{"id":"https://openalex.org/W4200449873","doi":"https://doi.org/10.3389/fimmu.2021.765741","title":"Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms","display_name":"Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms","publication_year":2021,"publication_date":"2021-12-03","ids":{"openalex":"https://openalex.org/W4200449873","doi":"https://doi.org/10.3389/fimmu.2021.765741","pmid":"https://pubmed.ncbi.nlm.nih.gov/34925335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8678127"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.765741","doi":"https://doi.org/10.3389/fimmu.2021.765741","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.765741","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2021.765741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083629282","display_name":"Bettina Sehnert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bettina Sehnert","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015265264","display_name":"Sandy Pohle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandy Pohle","raw_affiliation_strings":["Department of Medicine 3, Friedrich-Alexander-University of Erlangen-Nuremberg, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine 3, Friedrich-Alexander-University of Erlangen-Nuremberg, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058494918","display_name":"Cornelia Heuberger","orcid":"https://orcid.org/0000-0003-3965-8363","observed_orcids":["https://orcid.org/0000-0003-3965-8363"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Heuberger","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rita Rzepka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rita Rzepka","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007620724","display_name":"Maximilian Seidl","orcid":"https://orcid.org/0000-0002-5559-4980","observed_orcids":["https://orcid.org/0000-0002-5559-4980"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Seidl","raw_affiliation_strings":["Institute for Surgical Pathology, Department of Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","Institute of Pathology, Heinrich-Heine University and University Hospital of D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Surgical Pathology, Department of Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University and University Hospital of D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086501578","display_name":"Falk Nimmerjahn","orcid":"https://orcid.org/0000-0002-5418-316X","observed_orcids":["https://orcid.org/0000-0002-5418-316X"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Falk Nimmerjahn","raw_affiliation_strings":["Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075148705","display_name":"Nina Chevalier","orcid":"https://orcid.org/0000-0002-1924-9530","observed_orcids":["https://orcid.org/0000-0002-1924-9530"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nina Chevalier","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037795671","display_name":"Jens Marc Titze","orcid":"https://orcid.org/0000-0001-8463-8404","observed_orcids":["https://orcid.org/0000-0001-8463-8404"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["DE","SG"],"is_corresponding":false,"raw_author_name":"Jens Titze","raw_affiliation_strings":["Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore","Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander-University, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Interdisciplinary Center for Clinical Research and Department of Nephrology and Hypertension, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander-University, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004962774","display_name":"Reinhard Edmund Voll","orcid":"https://orcid.org/0000-0002-5542-9133","observed_orcids":["https://orcid.org/0000-0002-5542-9133"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Reinhard E. Voll","raw_affiliation_strings":["Center for Chronic Immunodeficiency (CCI) Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Chronic Immunodeficiency (CCI) Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004962774","https://openalex.org/A5083629282"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.6672,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83285338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"765741","last_page":"765741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-salt-restriction","display_name":"dietary salt restriction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.6079999804496765},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/experimental-arthritis","display_name":"experimental arthritis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6110000014305115},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/anti-type-ii-collagen-antibodies","display_name":"anti-collagen type II antibodies","score":0.7749999761581421},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7319999933242798},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.949999988079071},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.984000027179718},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/leukocyte-extravasation","display_name":"leukocyte