{"id":"https://openalex.org/W4200429710","doi":"https://doi.org/10.3390/antibiotics11010019","title":"Anti-Mycobacterial Drug Resistance in Japan: How to Approach This Problem?","display_name":"Anti-Mycobacterial Drug Resistance in Japan: How to Approach This Problem?","publication_year":2021,"publication_date":"2021-12-24","ids":{"openalex":"https://openalex.org/W4200429710","doi":"https://doi.org/10.3390/antibiotics11010019","pmid":"https://pubmed.ncbi.nlm.nih.gov/35052896","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8773147"},"language":"en","primary_location":{"id":"doi:10.3390/antibiotics11010019","doi":"https://doi.org/10.3390/antibiotics11010019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics11010019","pdf_url":"https://www.mdpi.com/2079-6382/11/1/19/pdf?version=1640346841","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-6382/11/1/19/pdf?version=1640346841","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000676978","display_name":"Keisuke Kamada","orcid":"https://orcid.org/0009-0008-5070-4272","observed_orcids":["https://orcid.org/0009-0008-5070-4272","https://orcid.org/0000-0001-7034-4376"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Kamada","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033788592","display_name":"Satoshi Mitarai","orcid":"https://orcid.org/0000-0002-2288-077X","observed_orcids":["https://orcid.org/0000-0002-2288-077X"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Mitarai","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2288-077X","affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo 204-8533, Japan","institution_ids":["https://openalex.org/I4210100133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033788592"],"corresponding_institution_ids":["https://openalex.org/I4210100133"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1944},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1944},"fwci":0.0428,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.11591356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/extensively-drug-resistant-tuberculosis","display_name":"extensively drug-resistant tuberculosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nontuberculous-mycobacteria","display_name":"nontuberculous mycobacteria","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mycobacterium-avium-intracellulare-complex","display_name":"Mycobacterium avium-intracellulare complex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mycobacterium-abscessus","display_name":"Mycobacterium abscessus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/macrolide-resistance","display_name":"macrolide resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clarithromycin","display_name":"clarithromycin","score":0.968999981880188},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.8399999737739563},{"id":"https://openalex.org/keywords/repurposed-drugs","display_name":"repurposed drugs","score":0.6600000262260437},{"id":"https://openalex.org/keywords/treatment-regimens","display_name":"treatment regimens","score":0.7009999752044678},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8125728368759155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6963627338409424},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6925184726715088},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6137582063674927},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.49481314420700073},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48472046852111816},{"id":"https://openalex.org/C2778679867","wikidata":"https://www.wikidata.org/wiki/Q1881705","display_name":"Nontuberculous mycobacteria","level":4,"score":0.4576704502105713},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4554656445980072},{"id":"https://openalex.org/C2777107064","wikidata":"https://www.wikidata.org/wiki/Q1040214","display_name":"Extensively drug-resistant tuberculosis","level":4,"score":0.44387584924697876},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.43212541937828064},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4241958260536194},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.4206858277320862},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.42015087604522705},{"id":"https://openalex.org/C2776111603","wikidata":"https://www.wikidata.org/wiki/Q6946978","display_name":"Mycobacterium abscessus","level":4,"score":0.4131603538990021},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.24618452787399292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1853763461112976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14425167441368103},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13867086172103882},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06604695320129395}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antibiotics11010019","doi":"https://doi.org/10.3390/antibiotics11010019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics11010019","pdf_url":"https://www.mdpi.com/2079-6382/11/1/19/pdf?version=1640346841","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8773147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8773147","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel)","raw_type":"Text"},{"id":"pmid:35052896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35052896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e7dee33bd1464e59b77aeb649d87a96b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e7dee33bd1464e59b77aeb649d87a96b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibiotics, Vol 11, Iss 1, p 19 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antibiotics11010019","doi":"https://doi.org/10.3390/antibiotics11010019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics11010019","pdf_url":"https://www.mdpi.com/2079-6382/11/1/19/pdf?version=1640346841","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1609530245","display_name":null,"funder_award_id":"JP21fk0108129h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G1975258244","display_name":null,"funder_award_id":"JP21fk0108607h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200429710.pdf","grobid_xml":"https://content.openalex.org/works/W4200429710.