{"id":"https://openalex.org/W4200439782","doi":"https://doi.org/10.1016/j.phyplu.2021.100209","title":"SPME and solvent-based GC\u2013MS metabolite profiling of Egyptian marketed Saussurea costus (Falc.) Lipsch. concerning its anticancer activity","display_name":"SPME and solvent-based GC\u2013MS metabolite profiling of Egyptian marketed Saussurea costus (Falc.) Lipsch. concerning its anticancer activity","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4200439782","doi":"https://doi.org/10.1016/j.phyplu.2021.100209"},"language":"en","primary_location":{"id":"doi:10.1016/j.phyplu.2021.100209","doi":"https://doi.org/10.1016/j.phyplu.2021.100209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phyplu.2021.100209","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667031321001913/pdf","source":{"id":"https://openalex.org/S4210212705","display_name":"Phytomedicine Plus","issn_l":"2667-0313","issn":["2667-0313"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine Plus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2667031321001913/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044300220","display_name":"Engy Mohsen","orcid":"https://orcid.org/0009-0007-5723-9476","observed_orcids":["https://orcid.org/0009-0007-5723-9476"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Engy Mohsen","raw_affiliation_strings":["Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010147041","display_name":"Ali H. El\u2010Far","orcid":"https://orcid.org/0000-0001-9721-4360","observed_orcids":["https://orcid.org/0000-0001-9721-4360","https://orcid.org/0009-0003-0156-5505"]},"institutions":[{"id":"https://openalex.org/I169744251","display_name":"Damanhour University","ror":"https://ror.org/03svthf85","country_code":"EG","type":"education","lineage":["https://openalex.org/I169744251"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ali H El-Far","raw_affiliation_strings":["Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt","institution_ids":["https://openalex.org/I169744251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018990882","display_name":"Kavitha Godugu","orcid":"https://orcid.org/0000-0002-1844-7041","observed_orcids":["https://orcid.org/0000-0002-1844-7041"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kavitha Godugu","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003245147","display_name":"Fatma Elsayed","orcid":"https://orcid.org/0000-0003-3198-3268","observed_orcids":["https://orcid.org/0000-0003-3198-3268"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma Elsayed","raw_affiliation_strings":["Medical Technology Center, Medical Research Institute, Alexandria University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Technology Center, Medical Research Institute, Alexandria University, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032045966","display_name":"Shaker A. Mousa","orcid":"https://orcid.org/0000-0002-9294-015X","observed_orcids":["https://orcid.org/0000-0002-9294-015X"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaker A Mousa","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050610396","display_name":"Inas Youssef Younis","orcid":"https://orcid.org/0000-0002-3084-0161","observed_orcids":["https://orcid.org/0000-0002-3084-0161","https://orcid.org/0000-0003-0873-8539"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Inas Y Younis","raw_affiliation_strings":["Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010147041","https://openalex.org/A5032045966"],"corresponding_institution_ids":["https://openalex.org/I169744251","https://openalex.org/I365282"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":1.3002,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77249461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"100209","last_page":"100209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.22120000422000885,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saussurea-costus","display_name":"Saussurea costus","score":1.0},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.7289999723434448},{"id":"https://openalex.org/keywords/phytochemical-constituents","display_name":"phytochemical constituents","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dehydrocostus-lactone","display_name":"dehydrocostus lactone","score":0.8870000243186951},{"id":"https://openalex.org/keywords/costunolide","display_name":"costunolide","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anethole","display_name":"anethole","score":0.828000009059906},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.8489999771118164},{"id":"https://openalex.org/keywords/caryophyllene-oxide","display_name":"caryophyllene oxide","score":0.8450000286102295},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-angiogenesis","display_name":"chorioallantoic membrane angiogenesis","score":0.699999988079071},{"id":"https://openalex.org/keywords/egyptian-medicinal-plants","display_name":"Egyptian medicinal plants","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7974032163619995},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7099133729934692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.663007378578186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12204068899154663}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phyplu.2021.100209","doi":"https://doi.org/10.1016/j.phyplu.2021.100209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phyplu.2021.100209","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667031321001913/pdf","source":{"id":"https://openalex.org/S4210212705","display_name":"Phytomedicine Plus","issn_l":"2667-0313","issn":["2667-0313"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine Plus","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1b63f791a2a04a429f8cd0db8c3287e8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b63f791a2a04a429f8cd0db8c3287e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phytomedicine Plus, Vol 2, Iss 1, Pp 100209- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.phyplu.2021.100209","doi":"https://doi.org/10.1016/j.phyplu.2021.100209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phyplu.2021.100209","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667031321001913/pdf","source":{"id":"https://openalex.org/S4210212705","display_name":"Phytomedicine Plus","issn_l":"2667-0313","issn":["2667-0313"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine Plus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200439782.pdf","grobid_xml":"https://content.openalex.org/works/W4200439782.