transmigration","score":0.7680000066757202},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6681987047195435},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6093041896820068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.572165846824646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5490635633468628},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.536604106426239},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5107769966125488},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4557298421859741},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.41580644249916077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3507750928401947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34544482827186584}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004039","descriptor_name":"Diet, Sodium-Restricted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023461","descriptor_name":"Myeloid Progenitor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D033023","descriptor_name":"Foot Joints","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D033023","descriptor_name":"Foot Joints","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2021.765741","doi":"https://doi.org/10.3389/fimmu.2021.765741","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.765741","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8678127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8678127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:34925335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34925335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:afe3df223e104ff19e5ff43728630389","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/afe3df223e104ff19e5ff43728630389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"},{"id":"pmh:oai:ub.uni-erlangen.de-opus:17933","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/files/17933/fimmu-12-765741-g006.tif","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.765741","doi":"https://doi.org/10.3389/fimmu.2021.765741","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.765741","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1078610655","display_name":null,"funder_award_id":"SFB-1160","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2301971903","display_name":null,"funder_award_id":"TRR130 to FN","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2367504651","display_name":null,"funder_award_id":"FOR2886","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2647167129","display_name":null,"funder_award_id":"project 12","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4092232107","display_name":null,"funder_award_id":"SFB 1160 project Z1 to MS","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G51279012","display_name":null,"funder_award_id":"TRR130 project 12 to REV, TRR130 to FN, SFB 1160 to REV and A. Triantafyllopoulou , SFB 1160 project Z1 to MS, FOR2886 to FN","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G551823739","display_name":null,"funder_award_id":"TRR130","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6178708426","display_name":null,"funder_award_id":"FOR2886 to FN","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G759286179","display_name":null,"funder_award_id":"TRR 130, project 12","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G974884716","display_name":null,"funder_award_id":"SFB 1160 to REV and A. Triantafyllopoulou","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337168","display_name":"Medizinische Fakult\u00e4t der Albert-Ludwigs-Universit\u00e4t Freiburg","ror":null},{"id":"https://openalex.org/F4320337753","display_name":"Interreg","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W51629266","https://openalex.org/W1535485604","https://openalex.org/W1698568152","https://openalex.org/W1935617463","https://openalex.org/W1974555324","https://openalex.org/W1974855426","https://openalex.org/W1978103379","https://openalex.org/W1980990177","https://openalex.org/W1983541797","https://openalex.org/W1991229004","https://openalex.org/W1991855740","https://openalex.org/W1994355238","https://openalex.org/W1996375401","https://openalex.org/W1998256351","https://openalex.org/W2001775594","https://openalex.org/W2007986629","https://openalex.org/W2017821597","https://openalex.org/W2022585333","https://openalex.org/W2025117799","https://openalex.org/W2029001868","https://openalex.org/W2032731042","https://openalex.org/W2033228977","https://openalex.org/W2047217935","https://openalex.org/W2055323879","https://openalex.org/W2060630008","https://openalex.org/W2062010118","https://openalex.org/W2070685885","https://openalex.org/W2070814647","https://openalex.org/W2085869287","https://openalex.org/W2087924560","https://openalex.org/W2100564391","https://openalex.org/W2100669634","https://openalex.org/W2105159644","https://openalex.org/W2107235439","https://openalex.org/W2110378444","https://openalex.org/W2110483909","https://openalex.org/W2110826367","https://openalex.org/W2119346564","https://openalex.org/W2120689672","https://