{"id":"https://openalex.org/W4200424339","doi":"https://doi.org/10.3390/antiox10122029","title":"Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1\u2212/\u2212 Mice: Impact on Redox Status and Metabolism","display_name":"Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1\u2212/\u2212 Mice: Impact on Redox Status and Metabolism","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200424339","doi":"https://doi.org/10.3390/antiox10122029","pmid":"https://pubmed.ncbi.nlm.nih.gov/34943131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8698966"},"language":"en","primary_location":{"id":"doi:10.3390/antiox10122029","doi":"https://doi.org/10.3390/antiox10122029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10122029","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/antiox10122029","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067375384","display_name":"Giulia Bortolussi","orcid":"https://orcid.org/0000-0001-9470-0902","observed_orcids":["https://orcid.org/0000-0001-9470-0902"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Bortolussi","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018054738","display_name":"Xiaoxia Shi","orcid":"https://orcid.org/0000-0003-1753-241X","observed_orcids":["https://orcid.org/0000-0003-1753-241X"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["CN","NL"],"is_corresponding":false,"raw_author_name":"Xiaoxia Shi","raw_affiliation_strings":["Key Laboratory of Protein Modification and Disease, School of Bioengineering, Dalian University of Technology, Dalian 116024, China","Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein Modification and Disease, School of Bioengineering, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070168455","display_name":"Lysbeth ten Bloemendaal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lysbeth ten Bloemendaal","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056628132","display_name":"Bhaswati Banerjee","orcid":"https://orcid.org/0000-0003-2231-7263","observed_orcids":["https://orcid.org/0000-0003-2231-7263"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bhaswati Banerjee","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2231-7263","affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044963611","display_name":"Dirk Rudi de Waart","orcid":"https://orcid.org/0000-0001-6662-1801","observed_orcids":["https://orcid.org/0000-0001-6662-1801"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dirk R. De Waart","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057073900","display_name":"Gabriele Baj","orcid":"https://orcid.org/0000-0002-2625-9454","observed_orcids":["https://orcid.org/0000-0002-2625-9454"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Baj","raw_affiliation_strings":["Light Microscopy Imaging Center, Department of Life Sciences, University of Trieste, 34127 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2625-9454","affiliations":[{"raw_affiliation_string":"Light Microscopy Imaging Center, Department of Life Sciences, University of Trieste, 34127 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038099773","display_name":"Wei\u2010Yu Chen","orcid":"https://orcid.org/0000-0002-9325-8734","observed_orcids":["https://orcid.org/0000-0002-9325-8734","https://orcid.org/0000-0003-1735-1037"]},"institutions":[{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Weiyu Chen","raw_affiliation_strings":["Heart Research Institute, Sydney, NSW 2042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Institute, Sydney, NSW 2042, Australia","institution_ids":["https://openalex.org/I2801241159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044314042","display_name":"Ronald P.J. Oude Elferink","orcid":"https://orcid.org/0000-0002-1779-0833","observed_orcids":["https://orcid.org/0000-0002-1779-0833"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald P. Oude Elferink","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018461629","display_name":"Ulrich H. Beuers","orcid":"https://orcid.org/0000-0001-5114-7799","observed_orcids":["https://orcid.org/0000-0001-5114-7799"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ulrich Beuers","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087413894","display_name":"Coen C. Paulusma","orcid":"https://orcid.org/0000-0001-7284-1974","observed_orcids":["https://orcid.org/0000-0001-7284-1974"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Coen C. Paulusma","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015511874","display_name":"Roland Stocker","orcid":"https://orcid.org/0000-0002-7414-6681","observed_orcids":["https://orcid.org/0000-0002-7414-6681"]},"institutions":[{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roland Stocker","raw_affiliation_strings":["Heart Research Institute, Sydney, NSW 2042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Institute, Sydney, NSW 2042, Australia","institution_ids":["https://openalex.org/I2801241159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031602453","display_name":"Andr\u00e9s Fernando Muro","orcid":"https://orcid.org/0000-0002-9628-0494","observed_orcids":["https://orcid.org/0000-0002-9628-0494"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andr\u00e9s F. Muro","raw_affiliation_strings":["International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9628-0494","affiliations":[{"raw_affiliation_string":"International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056720047","display_name":"Piter