{"id":"https://openalex.org/W4200422103","doi":"https://doi.org/10.1080/19490976.2021.2009297","title":"Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men","display_name":"Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200422103","doi":"https://doi.org/10.1080/19490976.2021.2009297","pmid":"https://pubmed.ncbi.nlm.nih.gov/34923911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8726743"},"language":"en","primary_location":{"id":"doi:10.1080/19490976.2021.2009297","doi":"https://doi.org/10.1080/19490976.2021.2009297","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.2009297","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.2009297?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.2009297?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046794058","display_name":"Emanuel E. Canfora","orcid":"https://orcid.org/0000-0003-0267-1097","observed_orcids":["https://orcid.org/0000-0003-0267-1097"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Emanuel E. Canfora","raw_affiliation_strings":["Maastricht University Medical Center+","Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0267-1097","affiliations":[{"raw_affiliation_string":"Maastricht University Medical Center+","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015350937","display_name":"Gerben D. A. Hermes","orcid":"https://orcid.org/0000-0003-4314-9553","observed_orcids":["https://orcid.org/0000-0003-4314-9553"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerben D.A. Hermes","raw_affiliation_strings":["Wageningen University&Research","Laboratory of Microbiology, Wageningen University&Research, Wageningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4314-9553","affiliations":[{"raw_affiliation_string":"Wageningen University&Research","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Laboratory of Microbiology, Wageningen University&Research, Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631453","display_name":"Mattea M\u00fcller","orcid":"https://orcid.org/0000-0002-3340-5122","observed_orcids":["https://orcid.org/0000-0002-3340-5122"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mattea M\u00fcller","raw_affiliation_strings":["Maastricht University Medical Center+","Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University Medical Center+","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001134583","display_name":"Jacco J.A.J. Bastings","orcid":"https://orcid.org/0000-0003-4363-8955","observed_orcids":["https://orcid.org/0000-0003-4363-8955"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jacco Bastings","raw_affiliation_strings":["Maastricht University Medical Center+","Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University Medical Center+","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109597454","display_name":"Elaine E. Vaughan","orcid":"https://orcid.org/0009-0007-5712-3617","observed_orcids":["https://orcid.org/0009-0007-5712-3617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine E. Vaughan","raw_affiliation_strings":["Sensus BV (Royal Cosun)","Sensus BV (Royal Cosun), Roosendaal, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sensus BV (Royal Cosun)","institution_ids":[]},{"raw_affiliation_string":"Sensus BV (Royal Cosun), Roosendaal, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113919498","display_name":"Marco A. van den Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127558574","display_name":"DSM (Netherlands)","ror":"https://ror.org/00k01kt20","country_code":"NL","type":"company","lineage":["https://openalex.org/I127558574"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marco A. van Den Berg","raw_affiliation_strings":["DSM Biotechnology Center","DSM Biotechnology Center, Delft, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DSM Biotechnology Center","institution_ids":[]},{"raw_affiliation_string":"DSM Biotechnology Center, Delft, Netherlands","institution_ids":["https://openalex.org/I127558574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085434984","display_name":"Jens Juul Holst","orcid":"https://orcid.org/0000-0001-6853-3805","observed_orcids":["https://orcid.org/0000-0001-6853-3805"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens J. Holst","raw_affiliation_strings":["NovoNordisk Center for Basic Metabolic Research and Department of Biomedical Sciences Faculty of Health and Medical Sciences, University of Copenhagen","NovoNordisk Center for Basic Metabolic Research and Department of Biomedical Sciences Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6853-3805","affiliations":[{"raw_affiliation_string":"NovoNordisk Center for Basic Metabolic Research and Department of Biomedical Sciences Faculty of Health and Medical Sciences, University of Copenhagen","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]},{"raw_affiliation_string":"NovoNordisk Center for Basic Metabolic Research and Department of Biomedical Sciences Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048065759","display_name":"Koen