{"id":"https://openalex.org/W4200410261","doi":"https://doi.org/10.1177/1934578x211067294","title":"Molecular Mechanism of Chrysin in Hepatocellular Carcinoma Treatment Based on Network Pharmacology and in Vitro Experiments","display_name":"Molecular Mechanism of Chrysin in Hepatocellular Carcinoma Treatment Based on Network Pharmacology and in Vitro Experiments","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200410261","doi":"https://doi.org/10.1177/1934578x211067294"},"language":"en","primary_location":{"id":"doi:10.1177/1934578x211067294","doi":"https://doi.org/10.1177/1934578x211067294","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x211067294","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/1934578x211067294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046963572","display_name":"Jialin Wei","orcid":"https://orcid.org/0000-0002-0072-5461","observed_orcids":["https://orcid.org/0000-0002-0072-5461"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialin Wei","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110829782","display_name":"Zhiyuan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Sun","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101557395","display_name":"Li Shi","orcid":"https://orcid.org/0000-0002-2998-3384","observed_orcids":["https://orcid.org/0000-0002-2998-3384"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Shi","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014944249","display_name":"Shaodan Hu","orcid":"https://orcid.org/0000-0003-1177-0679","observed_orcids":["https://orcid.org/0000-0003-1177-0679"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaodan Hu","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003392018","display_name":"Da Liu","orcid":"https://orcid.org/0000-0003-0024-6329","observed_orcids":["https://orcid.org/0000-0003-0024-6329"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Da Liu","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China","Key Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0003-0024-6329","affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]},{"raw_affiliation_string":"Key Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101702658","display_name":"Hong Wei","orcid":"https://orcid.org/0000-0001-8940-9029","observed_orcids":["https://orcid.org/0000-0001-8940-9029"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong Wei","raw_affiliation_strings":["Changchun University of Chinese Medicine, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun University of Chinese Medicine, Changchun, China","institution_ids":["https://openalex.org/I4210128075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003392018","https://openalex.org/A5101702658"],"corresponding_institution_ids":["https://openalex.org/I4210128075"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.1289,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.37842006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chrysin","display_name":"chrysin","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":1.0},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8429999947547913},{"id":"https://openalex.org/keywords/g2-phase","display_name":"G2 phase","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hepatoma-cell-lines","display_name":"hepatoma cell lines","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bel-7402-cells","display_name":"BEL-7402 cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2779478871","wikidata":"https://www.wikidata.org/wiki/Q973741","display_name":"Chrysin","level":4,"score":0.9188514947891235},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7610577344894409},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5839653611183167},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.508904218673706},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43351277709007263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4103851914405823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3518846035003662},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3403918147087097},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.327951580286026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3226606249809265},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.23604780435562134},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17189759016036987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17186787724494934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16728797554969788},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/1934578x211067294","doi":"https://doi.org/10.1177/1934578x211067294","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x211067294","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:618768f067514c56b2a2d810e3150aea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/618768f067514c56b2a2d810e3150aea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural Product Communications, Vol 16 