{"id":"https://openalex.org/W4200418640","doi":"https://doi.org/10.3390/pharmaceutics13122140","title":"Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape","display_name":"Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4200418640","doi":"https://doi.org/10.3390/pharmaceutics13122140","pmid":"https://pubmed.ncbi.nlm.nih.gov/34959421","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8706418"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics13122140","doi":"https://doi.org/10.3390/pharmaceutics13122140","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13122140","pdf_url":"https://www.mdpi.com/1999-4923/13/12/2140/pdf?version=1639980271","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/13/12/2140/pdf?version=1639980271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049199328","display_name":"Francisco Javier Acebedo-Mart\u00ednez","orcid":"https://orcid.org/0000-0001-9486-2645","observed_orcids":["https://orcid.org/0000-0001-9486-2645"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Javier Acebedo-Mart\u00ednez","raw_affiliation_strings":["Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9486-2645","affiliations":[{"raw_affiliation_string":"Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065086080","display_name":"Carolina Alarc\u00f3n-Payer","orcid":"https://orcid.org/0000-0001-5836-1050","observed_orcids":["https://orcid.org/0000-0001-5836-1050"]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina Alarc\u00f3n-Payer","raw_affiliation_strings":["Servicio de Farmacia, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5836-1050","affiliations":[{"raw_affiliation_string":"Servicio de Farmacia, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain","institution_ids":["https://openalex.org/I4210116170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032730516","display_name":"Antonio Frontera","orcid":"https://orcid.org/0000-0001-7840-2139","observed_orcids":["https://orcid.org/0000-0001-7840-2139"]},"institutions":[{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Frontera","raw_affiliation_strings":["Department of Chemistry, Universitat de les Illes Balears, Crta de Valldemossa km 7.5, 07122 Palma de Mallorca, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7840-2139","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universitat de les Illes Balears, Crta de Valldemossa km 7.5, 07122 Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I50441567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039465542","display_name":"Rafael Barbas","orcid":"https://orcid.org/0000-0002-1603-3689","observed_orcids":["https://orcid.org/0000-0002-1603-3689"]},"institutions":[{"id":"https://openalex.org/I4405284819","display_name":"Centres Cient\u00edfics i Tecnol\u00f2gics de la Universitat de Barcelona","ror":"https://ror.org/048kkhy84","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405284819","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Barbas","raw_affiliation_strings":["Unitat de Polimorfisme i Calorimetria, Centres Cient\u00edfics i Tecnol\u00f2gics, Universitat de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Polimorfisme i Calorimetria, Centres Cient\u00edfics i Tecnol\u00f2gics, Universitat de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I4405284819","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070080960","display_name":"Rafel Prohens","orcid":"https://orcid.org/0000-0003-0294-1720","observed_orcids":["https://orcid.org/0000-0003-0294-1720"]},"institutions":[{"id":"https://openalex.org/I4405284819","display_name":"Centres Cient\u00edfics i Tecnol\u00f2gics de la Universitat de Barcelona","ror":"https://ror.org/048kkhy84","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405284819","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rafel Prohens","raw_affiliation_strings":["Unitat de Polimorfisme i Calorimetria, Centres Cient\u00edfics i Tecnol\u00f2gics, Universitat de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0294-1720","affiliations":[{"raw_affiliation_string":"Unitat de Polimorfisme i Calorimetria, Centres Cient\u00edfics i Tecnol\u00f2gics, Universitat de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain","institution_ids":["https://openalex.org/I4405284819","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028937483","display_name":"Milena Di Crisci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milena Di Crisci","raw_affiliation_strings":["Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain","Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]},{"raw_affiliation_string":"Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091353739","display_name":"Alicia Dom\u00ednguez\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0001-8669-6712","observed_orcids":["https://orcid.org/0000-0001-8669-6712"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alicia Dom\u00ednguez-Mart\u00edn","raw_affiliation_strings":["Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8669-6712","affiliations":[{"raw_affiliation_string":"Department