{"id":"https://openalex.org/W4200433816","doi":"https://doi.org/10.1016/j.celrep.2021.110129","title":"Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2","display_name":"Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200433816","doi":"https://doi.org/10.1016/j.celrep.2021.110129","pmid":"https://pubmed.ncbi.nlm.nih.gov/34936867"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2021.110129","doi":"https://doi.org/10.1016/j.celrep.2021.110129","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110129","pdf_url":"http://www.cell.com/article/S2211124721016259/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124721016259/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087659225","display_name":"Martin Marek","orcid":"https://orcid.org/0000-0001-7220-5644","observed_orcids":["https://orcid.org/0000-0001-7220-5644"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martin Marek","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France"],"raw_orcid":"https://orcid.org/0000-0001-7220-5644","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042879365","display_name":"Elizabeth Ramos\u2010Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elizabeth Ramos-Morales","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060090837","display_name":"Gisele Fernanda Assine Picchi","orcid":"https://orcid.org/0000-0002-2516-3178","observed_orcids":["https://orcid.org/0000-0002-2516-3178"]},"institutions":[{"id":"https://openalex.org/I4405286366","display_name":"Instituto Carlos Chagas","ror":"https://ror.org/01y8gmz47","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286366","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gisele F.A. Picchi-Constante","raw_affiliation_strings":["Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil","institution_ids":["https://openalex.org/I4405286366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024331582","display_name":"Theresa Bayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresa Bayer","raw_affiliation_strings":["Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017891602","display_name":"Carina Norstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carina Norstr\u00f6m","raw_affiliation_strings":["Kancera AB, Nanna Svartz V\u00e4g 4, SE-17165 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kancera AB, Nanna Svartz V\u00e4g 4, SE-17165 Solna, Sweden","institution_ids":["https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072974716","display_name":"Daniel Herp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Herp","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062461662","display_name":"Policarpo A. Sales-Junior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Policarpo A. Sales-Junior","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040462632","display_name":"Eloise Pav\u00e3o Guerra-Slompo","orcid":"https://orcid.org/0000-0003-2379-5099","observed_orcids":["https://orcid.org/0000-0003-2379-5099"]},"institutions":[{"id":"https://openalex.org/I4405286366","display_name":"Instituto Carlos Chagas","ror":"https://ror.org/01y8gmz47","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286366","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eloise P. Guerra-Slompo","raw_affiliation_strings":["Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil","institution_ids":["https://openalex.org/I4405286366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087659185","display_name":"Kristin Hausmann","orcid":"https://orcid.org/0000-0003-3419-5769","observed_orcids":["https://orcid.org/0000-0003-3419-5769"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristin Hausmann","raw_affiliation_strings":["Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3419-5769","affiliations":[{"raw_affiliation_string":"Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015122219","display_name":"Alokta Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alokta Chakrabarti","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013849860","display_name":"Tajith Baba Shaik","orcid":"https://orcid.org/0000-0001-6983-7966","observed_orcids":["https://orcid.org/0000-0001-6983-7966"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tajith B. Shaik","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108784138","display_name":"Annika Merz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Merz","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066277292","display_name":"Edouard Troesch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edouard Troesch","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karin Schmidtkunz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Schmidtkunz","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031222519","display_name":"Samuel Goldenberg","orcid":"https://orcid.org/0000-0002-4892-163X","observed_orcids":["https://orcid.org/0000-0002-4892-163X"]},"institutions":[{"id":"https://openalex.org/I4405286366","display_name":"Instituto Carlos Chagas","ror":"https://ror.org/01y8gmz47","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286366","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Samuel Goldenberg","raw_affiliation_strings":["Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil","institution_ids":["https://openalex.org/I4405286366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061931567","display_name":"Raymond John Pierce","orcid":"https://orcid.org/0000-0001-9820-8608","observed_orcids":["https://orcid.org/0000-0001-9820-8608"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raymond J. Pierce","raw_affiliation_strings":["Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL -Centre d'Infection et d'Immunit\u00e9 de Lille, 59000 Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL -Centre d'Infection et d'Immunit\u00e9 de Lille, 59000 Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053530501","display_name":"Marina de Moraes Mour\u00e3o","orcid":"https://orcid.org/0000-0003-1348-5521","observed_orcids":["https://orcid.org/0000-0003-1348-5521"]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina