{"id":"https://openalex.org/W4200420556","doi":"https://doi.org/10.1158/1535-7163.targ-21-p088","title":"Abstract P088: Combined inhibition of histone deacetylases and EZH2 for the treatment of Wilms tumors","display_name":"Abstract P088: Combined inhibition of histone deacetylases and EZH2 for the treatment of Wilms tumors","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200420556","doi":"https://doi.org/10.1158/1535-7163.targ-21-p088"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-21-p088","doi":"https://doi.org/10.1158/1535-7163.targ-21-p088","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-21-p088","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100599490","display_name":"Hongbing Liu","orcid":"https://orcid.org/0000-0002-3411-4597","observed_orcids":["https://orcid.org/0000-0002-3411-4597"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbing Liu","raw_affiliation_strings":["Tulane, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nhi Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhi Ngo","raw_affiliation_strings":["Tulane, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084496049","display_name":"Chao\u2010Hui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao-Hui Chen","raw_affiliation_strings":["Tulane, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044765791","display_name":"Samir Sayem El-Dahr","orcid":"https://orcid.org/0000-0001-7571-4292","observed_orcids":["https://orcid.org/0000-0001-7571-4292"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir S. El-Dahr","raw_affiliation_strings":["Tulane, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"12_Supplement","first_page":"P088","last_page":"P088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.996999979019165},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ezh2-inhibition","display_name":"EZH2 inhibition","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hdac1-2","display_name":"HDAC1/2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nephron-progenitor-cells","display_name":"nephron progenitor cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.7170000076293945},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9419999718666077},{"id":"https://openalex.org/keywords/h3k27-methylation","display_name":"H3K27 methylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pediatric-kidney-tumors","display_name":"pediatric kidney cancer","score":0.6759999990463257},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.47699999809265137},{"id":"https://openalex.org/keywords/differentiation","display_name":"differentiation","score":0.36800000071525574},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.7781921625137329},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7356747984886169},{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.640855610370636},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.6138613224029541},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.5921945571899414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5730816721916199},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5264295339584351},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5236018300056458},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5190642476081848},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4700906276702881},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.43216848373413086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39195719361305237},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3677752614021301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2507017254829407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13282886147499084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-21-p088","doi":"https://doi.org/10.1158/1535-7163.targ-21-p088","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-21-p088","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385837023","https://openalex.org/W4310262047","https://openalex.org/W2885511106","https://openalex.org/W2740040046","https://openalex.org/W4403130198","https://openalex.org/W1972731560","https://openalex.org/W1997018084","https://openalex.org/W2000948510","https://openalex.org/W2260543467","https://openalex.org/W2065560906"],"abstract_inverted_index":{"Abstract":[0],"Wilms":[1,283,471],"tumor":[2,199,405],"(WT)":[3],"is":[4,12,30,144],"the":[5,52,116,126,198,212,216,248,300,314,337,441,468,477],"most":[6,117],"common":[7],"childhood":[8],"kidney":[9,18,274,425],"cancer.":[10],"It":[11],"believed":[13],"to":[14,25,32,44,77,105,135,153,171,219,233,329,419],"arise":[15],"from":[16,164,281],"immature":[17],"cells\u2013nephron":[19],"progenitor":[20,89,168],"cells":[21,90,169,276,279],"(NPCs)\u2014which":[22],"have":[23,74,102],"failed":[24],"differentiate":[26],"properly.":[27],"Altered":[28],"epigenetics":[29],"central":[31],"oncogenesis":[33