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1556539514","https://openalex.org/W1993817085","https://openalex.org/W2006692601","https://openalex.org/W2038526366","https://openalex.org/W2045132255","https://openalex.org/W2052422622","https://openalex.org/W2055306969","https://openalex.org/W2075453637","https://openalex.org/W2093403095","https://openalex.org/W2113926700","https://openalex.org/W2114152855","https://openalex.org/W2119413839","https://openalex.org/W2138282457","https://openalex.org/W2143497620","https://openalex.org/W2157211382","https://openalex.org/W2160434710","https://openalex.org/W2297720899","https://openalex.org/W2338750746","https://openalex.org/W2345743845","https://openalex.org/W2414255013","https://openalex.org/W2515774853","https://openalex.org/W2516938750","https://openalex.org/W2543191549","https://openalex.org/W2555261317","https://openalex.org/W2557635410","https://openalex.org/W2560301785","https://openalex.org/W2592766013","https://openalex.org/W2610803530","https://openalex.org/W2736151488","https://openalex.org/W2748145826","https://openalex.org/W2787709298","https://openalex.org/W2889393910","https://openalex.org/W2892323117","https://openalex.org/W2895940925","https://openalex.org/W2901972975","https://openalex.org/W2913591895","https://openalex.org/W2920824163","https://openalex.org/W2921372111","https://openalex.org/W2939839920","https://openalex.org/W2946893588","https://openalex.org/W2952312012","https://openalex.org/W2954390328","https://openalex.org/W2955148412","https://openalex.org/W2963911688","https://openalex.org/W2969057284","https://openalex.org/W2980659148","https://openalex.org/W2981035769","https://openalex.org/W2989551129","https://openalex.org/W2997722168","https://openalex.org/W2998952059","https://openalex.org/W2999750593","https://openalex.org/W3009599329","https://openalex.org/W3013235206","https://openalex.org/W3019572563","https://openalex.org/W3022473231","https://openalex.org/W3024438245","https://openalex.org/W3028458967","https://openalex.org/W3044657223","https://openalex.org/W3048125220","https://openalex.org/W3049339260","https://openalex.org/W3082908627","https://openalex.org/W3092843994","https://openalex.org/W3093313684","https://openalex.org/W3101383634","https://openalex.org/W3108150642","https://openalex.org/W3112167093","https://openalex.org/W3114773135","https://openalex.org/W3120846591","https://openalex.org/W3125736681","https://openalex.org/W3131040959","https://openalex.org/W3133634705","https://openalex.org/W3134934265","https://openalex.org/W3140986560","https://openalex.org/W3159002700","https://openalex.org/W3163596838","https://openalex.org/W3193190779","https://openalex.org/W4200205564","https://openalex.org/W4233003559","https://openalex.org/W4300447157"],"related_works":["https://openalex.org/W2983281069","https://openalex.org/W4387662265","https://openalex.org/W2810997016","https://openalex.org/W112724496","https://openalex.org/W2052889788","https://openalex.org/W7057249073","https://openalex.org/W1523482406","https://openalex.org/W37631847","https://openalex.org/W4411384753","https://openalex.org/W104553977"],"abstract_inverted_index":{"Mycobacteriosis":[0],"is":[1,35,40,54,205],"mainly":[2],"caused":[3],"by":[4,172],"two":[5],"groups":[6],"of":[7,33,52,70,73,83,106,125,153,167,188,194,247,258],"species:":[8],"Mycobacterium":[9,140,145],"tuberculosis":[10,61,75],"and":[11,62,85,98,144,175,197,217,242,255],"non-tuberculosis":[12],"mycobacteria":[13],"(NTM).":[14],"The":[15,26],"pathogens":[16,31],"cause":[17],"not":[18],"only":[19],"respiratory":[20],"infections,":[21],"but":[22],"also":[23],"general":[24],"diseases.":[25],"common":[27],"problem":[28],"in":[29,49,89,128,156,220,226,240,265],"these":[30,113],"as":[32,93],"today":[34],"drug":[36,56,252],"resistance.":[37],"Tuberculosis":[38],"(TB)":[39],"a":[41,164,266],"major":[42,47,151],"public":[43],"health":[44],"concern.":[45],"A":[46],"challenge":[48],"the":[50,67,71,81,99,104,126,129,150,186,192,237,244,256],"treatment":[51,72,97,105,116,183,193,212],"TB":[53,241],"anti-mycobacterial":[55],"resistance":[57],"(AMR),":[58],"including":[59],"multidrug-resistant":[60],"extensively":[63],"drug-resistant":[64,74],"tuberculosis.":[65],"Recently,":[66],"success":[68],"rate":[69],"(DR-TB)":[76],"has":[77],"improved":[78],"significantly":[79],"with":[80,103,182,231,234],"introduction":[82],"new":[84,259],"repurposed":[86],"drugs,":[87],"especially":[88],"industrialized":[90],"countries":[91],"such":[92],"Japan.":[94,157],"However,":[95,185],"long-term":[96],"adverse":[100],"events":[101],"associated":[102,233],"DR-TB":[107],"are":[108,122,137,149,160,199,223,262],"still":[109],"problematic.":[110],"To":[111],"solve":[112],"problems,":[114],"optimal":[115],"regimens":[117],"designed/tailor-made":[118],"for":[119,191,214],"each":[120],"patient":[121],"necessary,":[123],"regardless":[124],"location":[127],"world.":[130],"In":[131],"contrast":[132],"to":[133,163,208],"TB,":[134],"NTM":[135,154,221],"infections":[136,155,222],"environmentally":[138],"oriented.":[139],"avium-intracellulare":[141],"complex":[142],"(MAC)":[143],"abscessus":[146],"species":[147],"(MABS)":[148],"causes":[152],"These":[158],"bacteria":[159],"naturally":[161],"resistant":[162],"wide":[165],"variation":[166],"antimicrobial":[168],"agents.":[169],"Macrolides,":[170],"represented":[171],"clarithromycin":[173],"(CLR)":[174],"amikacin":[176],"(AMK),":[177],"show":[178],"relatively":[179],"good":[180],"correlation":[181],"success.":[184],"efficacies":[187],"potential":[189],"drugs":[190,248],"macrolide-resistant":[195,215],"MAC":[196,216],"MABS":[198],"currently":[200],"under":[201],"evaluation.":[202],"Thus,":[203],"it":[204],"particularly":[206],"difficult":[207],"construct":[209],"an":[210],"effective":[211],"regimen":[213],"MABS.":[218],"AMR":[219,238],"rather":[224],"serious":[225],"Japan,":[227],"even":[228],"when":[229],"compared":[230],"challenges":[232],"DR-TB.":[235],"Given":[236],"problems":[239],"NTM,":[243],"appropriate":[245],"use":[246],"based":[249],"on":[250],"accurate":[251],"susceptibility":[253],"testing":[254],"development":[257],"compounds/regimens":[260],"that":[261],"strongly":[263],"bactericidal":[264],"short-time":[267],"course":[268],"will":[269],"be":[270],"highly":[271],"expected.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-12-31T00:00:00"}