M. Mour\u00e3o","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016266091","display_name":"Manfred Jung","orcid":"https://orcid.org/0000-0002-6361-7716","observed_orcids":["https://orcid.org/0000-0002-6361-7716"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Jung","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000797680","display_name":"Johan Schultz","orcid":"https://orcid.org/0000-0002-8211-1681","observed_orcids":["https://orcid.org/0000-0002-8211-1681"]},"institutions":[{"id":"https://openalex.org/I4210112557","display_name":"Kancera (Sweden)","ror":"https://ror.org/01sqjdr55","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210112557"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Schultz","raw_affiliation_strings":["Kancera AB, Nanna Svartz V\u00e4g 4, SE-17165 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kancera AB, Nanna Svartz V\u00e4g 4, SE-17165 Solna, Sweden","institution_ids":["https://openalex.org/I4210112557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055328126","display_name":"Wolfgang Sippl","orcid":"https://orcid.org/0000-0002-5985-9261","observed_orcids":["https://orcid.org/0000-0002-5985-9261"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Sippl","raw_affiliation_strings":["Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Wolfgang-Langenbeck-Stra\u00dfe 4, 06120 Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074172780","display_name":"Nilson Ivo Tonin Zanchin","orcid":"https://orcid.org/0000-0002-1153-0694","observed_orcids":["https://orcid.org/0000-0002-1153-0694"]},"institutions":[{"id":"https://openalex.org/I4405286366","display_name":"Instituto Carlos Chagas","ror":"https://ror.org/01y8gmz47","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286366","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Nilson I.T. Zanchin","raw_affiliation_strings":["Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil. Electronic address: nilson.zanchin@fiocruz.br","Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1153-0694","affiliations":[{"raw_affiliation_string":"Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil. Electronic address: nilson.zanchin@fiocruz.br","institution_ids":["https://openalex.org/I4405286366"]},{"raw_affiliation_string":"Instituto Carlos Chagas, Fiocruz Paran\u00e1, Curitiba, Paran\u00e1 81350-010, Brazil","institution_ids":["https://openalex.org/I4405286366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090497813","display_name":"Christophe Romier","orcid":"https://orcid.org/0000-0002-3680-935X","observed_orcids":["https://orcid.org/0000-0002-3680-935X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christophe Romier","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France. Electronic address: romier@igbmc.fr","IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France"],"raw_orcid":"https://orcid.org/0000-0002-3680-935X","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France; IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France. Electronic address: romier@igbmc.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"IGBMC, Department of Integrated Structural Biology, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch Cedex, France","institution_ids":["https://openalex.org/I4210086872"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, CNRS, INSERM, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, UMR 7104, U 1258, 67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5074172780","https://openalex.org/A5090497813"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4405286366","https://openalex.org/I68947357"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":4500,"currency":"EUR","value_usd":4853},"fwci":2.3684,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.88736602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"37","issue":"12","first_page":"110129","last_page":"110129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/class-i-hdacs","display_name":"class I HDACs","score":0.7429999709129333},{"id":"https://openalex.org/keywords/active-site-structure","display_name":"active site structure","score":0.6650000214576721},{"id":"https://openalex.org/keywords/deacetylase-inhibitors","display_name":"deacetylase inhibitors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5879999995231628},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.6629999876022339},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6179999709129333},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8191723227500916},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.8093931078910828},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.7623770833015442},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5286622047424316},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.4990878105163574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4017932415008545},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35407114028930664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2917216420173645},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.1550585925579071},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09534236788749695},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.celrep.2021.110129","doi":"https://doi.org/10.1016/j.celrep.2021.110129","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110129","pdf_url":"http://www.cell.com/article/S2211124721016259/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:34936867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34936867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:dora:psi_40887","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:40887","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:40887/PDF/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-03504175v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03504175","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, 2021, 37, &#x27E8;10.1016/j.celrep.2021.110129&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arca.fiocruz.br:icict/50761","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/50761","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/50761","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/50761","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2021.110129","doi":"https://doi.org/10.1016/j.celrep.2021.110129","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110129","pdf_url":"http://www.cell.com/article/S2211124721016259/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1922090316","display_name":"Anti-Parasitic Drug Discovery in Epigenetics","funder_award_id":"602080","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G869047677","display_name":"Infrastructure Fran\u00e7aise pour la Biologie Structurale Int\u00e9gr\u00e9e","funder_award_id":"ANR-10-INBS-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200433816.pdf","grobid_xml":"https://content.openalex.org/works/W4200433816.