{"id":"https://openalex.org/W4200432178","doi":"https://doi.org/10.21203/rs.3.rs-1084831/v1","title":"Reduced BDNF Expression in Auditory Cortex Contributed to Neonatal Pain Induced Hearing Impairment and Dendritic Pruning Deficiency in Mice","display_name":"Reduced BDNF Expression in Auditory Cortex Contributed to Neonatal Pain Induced Hearing Impairment and Dendritic Pruning Deficiency in Mice","publication_year":2021,"publication_date":"2021-12-06","ids":{"openalex":"https://openalex.org/W4200432178","doi":"https://doi.org/10.21203/rs.3.rs-1084831/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1084831/v1","doi":"https://doi.org/10.21203/rs.3.rs-1084831/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1084831/v1","pdf_url":"https://www.researchsquare.com/article/rs-1084831/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1084831/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076118818","display_name":"Nanqi Li","orcid":"https://orcid.org/0000-0003-2743-7723","observed_orcids":["https://orcid.org/0000-0003-2743-7723"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanqi Li","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2743-7723","affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443095","display_name":"Bing Chen","orcid":"https://orcid.org/0000-0002-0988-9534","observed_orcids":["https://orcid.org/0000-0002-0988-9534"]},"institutions":[{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Chen","raw_affiliation_strings":["Zhongshan Hospital Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan Hospital Fudan University","institution_ids":["https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044693285","display_name":"Gaogan Jia","orcid":"https://orcid.org/0009-0003-4722-1433","observed_orcids":["https://orcid.org/0009-0003-4722-1433"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaogan Jia","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691839","display_name":"Rui Xu","orcid":"https://orcid.org/0000-0003-2298-7582","observed_orcids":["https://orcid.org/0000-0003-2298-7582","https://orcid.org/0009-0008-9816-1246"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Xu","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xia","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060437658","display_name":"Chuijin Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuijin Lai","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438661","display_name":"Gang Li","orcid":"https://orcid.org/0000-0002-0348-6953","observed_orcids":["https://orcid.org/0000-0002-0348-6953"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744440","display_name":"Wenxian Li","orcid":"https://orcid.org/0000-0002-4485-7239","observed_orcids":["https://orcid.org/0000-0002-4485-7239"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxian Li","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111551276","display_name":"Yuan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Han","raw_affiliation_strings":["Fudan University Eye Ear Nose and Throat Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Eye Ear Nose and Throat Hospital","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-pain","display_name":"neonatal pain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.6639999747276306},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/auditory-cortex","display_name":"auditory cortex","score":0.9819999933242798},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.718999981880188},{"id":"https://openalex.org/keywords/sufentanil","display_name":"sufentanil","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":1.0},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ribbon-synapses","display_name":"ribbon synapses","score":0.7350000143051147},{"id":"https://openalex.org/keywords/inner-hair-cells","display_name":"inner hair cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/auditory-brainstem-response","display_name":"auditory brainstem response","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cochlear-development","display_name":"cochlear development","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2780297895","wikidata":"https://www.wikidata.org/wiki/Q18676","display_name":"Auditory cortex","level":2,"score":0.6433229446411133},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.6149255037307739},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5555727481842041},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.495639443397522},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4620937407016754},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.44836872816085815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.439565509557724},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3709392249584198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20352229475975037},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0592578649520874},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1084831/v1","doi":"https://doi.org/10.21203/rs.3.rs-1084831/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1084831/v1","pdf_url":"https://www.researchsquare.com/article/rs-1084831/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1084831/v1","doi":"https://doi.org/10.21203/rs.3.rs-1084831/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1084831/v1","pdf_url":"https://www.researchsquare.com/article/rs-1084831/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200432178.pdf","grobid_xml":"https://content.openalex.org/works/W4200432178.