{"id":"https://openalex.org/W4200440329","doi":"https://doi.org/10.18632/aging.203751","title":"Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis","display_name":"Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis","publication_year":2021,"publication_date":"2021-12-10","ids":{"openalex":"https://openalex.org/W4200440329","doi":"https://doi.org/10.18632/aging.203751","pmid":"https://pubmed.ncbi.nlm.nih.gov/34890366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8714157"},"language":"en","primary_location":{"id":"doi:10.18632/aging.203751","doi":"https://doi.org/10.18632/aging.203751","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203751","pdf_url":"https://www.aging-us.com/article/203751/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/203751/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xing He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xing He","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074697747","display_name":"Jun Tang","orcid":"https://orcid.org/0000-0003-4711-1341","observed_orcids":["https://orcid.org/0000-0003-4711-1341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Tang","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100953362","display_name":"Hezhong Yan","orcid":"https://orcid.org/0000-0002-0418-8050","observed_orcids":["https://orcid.org/0000-0002-0418-8050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"He-Zhong Yan","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047441564","display_name":"Jiaoxue Wang","orcid":"https://orcid.org/0000-0002-2305-0735","observed_orcids":["https://orcid.org/0000-0002-2305-0735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiao-Xue Wang","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675986","display_name":"Haiqing Li","orcid":"https://orcid.org/0000-0001-5583-2240","observed_orcids":["https://orcid.org/0000-0001-5583-2240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Qing Li","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110812238","display_name":"Xiaowei Duan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Wei Duan","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018500447","display_name":"Sen-Yuan Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sen-Yuan Yu","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110830299","display_name":"Xi-Lu Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi-Lu Hou","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035651264","display_name":"Guobin Liao","orcid":"https://orcid.org/0000-0002-9861-8161","observed_orcids":["https://orcid.org/0000-0002-9861-8161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo-Bin Liao","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100431831","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0002-5739-9986","observed_orcids":["https://orcid.org/0000-0002-5739-9986"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei 230031, Anhui, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100431831"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3832,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.40967058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"23","first_page":"25365","last_page":"25376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anemoside-b4","display_name":"anemoside B4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9070000052452087},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8619999885559082},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.6769999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/triterpenoid-saponins","display_name":"triterpenoid saponins","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8940038084983826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7447411417961121},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7072048783302307},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5453460216522217},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5432192087173462},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.54075688123703},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4563097059726715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4518432915210724},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42363429069519043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11847147345542908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.203751","doi":"https://doi.org/10.18632/aging.203751","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203751","pdf_url":"https://www.aging-us.com/article/203751/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmid:34890366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34890366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8714157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8714157/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/aging.203751","doi":"https://doi.org/10.18632/aging.203751","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203751","pdf_url":"https://www.aging-us.com/article/203751/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200440329.pdf","grobid_xml":"https://content.openalex.org/works/W4200440329.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1589166971","https://openalex.org/W1914685501","https://openalex.org/W1970213932","https://openalex.org/W1991455654","https://openalex.org/W2004294452","https://openalex.org/W2026279585","https://openalex.org/W2098516100","https://openalex.org/W2099853576","https://openalex.org/W2119683782","https://openalex.org/W2127951115","https://openalex.org/W2130392703","https://openalex.org/W2136372437","https://openalex.org/W2139095510","https://openalex.org/W2143546230","https://openalex.org/W2147297736","https://openalex.org/W2169361184","https://openalex.org/W2313842338","https://openalex.org/W2576899770","https://openalex.org/W2586339216","https://openalex.org/W2773564046","https://openalex.org/W2775461490","https://openalex.org/W2783225392","https://openalex.org/W2804410421","https://openalex.org/W2810475801","https://openalex.org/W2899060140","https://openalex.org/W2935977207","https://openalex.org/W2945631116","https://openalex.org/W2980595974","https://openalex.org/W2997653992","https://openalex.org/W3042661441","https://openalex.org/W3043064050","https://openalex.org/W3089472926"],"related_works":["https://openalex.org/W2136372437","https://openalex.org/W3200708299","https://openalex.org/W2789852417","https://openalex.org/W3083629477","https://openalex.org/W1568746901","https://openalex.org/W3098111725","https://openalex.org/W7127396949","https://openalex.org/W2553901524","https://openalex.org/W4383823224","https://openalex.org/W4399043123"],"abstract_inverted_index":{"Currently,":[0],"5-Fluorouracil":[1],"(5-FU)":[2],"based":[3],"chemotherapy":[4,15,52,135],"is":[5,19,30],"the":[6,46,58,133],"primary":[7],"option":[8],"for":[9],"colorectal":[10,54,74,81,93,104,122,137,151],"cancer":[11,55,75,82,94,105,114,123],"after":[12],"surgery,":[13],"whereas":[14],"resistance":[16],"related":[17],"mortality":[18],"observed":[20],"in":[21,39,50,53,71,90,101,119,132,150],"a":[22,31,36,65,143],"large":[23],"proportion":[24],"of":[25,48,69,136],"patients.":[26],"Anemoside":[27],"B4":[28],"(AB4)":[29],"triterpene":[32],"saponin,":[33],"which":[34],"exhibits":[35],"considerable":[37],"activity":[38,68,109],"oncotherapy.":[40],"In":[41,125],"this":[42],"study,":[43],"we":[44],"explored":[45],"efficacy":[47],"AB4":[49,70,78,97,120,127],"FU-based":[51,134,147],"cells":[56,84,116],"and":[57,113],"underlying":[59],"molecular":[60],"mechanisms.":[61],"Our":[62,139],"results":[63],"indicated":[64],"significant":[66],"synergistic":[67],"5-FU":[72,91,102],"treated":[73,121],"cells.":[76,95,106,124],"Furthermore,":[77],"treatment":[79],"eliminated":[80],"stem":[83,115],"by":[85],"promoting":[86],"apoptotic":[87],"cell":[88,111],"death":[89],"resistant":[92,103],"Mechanically,":[96],"activated":[98],"caspase-9":[99],"pathway":[100],"Elevated":[107],"Src":[108],"induced":[110],"apoptosis":[112],"elimination":[117],"effects":[118],"conclusion,":[126],"showed":[128],"promising":[129],"sensitization":[130],"effect":[131],"cancer.":[138,152],"study":[140],"may":[141],"pave":[142],"way":[144],"to":[145],"ameliorate":[146],"chemotherapeutic":[148],"efficiency":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}