Venema","orcid":"https://orcid.org/0000-0001-7046-5127","observed_orcids":["https://orcid.org/0000-0001-7046-5127","https://orcid.org/0000-0002-1081-2753"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen Venema","raw_affiliation_strings":["Maastricht University - Campus Venlo","Maastricht University Medical Center+","Centre for Healthy Eating & Food Innovation, Maastricht University - Campus Venlo, Venlo, The Netherlands","Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7046-5127","affiliations":[{"raw_affiliation_string":"Maastricht University - Campus Venlo","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Maastricht University Medical Center+","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Centre for Healthy Eating & Food Innovation, Maastricht University - Campus Venlo, Venlo, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057074180","display_name":"Erwin G. Zoetendal","orcid":"https://orcid.org/0000-0002-7149-0727","observed_orcids":["https://orcid.org/0000-0002-7149-0727"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erwin G. Zoetendal","raw_affiliation_strings":["Wageningen University&Research","Laboratory of Microbiology, Wageningen University&Research, Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wageningen University&Research","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Laboratory of Microbiology, Wageningen University&Research, Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081222354","display_name":"Ellen E. Blaak","orcid":"https://orcid.org/0000-0002-2496-3464","observed_orcids":["https://orcid.org/0000-0002-2496-3464"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ellen E. Blaak","raw_affiliation_strings":["Maastricht University Medical Center+","Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2496-3464","affiliations":[{"raw_affiliation_string":"Maastricht University Medical Center+","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"Human Biology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center+, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5046794058"],"corresponding_institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"],"apc_list":{"value":2495,"currency":"GBP","value_usd":3060},"apc_paid":{"value":2495,"currency":"GBP","value_usd":3060},"fwci":1.5416,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.84087881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"2009297","last_page":"2009297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.9179999828338623},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/metabolic-health","display_name":"metabolic health","score":0.7570000290870667},{"id":"https://openalex.org/keywords/inulin","display_name":"inulin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/resistant-starch","display_name":"resistant starch","score":0.9810000061988831},{"id":"https://openalex.org/keywords/beta-glucan","display_name":"\u03b2-glucan","score":0.859000027179718},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.7760000228881836},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.7139999866485596},{"id":"https://openalex.org/keywords/postprandial-blood-glucose","display_name":"postprandial blood glucose","score":0.8370000123977661},{"id":"https://openalex.org/keywords/breath-hydrogen","display_name":"breath hydrogen","score":0.625},{"id":"https://openalex.org/keywords/plasma-metabolites","display_name":"plasma metabolites","score":0.6309999823570251},{"id":"https://openalex.org/keywords/peptide-yy","display_name":"peptide YY","score":0.5649999976158142},{"id":"https://openalex.org/keywords/overweight-and-obesity","display_name":"overweight and obesity","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.79346764087677},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.6491529941558838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5744008421897888},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5512255430221558},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5415089726448059},{"id":"https://openalex.org/C2776633847","wikidata":"https://www.wikidata.org/wiki/Q574416","display_name":"Resistant starch","level":3,"score":0.5219404101371765},{"id":"https://openalex.org/C2779742124","wikidata":"https://www.wikidata.org/wiki/Q201552","display_name":"Inulin","level":2,"score":0.49505415558815},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.46090754866600037},{"id":"https://openalex.org/C2780014933","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionate","level":2,"score":0.41708481311798096},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3828163146972656},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3675549030303955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.367426335811615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36661744117736816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2803182601928711},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.23676139116287231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23138907551765442},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.16880512237548828},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004043","descriptor_name":"Dietary