{"id":"https://openalex.org/W4200414211","doi":"https://doi.org/10.1201/9780429087592-10","title":"Synthetic polymer-protein hybrids: modification of L-asparaginase with polyethylene glycol","display_name":"Synthetic polymer-protein hybrids: modification of L-asparaginase with polyethylene glycol","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200414211","doi":"https://doi.org/10.1201/9780429087592-10"},"language":"en","primary_location":{"id":"doi:10.1201/9780429087592-10","doi":"https://doi.org/10.1201/9780429087592-10","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9780429087592-10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiphase Biomedical Materials","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4205873489","display_name":"Multiphase Biomedical Materials"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y. Inada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Inada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Matsushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Matsushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079583545","display_name":"Yuji Saito","orcid":"https://orcid.org/0000-0003-2804-8076","observed_orcids":["https://orcid.org/0000-0003-2804-8076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001884814","display_name":"Takayuki Yoshimoto","orcid":"https://orcid.org/0000-0002-2847-0341","observed_orcids":["https://orcid.org/0000-0002-2847-0341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Yoshimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026854132","display_name":"Hitoshi Nishimura","orcid":"https://orcid.org/0000-0001-5068-1738","observed_orcids":["https://orcid.org/0000-0001-5068-1738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Nishimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058914338","display_name":"Hisayuki Wada","orcid":"https://orcid.org/0009-0005-5132-4130","observed_orcids":["https://orcid.org/0009-0005-5132-4130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Wada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28798914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"153","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.3208000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.3208000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.09920000284910202,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.9589999914169312},{"id":"https://openalex.org/keywords/protein-drug-conjugates","display_name":"protein-drug conjugates","score":0.6629999876022339},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.5519999861717224},{"id":"https://openalex.org/keywords/immunogenicity-reduction","display_name":"immunogenicity reduction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/protein-clearance","display_name":"protein clearance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/leukemia-treatment","display_name":"leukemia treatment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/escherichia-coli-asparaginase","display_name":"Escherichia coli asparaginase","score":0.906000018119812},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.8282819986343384},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5147016644477844},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4180571138858795},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.3618224859237671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3141855299472809},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.235081285238266},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1715443730354309}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9780429087592-10","doi":"https://doi.org/10.1201/9780429087592-10","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9780429087592-10","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiphase Biomedical Materials","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2437485144","https://openalex.org/W2324166948","https://openalex.org/W2078263947","https://openalex.org/W2024374898","https://openalex.org/W2410061579","https://openalex.org/W1821438013","https://openalex.org/W2013393135","https://openalex.org/W2376397281","https://openalex.org/W2908369611","https://openalex.org/W1963647288"],"abstract_inverted_index":{"Summary":[0],"\u2014Proteins":[1],"can":[2,16],"be":[3,31],"modified":[4,48,88,95],"by":[5],"chemical":[6],"binding":[7],"of":[8,19,22,40,44,46,53,58,71,80,93],"synthetic":[9],"macromolecules":[10],"to":[11,97],"their":[12,28,34],"surface.":[13],"This":[14],"modification":[15],"counteract":[17],"some":[18],"the":[20,41,51,54,65,68,78,94],"drawbacks":[21],"native":[23],"proteins,":[24],"and":[25,62],"changes":[26],"in":[27,67,77],"properties":[29],"could":[30],"important":[32],"for":[33],"use":[35,76],"as":[36],"protein":[37,72],"drugs.":[38,73],"One":[39],"main":[42],"advantages":[43],"construction":[45],"such":[47],"proteins":[49,61],"is":[50,64],"reduction":[52,66],"immunoreactivity":[55],"or":[56],"immunogenicity":[57],"antigenically":[59],"active":[60],"another":[63],"clearance":[69],"rate":[70],"For":[74],"clinical":[75],"therapy":[79],"human":[81],"leukemia,":[82],"L-asparaginase":[83],"from":[84],"Escherichia":[85],"coli":[86],"was":[87,100],"with":[89],"polyethylene":[90],"glycol.":[91],"Administration":[92],"asparaginase":[96],"three":[98],"patients":[99],"therapeutically":[101],"effective":[102],"without":[103],"causing":[104],"any":[105],"allergic":[106],"reaction.":[107]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-31T00:00:00"}