{"id":"https://openalex.org/W4200410909","doi":"https://doi.org/10.1186/s40733-021-00082-0","title":"The link between atopic dermatitis and asthma- immunological imbalance and beyond","display_name":"The link between atopic dermatitis and asthma- immunological imbalance and beyond","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200410909","doi":"https://doi.org/10.1186/s40733-021-00082-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/34911576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8672460"},"language":"en","primary_location":{"id":"doi:10.1186/s40733-021-00082-0","doi":"https://doi.org/10.1186/s40733-021-00082-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40733-021-00082-0","pdf_url":"https://asthmarp.biomedcentral.com/counter/pdf/10.1186/s40733-021-00082-0","source":{"id":"https://openalex.org/S4210233379","display_name":"Asthma Research and Practice","issn_l":"2054-7064","issn":["2054-7064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asthma Research and Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://asthmarp.biomedcentral.com/counter/pdf/10.1186/s40733-021-00082-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079632965","display_name":"Martina Yaneva","orcid":"https://orcid.org/0000-0002-2550-3187","observed_orcids":["https://orcid.org/0000-0002-2550-3187"]},"institutions":[{"id":"https://openalex.org/I4210093677","display_name":"Acibadem City Clinic","ror":"https://ror.org/00jrbwm32","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210093677"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Martina Yaneva","raw_affiliation_strings":["Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria. yaneva.martina@yahoo.com","Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-2550-3187","affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria. yaneva.martina@yahoo.com","institution_ids":["https://openalex.org/I4210093677"]},{"raw_affiliation_string":"Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210093677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059222977","display_name":"Razvigor Darlenski","orcid":"https://orcid.org/0000-0002-4220-8040","observed_orcids":["https://orcid.org/0000-0002-4220-8040"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]},{"id":"https://openalex.org/I4210093677","display_name":"Acibadem City Clinic","ror":"https://ror.org/00jrbwm32","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210093677"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Razvigor Darlenski","raw_affiliation_strings":["Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria","Section of Dermatovenereology, Trakia University, Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Acibadem City Clinic, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210093677"]},{"raw_affiliation_string":"Section of Dermatovenereology, Trakia University, Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079632965"],"corresponding_institution_ids":["https://openalex.org/I4210093677"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":1.9513,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.88019967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.14489999413490295,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/atopic-march","display_name":"atopic march","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunological-imbalance","display_name":"immunological imbalance","score":0.8180000185966492},{"id":"https://openalex.org/keywords/atopic-diseases","display_name":"atopic diseases","score":0.6880000233650208},{"id":"https://openalex.org/keywords/disease-phenotype","display_name":"disease phenotypes","score":0.6579999923706055},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9950000047683716},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7080000042915344},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8420000076293945},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8563016653060913},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7573172450065613},{"id":"https://openalex.org/C2778753846","wikidata":"https://www.wikidata.org/wiki/Q6554239","display_name":"Link (geometry)","level":2,"score":0.7227972745895386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5313007831573486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.475501149892807},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4268417954444885},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09015130996704102},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0449332594871521}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40733-021-00082-0","doi":"https://doi.org/10.1186/s40733-021-00082-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40733-021-00082-0","pdf_url":"https://asthmarp.biomedcentral.com/counter/pdf/10.1186/s40733-021-00082-0","source":{"id":"https://openalex.org/S4210233379","display_name":"Asthma Research and Practice","issn_l":"2054-7064","issn":["2054-7064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asthma Research and Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8672460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8672460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asthma Res Pract","raw_type":"Text"},{"id":"pmid:34911576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34911576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asthma research and practice","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:744a6ce04ed84fbba6f1c195e280f131","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/744a6ce04ed84fbba6f1c195e280f131","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asthma Research and Practice, Vol 7, Iss 1, Pp 1-8 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40733-021-00082-0","doi":"https://doi.org/10.1186/s40733-021-00082-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40733-021-00082-0","pdf_url":"https://asthmarp.biomedcentral.com/counter/pdf/10.1186/s40733-021-00082-0","source":{"id":"https://openalex.org/S4210233379","display_name":"Asthma Research and Practice","issn_l":"2054-7064","issn":["2054-7064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asthma Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200410909.pdf","grobid_xml":"https://content.openalex.org/works/W4200410909.