],"in":[34,82,147,197,215,223,253,267,271,303,362,369,385,403],"many":[35,106,340],"pediatric":[36,45,424],"cancers.":[37,344],"The":[38],"critical":[39,80,209],"contribution":[40],"of":[41,55,65,86,98,128,140,167,191,226,243,258,269,291,316,323,339,342,366,383,389,398,436,443,462,470,476],"epigenetic":[42,56,437],"dysregulation":[43],"tumors":[46,472],"provides":[47],"a":[48,70,79,208,282,363,415],"compelling":[49],"rationale":[50],"for":[51,121,211,336,467],"therapeutic":[53,119,417],"potential":[54],"drugs.":[57],"Histone":[58],"deacetylases":[59,464],"(HDACs,":[60],"especially":[61],"HDAC1/2)":[62],"and":[63,84,96,100,137,149,175,195,240,277,307,325,333,352,371,381,395,400,411,422,430,465,485],"Enhancer":[64],"Zeste":[66],"Homolog":[67],"2":[68],"(EZH2),":[69],"histone":[71,463],"H3K27":[72],"methyltransferase,":[73],"been":[75,103,151,231],"demonstrated":[76,152,187,232,378],"play":[78],"role":[81,210],"self-renewal":[83],"differentiation":[85,242],"mouse":[87],"nephron":[88],"(NPCs).":[91],"In":[92,255,374],"addition,":[93,256],"altered":[94],"expression":[95,302,318,380],"mutations":[97],"HDACs":[99,324],"EZH2":[101,143,326,356,401,412,466],"linked":[104],"human":[107,183,272,343],"cancers,":[108],"including":[109],"WT.":[110,224,244,254],"As":[111],"such,":[112],"they":[113],"are":[114],"among":[115],"promising":[118,416],"targets":[120],"cancer":[122,249,426],"treatment.":[123],"For":[124],"sinstance,":[125],"treatment":[127,290,338,347,469],"Panobinostat,":[129],"an":[130],"FDA-approved":[131,355],"pan-HDAC":[132],"inhibitor,":[133],"leaded":[134],"apoptosis":[136],"growth":[138,361],"suppression":[139],"WT":[141,148,157,162,184,421],"cells.":[142,310,373],"highly":[145,331],"expressed":[146],"has":[150,230,327],"be":[154,234,330],"associated":[155],"with":[156,202,237,427],"progression.":[158],"We":[159],"reasoned":[160],"that":[161,289],"results":[163],"unrestrained":[165],"proliferation":[166,222,239],"due":[170],"overactive":[172,213],"HDAC1,":[173,192],"HDAC2,":[174,193],"EZH2.":[176],"To":[177],"prove":[178],"this,":[179],"we":[180],"collected":[181],"5":[182],"specimens.":[185],"Immunostaining":[186],"dramatically":[188],"higher":[189],"level":[190],"SIX1,":[194],"SIX2":[196,229,246],"tissues":[200],"compared":[201],"adjacent":[203],"normal":[204],"tissues,":[205],"strongly":[206],"suggesting":[207],"HDAC1/2":[214,259,384,399,410],"SIX1/2":[217,270,317],"activation":[218],"promote":[220],"cell":[221,251,360,406],"Gain-of-function":[225],"SIX1":[227],"or":[228,262],"closely":[235],"correlated":[236],"high":[238],"aberrant":[241],"Importantly,":[245],"marks":[247],"stem":[250],"population":[252],"knockdown":[257],"by":[260,319,391],"siRNAs":[261],"CRISPR":[263],"gene":[264],"editing":[265],"resulted":[266],"downregulation":[268],"embryonic":[273],"293":[275],"G401":[278,372],"derived":[280],"tumor.":[284],"Published":[285],"studies":[286,377],"also":[287],"showed":[288],"Trichostain":[292],"(a":[293],"potent":[294,335],"pan":[295],"HDAC":[296],"inhibitor)":[297,357],"significantly":[298],"reduced":[299],"Six1":[301],"vertebrate":[304],"neural":[305],"crest":[306],"Hodgkin":[308],"lymphoma":[309],"All":[311],"these":[312],"support":[313],"regulation":[315,388],"HDAC1/2.":[320],"Concomitant":[321],"inhibition":[322,402,461],"proven":[328],"synergistic":[332],"very":[334],"types":[341],"Promisingly,":[345],"combined":[346],"benzamide-based":[348],"HDAC1/2-selective":[349],"inhibitor":[350],"Merck60":[351],"Tazemetostat":[353],"(an":[354],"synergistically":[358],"suppressed":[359],"wide":[364],"range":[365],"dose":[367],"combinations":[368],"293T":[370],"summary,":[375],"our":[376],"elevated":[379],"activity":[382],"WT,":[386],"positive":[387],"SIX1/SIX2":[390],"HDAc1//2":[392],"during":[393],"tumorigenesis,":[394],"synergic":[396],"effect":[397],"suppressing":[404],"proliferation.":[407],"Thus,":[408],"targeting":[409],"may":[413],"provide":[414],"approach":[418],"treat":[420],"other":[423],"low":[428,431],"toxicity":[429],"side":[432],"effects.":[433],"Furthermore,":[434],"availability":[435],"drugs":[438],"will":[439],"facilitate":[440],"translation":[442],"this":[444],"research":[445],"into":[446],"effective":[447],"therapies.":[448],"Citation":[449],"Format:":[450],"Hongbing":[451],"Liu,":[452],"Nhi":[453],"Ngo,":[454],"Chao-Hui":[455],"Chen,":[456],"Samir":[457],"S.":[458],"El-Dahr.":[459],"Combined":[460],"[abstract].":[473],"In:":[474],"Proceedings":[475],"AACR-NCI-EORTC":[478],"Virtual":[479],"International":[480],"Conference":[481],"on":[482],"Molecular":[483],"Targets":[484],"Cancer":[486,495],"Therapeutics;":[487],"2021":[488],"Oct":[489],"7-10.":[490],"Philadelphia":[491],"(PA):":[492],"AACR;":[493],"Mol":[494],"Ther":[496],"2021;20(12":[497],"Suppl):Abstract":[498],"nr":[499],"P088.":[500]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2021-12-31T00:00:00"}