J. Bosma","orcid":"https://orcid.org/0000-0001-8302-1672","observed_orcids":["https://orcid.org/0000-0001-8302-1672"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Piter J. Bosma","raw_affiliation_strings":["Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031602453","https://openalex.org/A5056720047"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4210151833","https://openalex.org/I887064364","https://openalex.org/I91080651"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.808,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82799767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"2029","last_page":"2029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliverdin-reductase-a","display_name":"biliverdin reductase A","score":0.890999972820282},{"id":"https://openalex.org/keywords/ugt1","display_name":"UGT1","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bilirubin-glucuronidation","display_name":"bilirubin glucuronidation","score":0.878000020980835},{"id":"https://openalex.org/keywords/unconjugated-hyperbilirubinemia","display_name":"unconjugated hyperbilirubinemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neonatal-hyperbilirubinemia","display_name":"neonatal hyperbilirubinemia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bilirubin-neurotoxicity","display_name":"bilirubin neurotoxicity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7070000171661377},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6499999761581421},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bilirubin-metabolism","display_name":"bilirubin metabolism","score":0.628000020980835},{"id":"https://openalex.org/keywords/genetic-mouse-models","display_name":"genetic mouse models","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.7783045768737793},{"id":"https://openalex.org/C23849879","wikidata":"https://www.wikidata.org/wiki/Q420000","display_name":"Biliverdin reductase","level":5,"score":0.7486201524734497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6590111255645752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6372338533401489},{"id":"https://openalex.org/C2776253728","wikidata":"https://www.wikidata.org/wiki/Q422964","display_name":"Biliverdin","level":5,"score":0.6284263134002686},{"id":"https://openalex.org/C2781278898","wikidata":"https://www.wikidata.org/wiki/Q419543","display_name":"Glucuronosyltransferase","level":4,"score":0.5860579013824463},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5436366200447083},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.5404857397079468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4309409260749817},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41686850786209106},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.357982337474823},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.24700060486793518},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21535152196884155},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.18435484170913696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1667514443397522},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.16181617975234985},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09604793787002563},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.06432971358299255}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/antiox10122029","doi":"https://doi.org/10.3390/antiox10122029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10122029","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmid:34943131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34943131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8698966","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8698966/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:arts.units.it:11368/3002410","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/2076-3921/10/12/2029","pdf_url":"https://www.mdpi.com/2076-3921/10/12/2029/pdf?version=1640180919","source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/a02608de-96d0-4ca1-910f-ee63fc10871f","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/longterm-effects-of-biliverdin-reductase-a-deficiency-in-ugt1-mice(a02608de-96d0-4ca1-910f-ee63fc10871f).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, 10(12):2029. MDPI Multidisciplinary Digital Publishing Institute","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9e009047432a43d0942b9885748f455b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9e009047432a43d0942b9885748f455b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 10, Iss 12, p 2029 (2021)","raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/3956d0e2-4b04-4914-b690-b15efc59971a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/3956d0e2-4b04-4914-b690-b15efc59971a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bortolussi, G, Shi, X, Bloemendaal, L T, Banerjee, B, de Waart, D R, Baj, G, Chen, W, Oude Elferink, R P, Beuers, U, Paulusma, C C, Stocker, R, Muro, A F & Bosma, P J 2021, 'Long-term effects of biliverdin reductase a deficiency in ugt1\u2212/\u2212 mice : impact on redox status and metabolism', Antioxidants, vol. 10, no. 12, 2029. https://doi.org/10.3390/antiox10122029","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/antiox10122029","doi":"https://doi.org/10.3390/antiox10122029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10122029","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200424339.pdf","grobid_xml":"https://content.openalex.org/works/W4200424339.