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W594638714","https://openalex.org/W1485278347","https://openalex.org/W1564468289","https://openalex.org/W1578008264","https://openalex.org/W1579720523","https://openalex.org/W1974937503","https://openalex.org/W1976568467","https://openalex.org/W1977581411","https://openalex.org/W1995221959","https://openalex.org/W1998181246","https://openalex.org/W2021937820","https://openalex.org/W2028888557","https://openalex.org/W2029208193","https://openalex.org/W2030480507","https://openalex.org/W2034313895","https://openalex.org/W2041515888","https://openalex.org/W2048809358","https://openalex.org/W2051547434","https://openalex.org/W2052816509","https://openalex.org/W2053815422","https://openalex.org/W2061911569","https://openalex.org/W2064089850","https://openalex.org/W2065008302","https://openalex.org/W2065746776","https://openalex.org/W2066945652","https://openalex.org/W2068176013","https://openalex.org/W2088438397","https://openalex.org/W2090646249","https://openalex.org/W2097569657","https://openalex.org/W2098817029","https://openalex.org/W2100589529","https://openalex.org/W2105559411","https://openalex.org/W2106715003","https://openalex.org/W2108664470","https://openalex.org/W2110940442","https://openalex.org/W2114156659","https://openalex.org/W2121580723","https://openalex.org/W2125081565","https://openalex.org/W2130942098","https://openalex.org/W2134041885","https://openalex.org/W2135250308","https://openalex.org/W2141479546","https://openalex.org/W2157425698","https://openalex.org/W2158909942","https://openalex.org/W2161876534","https://openalex.org/W2168068371","https://openalex.org/W2168301089","https://openalex.org/W2219506845","https://openalex.org/W2239108612","https://openalex.org/W2279757418","https://openalex.org/W2289935030","https://openalex.org/W2330028620","https://openalex.org/W2342887013","https://openalex.org/W2345037755","https://openalex.org/W2415224593","https://openalex.org/W2509919933","https://openalex.org/W2511126932","https://openalex.org/W2554577243","https://openalex.org/W2588720057","https://openalex.org/W2594112302","https://openalex.org/W2594455611","https://openalex.org/W2604249065","https://openalex.org/W2715716507","https://openalex.org/W2731948244","https://openalex.org/W2767760039","https://openalex.org/W2768589100","https://openalex.org/W2770925577","https://openalex.org/W2784164089","https://openalex.org/W2792596323","https://openalex.org/W2796607295","https://openalex.org/W2801660094","https://openalex.org/W2807789068","https://openalex.org/W2889501685","https://openalex.org/W2892288216","https://openalex.org/W2901011713","https://openalex.org/W2901343691","https://openalex.org/W3008661668","https://openalex.org/W3011387478","https://openalex.org/W3016797498","https://openalex.org/W3195786665","https://openalex.org/W3202339277","https://openalex.org/W4211026773","https://openalex.org/W4211145137"],"related_works":["https://openalex.org/W2011290121","https://openalex.org/W7168411733","https://openalex.org/W3042238343","https://openalex.org/W7160412369","https://openalex.org/W4411261579","https://openalex.org/W2784144205","https://openalex.org/W2487120205","https://openalex.org/W2016345560","https://openalex.org/W2165676713","https://openalex.org/W2052849297"],"abstract_inverted_index":{"Atopic":[0,17],"diseases":[1,47,74],"are":[2],"multifactorial":[3],"chronic":[4],"disturbances":[5],"which":[6],"may":[7],"evolve":[8],"one":[9],"into":[10],"another":[11],"and":[12,33,51,96,118,150,155,167],"have":[13,75],"overlapping":[14],"pathogenetic":[15],"mechanisms.":[16],"dermatitis":[18,95],"is":[19,48,84],"in":[20,39,52,101,136,161],"most":[21],"cases":[22,54],"the":[23,27,30,40,63,66,69,72,91,102,112,129,134,145,148,153],"first":[24],"step":[25],"towards":[26],"development":[28,64],"of":[29,45,65,81,115,133,147,157],"atopic":[31,46,67,73,94],"march":[32],"represents":[34],"a":[35,99],"major":[36,88],"socio-economic":[37],"burden":[38],"industrialized":[41],"countries.":[42],"The":[43,79],"treatment":[44],"often":[49],"long-lasting":[50],"some":[53,87],"with":[55],"lower":[56],"effectiveness":[57],"than":[58],"expected.In":[59],"order":[60,162],"to":[61,76,85,111,120,127,163],"prevent":[62],"march,":[68],"links":[70],"between":[71,93],"be":[77],"understood.":[78],"aim":[80],"this":[82,165],"review":[83],"present":[86],"points":[89],"outlining":[90],"link":[92],"asthma,":[97],"through":[98],"research":[100,156],"medical":[103],"literature":[104],"from":[105],"recent":[106],"years.Stratifying":[107],"patient":[108],"populations":[109],"according":[110,119],"clinical":[113],"phenotype":[114],"their":[116],"disease":[117,135],"specific":[121],"measurable":[122],"values":[123],"(biomarkers)":[124],"can":[125],"help":[126],"establish":[128],"main":[130],"etiopathogenetic":[131],"mechanisms":[132],"these":[137],"populations.":[138],"This":[139],"will":[140,151],"add":[141],"predictive":[142],"value":[143],"for":[144],"evolution":[146,166],"disease,":[149],"allow":[152],"use":[154],"more":[158],"targeted":[159],"therapy":[160],"stop":[164],"comorbidities.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}