of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078270809","display_name":"Jaime G\u00f3mez\u2010Morales","orcid":"https://orcid.org/0000-0002-9395-7797","observed_orcids":["https://orcid.org/0000-0002-9395-7797"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaime G\u00f3mez-Morales","raw_affiliation_strings":["Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9395-7797","affiliations":[{"raw_affiliation_string":"Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091147103","display_name":"Duane Choquesillo\u2010Lazarte","orcid":"https://orcid.org/0000-0002-7077-8972","observed_orcids":["https://orcid.org/0000-0002-7077-8972"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Duane Choquesillo-Lazarte","raw_affiliation_strings":["Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7077-8972","affiliations":[{"raw_affiliation_string":"Laboratorio de Estudios Cristalogr\u00e1ficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5070080960","https://openalex.org/A5091147103","https://openalex.org/A5091353739"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I173304897","https://openalex.org/I4405284819","https://openalex.org/I71999127"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.9235,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.67654996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"12","first_page":"2140","last_page":"2140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niflumic-acid","display_name":"niflumic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cocrystals","display_name":"cocrystals","score":0.9120000004768372},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.902999997138977},{"id":"https://openalex.org/keywords/conformational-polymorphism","display_name":"conformational polymorphism","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.925000011920929},{"id":"https://openalex.org/keywords/mechanochemical-synthesis","display_name":"mechanochemical synthesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/polymorphic-stability","display_name":"polymorphic stability","score":0.5569999814033508},{"id":"https://openalex.org/keywords/solid-state-structure","display_name":"solid-state structure","score":0.5820000171661377},{"id":"https://openalex.org/keywords/polymorphic-transition","display_name":"polymorphic transformation","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C100687433","wikidata":"https://www.wikidata.org/wiki/Q5139913","display_name":"Cocrystal","level":4,"score":0.9653560519218445},{"id":"https://openalex.org/C2779700409","wikidata":"https://www.wikidata.org/wiki/Q304285","display_name":"Niflumic acid","level":2,"score":0.7996411919593811},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7541695833206177},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.7056600451469421},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.6308110952377319},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.5888729691505432},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.569091796875},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46135613322257996},{"id":"https://openalex.org/C5716244","wikidata":"https://www.wikidata.org/wiki/Q5191408","display_name":"Crystal engineering","level":4,"score":0.4235376715660095},{"id":"https://openalex.org/C185039092","wikidata":"https://www.wikidata.org/wiki/Q376044","display_name":"Powder diffraction","level":2,"score":0.4234086871147156},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.34731054306030273},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3324568569660187},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.27891767024993896},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.2529640793800354},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24253994226455688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12025880813598633},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.1001160740852356},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.07996508479118347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07528948783874512},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/pharmaceutics13122140","doi":"https://doi.org/10.3390/pharmaceutics13122140","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13122140","pdf_url":"https://www.mdpi.com/1999-4923/13/12/2140/pdf?version=1639980271","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:34959421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34959421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8706418","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8706418/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/266206","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/266206","pdf_url":"http://hdl.handle.net/10261/266206","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:digibug.ugr.es:10481/72580","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/72580","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:diposit.ub.edu:2445/232650","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/232650","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:89dbc99e9187492d9c72e36752169efa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/89dbc99e9187492d9c72e36752169efa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 13, Iss 12, p 2140 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics13122140","doi":"https://doi.org/10.3390/pharmaceutics13122140","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13122140","pdf_url":"https://www.mdpi.com/1999-4923/13/12/2140/pdf?version=1639980271","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200418640.pdf","grobid_xml":"https://content.openalex.org/works/W4200418640.