Fiber","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004043","descriptor_name":"Dietary Fiber","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013851","descriptor_name":"Thinness","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D013851","descriptor_name":"Thinness","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013851","descriptor_name":"Thinness","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1080/19490976.2021.2009297","doi":"https://doi.org/10.1080/19490976.2021.2009297","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.2009297","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.2009297?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8726743","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8726743","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"Text"},{"id":"pmid:34923911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34923911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut microbes","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/59f6effc-f5df-484d-a480-eeaaeb04cd7b","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/59f6effc-f5df-484d-a480-eeaaeb04cd7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canfora, E E, Hermes, G D A, Mueller, M, Bastings, J, Vaughan, E E, van den Berg, M A, Holst, J J, Venema, K, Zoetendal, E G & Blaak, E E 2022, 'Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men', Gut Microbes, vol. 14, no. 1. https://doi.org/10.1080/19490976.2021.2009297","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:library.wur.nl:wurpubs/595732","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/fiber-mixture-specific-effect-on-distal-colonic-fermentation-and-","pdf_url":"https://edepot.wur.nl/566989","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1949-0976","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/db3d32f1-7c6f-4d7b-92b3-d5f17b6cf031","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/db3d32f1-7c6f-4d7b-92b3-d5f17b6cf031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Canfora, E E, Hermes, G D A, M\u00fcller, M, Bastings, J, Vaughan, E E, van Den Berg, M A, Holst, J J, Venema, K, Zoetendal, E G & Blaak, E E 2022, 'Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men', Gut Microbes, vol. 14, no. 1, 2009297. https://doi.org/10.1080/19490976.2021.2009297","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:36c3f926030f4cff86c3aa828739a166","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/36c3f926030f4cff86c3aa828739a166","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, Vol 14, Iss 1 (2022)","raw_type":"article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/db3d32f1-7c6f-4d7b-92b3-d5f17b6cf031","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/db3d32f1-7c6f-4d7b-92b3-d5f17b6cf031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, 14(1):2009297. Landes Bioscience","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/595732","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/fiber-mixture-specific-effect-on-distal-colonic-fermentation-and-","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut Microbes, 14(1)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1080/19490976.2021.2009297","doi":"https://doi.org/10.1080/19490976.2021.2009297","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19490976.2021.2009297","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.2009297?needAccess=true","source":{"id":"https://openalex.org/S2764770702","display_name":"Gut Microbes","issn_l":"1949-0976","issn":["1949-0976","1949-0984"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Microbes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2224786099","display_name":"Acetate as metabolic target in the prevention of overweight-related chronic metabolic disorders","funder_award_id":"ALWCC.2015.5a","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320330833","display_name":"FrieslandCampina","ror":"https://ror.org/025mtxh67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200422103.pdf","grobid_xml":"https://content.openalex.org/works/W4200422103.