{"id":"https://openalex.org/W4200419249","doi":"https://doi.org/10.1055/s-0041-1736775","title":"Isolation of cytotoxic compounds from the underground parts of Valeriana sisymbriifolia Vahl. through activity-guided fractionation","display_name":"Isolation of cytotoxic compounds from the underground parts of Valeriana sisymbriifolia Vahl. through activity-guided fractionation","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200419249","doi":"https://doi.org/10.1055/s-0041-1736775"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1736775","doi":"https://doi.org/10.1055/s-0041-1736775","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1736775","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057193219","display_name":"Murat Erdo\u011fan","orcid":"https://orcid.org/0000-0001-7374-3962","observed_orcids":["https://orcid.org/0000-0001-7374-3962"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M Erdo\u011fan","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037585911","display_name":"Ba\u015fak Aru","orcid":"https://orcid.org/0000-0002-2987-0523","observed_orcids":["https://orcid.org/0000-0002-2987-0523"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B Aru","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054856739","display_name":"\u015eT Y\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eT Y\u0131lmaz","raw_affiliation_strings":["Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027729212","display_name":"Erdem Ye\u015filada","orcid":"https://orcid.org/0000-0002-1348-6033","observed_orcids":["https://orcid.org/0000-0002-1348-6033"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E Ye\u015filada","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054324577","display_name":"G\u00fclderen Yan\u0131kkaya Demirel","orcid":"https://orcid.org/0000-0001-5775-491X","observed_orcids":["https://orcid.org/0000-0001-5775-491X"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G Yan\u0131kkaya Demirel","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076099684","display_name":"Hasan K\u0131rm\u0131z\u0131bekmez","orcid":"https://orcid.org/0000-0002-6118-8225","observed_orcids":["https://orcid.org/0000-0002-6118-8225"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H K\u0131rm\u0131z\u0131bekmez","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I100072489"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxic-compounds","display_name":"cytotoxic compounds","score":0.9480000138282776},{"id":"https://openalex.org/keywords/iridoids","display_name":"iridoids","score":0.8690000176429749},{"id":"https://openalex.org/keywords/sesquiterpene-lactones","display_name":"sesquiterpene lactones","score":0.9869999885559082},{"id":"https://openalex.org/keywords/activity-guided-fractionation","display_name":"activity-guided fractionation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.628000020980835},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/valtrate","display_name":"valtrate","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7710469961166382},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.5442162156105042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5441417098045349},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.488429456949234},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.48801174759864807},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4684446156024933},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4589496850967407},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36235928535461426},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3251793384552002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2757313549518585},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2700214982032776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26168936491012573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1263459324836731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0041-1736775","doi":"https://doi.org/10.1055