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1533677192","https://openalex.org/W1583940462","https://openalex.org/W1798572012","https://openalex.org/W1869396256","https://openalex.org/W1963989090","https://openalex.org/W1966582616","https://openalex.org/W1973466019","https://openalex.org/W1973646725","https://openalex.org/W1976866228","https://openalex.org/W1981427672","https://openalex.org/W1983329266","https://openalex.org/W1987777210","https://openalex.org/W1993996596","https://openalex.org/W1996626059","https://openalex.org/W2003292110","https://openalex.org/W2031289099","https://openalex.org/W2031579831","https://openalex.org/W2034636398","https://openalex.org/W2035372905","https://openalex.org/W2036214482","https://openalex.org/W2042703845","https://openalex.org/W2044563258","https://openalex.org/W2047523700","https://openalex.org/W2053494209","https://openalex.org/W2054846013","https://openalex.org/W2059070513","https://openalex.org/W2064856616","https://openalex.org/W2067203989","https://openalex.org/W2071307185","https://openalex.org/W2074905732","https://openalex.org/W2075577178","https://openalex.org/W2077587761","https://openalex.org/W2087583408","https://openalex.org/W2089095625","https://openalex.org/W2091847597","https://openalex.org/W2093240125","https://openalex.org/W2094147305","https://openalex.org/W2097579242","https://openalex.org/W2097639266","https://openalex.org/W2098340069","https://openalex.org/W2103317372","https://openalex.org/W2108346413","https://openalex.org/W2111884823","https://openalex.org/W2122025820","https://openalex.org/W2122054295","https://openalex.org/W2128849018","https://openalex.org/W2145511446","https://openalex.org/W2166016178","https://openalex.org/W2169374003","https://openalex.org/W2173292682","https://openalex.org/W2281876466","https://openalex.org/W2374911344","https://openalex.org/W2467585178","https://openalex.org/W2531283659","https://openalex.org/W2553346776","https://openalex.org/W2611568949","https://openalex.org/W2744457794","https://openalex.org/W2771396880","https://openalex.org/W2771706219","https://openalex.org/W2792566138","https://openalex.org/W2795332959","https://openalex.org/W2941091531","https://openalex.org/W2944482549","https://openalex.org/W2964054943","https://openalex.org/W2970381536","https://openalex.org/W2985615657","https://openalex.org/W2999262601","https://openalex.org/W3134063318","https://openalex.org/W3203614162","https://openalex.org/W4234144206","https://openalex.org/W4246178975"],"related_works":["https://openalex.org/W316239139","https://openalex.org/W2611568949","https://openalex.org/W2744457794","https://openalex.org/W7126157460","https://openalex.org/W7126480275","https://openalex.org/W2097639266","https://openalex.org/W2008736029","https://openalex.org/W2056781427","https://openalex.org/W2765106550","https://openalex.org/W2563924939"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,13,43,54,66,129],"neurotoxic":[2],"bilirubin":[3,14,27,59,84],"due":[4],"to":[5,25,78,82,183],"a":[6,52],"transient":[7],"neonatal":[8,33,47],"or":[9],"persistent":[10],"inherited":[11],"deficiency":[12,45,75],"glucuronidation":[15],"activity":[16],"can":[17],"cause":[18],"irreversible":[19],"brain":[20],"damage":[21],"and":[22,29,34,48,81,96,101,108,123,132,144,189],"death.":[23],"Strategies":[24],"inhibit":[26],"production":[28],"prevent":[30,79],"neurotoxicity":[31],"in":[32,46,51,86,91,116,139,154,173],"adult":[35],"settings":[36],"seem":[37],"promising.":[38],"We":[39,61],"evaluated":[40],"the":[41,64,117,136],"impact":[42],"Bvra":[44,74,181],"aged":[49],"mice,":[50,73],"background":[53],"unconjugated":[55,185],"hyperbilirubinemia,":[56],"by":[57],"abolishing":[58],"production.":[60],"also":[62],"investigated":[63],"disposal":[65],"biliverdin":[67,89],"during":[68],"fetal":[69],"development.":[70],"In":[71,150],"Ugt1\u2212/\u2212":[72],"appeared":[76],"sufficient":[77],"lethality":[80],"normalize":[83],"level":[85],"adults.":[87],"Although":[88],"accumulated":[90],"Bvra-deficient":[92],"fetuses,":[93],"both":[94,121],"Bvra\u2212/\u2212":[95,122,143,157],"Bvra\u2212/\u2212Ugt1\u2212/\u2212":[97,124,145,166,174],"pups":[98],"were":[99,159],"healthy":[100],"reached":[102],"adulthood":[103],"having":[104],"normal":[105,127,170],"liver,":[106],"brain,":[107],"spleen":[109],"histology,":[110],"albeit":[111],"with":[112],"increased":[113],"iron":[114],"levels":[115,128,153],"latter.":[118],"During":[119],"aging,":[120],"mice":[125,146,158,175],"presented":[126],"relevant":[130],"hematological":[131],"metabolic":[133],"parameters.":[134],"Interestingly,":[135],"oxidative":[137],"status":[138],"erythrocytes":[140],"from":[141],"9-months-old":[142,156],"was":[147],"significantly":[148,160],"reduced.":[149],"addition,":[151],"triglycerides":[152],"these":[155],"higher":[161],"than":[162],"WT":[163],"controls,":[164],"while":[165],"tested":[167],"normal.":[168],"The":[169],"parameters":[171],"observed":[172],"fed":[176],"chow":[177],"diet":[178],"indicate":[179],"that":[180],"inhibition":[182],"treat":[184],"hyperbilirubinemia":[186],"seems":[187],"safe":[188],"effective.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}