{"id":"https://openalex.org/W4200417396","doi":"https://doi.org/10.1016/j.phymed.2021.153885","title":"The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells","display_name":"The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200417396","doi":"https://doi.org/10.1016/j.phymed.2021.153885","pmid":"https://pubmed.ncbi.nlm.nih.gov/34920321"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2021.153885","doi":"https://doi.org/10.1016/j.phymed.2021.153885","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153885","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029093948","display_name":"Biji Chatterjee","orcid":"https://orcid.org/0000-0002-3854-8181","observed_orcids":["https://orcid.org/0000-0002-3854-8181"]},"institutions":[{"id":"https://openalex.org/I35340524","display_name":"Central University of Kerala","ror":"https://ror.org/00cy1zs35","country_code":"IN","type":"education","lineage":["https://openalex.org/I35340524"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Biji Chatterjee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod-671316, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod-671316, Kerala, India","institution_ids":["https://openalex.org/I35340524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025439584","display_name":"Krishna Kanta Ghosh","orcid":"https://orcid.org/0000-0003-0718-3498","observed_orcids":["https://orcid.org/0000-0003-0718-3498"]},"institutions":[{"id":"https://openalex.org/I35340524","display_name":"Central University of Kerala","ror":"https://ror.org/00cy1zs35","country_code":"IN","type":"education","lineage":["https://openalex.org/I35340524"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishna Ghosh","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod-671316, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod-671316, Kerala, India","institution_ids":["https://openalex.org/I35340524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004071605","display_name":"Aishwarya Swain","orcid":"https://orcid.org/0000-0002-6052-4848","observed_orcids":["https://orcid.org/0000-0002-6052-4848"]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aishwarya Swain","raw_affiliation_strings":["Centre for Bioinformatics, Pondicherry University, Puducherry-605014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bioinformatics, Pondicherry University, Puducherry-605014, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082588604","display_name":"Kirankumar Nalla","orcid":"https://orcid.org/0000-0003-4660-0696","observed_orcids":["https://orcid.org/0000-0003-4660-0696"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kiran Kumar Nalla","raw_affiliation_strings":["Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062965634","display_name":"Haritha Ravula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Haritha Ravula","raw_affiliation_strings":["Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012287683","display_name":"Archana Pan","orcid":"https://orcid.org/0000-0002-3568-7047","observed_orcids":["https://orcid.org/0000-0002-3568-7047"]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Archana Pan","raw_affiliation_strings":["Centre for Bioinformatics, Pondicherry University, Puducherry-605014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bioinformatics, Pondicherry University, Puducherry-605014, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064248019","display_name":"Santosh Raja Kanade","orcid":"https://orcid.org/0000-0002-2184-9973","observed_orcids":["https://orcid.org/0000-0002-2184-9973"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Santosh R. Kanade","raw_affiliation_strings":["Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India. Electronic address: san@uohyd.ac.in","Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India. Electronic address: san@uohyd.ac.in","institution_ids":["https://openalex.org/I36893310"]},{"raw_affiliation_string":"Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad-500046, Telangana, India","institution_ids":["https://openalex.org/I36893310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064248019"],"corresponding_institution_ids":["https://openalex.org/I36893310"],"apc_list":{"value":2930,"currency":"USD","value_usd":2930},"apc_paid":null,"fwci":0.6273,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.62574716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"95","issue":null,"first_page":"153885","last_page":"153885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13921","display_name":"Biological Stains and Phytochemicals","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brazilin","display_name":"brazilin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9129999876022339},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9929999709129333},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7310000061988831},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9079999923706055},{"id":"https://openalex.org/keywords/caesalpinia-sappan","display_name":"Caesalpinia sappan","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dna-methyltransferase-inhibition","display_name":"DNA methyltransferase inhibition","score":0.5619999766349792},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-reactivation","display_name":"tumor