["Karius, Inc, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc, Redwood City, CA","institution_ids":["https://openalex.org/I4405267391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088941685","display_name":"Matthew Smollin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267391","display_name":"Karius, Inc. (United States)","ror":"https://ror.org/02jemby36","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Smollin","raw_affiliation_strings":["Karius, Inc., Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karius, Inc., Orlando, Florida","institution_ids":["https://openalex.org/I4405267391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405267391"],"apc_list":{"value":3465,"currency":"USD","value_usd":3465},"apc_paid":{"value":3465,"currency":"USD","value_usd":3465},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"Supplement_1","first_page":"S438","last_page":"S439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.9520000219345093},{"id":"https://openalex.org/keywords/plasma-cell-free-dna","display_name":"plasma cell-free DNA","score":0.6449999809265137},{"id":"https://openalex.org/keywords/karius-test","display_name":"Karius test","score":0.7149999737739563},{"id":"https://openalex.org/keywords/age-distribution-of-infection","display_name":"age distribution of infection","score":0.722000002861023},{"id":"https://openalex.org/keywords/viral-load-quantification","display_name":"viral load quantification","score":0.7839999794960022},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.42899999022483826},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.30799999833106995},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.5910000205039978},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.46299999952316284},{"id":"https://openalex.org/keywords/metagenomic-sequencing","display_name":"metagenomic sequencing","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6010754704475403},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5438310503959656},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.5379721522331238},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.49569475650787354},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.4483019709587097},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.42962098121643066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42021989822387695},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3856990933418274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3416685163974762},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3167862892150879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.310211181640625},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2924952507019043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2890470623970032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22803759574890137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20135384798049927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ofid/ofab466.870","doi":"https://doi.org/10.1093/ofid/ofab466.870","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.870","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofab466.870","doi":"https://doi.org/10.1093/ofid/ofab466.870","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.870","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007608712","https://openalex.org/W2092221540","https://openalex.org/W1965038289","https://openalex.org/W2122633160","https://openalex.org/W1989844967","https://openalex.org/W2161342571","https://openalex.org/W2115889739","https://openalex.org/W2118993092","https://openalex.org/W1564656636","https://openalex.org/W2289496256"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Human":[2],"herpesvirus":[3],"6":[4],"(HHV6)":[5],"has":[6],"been":[7],"classified":[8],"in":[9,44,121,209,237],"two":[10,94],"distinct":[11,17],"variants,":[12],"HHV6A":[13,34,190,197,224,251,279],"and":[14,22,62,83,119,139,160,191,198,204,225,280,315,325],"HHV6B.":[15,192],"Although":[16],"epidemiology,":[18],"disease":[19],"association,":[20],"biological":[21],"immunological":[23],"properties,":[24],"their":[25,201,205],"genomes":[26],"are":[27,89,158],"90%":[28,226],"homologous.":[29],"Less":[30],"is":[31,36,132,172],"known":[32],"about":[33],"which":[35],"typically