openalex.org/W2134044403","https://openalex.org/W2143333940","https://openalex.org/W2153047018","https://openalex.org/W2154911070","https://openalex.org/W2155702314","https://openalex.org/W2166335159","https://openalex.org/W2171784256","https://openalex.org/W2176959251","https://openalex.org/W2239738050","https://openalex.org/W2325111718","https://openalex.org/W2419653009","https://openalex.org/W2440644257","https://openalex.org/W2473880663","https://openalex.org/W2485152952","https://openalex.org/W2515910935","https://openalex.org/W2599790911","https://openalex.org/W2599956086","https://openalex.org/W2721896667","https://openalex.org/W2751900542","https://openalex.org/W2766871540","https://openalex.org/W2786666585","https://openalex.org/W2791503686","https://openalex.org/W2800826112","https://openalex.org/W2804793107","https://openalex.org/W2903593298","https://openalex.org/W4230982340","https://openalex.org/W4313347845"],"related_works":["https://openalex.org/W2412746821","https://openalex.org/W2322085724","https://openalex.org/W2903593298","https://openalex.org/W2636344960","https://openalex.org/W2802458413","https://openalex.org/W2751900542","https://openalex.org/W3164693118","https://openalex.org/W2905111762","https://openalex.org/W4249220642","https://openalex.org/W3119897963"],"abstract_inverted_index":{"A":[0],"link":[1,237],"between":[2,238],"high":[3,108],"sodium":[4],"chloride":[5],"(salt)":[6],"intake":[7,31,47],"and":[8,26,35,65,76,107,150,161,178,190,194,233,241,276,289,301],"the":[9,42,83,163,195,244,287,298,302],"development":[10],"of":[11,22,44,89,118,186,230,243,252,282,292,305],"autoimmune":[12,24],"diseases":[13,331],"was":[14,132],"previously":[15],"reported.":[16],"These":[17],"earlier":[18],"studies":[19],"demonstrated":[20],"exacerbation":[21],"experimental":[23,49],"encephalomyelitis":[25],"colitis":[27],"by":[28,295],"excess":[29],"salt":[30,46,55,95,105,109,225,272,310],"associated":[32,145,181],"with":[33,120,146,182],"Th17-":[34],"macrophage-mediated":[36],"mechanisms.":[37],"Little":[38],"is":[39],"known":[40],"about":[41],"impact":[43],"dietary":[45,271,316],"on":[48,61,73],"arthritides.":[50],"Here,":[51],"we":[52,213],"investigated":[53],"if":[54],"restriction":[56,226,273,311],"can":[57],"exert":[58],"beneficial":[59,280],"effects":[60],"collagen-induced":[62],"arthritis":[63,69,100,119],"(CIA)":[64,200],"K/BxN":[66],"serum":[67],"transfer-induced":[68],"(STIA).":[70],"CIA":[71,160,275],"depends":[72],"both":[74,92,286],"adaptive":[75],"innate":[77,84],"immunity,":[78],"while":[79],"STIA":[80],"predominantly":[81,296],"mimics":[82],"immune":[85],"cell-driven":[86],"effector":[87,290],"phase":[88,291],"arthritis.":[90,334],"In":[91,269],"models,":[93],"low":[94],"(LS)":[96],"diet":[97,122,131,154,207,240,284],"significantly":[98],"decreased":[99,162,264],"severity":[101],"compared":[102,123,208],"to":[103,124,209,320,326],"regular":[104],"(RS)":[106],"(HS)":[110],"diet.":[111,126,211],"We":[112],"did":[113,214],"not":[114,215,318],"observe":[115],"an":[116],"aggravation":[117],"HS":[121,210],"RS":[125],"Remarkably,":[127],"in":[128,159,203,221,227,258],"STIA,":[129,277],"LS":[130,153,206,239,267,283],"as":[133,135],"effective":[134],"IL-1":[136,187],"receptor":[137],"blocking":[138],"treatment.":[139],"Complement-fixing":[140],"anti-CII":[141,156,164],"IgG2a":[142,157],"antibodies":[143],"are":[144],"inflammatory":[147,175,329],"cell":[148],"infiltration":[149],"cartilage":[151,179],"destruction.":[152],"reduced":[155,183,218],"levels":[158],"IgG2a/IgG1":[165],"ratios":[166],"pointing":[167],"toward":[168],"a":[169,217,236,263,279,314],"more":[170],"Th2-like":[171],"response.":[172],"Significantly":[173],"less":[174],"joint":[176,330],"infiltrates":[177],"breakdown":[180],"protein":[184,248],"concentrations":[185],"beta":[188],"(CIA":[189],"STIA),":[191],"IL-17":[192],"(CIA),":[193],"monocyte":[196],"chemoattractant":[197],"protein-1":[198],"(MCP-1)":[199],"were":[201],"detected":[202],"mice":[204],"receiving":[205],"However,":[212],"find":[216],"IL-17A":[219],"expression":[220],"CD4+T":[222],"cells":[223],"upon":[224],"CIA.":[228],"Analysis":[229],"mRNA":[231],"transcripts":[232],"immunoblots":[234],"revealed":[235],"inhibition":[242],"p38":[245],"MAPK":[246],"(mitogen-activated":[247],"kinase)/NFAT5":[249],"(nuclear":[250],"factor":[251],"activated":[253],"T-cells":[254],"5)":[255],"signaling":[256],"axis":[257],"STIA.":[259],"Further":[260],"experiments":[261],"indicated":[262],"leukodiapedesis":[265],"under":[266],"conditions.":[268],"conclusion,":[270],"ameliorates":[274],"indicating":[278],"role":[281],"during":[285],"immunization":[288],"immune-mediated":[293],"arthritides":[294],"modulating":[297],"humoral":[299],"immunity":[300],"activation":[303],"status":[304],"myeloid":[306],"lineage":[307],"cells.":[308],"Hence,":[309],"might":[312],"represent":[313],"supportive":[315],"intervention":[317],"only":[319],"reduce":[321],"cardiovascular":[322],"risk,":[323],"but":[324],"also":[325],"improve":[327],"human":[328],"like":[332],"rheumatoid":[333]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}