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W151714794","https://openalex.org/W271993543","https://openalex.org/W784953694","https://openalex.org/W1479760774","https://openalex.org/W1900589173","https://openalex.org/W1964248507","https://openalex.org/W1973577140","https://openalex.org/W1983315005","https://openalex.org/W1986891879","https://openalex.org/W1993334278","https://openalex.org/W1994582254","https://openalex.org/W2003812830","https://openalex.org/W2009826707","https://openalex.org/W2013434401","https://openalex.org/W2019071362","https://openalex.org/W2024653706","https://openalex.org/W2028794696","https://openalex.org/W2046345187","https://openalex.org/W2049453822","https://openalex.org/W2055397908","https://openalex.org/W2064437293","https://openalex.org/W2080134654","https://openalex.org/W2083784041","https://openalex.org/W2084090563","https://openalex.org/W2094383719","https://openalex.org/W2116381732","https://openalex.org/W2124026197","https://openalex.org/W2125888372","https://openalex.org/W2132629607","https://openalex.org/W2136478722","https://openalex.org/W2143277424","https://openalex.org/W2146071910","https://openalex.org/W2163062563","https://openalex.org/W2163341755","https://openalex.org/W2168974130","https://openalex.org/W2170618531","https://openalex.org/W2171765967","https://openalex.org/W2227008202","https://openalex.org/W2291959355","https://openalex.org/W2320230258","https://openalex.org/W2325412747","https://openalex.org/W2389600572","https://openalex.org/W2400007510","https://openalex.org/W2424468219","https://openalex.org/W2431163235","https://openalex.org/W2482664294","https://openalex.org/W2499955277","https://openalex.org/W2511667040","https://openalex.org/W2560129407","https://openalex.org/W2561130038","https://openalex.org/W2566479072","https://openalex.org/W2568322231","https://openalex.org/W2575762096","https://openalex.org/W2592229680","https://openalex.org/W2614007362","https://openalex.org/W2615685872","https://openalex.org/W2626094397","https://openalex.org/W2724336500","https://openalex.org/W2727942116","https://openalex.org/W2751583588","https://openalex.org/W2765322245","https://openalex.org/W2769348305","https://openalex.org/W2771049087","https://openalex.org/W2771762430","https://openalex.org/W2806343349","https://openalex.org/W2807259211","https://openalex.org/W2808947823","https://openalex.org/W2811262510","https://openalex.org/W2834880700","https://openalex.org/W2845131077","https://openalex.org/W2884140817","https://openalex.org/W2896021495","https://openalex.org/W2897192913","https://openalex.org/W2901164269","https://openalex.org/W2903053258","https://openalex.org/W2938574745","https://openalex.org/W2947642477","https://openalex.org/W2973020364","https://openalex.org/W2973457155","https://openalex.org/W2980170804","https://openalex.org/W2989865200","https://openalex.org/W3015189679","https://openalex.org/W3039830754","https://openalex.org/W4210992500","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W7126812546","https://openalex.org/W7126614274","https://openalex.org/W2561130038","https://openalex.org/W2884140817","https://openalex.org/W4403500786","https://openalex.org/W1986891879","https://openalex.org/W2212499115","https://openalex.org/W3207991879","https://openalex.org/W2049453822","https://openalex.org/W2101478195"],"abstract_inverted_index":{"Writing":[0],"and":[1,11,35,80,85,101,129],"erasing":[2],"of":[3,14,32,38,55,73,135],"posttranslational":[4],"modifications":[5],"are":[6,61],"crucial":[7],"to":[8,26,88,98],"phenotypic":[9],"plasticity":[10],"antigenic":[12],"variation":[13],"eukaryotic":[15],"pathogens.":[16],"Targeting":[17],"pathogens'":[18],"modification":[19],"machineries,":[20],"thus,":[21],"represents":[22],"a":[23,94,112,117],"valid":[24],"approach":[25],"fighting":[27],"parasitic":[28,33],"diseases.":[29],"However,":[30],"identification":[31],"targets":[34],"the":[36,50,56,99,133,136],"development":[37],"selective":[39,145],"anti-parasitic":[40,125,144],"drugs":[41],"still":[42],"represent":[43],"major":[44,103],"bottlenecks.":[45],"Here,":[46],"we":[47],"show":[48],"that":[49,64],"zinc-dependent":[51],"histone":[52],"deacetylases":[53],"(HDACs)":[54],"protozoan":[57],"parasite":[58,100],"Trypanosoma":[59],"cruzi":[60,75],"key":[62],"regulators":[63],"have":[65],"significantly":[66],"diverged":[67],"from":[68],"their":[69],"human":[70,107],"counterparts.":[71],"Depletion":[72],"T.":[74],"class":[76],"I":[77],"HDACs":[78,139],"tcDAC1":[79],"tcDAC2":[81,92,110],"compromises":[82],"cell-cycle":[83],"progression":[84],"division,":[86],"leading":[87],"cell":[89],"death.":[90],"Notably,":[91],"displays":[93],"deacetylase":[95],"activity":[96],"essential":[97],"shows":[102],"structural":[104],"differences":[105],"with":[106,116],"HDACs.":[108],"Specifically,":[109],"harbors":[111],"modular":[113],"active":[114],"site":[115],"unique":[118],"subpocket":[119],"targeted":[120],"by":[121],"inhibitors":[122],"showing":[123],"substantial":[124],"effects":[126],"in":[127,130,140],"cellulo":[128],"vivo.":[131],"Thus,":[132],"targeting":[134],"many":[137],"atypical":[138],"pathogens":[141],"can":[142],"enable":[143],"chemical":[146],"impairment.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}
