{"id":"https://openalex.org/W4200426683","doi":"https://doi.org/10.1021/acschemneuro.1c00443","title":"Exploration of Neuroprotective Properties of a Naturally Inspired Multifunctional Molecule (F24) against Oxidative Stress and Amyloid \u03b2 Induced Neurotoxicity in Alzheimer\u2019s Disease Models","display_name":"Exploration of Neuroprotective Properties of a Naturally Inspired Multifunctional Molecule (F24) against Oxidative Stress and Amyloid \u03b2 Induced Neurotoxicity in Alzheimer\u2019s Disease Models","publication_year":2021,"publication_date":"2021-12-21","ids":{"openalex":"https://openalex.org/W4200426683","doi":"https://doi.org/10.1021/acschemneuro.1c00443","pmid":"https://pubmed.ncbi.nlm.nih.gov/34931800"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.1c00443","doi":"https://doi.org/10.1021/acschemneuro.1c00443","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.1c00443","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009751565","display_name":"Yash Pal Singh","orcid":"https://orcid.org/0000-0003-1535-2829","observed_orcids":["https://orcid.org/0000-0003-1535-2829"]},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yash Pal Singh","raw_affiliation_strings":["Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"],"raw_orcid":"https://orcid.org/0000-0003-1535-2829","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016806799","display_name":"Navneet Kumar","orcid":"https://orcid.org/0000-0003-4104-5187","observed_orcids":["https://orcid.org/0000-0003-4104-5187"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navneet Kumar","raw_affiliation_strings":["Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, 160062 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-4104-5187","affiliations":[{"raw_affiliation_string":"Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, 160062 Punjab, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073831588","display_name":"Khushbu Priya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Khushbu Priya","raw_affiliation_strings":["Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221005, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061625079","display_name":"Brijesh Singh Chauhan","orcid":"https://orcid.org/0000-0001-5641-8068","observed_orcids":["https://orcid.org/0000-0001-5641-8068"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Brijesh Singh Chauhan","raw_affiliation_strings":["Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007653652","display_name":"Gauri Shankar","orcid":"https://orcid.org/0000-0002-8958-4684","observed_orcids":["https://orcid.org/0000-0002-8958-4684"]},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gauri Shankar","raw_affiliation_strings":["Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420257","display_name":"Saroj Kumar","orcid":"https://orcid.org/0000-0001-7029-1163","observed_orcids":["https://orcid.org/0000-0001-7029-1163"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saroj Kumar","raw_affiliation_strings":["Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088874068","display_name":"Gireesh Kumar Singh","orcid":"https://orcid.org/0000-0002-6992-0804","observed_orcids":["https://orcid.org/0000-0002-6992-0804"]},"institutions":[{"id":"https://openalex.org/I343503978","display_name":"Central University of South Bihar","ror":"https://ror.org/01t1agx36","country_code":"IN","type":"education","lineage":["https://openalex.org/I343503978"]},{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gireesh Kumar Singh","raw_affiliation_strings":["Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, 824236 Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"raw_affiliation_string":"Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, 824236 Bihar, India","institution_ids":["https://openalex.org/I343503978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011486337","display_name":"Saripella Srikrishna","orcid":"https://orcid.org/0000-0002-6019-1588","observed_orcids":["https://orcid.org/0000-0002-6019-1588"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saripella Srikrishna","raw_affiliation_strings":["Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053019716","display_name":"Prabha Garg","orcid":"https://orcid.org/0000-0002-6922-4809","observed_orcids":["https://orcid.org/0000-0002-6922-4809"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabha Garg","raw_affiliation_strings":["Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, 160062 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0002-6922-4809","affiliations":[{"raw_affiliation_string":"Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, 160062 Punjab, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103266279","display_name":"Gourav Singh","orcid":"https://orcid.org/0000-0002-8234-9489","observed_orcids":["https://orcid.org/0000-0002-8234-9489","https://orcid.org/0009-0003-4289-8939"]},"institutions":[{"id":"https://openalex.org/I343503978","display_name":"Central