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1581483950","https://openalex.org/W1966949133","https://openalex.org/W1969360633","https://openalex.org/W1969913564","https://openalex.org/W1972356290","https://openalex.org/W1978633893","https://openalex.org/W1979368277","https://openalex.org/W1983436447","https://openalex.org/W1990472537","https://openalex.org/W1998920258","https://openalex.org/W2011134011","https://openalex.org/W2057448579","https://openalex.org/W2059205366","https://openalex.org/W2064981002","https://openalex.org/W2073349723","https://openalex.org/W2074375023","https://openalex.org/W2078564106","https://openalex.org/W2080937409","https://openalex.org/W2081656744","https://openalex.org/W2081957849","https://openalex.org/W2088564165","https://openalex.org/W2090178041","https://openalex.org/W2092157292","https://openalex.org/W2104919283","https://openalex.org/W2119547517","https://openalex.org/W2132454074","https://openalex.org/W2134565451","https://openalex.org/W2145538332","https://openalex.org/W2148941593","https://openalex.org/W2330736438","https://openalex.org/W2335554635","https://openalex.org/W2356915594","https://openalex.org/W2603899979","https://openalex.org/W2607543751","https://openalex.org/W2775907621","https://openalex.org/W2784103179","https://openalex.org/W2799792551","https://openalex.org/W2888377531","https://openalex.org/W2896731412","https://openalex.org/W2912406497","https://openalex.org/W2921936306","https://openalex.org/W2971379320","https://openalex.org/W3026222144","https://openalex.org/W3097775881","https://openalex.org/W3109931825","https://openalex.org/W3167792800","https://openalex.org/W4229700293","https://openalex.org/W4237900904","https://openalex.org/W4243356458"],"related_works":["https://openalex.org/W4211040555","https://openalex.org/W4414908563","https://openalex.org/W2031773496","https://openalex.org/W2614801978","https://openalex.org/W2998332333","https://openalex.org/W2114739351","https://openalex.org/W7131406427","https://openalex.org/W7124852057","https://openalex.org/W7155015901","https://openalex.org/W1980478891"],"abstract_inverted_index":{"Any":[0],"time":[1],"the":[2,25,66],"pharmaceutical":[3,20,28],"industry":[4],"develops":[5],"a":[6,18,119],"new":[7],"drug,":[8],"potential":[9],"polymorphic":[10],"events":[11],"must":[12],"be":[13,39,55],"thoroughly":[14,84],"described,":[15],"because":[16],"in":[17,51,86,116],"crystalline":[19],"solid,":[21],"different":[22,34,62],"arrangements":[23],"of":[24,65],"same":[26],"active":[27],"ingredient":[29],"can":[30],"yield":[31],"to":[32,134,151],"very":[33],"physicochemical":[35],"properties":[36],"that":[37],"might":[38],"crucial":[40],"for":[41],"its":[42],"efficacy,":[43],"such":[44,101],"as":[45,96,98,102],"dissolution,":[46],"solubility,":[47],"or":[48],"stability.":[49],"Polymorphism":[50],"cocrystal":[52,63],"formulation":[53],"cannot":[54],"neglected,":[56],"either.":[57],"In":[58],"this":[59],"work,":[60],"two":[61],"polymorphs":[64,154],"non-steroidal":[67],"anti-inflammatory":[68],"drug":[69],"niflumic":[70],"acid":[71],"and":[72,83,90,107,112,130,155],"caffeine":[73],"are":[74,115],"reported.":[75],"They":[76],"have":[77,158],"been":[78,159],"synthesized":[79],"by":[80,88],"mechanochemical":[81],"methods":[82],"characterized":[85],"solid-state":[87],"powder":[89],"single":[91],"crystal":[92],"X-ray":[93],"diffraction":[94],"respectively,":[95],"well":[97],"other":[99],"techniques":[100],"thermal":[103],"analyses,":[104],"infrared":[105],"spectroscopy":[106],"computational":[108],"methods.":[109],"Both":[110],"theoretical":[111],"experimental":[113],"results":[114],"agreement,":[117],"confirming":[118],"conformational":[120],"polymorphism.":[121],"The":[122,148],"polymorph":[123],"NIF-CAF":[124,135],"Form":[125,136,139,146],"I":[126],"exhibits":[127],"improved":[128],"solubility":[129],"dissolution":[131],"rate":[132],"compared":[133],"II,":[137],"although":[138],"II":[140],"is":[141],"significantly":[142],"more":[143],"stable":[144],"than":[145],"I.":[147],"conditions":[149],"needed":[150],"obtain":[152],"these":[153],"their":[156],"transition":[157],"carefully":[160],"characterized,":[161],"revealing":[162],"an":[163],"intricate":[164],"system.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}