":[37],"asymptomatic":[38],"but":[39,56],"can":[40,57],"cause":[41],"severe":[42],"infection":[43,52],"patients":[45],"with":[46,340],"neurological":[47],"disorders":[48],"or":[49,72],"HIV.":[50],"HHV6B":[51,228,231,261,281,301],"occurs":[53],"during":[54],"childhood,":[55],"reactivate":[58],"after":[59],"solid":[60],"organ":[61],"stem":[63],"cell":[64],"transplantation.":[65],"Antibody":[66],"assays":[67,88],"may":[68,110,329],"indicate":[69],"previous,":[70],"recent":[71],"current":[73],"infection.":[74],"Quantitative":[75],"PCR":[76,87,326],"cannot":[77],"differentiate":[78,92],"active":[79],"from":[80,129,176,183],"latent":[81],"infections":[82],"some":[84],"available":[85],"qualitative":[86],"unable":[90],"to":[91,143,169,185,245,302],"the":[93,167,173,259,289,334],"variants.":[95],"A":[96],"single":[97],"open-ended":[98,311],"test":[99],"through":[100,293],"plasma-based":[101],"microbial":[102],"cell-free":[103],"DNA":[104],"(mcfDNA)":[105],"metagenomic":[106,308],"next-generation":[107],"sequencing":[108,309],"(NGS)":[109],"overcome":[111],"these":[112],"limitations.":[113],"Methods":[114],"Karius":[115,356,361,369,377,383],"TestTM":[116],"(KT)":[117],"developed":[118],"validated":[120],"Karius\u2019s":[122],"CLIA":[123],"certified/CAP":[124],"accredited":[125],"lab,":[126],"detects":[127],"mcfDNA":[128,131,307],"plasma.":[130],"extracted,":[133],"NGS":[134],"performed,":[135],"human":[136],"sequences":[137,141],"removed":[138],"remaining":[140],"aligned":[142],"a":[144,155,233,240],"curated":[145],"pathogen":[146],"database":[147],"of":[148,165,189,196,219,272,278,288,300,306,317,336],">":[149,163],"1500":[150],"organisms.":[151],"Organisms":[152],"present":[153],"above":[154],"statistical":[156],"threshold":[157],"reported":[159],"quantified.":[161],"For":[162],"85%":[164],"tests":[166],"time":[168],"result":[170],"reporting":[171],"next":[174],"day":[175],"sample":[177],"receipt.":[178],"KT":[179,215,294,328],"results":[180],"were":[181,212,223],"reviewed":[182],"November-2018":[184],"May-2021":[186],"for":[187,310],"detections":[188],"The":[193,249,286,304],"comparative":[194],"incidence":[195],"HHVB":[199],"detections,":[200],"age":[202],"distributions":[203],"quantitative":[206],"viral":[207],"concentration":[208],"molecules/\u00b5L":[210],"(MPM)":[211],"assessed.":[213],"Results":[214],"detected":[216,292],"322":[217],"cases":[218],"HHV6;":[220],"10%":[221],"(n=32)":[222],"(n=290)":[227],"(Table":[229],"1).":[230,248],"had":[232],"higher":[234],"relative":[235],"abundance":[236],"children":[238],"(with":[239],"distribution":[241,287],"into":[242,333],"adolescence)":[243],"compared":[244],"adults":[246],"(Figure":[247],"average":[250,260],"MPM":[252,262],"was":[253,263],"860":[254],"(range":[255,265],"27":[256],"-":[257,267],"10,472);":[258],"3,361":[264],"21":[266],"131,518).":[268],"Table":[269],"1.":[270,276],"Summary":[271],"HHV-6":[273],"Detections":[274],"Figure":[275],"Distribution":[277],"by":[282],"Age":[283],"Group":[284],"Conclusion":[285],"HHV6":[290,318,338],"variants":[291,339],"shows":[295],"an":[296],"overwhelming":[297],"9:1":[298],"predominance":[299],"HHV6A.":[303],"application":[305],"detection,":[312],"variant":[313],"determination":[314],"quantification":[316],"provides":[319],"more":[320],"specific":[321,337],"resolution":[322],"than":[323],"serological":[324],"methods.":[327],"lend":[330],"important":[331],"insights":[332],"association":[335],"clinical":[341],"syndromes":[342],"affecting":[343],"vulnerable":[344],"populations.":[345],"Disclosures":[346],"Jose":[347],"Alexander,":[348],"MD,":[349,366,382,393,400],"D(ABMM),":[350],"FCCM,":[351],"CIC,":[352],"SM,":[353],"MB(ASCP),":[354],"BCMAS,":[355],"(Employee)":[357,362,384,390,396,403,409],"Sivan":[358],"Bercovici,":[359],"PhD,":[360],"Nicholas":[363],"R.":[364],"Degner,":[365],"MPH,":[367,376],"MS,":[368],"Inc.":[370,378,389,395,402,408],"(Employee,":[371],"Shareholder)":[372],"Ricardo":[373],"Castillo-Galvan,":[374],"MD":[375],"(Consultant)":[379],"Aparna":[380],"Arun,":[381],"Ann":[385],"Macintyre,":[386],"DO,":[387],"Karius,":[388,394,401,407],"Bradley":[391],"Perkins,":[392],"Asim":[397],"A.":[398],"Ahmed,":[399],"Matthew":[404],"Smollin,":[405],"PharmD,":[406]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-12-31T00:00:00"}