/s-0041-1736775","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1736775","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2036374607","https://openalex.org/W2105796335"],"related_works":["https://openalex.org/W4317702611","https://openalex.org/W4296037325","https://openalex.org/W2019886623","https://openalex.org/W2004264196","https://openalex.org/W4283258019","https://openalex.org/W2758231804","https://openalex.org/W3208587531","https://openalex.org/W4410204570","https://openalex.org/W2363504242","https://openalex.org/W2559842140"],"abstract_inverted_index":{"Valeriana":[0,21],"sisymbriifolia":[1,57],"is":[2,7],"a":[3],"perennial":[4],"herb":[5],"that":[6],"particularly":[8],"distributed":[9],"in":[10,59],"Turkey,":[11],"Iran":[12],"and":[13,27,37,69,86,97,118,133,136,143,184,199,225,247,262,269],"Iraq":[14],"[":[15,39],"1":[16,132],"].":[17,41],"Previous":[18],"studies":[19],"on":[20,207,231],"species":[22],"indicated":[23,249],"sedative,":[24],"anxiolytic,":[25],"neuroprotective":[26],"cytotoxic":[28,50,75,102,205,229,252,273,286],"activities":[29,76,230,253,287],"which":[30],"are":[31,288],"mainly":[32],"attributed":[33],"to":[34,47,126,242],"its":[35,67],"iridoids":[36,130],"sesquiterpenes":[38],"2":[40,134],"In":[42],"this":[43],"study,":[44],"we":[45],"aimed":[46],"isolate":[48],"the":[49,105,193,250,285],"compounds":[51],"from":[52,240],"underground":[53],"parts":[54],"of":[55,192,215],"V.":[56],"through":[58],"vitro":[60],"activity-guided":[61],"fractionation":[62],"technique.":[63],"The":[64,94,190,282],"EtOH":[65],"extract,":[66],"fractions":[68,99,120],"isolates":[70,194],"were":[71,121,195],"evaluated":[72],"for":[73],"their":[74],"against":[77,87,104,254,275],"four":[78],"cancer":[79,107],"cell":[80,89,108,209,233,256],"lines":[81,109],"(MCF-7,":[82],"HGC-27,":[83],"PC-3,":[84],"A549)":[85],"HUVEC":[88],"line":[90,210,234,257],"by":[91,123,197,295],"MTS":[92],"assay.":[93],"CHCl":[95,116],"3":[96,117,142],"EtOAc":[98,119],"exhibited":[100,227],"remarkable":[101],"activity":[103,206,274],"tested":[106],"(IC":[110,258,277],"50":[111,213,237,259,278],":":[112,260,279],"2.4-16.3":[113],"\u00b5g/mL).":[114],"Thus,":[115],"separated":[122],"chromatographic":[124],"methods":[125],"give":[127],"two":[128,137],"new":[129,138],"(":[131,141,152,156,160,164,168,172,176,181,187],")":[135,145,183],"sesquiterpene":[139],"lactones":[140],"4":[144],"together":[146],"with":[147,211,235],"nine":[148],"known":[149],"compounds,":[150],"didrovaltrate":[151],"5":[153,219],"),":[154,158,162,166,170,174,178],"valtrate":[155],"6":[157,202,221,246,266],"7-homovaltrate":[159],"7":[161,223,248,268],"1-\u03b1-acevaltrate":[163],"8":[165,226,270],"baldrinal":[167],"9":[169],"11-ethoxyviburtinal":[171],"10":[173],"patriscabrol":[175],"11":[177],"bornyl":[179],"caffeate":[180],"12":[182],"caproleic":[185],"acid":[186],"13":[188,305],").":[189],"structures":[191],"elucidated":[196],"NMR":[198],"HR-MS":[200],"analyses.":[201],"showed":[203,271],"strong":[204],"A549":[208],"IC":[212,236],"value":[214],"7.5":[216],"\u00b5M":[217,264],"while":[218],",":[220,222,224,267],"significant":[228],"MCF-7":[232],"values":[238],"ranging":[239],"2.5":[241],"5.9":[243],"\u00b5M.":[244],"Also,":[245],"best":[251],"HGC-27":[255],"2.3":[261],"3.7":[263],"respectively).":[265],"noteworthy":[272],"PC-3":[276],"2.3-9.7":[280],"\u00b5M).":[281],"mechanisms":[283],"behind":[284],"underway.":[289],"Acknowledgements":[290],"This":[291],"study":[292],"was":[293],"supported":[294],"T\u00dcB\u0130TAK":[296],"(Project":[297],"No:":[298],"119Z094)":[299],"Publication":[300],"History":[301],"Article":[302],"published":[303],"online:":[304],"December":[306],"2021":[307],"\u00a9":[308],"2021.":[309],"Thieme.":[310],"All":[311],"rights":[312],"reserved.":[313],"Georg":[314],"Thieme":[315],"Verlag":[316],"R\u00fcdigerstra\u00dfe":[317],"14,":[318],"70469":[319],"Stuttgart,":[320],"Germany":[321]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2021-12-31T00:00:00"}