University of South Bihar","ror":"https://ror.org/01t1agx36","country_code":"IN","type":"education","lineage":["https://openalex.org/I343503978"]},{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gourav Singh","raw_affiliation_strings":["Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, 824236 Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"raw_affiliation_string":"Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, 824236 Bihar, India","institution_ids":["https://openalex.org/I343503978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062935442","display_name":"Geeta Rai","orcid":"https://orcid.org/0000-0001-8162-8964","observed_orcids":["https://orcid.org/0000-0001-8162-8964"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Geeta Rai","raw_affiliation_strings":["Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221005, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025358021","display_name":"Gyan Prakash Modi","orcid":"https://orcid.org/0000-0002-8003-5566","observed_orcids":["https://orcid.org/0000-0002-8003-5566"]},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289","https://openalex.org/I91357014"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gyan Modi","raw_affiliation_strings":["Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"],"raw_orcid":"https://orcid.org/0000-0002-8003-5566","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025358021","https://openalex.org/A5062935442"],"corresponding_institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.3634,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93359253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"27","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9039999842643738},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/brain-permeability","display_name":"brain permeability","score":0.6000000238418579},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.7680000066757202},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lead-molecules","display_name":"lead molecules","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8953666090965271},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8391573429107666},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8057090640068054},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5905086994171143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5411535501480103},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5375288724899292},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.4943580627441406},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.4849576950073242},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4160325527191162},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3809453845024109},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3409423530101776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3332309126853943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30277448892593384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20727285742759705},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10574334859848022},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.08119896054267883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08052986860275269}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acschemneuro.1c00443","doi":"https://doi.org/10.1021/acschemneuro.1c00443","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.1c00443","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmid:34931800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34931800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1443697735","display_name":null,"funder_award_id":"SERB-CRG/2018/003490","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G6483724256","display_name":null,"funder_award_id":"S.M./2016-17/1198/L","funder_id":"https://openalex.org/F4320330011","funder_display_name":"Indian Institute of Technology (BHU) Varanasi"}],"funders":[{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320330011","display_name":"Indian Institute of Technology (BHU) Varanasi","ror":"https://ror.org/01kh5gc44"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W99383509","https://openalex.org/W1562398969","https://openalex.org/W1967061503","https://openalex.org/W1998616690","https://openalex.org/W2006882273","https://openalex.org/W2008708467","https://openalex.org/W2016047921","https://openalex.org/W2021280501","https://openalex.org/W2023695511","https://openalex.org/W2026976753","https://openalex.org/W2039093830","https://openalex.org/W2041863676","https://openalex.org/W2044172327","https://openalex.org/W2057477511","https://openalex.org/W2060079863","https://openalex.org/W2067174909","https://openalex.org/W2070753604","https://openalex.org/W2073663144","https://openalex.org/W2081693079","https://openalex.org/W2084107396