{"id":"https://openalex.org/W4200426322","doi":"https://doi.org/10.3389/fphar.2021.796565","title":"Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis","display_name":"Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis","publication_year":2021,"publication_date":"2021-12-10","ids":{"openalex":"https://openalex.org/W4200426322","doi":"https://doi.org/10.3389/fphar.2021.796565","pmid":"https://pubmed.ncbi.nlm.nih.gov/34955862"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2021.796565","doi":"https://doi.org/10.3389/fphar.2021.796565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.796565","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.796565/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.796565/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087398659","display_name":"Ting Xie","orcid":"https://orcid.org/0000-0002-9958-3888","observed_orcids":["https://orcid.org/0000-0002-9958-3888"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Xie","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","Medical Technology Experimental Teaching Center, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Medical Technology Experimental Teaching Center, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101308357","display_name":"Xiaodong Chen","orcid":"https://orcid.org/0009-0002-2662-2206","observed_orcids":["https://orcid.org/0009-0002-2662-2206"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Chen","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101815639","display_name":"Wenyi Chen","orcid":"https://orcid.org/0000-0003-4874-8985","observed_orcids":["https://orcid.org/0000-0003-4874-8985"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyi Chen","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","Medical Technology Experimental Teaching Center, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Medical Technology Experimental Teaching Center, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102437440","display_name":"Sien Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sien Huang","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110830236","display_name":"Xinye Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinye Peng","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001830826","display_name":"Lingmei Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingmei Tian","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026840244","display_name":"Xuejie Wu","orcid":"https://orcid.org/0000-0001-9080-7155","observed_orcids":["https://orcid.org/0000-0001-9080-7155"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejie Wu","raw_affiliation_strings":["Department of Medical Imaging Technology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging Technology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111772840","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0002-5588-0274","observed_orcids":["https://orcid.org/0000-0002-5588-0274"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Huang","raw_affiliation_strings":["Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111772840"],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.5613,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95829632,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":null,"first_page":"796565","last_page":"796565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.3163999915122986,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.890999972820282},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.515999972820282},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.8330000042915344},{"id":"https://openalex.org/keywords/age-rage-signaling-pathway","display_name":"AGE-RAGE signaling pathway","score":0.9309999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix-receptor-interaction","display_name":"extracellular matrix-receptor interaction","score":0.9789999723434448},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/polyphenolic-antioxidants","display_name":"antioxidant polyphenols","score":0.5450000166893005},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9178959131240845},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7856402397155762},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5861733555793762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5233263969421387},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5087001919746399},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.48811373114585876},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4644475281238556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4339587390422821},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39638301730155945}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2021.796565","doi":"https://doi.org/10.3389/fphar.2021.796565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.796565","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.796565/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:34955862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34955862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8702852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8702852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5c7e5911a14c4454ad142e8fb28b960d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5c7e5911a14c4454ad142e8fb28b960d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2021.796565","doi":"https://doi.org/10.3389/fphar.2021.796565","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.796565","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.796565/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6709743597","display_name":null,"funder_award_id":"2020J01652","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200426322.pdf","grobid_xml":"https://content.openalex.org/works/W4200426322.