{"id":"https://openalex.org/W4200433382","doi":"https://doi.org/10.3791/52247-v","title":"Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension","display_name":"Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension","publication_year":2015,"publication_date":"2015-01-23","ids":{"openalex":"https://openalex.org/W4200433382","doi":"https://doi.org/10.3791/52247-v"},"language":"en","primary_location":{"id":"doi:10.3791/52247-v","doi":"https://doi.org/10.3791/52247-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/52247-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022101366","display_name":"Peter D. Westenskow","orcid":"https://orcid.org/0000-0001-9841-6220","observed_orcids":["https://orcid.org/0000-0001-9841-6220"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Westenskow","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute","Lowy Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Lowy Medical Research Institute","institution_ids":["https://openalex.org/I4210108657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103150995","display_name":"Toshihide Kurihara","orcid":"https://orcid.org/0000-0002-5457-2720","observed_orcids":["https://orcid.org/0000-0002-5457-2720"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihide Kurihara","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037362279","display_name":"Stephen Bravo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Bravo","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088445124","display_name":"Daniel Feitelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Feitelberg","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022037233","display_name":"Zack A. Sedillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zack A. Sedillo","raw_affiliation_strings":["Lowy Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute","institution_ids":["https://openalex.org/I4210108657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068500478","display_name":"Edith Aguilar","orcid":"https://orcid.org/0000-0003-2507-6637","observed_orcids":["https://orcid.org/0000-0003-2507-6637"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith Aguilar","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040174959","display_name":"Martin Friedlander","orcid":"https://orcid.org/0000-0003-4238-9651","observed_orcids":["https://orcid.org/0000-0003-4238-9651"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Friedlander","raw_affiliation_strings":["Department of Cell and Molecular Biology, The Scripps Research Institute","Lowy Medical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Lowy Medical Research Institute","institution_ids":["https://openalex.org/I4210108657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2892,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60620794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":"95","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subretinal-injection","display_name":"subretinal injection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8970000147819519},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.7960000038146973},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.6209999918937683},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.8306621313095093},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7026256918907166},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.6720994710922241},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5439742207527161},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.47747325897216797},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.4680860638618469},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.43439990282058716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4309229254722595},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3803378939628601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3439108729362488},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3420184850692749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30196818709373474},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2656875252723694},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.13790404796600342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3791/52247-v","doi":"https://doi.org/10.3791/52247-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/52247-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200370132","https://openalex.org/W4312032388","https://openalex.org/W3160422031","https://openalex.org/W1897352926","https://openalex.org/W4387394606","https://openalex.org/W2154285097","https://openalex.org/W2214528667","https://openalex.org/W3127586036","https://openalex.org/W1974378004","https://openalex.org/W4384561192"],"abstract_inverted_index":{"The":[0,125],"conversion":[1],"of":[2,37,42,50,69,85,104,195,209,218,230,258],"light":[3],"into":[4,246,277],"electrical":[5],"impulses":[6],"occurs":[7],"in":[8,54,72,112,135,144,200,212,251],"the":[9,47,100,145,164,169,175,202,219,228,231,235,242,247,256,278],"outer":[10],"retina":[11],"and":[12,18,21,33,58,82,102,115,138,166,185,192,237],"is":[13,40,161,182,261],"accomplished":[14],"largely":[15],"by":[16,132,234],"rod":[17],"cone":[19],"photoreceptors":[20,32],"retinal":[22],"pigment":[23],"epithelium":[24],"(RPE)":[25],"cells.":[26,95],"RPE":[27,38,71,86,105,121,198,204,265],"provide":[28],"critical":[29],"support":[30],"for":[31,63],"death":[34],"or":[35,275],"dysfunction":[36],"cells":[39,87,160,199,243],"characteristic":[41],"age-related":[43],"macular":[44],"degeneration":[45,211],"(AMD),":[46],"leading":[48],"cause":[49],"permanent":[51],"vision":[52],"loss":[53],"people":[55],"age":[56],"55":[57],"older.":[59],"While":[60,215],"no":[61],"cure":[62],"AMD":[64],"has":[65,129],"been":[66,123,130],"identified,":[67],"implantation":[68],"healthy":[70],"diseased":[73],"eyes":[74],"may":[75,268],"prove":[76],"to":[77,119,226,239,264,271],"be":[78,89,110,269],"an":[79],"effective":[80],"treatment,":[81],"large":[83],"numbers":[84],"can":[88,108],"readily":[90],"generated":[91],"from":[92],"pluripotent":[93],"stem":[94,196],"Several":[96],"interesting":[97],"questions":[98],"regarding":[99],"safety":[101],"efficacy":[103],"cell":[106,276],"delivery":[107],"still":[109],"examined":[111],"animal":[113,213],"models,":[114],"well-accepted":[116],"protocols":[117],"used":[118,131,270],"inject":[120,272],"have":[122],"developed.":[124],"technique":[126],"described":[127],"here":[128],"multiple":[133],"groups":[134],"various":[136],"studies":[137],"involves":[139],"first":[140],"creating":[141],"a":[142,148,152,155],"hole":[143,165],"eye":[146],"with":[147,154,159],"sharp":[149],"needle.":[150],"Then":[151],"syringe":[153],"blunt":[156],"needle":[157],"loaded":[158],"inserted":[162],"through":[163,168],"passed":[167],"vitreous":[170],"until":[171],"it":[172,267],"gently":[173],"touches":[174],"RPE.":[176],"Using":[177],"this":[178,259],"injection":[179],"method,":[180],"which":[181],"relatively":[183],"simple":[184],"requires":[186],"minimal":[187],"equipment,":[188],"we":[189,222],"achieve":[190],"consistent":[191],"efficient":[193],"integration":[194],"cell-derived":[197],"between":[201],"host":[203],"that":[205,241],"prevents":[206],"significant":[207],"amount":[208],"photoreceptor":[210],"models.":[214],"not":[216,262],"part":[217],"actual":[220],"protocol,":[221],"also":[223],"describe":[224],"how":[225,238],"determine":[227],"extent":[229],"trauma":[232],"induced":[233],"injection,":[236],"verify":[240],"were":[244],"injected":[245],"subretinal":[248,279],"space":[249],"using":[250],"vivo":[252],"imaging":[253],"modalities.":[254],"Finally,":[255],"use":[257],"protocol":[260],"limited":[263],"cells;":[266],"any":[273],"compound":[274],"space.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2021-12-31T00:00:00"}