","https://openalex.org/W2092984629","https://openalex.org/W2103440561","https://openalex.org/W2109154308","https://openalex.org/W2112006614","https://openalex.org/W2114468387","https://openalex.org/W2122294662","https://openalex.org/W2123333780","https://openalex.org/W2130479394","https://openalex.org/W2141205833","https://openalex.org/W2153821084","https://openalex.org/W2154319440","https://openalex.org/W2171268876","https://openalex.org/W2256742438","https://openalex.org/W2286748995","https://openalex.org/W2333346687","https://openalex.org/W2338506659","https://openalex.org/W2412804379","https://openalex.org/W2435165854","https://openalex.org/W2485452248","https://openalex.org/W2568450381","https://openalex.org/W2590350493","https://openalex.org/W2604840146","https://openalex.org/W2612672600","https://openalex.org/W2627059073","https://openalex.org/W2734651019","https://openalex.org/W2792609242","https://openalex.org/W2809078375","https://openalex.org/W2810491578","https://openalex.org/W2883135615","https://openalex.org/W2892906130","https://openalex.org/W2895004036","https://openalex.org/W2904361233","https://openalex.org/W2906263965","https://openalex.org/W2913141494","https://openalex.org/W2954613999","https://openalex.org/W2954735548","https://openalex.org/W2995023556","https://openalex.org/W2997887045","https://openalex.org/W3015770227","https://openalex.org/W3039786831","https://openalex.org/W3043986491","https://openalex.org/W3056264410","https://openalex.org/W3086481192","https://openalex.org/W3113989042","https://openalex.org/W3198352952","https://openalex.org/W4210987525","https://openalex.org/W4363672532"],"related_works":["https://openalex.org/W7169758119","https://openalex.org/W2939457969","https://openalex.org/W4294363557","https://openalex.org/W7171427617","https://openalex.org/W7214520365","https://openalex.org/W1490179748","https://openalex.org/W3210732039","https://openalex.org/W7154610052","https://openalex.org/W2163290644","https://openalex.org/W4408929518"],"abstract_inverted_index":{"The":[0,53,69,158,177,210,238],"pathological":[1],"hallmarks":[2],"of":[3,15,20,56,74,80,106,175,181,198,221,236],"Alzheimer\u2019s":[4],"disease":[5],"(AD)":[6],"are":[7],"manifested":[8],"as":[9,229,251],"an":[10,127],"increase":[11],"in":[12,26,29,50,60,84,103,126,128,163,166,185,203,233],"the":[13,21,86,104,150,186,204,234],"level":[14],"oxidative":[16],"stress":[17],"and":[18,28,34,71,113,154,165,200,227],"aggregation":[19,172],"amyloid-\u03b2":[22],"protein.":[23],"In":[24],"vitro,":[25],"vivo,":[27],"silico":[30],"experiments":[31,242],"were":[32,98,145],"designed":[33],"carried":[35,146],"out":[36,147],"with":[37,77],"multifunctional":[38,219,260],"cholinergic":[39],"inhibitor,":[40],"F24":[41,57,81,95,123,153,182,193,215,248],"(EJMC-":[42],"7a":[43],")":[44],"to":[45,100,148,258],"explore":[46,259],"its":[47,120],"neuroprotective":[48,121,211],"effects":[49],"AD":[51,208,264],"models.":[52],"neuroprotection":[54],"ability":[55,174,180],"was":[58,82,183,194],"tested":[59,195],"SH-SY5Y":[61,75],"cells,":[62],"a":[63,230,252],"widely":[64],"used":[65],"neuronal":[66],"cell":[67],"line.":[68],"pretreatment":[70],"subsequent":[72],"co-treatment":[73],"cells":[76,87,97],"different":[78],"doses":[79,197],"effective":[83,102],"rescuing":[85,133],"from":[88,136,240],"H":[89],"2":[90,92],"O":[91],"induced":[93,116],"neurotoxicity.":[94],"treated":[96],"found":[99],"be":[101],"reduction":[105],"cellular":[107],"reactive":[108],"oxygen":[109],"species,":[110],"DNA":[111],"damage,":[112],"A\u03b2":[114,140,155,170],"1\u201342":[115,156,171],"neurotoxicity,":[117],"which":[118],"validated":[119],"effectiveness.":[122],"exhibited":[124],"efficacy":[125],"vivo":[129,167],"Drosophila":[130],"model":[131],"by":[132,139,214],"eye":[134],"phenotypes":[135],"degeneration":[137],"caused":[138],"toxicity.":[141],"Further,":[142],"computational":[143,159],"studies":[144,160,168],"monitor":[149],"interaction":[151],"between":[152],"aggregates.":[157],"corroborated":[161],"our":[162,241],"vitro":[164],"suggesting":[169],"modulation":[173],"F24.":[176],"brain":[178],"entry":[179],"studied":[184],"parallel":[187],"artificial":[188],"membrane":[189],"permeability":[190],"assay.":[191],"Finally,":[192],"at":[196],"1":[199],"2.5":[201],"mg/kg":[202],"Morris":[205],"water":[206],"maze":[207],"model.":[209],"properties":[212],"shown":[213],"strongly":[216,243],"suggest":[217],"that":[218,245],"features":[220],"this":[222],"molecule":[223,254],"provide":[224],"symptomatic":[225],"relief":[226],"act":[228],"disease-modifying":[231],"agent":[232],"treatment":[235],"AD.":[237],"results":[239],"indicated":[244],"natural":[246],"template-based":[247],"could":[249],"serve":[250],"lead":[253],"for":[255,263],"further":[256],"investigation":[257],"therapeutic":[261],"agents":[262],"management.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}