suppressor gene reactivation","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.5740000009536743},{"id":"https://openalex.org/keywords/anticancer-phytochemicals","display_name":"anticancer phytochemicals","score":0.6949999928474426},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7488849759101868},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.6769196391105652},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6488677859306335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6417491436004639},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.5652441382408142},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5282078385353088},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5080047249794006},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5044540166854858},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.47884392738342285},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4689564108848572},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4386771619319916},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4361395537853241},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.42048200964927673},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4167071580886841},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4084191620349884},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3764919638633728},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29780909419059753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20957279205322266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16853275895118713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15341585874557495}],"mesh":[{"descriptor_ui":"D000076123","descriptor_name":"DNA (Cytosine-5-)-Methyltransferase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2021.153885","doi":"https://doi.org/10.1016/j.phymed.2021.153885","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153885","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:34920321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34920321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3954825051","display_name":null,"funder_award_id":"EEQ-2016/000251","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W577326606","https://openalex.org/W1508329710","https://openalex.org/W1971423434","https://openalex.org/W1972368989","https://openalex.org/W1985542606","https://openalex.org/W1993108335","https://openalex.org/W1995728036","https://openalex.org/W2000468479","https://openalex.org/W2014203415","https://openalex.org/W2015999693","https://openalex.org/W2028743684","https://openalex.org/W2029459160","https://openalex.org/W2029860792","https://openalex.org/W2035393182","https://openalex.org/W2056927568","https://openalex.org/W2067715644","https://openalex.org/W2070746165","https://openalex.org/W2072301590","https://openalex.org/W2082551234","https://openalex.org/W2086492419","https://openalex.org/W2093891424","https://openalex.org/W2099618301","https://openalex.org/W2101926267","https://openalex.org/W2102377211","https://openalex.org/W2138255873","https://openalex.org/W2139122477","https://openalex.org/W2149816812","https://openalex.org/W2152264000","https://openalex.org/W2152896792","https://openalex.org/W2153550523","https://openalex.org/W2162262059","https://openalex.org/W2167362145","https://openalex.org/W2167637569","https://openalex.org/W2181892250","https://openalex.org/W2258255719","https://openalex.org/W2260494368","https://openalex.org/W2326246873","https://openalex.org/W2569274667","https://openalex.org/W2572742978","https://openalex.org/W2594519469","https://openalex.org/W2613822734","https://openalex.org/W2754250453","https://openalex.org/W2766704091","https://openalex.org/W2794563065","https://openalex.org/W2804191072","https://openalex.org/W2870041153","https://openalex.org/W2889517927","https://openalex.org/W2889646458","https://openalex.org/W2890450861","https://openalex.org/W2893052697","https://openalex.org/W2903826068","https://openalex.org/W2912993657","https://openalex.org/W2919977311","https://openalex.org/W2931309428","https://openalex.org/W2946296908","https://openalex.org/W2958964287","https://openalex.org/W2962348202","https://openalex.org/W2965004154","https://openalex.org/W2968190332","https://openalex.org/W2972541713","https://openalex.org/W2999417355","https://openalex.org/W3023341510","https://openalex.org/W3026114757","https://openalex.org/W3031064217","https://openalex.org/W3033113467","https://openalex.org/W3038126636","https://openalex.org/W3091173199","https://openalex.org/W3129273166","https://openalex.org/W3199418793","https://openalex.org/W4205724345","https://openalex.org/W4386041144","https://openalex.org/W6675067053","https://openalex.org/W6682221126","https://openalex.org/W6760755693","https://openalex.org/W6778658231"],"related_works":["https://openalex.org/W2029860792","https://openalex.org/W2955954722","https://openalex.org/W4393167648","https://openalex.org/W2031452608","https://openalex.org/W2152264000","https://openalex.org/W1835794460","https://openalex.org/W1598891758","https://openalex.org/W2116572561","https://openalex.org/W4220816330","https://openalex.org/W2314139516"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