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1793035576","https://openalex.org/W1850288252","https://openalex.org/W1967246991","https://openalex.org/W1975202380","https://openalex.org/W1980329543","https://openalex.org/W1983518876","https://openalex.org/W1986142882","https://openalex.org/W1996056871","https://openalex.org/W2020234015","https://openalex.org/W2021419192","https://openalex.org/W2023615726","https://openalex.org/W2034285706","https://openalex.org/W2041616502","https://openalex.org/W2041811148","https://openalex.org/W2048853985","https://openalex.org/W2052547316","https://openalex.org/W2056279562","https://openalex.org/W2057039181","https://openalex.org/W2071841602","https://openalex.org/W2080283023","https://openalex.org/W2096459471","https://openalex.org/W2098278200","https://openalex.org/W2109392327","https://openalex.org/W2109755334","https://openalex.org/W2113707020","https://openalex.org/W2131501155","https://openalex.org/W2132033020","https://openalex.org/W2136852526","https://openalex.org/W2166073051","https://openalex.org/W2170024099","https://openalex.org/W2220098999","https://openalex.org/W2261667570","https://openalex.org/W2298480753","https://openalex.org/W2341428856","https://openalex.org/W2403780473","https://openalex.org/W2409656339","https://openalex.org/W2480225869","https://openalex.org/W2482094715","https://openalex.org/W2508203511","https://openalex.org/W2547640677","https://openalex.org/W2557766453","https://openalex.org/W2604312812","https://openalex.org/W2605990004","https://openalex.org/W2614800736","https://openalex.org/W2775323386","https://openalex.org/W2790152383","https://openalex.org/W2796439882","https://openalex.org/W2800240433","https://openalex.org/W2803279161","https://openalex.org/W2908821703","https://openalex.org/W2910727162","https://openalex.org/W2912465744","https://openalex.org/W2913914265","https://openalex.org/W3001942158","https://openalex.org/W3080685158","https://openalex.org/W4230096730"],"related_works":["https://openalex.org/W2482094715","https://openalex.org/W4408496079","https://openalex.org/W2763467847","https://openalex.org/W4384522297","https://openalex.org/W4413983897","https://openalex.org/W2811437307","https://openalex.org/W4388703752","https://openalex.org/W7117466012","https://openalex.org/W2566583580","https://openalex.org/W2614800736"],"abstract_inverted_index":{"Infusions":[0],"of":[1,45,80,227],"the":[2,9,46,90,231],"short-chain":[3],"fatty":[4],"acid":[5],"(SCFA)":[6],"acetate":[7,31,59,140],"in":[8,15,41,62,199,209,214,239,243,268],"distal":[10,29,57],"colon":[11,47],"improved":[12,236],"metabolic":[13,35,153,237,266],"parameters":[14,238],"men.":[16],"Here,":[17],"we":[18],"hypothesized":[19],"that":[20,54,247],"combining":[21],"rapidly":[22],"and":[23,33,68,108,123,130,162,175,177,219,251,280],"slowly":[24],"fermentable":[25],"fibers":[26],"will":[27],"enhance":[28],"colonic":[30,58],"production":[32],"improve":[34],"health.":[36],"In":[37,74,134,155],"vitro":[38],"cultivation":[39],"studies":[40],"a":[42,94],"validated":[43],"model":[44],"were":[48,72,119,132,217,249],"used":[49],"to":[50,93,142,187,194,234,263],"identify":[51],"fiber":[52],"mixtures":[53],"yielded":[55],"high":[56],"production.":[60],"Subsequently,":[61],"two":[63],"randomized":[64],"crossover":[65],"studies,":[66],"lean":[67,156,240],"prediabetic":[69,135,200,244,269],"overweight/obese":[70],"men":[71],"included.":[73],"one":[75],"study,":[76],"participants":[77],"received":[78],"supplements":[79],"either":[81],"long-chain":[82],"inulin+resistant":[83],"starch":[84],"(INU+RS),":[85],"INU":[86,143],"or":[87,144],"maltodextrin":[88],"(PLA)":[89],"day":[91,97,232],"prior":[92,233],"clinical":[95],"investigation":[96,235],"(CID).":[98],"The":[99],"second":[100],"trial":[101,275,282],"studied":[102],"beta":[103],"glucan+RS":[104],"(BG+RS)":[105],"versus":[106,224],"BG":[107],"PLA.":[109,188],"During":[110],"each":[111],"CID,":[112],"breath":[113,160],"hydrogen,":[114],"indirect":[115],"calorimetry,":[116],"plasma":[117,139,164,191],"metabolites/hormones":[118],"assessed":[120],"during":[121],"fasting":[122,163],"postprandial":[124,179],"conditions.":[125],"Additionally,":[126],"fecal":[127,215],"microbiota":[128,216],"composition":[129],"SCFA":[131],"determined.":[133],"men,":[136,157],"INU+RS":[137,158,223,228],"increased":[138,159,170,190],"compared":[141,186,193],"PLA":[145,195],"(P":[146,196],"<":[147,184,197],".05),":[148],"but":[149,202,241],"did":[150,203],"not":[151,204,242],"affect":[152,205],"parameters.":[154],"hydrogen":[161],"butyrate,":[165],"which":[166],"was":[167],"accompanied":[168],"by":[169],"energy":[171],"expenditure,":[172],"carbohydrate":[173],"oxidation":[174],"PYY":[176],"decreased":[178],"glucose":[180],"concentrations":[181],"(all":[182],"P":[183],".05)":[185,198],"BG+RS":[189],"butyrate":[192],"individuals,":[201,245],"other":[206],"fermentation/metabolic":[207],"markers":[208],"both":[210],"phenotypes.":[211],"Fiber-induced":[212],"shifts":[213],"individual-specific":[218],"more":[220],"pronounced":[221],"with":[222],"BG+RS.":[225],"Administration":[226],"(not":[229],"BG+RS)":[230],"demonstrating":[246],"effects":[248],"phenotype-":[250],"fiber-specific.":[252],"Further":[253],"research":[254],"should":[255],"study":[256],"whether":[257],"longer-term":[258],"supplementation":[259],"periods":[260],"are":[261],"required":[262],"elicit":[264],"beneficial":[265],"health":[267],"individuals.":[270],"Trial":[271],"registration":[272],"numbers:":[273],"Clinical":[274,281],"No.":[276,283],"NCT03711383":[277],"(Inulin":[278],"study)":[279],"NCT03714646":[284],"(Beta":[285],"glucan":[286],"study).":[287]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}