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W568495147","https://openalex.org/W575331073","https://openalex.org/W1518103124","https://openalex.org/W1785455093","https://openalex.org/W1906789665","https://openalex.org/W1963561631","https://openalex.org/W1978553979","https://openalex.org/W1992637754","https://openalex.org/W2010720331","https://openalex.org/W2024251603","https://openalex.org/W2042549883","https://openalex.org/W2063683869","https://openalex.org/W2077811732","https://openalex.org/W2079253126","https://openalex.org/W2081352671","https://openalex.org/W2088950533","https://openalex.org/W2106842874","https://openalex.org/W2107277218","https://openalex.org/W2115338196","https://openalex.org/W2121188499","https://openalex.org/W2126728583","https://openalex.org/W2136497849","https://openalex.org/W2146558971","https://openalex.org/W2154049977","https://openalex.org/W2162883084","https://openalex.org/W2290981871","https://openalex.org/W2320485124","https://openalex.org/W2431321293","https://openalex.org/W2460530547","https://openalex.org/W2471883234","https://openalex.org/W2513367245","https://openalex.org/W2557738935","https://openalex.org/W2562584932","https://openalex.org/W2566469811","https://openalex.org/W2609735865","https://openalex.org/W2770513830","https://openalex.org/W2778425750","https://openalex.org/W2795310063","https://openalex.org/W2806875030","https://openalex.org/W2886436169","https://openalex.org/W2893186772","https://openalex.org/W2893585093","https://openalex.org/W2900068552","https://openalex.org/W2907393697","https://openalex.org/W2912721012","https://openalex.org/W2913281433","https://openalex.org/W2920093563","https://openalex.org/W2957289901","https://openalex.org/W2967611022","https://openalex.org/W2999764161","https://openalex.org/W3028594276","https://openalex.org/W3070136943","https://openalex.org/W3093833227","https://openalex.org/W3097237610"],"related_works":["https://openalex.org/W2589512255","https://openalex.org/W2887769962","https://openalex.org/W4379468034","https://openalex.org/W2581018598","https://openalex.org/W1984122016","https://openalex.org/W2117116660","https://openalex.org/W1971462710","https://openalex.org/W4360797513","https://openalex.org/W2047540814","https://openalex.org/W2736387565"],"abstract_inverted_index":{"Curcumin":[0,120],"is":[1,29],"a":[2,30,130,264],"natural":[3],"polyphenol":[4],"compound":[5],"with":[6,80,195,223,271],"anti-diabetic,":[7],"anti-oxidative,":[8],"and":[9,77,82,93,113,230],"anti-inflammatory":[10],"effects.":[11],"Although":[12],"many":[13],"studies":[14],"have":[15],"reported":[16],"the":[17,47,53,138,143,149,152,156,168,172,197,226,231,237,242],"protective":[18],"effect":[19,134,198],"of":[20,32,41,50,141,145,155,165,171,181,199,211,245],"curcumin":[21,35,51,69,81,166,193,218,247,262],"in":[22,36,117,148,204,236,269],"diabetes":[23],"mellitus":[24],"or":[25,103,221],"diabetic":[26,37,54,59,118,205,238,253,283],"nephropathy,":[27],"there":[28],"lack":[31],"research":[33],"on":[34,52],"retinopathy.":[38],"The":[39],"purpose":[40],"this":[42],"study":[43],"was":[44,207],"to":[45,185,189,251,277],"investigate":[46],"therapeutic":[48,267,280],"effects":[49],"retinal":[55,125,254],"injury.":[56],"Streptozotocin":[57],"(STZ)-induced":[58],"rats":[60,206],"(60,":[61],"n":[62],"=":[63],"12":[64],"each)":[65],"were":[66,99],"respectively":[67],"given":[68],"orally":[70],"(200":[71],"mg/kg/day),":[72],"insulin":[73,83,212],"subcutaneously":[74],"(4\u20136":[75],"IU/day),":[76],"combined":[78,194,222],"therapy":[79,105],"for":[84],"4":[85],"weeks.":[86],"Retinal":[87],"histopathological":[88],"changes,":[89],"oxidative":[90,111,146,177],"stress":[91,147],"markers,":[92],"transcriptome":[94],"profiles":[95],"from":[96],"each":[97],"group":[98],"observed.":[100],"Curcumin,":[101],"insulin,":[102,196,224],"combination":[104,270],"significantly":[106,123],"reduced":[107,124],"blood":[108],"glucose,":[109],"alleviated":[110,167],"stress,":[112,178],"improved":[114],"pathological":[115],"damage":[116],"rats.":[119],"not":[121],"only":[122],"edema":[126],"but":[127],"also":[128],"had":[129],"better":[131,208],"anti-photoreceptor":[132],"apoptosis":[133],"than":[135,209],"insulin.":[136],"In":[137],"early":[139,243],"stage":[140,244],"diabetes,":[142,246],"enhancement":[144],"retina":[150],"induced":[151,175],"adaptive":[153],"activation":[154,170],"nuclear":[157],"factor":[158,160],"E2-associated":[159],"2":[161],"(Nrf2)":[162],"pathway.":[163],"Treatment":[164],"compensatory":[169],"Nrf2":[173,201],"pathway":[174,202,229],"by":[176,179],"virtue":[180],"its":[182,257],"antioxidant":[183],"ability":[184],"transfer":[186],"hydrogen":[187],"atoms":[188],"free":[190],"radicals.":[191],"When":[192],"maintaining":[200],"homeostasis":[203],"that":[210,217],"alone.":[213],"Transcriptomic":[214],"analyses":[215],"revealed":[216],"either":[219],"alone,":[220],"inhibited":[225],"AGE-RAGE":[227],"signaling":[228],"extracellular":[232],"matrix":[233],"(ECM)-receptor":[234],"interaction":[235],"retina.":[239],"Thus,":[240],"at":[241],"can":[248],"be":[249],"used":[250],"alleviate":[252],"injury":[255],"through":[256],"anti-oxidative":[258],"effect.":[259],"If":[260],"taking":[261],"as":[263],"potential":[265],"complementary":[266],"option":[268],"antihyperglycemic":[272],"agents,":[273],"which":[274],"would":[275],"lead":[276],"more":[278],"effective":[279],"outcomes":[281],"against":[282],"complications.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