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1934578x211067294","doi":"https://doi.org/10.1177/1934578x211067294","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x211067294","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1082361011","display_name":null,"funder_award_id":"JJKH20210969KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G1301934044","display_name":null,"funder_award_id":"JJKH20210995KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320326270","display_name":"Education Department of Jilin Province","ror":"https://ror.org/05782e512"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1508291825","https://openalex.org/W1552243592","https://openalex.org/W1709909846","https://openalex.org/W1821077834","https://openalex.org/W1822286893","https://openalex.org/W1951827223","https://openalex.org/W1976309438","https://openalex.org/W1976586638","https://openalex.org/W1994724667","https://openalex.org/W2008701562","https://openalex.org/W2044862721","https://openalex.org/W2048793404","https://openalex.org/W2052273047","https://openalex.org/W2064641041","https://openalex.org/W2074451871","https://openalex.org/W2084590325","https://openalex.org/W2087326187","https://openalex.org/W2090803856","https://openalex.org/W2096108416","https://openalex.org/W2108515940","https://openalex.org/W2113928060","https://openalex.org/W2129802218","https://openalex.org/W2137168958","https://openalex.org/W2140309325","https://openalex.org/W2151602082","https://openalex.org/W2158504441","https://openalex.org/W2171239378","https://openalex.org/W2476612720","https://openalex.org/W2562699650","https://openalex.org/W2570611720","https://openalex.org/W2800000475","https://openalex.org/W2911414913","https://openalex.org/W2987312822","https://openalex.org/W3110719976","https://openalex.org/W3156383435","https://openalex.org/W3157731448","https://openalex.org/W3193658761"],"related_works":["https://openalex.org/W7084157063","https://openalex.org/W2340216997","https://openalex.org/W4402938456","https://openalex.org/W4321606121","https://openalex.org/W3160274193","https://openalex.org/W4417362529","https://openalex.org/W3132753508","https://openalex.org/W4220968431","https://openalex.org/W3096410109","https://openalex.org/W3158051536"],"abstract_inverted_index":{"This":[0],"study":[1,279],"elucidated":[2],"the":[3,30,47,92,112,119,141,153,195,214,239,243,261,275,281],"potential":[4],"molecular":[5,72],"mechanism":[6,282],"of":[7,25,40,50,57,91,102,111,129,159,169,173,190,216,247,283],"chrysin":[8,41,51,58,127,212,228,284],"in":[9,18,52,165,223,233,238,286],"hepatocellular":[10],"carcinoma":[11],"(HCC)":[12],"treatment":[13,128],"using":[14,118],"network":[15,269],"pharmacology":[16,123,270],"and":[17,22,32,38,42,59,77,88,99,104,137,146,156,163,178,194,204,221,235,242,252,264],"vitro":[19,208],"experiments.":[20],"Chrysin":[21,254],"candidate":[23],"targets":[24,44,49,172,181,193],"HCC":[26,43,53,130,257],"were":[27,69,82,116,149,182,272],"obtained":[28],"from":[29],"TCMSP":[31],"DrugBank":[33],"databases,":[34],"followed":[35],"by":[36,71,259],"mapping":[37],"screening":[39],"to":[45,84,134,151],"identify":[46],"core":[48,93,113,192],"treatment.":[54],"The":[55,74,184,268],"interaction":[56],"its":[60],"targets,":[61,177],"including":[62],"CDK1,":[63],"CDK5,":[64],"as":[65,67],"well":[66],"MMP9,":[68],"evaluated":[70],"docking.":[73],"STRING":[75],"database":[76],"Cytoscape":[78],"(version":[79],"3.8.2)":[80],"software":[81],"used":[83,150],"construct":[85],"protein":[86],"interactions":[87],"component-target":[89],"networks":[90],"targets.":[94],"Gene":[95],"Ontology":[96],"(GO)":[97],"annotation":[98],"Kyoto":[100],"Encyclopedia":[101],"Genes":[103],"Genomes":[105],"(KEGG)":[106],"signaling":[107],"pathway":[108],"enrichment":[109],"analysis":[110],"target":[114],"genes":[115],"performed":[117],"DAVID":[120],"database.":[121],"Network":[122],"results":[124,271],"showed":[125,210],"that":[126,211],"was":[131,245],"mainly":[132,200,258],"related":[133],"cell":[135,138,142,154,157,202,205,230,262,266],"proliferation":[136,203,215],"cycle.":[139,206],"Accordingly,":[140],"counting":[143],"kit-8":[144],"method":[145],"flow":[147],"cytometry":[148],"detect":[152],"viability":[155],"cycle":[158,231,263],"hepatocarcinoma":[160,218],"cells":[161,219,237],"HCCLM3":[162,234],"BEL-7402":[164,236],"vitro.":[166],"A":[167],"total":[168],"142":[170],"compound":[171],"chrysin,":[174],"12,179":[175],"HCC-related":[176],"116":[179],"intersecting":[180],"screened.":[183],"first":[185,196],"20":[186,197],"GO":[187],"biological":[188],"annotations":[189],"17":[191],"KEGG":[198],"pathways":[199],"involved":[201],"In":[207],"experiments":[209],"inhibits":[213],"human":[217],"(HCCLM3":[220],"BEL-7402)":[222],"a":[224],"dose-dependent":[225],"manner.":[226],"Moreover,":[227],"induced":[229],"arrest":[232],"G2":[240],"phase,":[241],"expression":[244],"downregulated":[246],"cyclin-dependent":[248],"kinases":[249],"(CDKs),":[250],"CDK2":[251],"CDK4.":[253],"can":[255],"offset":[256],"regulating":[260],"inhibiting":[265],"proliferation.":[267],"verified,":[273],"providing":[274],"basis":[276],"for":[277],"further":[278],"on":[280],"intervention":[285],"HCC.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
