{"id":"https://openalex.org/W4200460925","doi":"https://doi.org/10.1016/j.ensci.2021.100384","title":"Zonisamide improves axial symptoms in dementia with Lewy bodies with parkinsonism: Post hoc analysis of clinical trials","display_name":"Zonisamide improves axial symptoms in dementia with Lewy bodies with parkinsonism: Post hoc analysis of clinical trials","publication_year":2021,"publication_date":"2021-12-07","ids":{"openalex":"https://openalex.org/W4200460925","doi":"https://doi.org/10.1016/j.ensci.2021.100384","pmid":"https://pubmed.ncbi.nlm.nih.gov/34988303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8703232"},"language":"en","primary_location":{"id":"doi:10.1016/j.ensci.2021.100384","doi":"https://doi.org/10.1016/j.ensci.2021.100384","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ensci.2021.100384","pdf_url":null,"source":{"id":"https://openalex.org/S2898211317","display_name":"eNeurologicalSci","issn_l":"2405-6502","issn":["2405-6502"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeurologicalSci","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ensci.2021.100384","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028175156","display_name":"Yoshio Tsuboi","orcid":"https://orcid.org/0000-0002-6758-0981","observed_orcids":["https://orcid.org/0000-0002-6758-0981"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshio Tsuboi","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078266284","display_name":"Kenji Kochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Kochi","raw_affiliation_strings":["Data Science, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018499375","display_name":"Hidenori Maruyama","orcid":"https://orcid.org/0000-0002-1356-8100","observed_orcids":["https://orcid.org/0000-0002-1356-8100"]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Maruyama","raw_affiliation_strings":["Medical Affairs, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009351503","display_name":"Yuji Matsumoto","orcid":"https://orcid.org/0000-0001-8901-2961","observed_orcids":["https://orcid.org/0000-0001-8901-2961"]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Matsumoto","raw_affiliation_strings":["Medical Affairs, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I31591830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028175156"],"corresponding_institution_ids":["https://openalex.org/I31784960"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"26","issue":null,"first_page":"100384","last_page":"100384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zonisamide","display_name":"zonisamide","score":1.0},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.9509999752044678},{"id":"https://openalex.org/keywords/axial-symptoms","display_name":"axial symptoms","score":0.996999979019165},{"id":"https://openalex.org/keywords/gait-and-balance","display_name":"gait and balance","score":0.847000002861023},{"id":"https://openalex.org/keywords/falls","display_name":"falls","score":0.5070000290870667},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.5550000071525574},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777138316","wikidata":"https://www.wikidata.org/wiki/Q219957","display_name":"Zonisamide","level":4,"score":0.9049360752105713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8095195889472961},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.7990396022796631},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.7326876521110535},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.5695008039474487},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5403734445571899},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5041526556015015},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.45342257618904114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4498077630996704},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44822177290916443},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.41731947660446167},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39835891127586365},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.39311766624450684},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.335960328578949},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.19607457518577576},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1842193901538849},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10040283203125},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ensci.2021.100384","doi":"https://doi.org/10.1016/j.ensci.2021.100384","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ensci.2021.100384","pdf_url":null,"source":{"id":"https://openalex.org/S2898211317","display_name":"eNeurologicalSci","issn_l":"2405-6502","issn":["2405-6502"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeurologicalSci","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8703232","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8703232/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8703232/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeurologicalSci","raw_type":"Text"},{"id":"pmid:34988303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34988303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeurologicalSci","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c1ff983c73644bf881dcfa6973e52d55","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c1ff983c73644bf881dcfa6973e52d55","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eNeurologicalSci, Vol 26, Iss , Pp 100384- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ensci.2021.100384","doi":"https://doi.org/10.1016/j.ensci.2021.100384","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ensci.2021.100384","pdf_url":null,"source":{"id":"https://openalex.org/S2898211317","display_name":"eNeurologicalSci","issn_l":"2405-6502","issn":["2405-6502"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eNeurologicalSci","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200460925.pdf","grobid_xml":"https://content.openalex.org/works/W4200460925.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1971135544","https://openalex.org/W1980774978","https://openalex.org/W1983875169","https://openalex.org/W2021640470","https://openalex.org/W2048855215","https://openalex.org/W2064689472","https://openalex.org/W2083449989","https://openalex.org/W2090385874","https://openalex.org/W2102572922","https://openalex.org/W2150328407","https://openalex.org/W2591811292","https://openalex.org/W2623521763","https://openalex.org/W2784949234","https://openalex.org/W2807915055","https://openalex.org/W2994939893","https://openalex.org/W3014856671","https://openalex.org/W3037562885","https://openalex.org/W3111912179","https://openalex.org/W4211253537","https://openalex.org/W4253194594"],"related_works":["https://openalex.org/W2994939893","https://openalex.org/W4389464530","https://openalex.org/W3111912179","https://openalex.org/W1594781653","https://openalex.org/W4389464492","https://openalex.org/W3183134657","https://openalex.org/W2791110743","https://openalex.org/W2784949234","https://openalex.org/W3158059323","https://openalex.org/W2512092937"],"abstract_inverted_index":{"Patients":[0],"with":[1,3,11,38,136,163],"dementia":[2],"Lewy":[4],"bodies":[5],"(DLB)":[6],"experience":[7],"worsening":[8],"axial":[9,68,90,129,159],"symptoms":[10,69,160],"disease":[12],"progression,":[13],"which":[14],"can":[15],"negatively":[16],"affect":[17],"quality":[18,176],"of":[19,50,65,97,112,149,172,177],"life.":[20],"Previous":[21],"phase":[22,56],"2":[23,57],"and":[24,58,123,141,174],"3":[25,59],"clinical":[26],"trials":[27,60],"conducted":[28],"in":[29,36,70,89,117,161,179],"Japan":[30],"showed":[31],"that":[32,155],"zonisamide":[33,66,156],"improved":[34],"parkinsonism":[35,164],"patients":[37,114],"DLB.":[39],"In":[40,74],"the":[41,54,63,78,82,95,128,170],"present":[42],"study,":[43],"we":[44],"performed":[45],"a":[46],"post":[47],"hoc":[48],"analysis":[49],"pooled":[51,76],"data":[52],"from":[53,84],"previous":[55],"to":[61,86,107],"examine":[62],"effect":[64],"on":[67],"this":[71,118,180],"patient":[72,182],"group.":[73],"our":[75],"analysis,":[77],"primary":[79],"outcome":[80],"was":[81],"change":[83],"baseline":[85],"12":[87,134],"weeks":[88],"symptom":[91,130],"score,":[92],"measured":[93],"as":[94],"sum":[96],"Unified":[98],"Parkinson's":[99],"Disease":[100],"Rating":[101],"Scale":[102],"Part":[103],"III":[104],"items":[105],"relevant":[106],"gait/balance/midline":[108],"function.":[109],"A":[110],"total":[111],"498":[113],"were":[115],"included":[116],"analysis.":[119],"Zonisamide":[120],"25":[121],"mg":[122,125],"50":[124],"significantly":[126],"reduced":[127],"score":[131],"at":[132],"week":[133],"compared":[135],"placebo":[137],"(p":[138],"<":[139,143],"0.01":[140],"p":[142],"0.001,":[144],"respectively,":[145],"by":[146],"mixed":[147],"model":[148],"repeated":[150],"measures).":[151],"Our":[152],"findings":[153],"indicate":[154],"may":[157,167],"improve":[158,175],"DLB":[162],"and,":[165],"thus,":[166],"potentially":[168],"reduce":[169],"risk":[171],"falls":[173],"life":[178],"vulnerable":[181],"population.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-12-31T00:00:00"}