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W4884274","https://openalex.org/W1671486925","https://openalex.org/W1933981160","https://openalex.org/W1977027255","https://openalex.org/W1981254316","https://openalex.org/W1996570833","https://openalex.org/W2016463083","https://openalex.org/W2044638102","https://openalex.org/W2051382518","https://openalex.org/W2067717121","https://openalex.org/W2073323691","https://openalex.org/W2104512654","https://openalex.org/W2122263638","https://openalex.org/W2126505493","https://openalex.org/W2347015734","https://openalex.org/W2414414166","https://openalex.org/W2481475642","https://openalex.org/W2559793373","https://openalex.org/W2595889917","https://openalex.org/W2620999518","https://openalex.org/W2737881752","https://openalex.org/W2754989229","https://openalex.org/W2786316555","https://openalex.org/W2794157688","https://openalex.org/W2794640116","https://openalex.org/W2899190489","https://openalex.org/W2905047533","https://openalex.org/W2943614520","https://openalex.org/W2947352957","https://openalex.org/W2976583878","https://openalex.org/W2992914688","https://openalex.org/W3000672460","https://openalex.org/W3004363853","https://openalex.org/W3004713496","https://openalex.org/W3007676206","https://openalex.org/W3010766973","https://openalex.org/W3012997341","https://openalex.org/W3016366032","https://openalex.org/W3039687229","https://openalex.org/W3045607994","https://openalex.org/W3046770176","https://openalex.org/W3049457192","https://openalex.org/W3093277047","https://openalex.org/W3110434093","https://openalex.org/W3117216686","https://openalex.org/W3128646645","https://openalex.org/W3158375590","https://openalex.org/W3164120166","https://openalex.org/W3171311019","https://openalex.org/W3174482405","https://openalex.org/W3175730834","https://openalex.org/W3188833558","https://openalex.org/W3190578461","https://openalex.org/W3193468599","https://openalex.org/W3198316134","https://openalex.org/W4210774372","https://openalex.org/W4286249733","https://openalex.org/W6749643850","https://openalex.org/W6769355075","https://openalex.org/W6799865817"],"related_works":["https://openalex.org/W4404451952","https://openalex.org/W4224325776","https://openalex.org/W2126505493","https://openalex.org/W7213552540","https://openalex.org/W3041510940","https://openalex.org/W4393051542","https://openalex.org/W4408957700","https://openalex.org/W4387745518","https://openalex.org/W4200246748","https://openalex.org/W1849454186"],"abstract_inverted_index":{"Saussurea":[0],"costus":[1,22,58,132,140,164,188],"Falc":[2],"with":[3,43,204],"synonymous":[4],"Aucklandia":[5],"costus,":[6],"S.":[7,21,57,139,163,187],"lappa,":[8,11],"and":[9,34,59,67,90,105,123,144,149,157,197],"A.":[10],"is":[12],"an":[13,24,113],"ancient":[14],"perennial":[15],"plant":[16],"native":[17],"to":[18,111],"Himalayan":[19],"region.":[20],"possesses":[23],"ethnopharmacological":[25],"background":[26],"for":[27,127,179,194],"treating":[28],"diarrhea,":[29],"tenesmus,":[30],"dyspepsia,":[31],"vomiting,":[32],"inflammation,":[33],"age-related":[35],"diseases":[36],"because":[37],"it":[38],"contains":[39],"many":[40],"chemical":[41,81],"compounds":[42,82],"different":[44,80,180],"biological":[45],"potentials.":[46],"In":[47,73],"the":[48,53,74,128,136,169,175],"current":[49,75,137],"study,":[50,76,138],"we":[51,77],"investigated":[52,91],"phytochemical":[54],"constituents":[55],"of":[56,172],"its":[60,92],"anticancer":[61,96,114,170],"potential":[62,115],"against":[63,147],"human":[64,195],"colon":[65,196],"(HCT116)":[66],"hepatic":[68,198],"(HepG2)":[69],"cancer":[70,151,181],"cell":[71,152],"lines.":[72],"identified":[78,126],"122":[79],"using":[83,154],"a":[84,191],"gas":[85],"chromatography-mass":[86],"spectrometry":[87],"(GC\u2013MS)":[88],"method":[89],"extract's":[93],"in":[94,118,131,135,155],"vitro":[95,156],"activity.":[97],"Dehydrocostus":[98],"lactone,":[99],"\u03b2-caryophyllene":[100],"oxide,":[101],"anethole,":[102],"costunolide,":[103],"\u03b2-sitosterol,":[104],"\u03b3-bisabolene":[106],"were":[107,125],"recognized":[108],"by":[109],"GC\u2013MS":[110],"have":[112],"as":[116,190],"stated":[117],"published":[119],"studies.":[120],"Vanillosmin,":[121],"santolinatriene":[122],"\u03b2-Sitosterol":[124],"first":[129],"time":[130],"oil.":[133],"Therefore,":[134],"extract":[141,165,189],"induced":[142],"apoptotic":[143],"anti-angiogenic":[145],"effects":[146],"HCT116":[148],"HepG2":[150],"lines":[153],"chorioallantoic":[158],"membrane":[159],"(CAM)":[160],"models.":[161],"Furthermore,":[162],"has":[166],"successfully":[167],"potentiated":[168],"effect":[171],"doxorubicin":[173],"(Dox),":[174],"common":[176],"chemotherapeutic":[177],"agent":[178,193],"type":[182],"treatment.":[183],"We":[184],"can":[185],"consider":[186],"promising":[192],"cancers":[199],"either":[200],"alone":[201],"or":[202],"combined":[203],"Dox.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-12-31T00:00:00"}