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1965670425","https://openalex.org/W1992695138","https://openalex.org/W1997408653","https://openalex.org/W2001716460","https://openalex.org/W2040834941","https://openalex.org/W2053516515","https://openalex.org/W2054970745","https://openalex.org/W2060012419","https://openalex.org/W2087657929","https://openalex.org/W2105549490","https://openalex.org/W2113399135","https://openalex.org/W2117720464","https://openalex.org/W2124147311","https://openalex.org/W2128375850","https://openalex.org/W2133700826","https://openalex.org/W2150096802","https://openalex.org/W2152297755","https://openalex.org/W2169162427","https://openalex.org/W2226637621","https://openalex.org/W2295261622","https://openalex.org/W2465910871","https://openalex.org/W2577040471","https://openalex.org/W2601045768","https://openalex.org/W2681967692","https://openalex.org/W2758989439","https://openalex.org/W2771616056","https://openalex.org/W3050136167","https://openalex.org/W3091321512","https://openalex.org/W3106805315","https://openalex.org/W3108696194","https://openalex.org/W4210319906","https://openalex.org/W4235150677"],"related_works":["https://openalex.org/W4309247808","https://openalex.org/W2144601597","https://openalex.org/W2354269291","https://openalex.org/W2101710718","https://openalex.org/W2010222731","https://openalex.org/W2094221504","https://openalex.org/W2411458293","https://openalex.org/W2592794167","https://openalex.org/W2018378208","https://openalex.org/W2942199491"],"abstract_inverted_index":{"Abstract":[0],"Hearing":[1],"loss":[2,37],"in":[3,8,15,59,122,177,215,231],"children":[4],"is":[5,30],"common":[6],"especially":[7],"NICU":[9,60],"with":[10],"consequences":[11],"of":[12,25,64,112,172],"worse":[13],"outcomes":[14],"speech,":[16],"language,":[17],"education,":[18],"social":[19],"functioning,":[20],"cognitive":[21],"abilities,":[22],"and":[23,51,81,85,97,109,131,146,152,155,189,195,223],"quality":[24],"life.":[26],"Whether":[27],"neonatal":[28,57,93,144,209],"pain":[29,58,145,210],"link":[31],"to":[32,39,55,74,91,103,117,199,218],"increase":[33],"risks":[34],"for":[35,235],"hearing":[36,65,77,213,236],"remains":[38],"be":[40],"explored.":[41],"Here,":[42],"we":[43],"implemented":[44],"Complete":[45],"Freund's":[46],"adjuvant":[47],"(CFA)":[48],"plantar":[49],"injection":[50],"needle":[52],"prick":[53],"model":[54],"mimic":[56],"during":[61],"critical":[62],"period":[63],"development.":[66,237],"Auditory":[67],"brainstem":[68],"response":[69],"(ABR)":[70],"test":[71],"was":[72,175],"used":[73,88],"determine":[75,118],"the":[76,156,164,170,200,219],"threshold":[78,148],"at":[79,150,186],"4w":[80,151],"8w":[82,153],"postnatal.":[83],"Sufentanil":[84],"Oxycodone":[86],"were":[87,101,115,134,158],"as":[89],"analgesic":[90,161,230],"treat":[92],"pain.":[94],"Hair":[95],"cell":[96,167],"ribbon":[98],"synapse":[99,171],"stanning":[100],"performed":[102,116],"detect":[104],"cochlear":[105],"function.":[106],"Golgi-cox":[107],"staining":[108],"BDNF":[110,191,221],"immunofluorescence":[111],"auditory":[113,123,187],"cortex":[114,188],"dendritic":[119,126,183,202,225],"spine":[120,184,203,226],"pruning":[121,127,227],"cortex.":[124],"The":[125],"related":[128],"protein":[129],"CaMKII":[130,196],"Rac1/2":[132,194],"level":[133,222],"detected":[135],"by":[136],"western":[137],"blot.":[138],"We":[139],"found":[140],"that":[141,208],"CFA":[142,173,179],"induced":[143,212],"ABR":[147],"increased":[149,182],"postnatal":[154],"impairment":[157,214],"attenuated":[159],"after":[160],"administration.":[162],"Neither":[163],"inner":[165],"hair":[166],"(IHC)":[168],"nor":[169],"mice":[174,180],"damaged":[176],"cochlear.":[178],"showed":[181],"density":[185],"reduced":[190,220],"level.":[192],"Furthermore,":[193],"might":[197],"contributed":[198],"disrupt":[201],"pruning.":[204],"Our":[205],"study":[206],"suggested":[207],"could":[211,233],"adulthood":[216],"ascribed":[217],"AC":[224],"deficiency,":[228],"optimal":[229],"early-life":[232],"beneficial":[234]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-31T00:00:00"}
