{"id":"https://openalex.org/W4200401272","doi":"https://doi.org/10.1371/journal.pmed.1003874","title":"Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study","display_name":"Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study","publication_year":2021,"publication_date":"2021-12-17","ids":{"openalex":"https://openalex.org/W4200401272","doi":"https://doi.org/10.1371/journal.pmed.1003874","pmid":"https://pubmed.ncbi.nlm.nih.gov/34919548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8726493"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.1003874","doi":"https://doi.org/10.1371/journal.pmed.1003874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1003874","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003874&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003874&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048360841","display_name":"Mie Agermose Gram","orcid":"https://orcid.org/0000-0001-7908-0039","observed_orcids":["https://orcid.org/0000-0001-7908-0039"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Mie Agermose Gram","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7908-0039","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101746972","display_name":"Jens Ole Nielsen","orcid":"https://orcid.org/0000-0001-6477-2219","observed_orcids":["https://orcid.org/0000-0001-6477-2219"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens Nielsen","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6477-2219","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076811809","display_name":"Astrid Blicher Schelde","orcid":"https://orcid.org/0000-0002-9187-7822","observed_orcids":["https://orcid.org/0000-0002-9187-7822"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Astrid Blicher Schelde","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9187-7822","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060964925","display_name":"Katrine Finderup Nielsen","orcid":"https://orcid.org/0000-0001-8847-9850","observed_orcids":["https://orcid.org/0000-0001-8847-9850"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Katrine Finderup Nielsen","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021147516","display_name":"Ida Rask Moustsen\u2010Helms","orcid":"https://orcid.org/0000-0002-1143-511X","observed_orcids":["https://orcid.org/0000-0002-1143-511X"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ida Rask Moustsen-Helms","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-1143-511X","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113954947","display_name":"Anne Katrine Bj\u00f8rkholt S\u00f8rensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne Katrine Bj\u00f8rkholt S\u00f8rensen","raw_affiliation_strings":["Department of Infectious Disease Preparedness, Data Integration and Analysis, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Preparedness, Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Preparedness, Data Integration and Analysis, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Preparedness, Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011135869","display_name":"Palle Valentiner\u2010Branth","orcid":"https://orcid.org/0000-0002-6229-5268","observed_orcids":["https://orcid.org/0000-0002-6229-5268"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Palle Valentiner-Branth","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6229-5268","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002806402","display_name":"Hanne\u2010Dorthe Emborg","orcid":"https://orcid.org/0000-0001-8062-0864","observed_orcids":["https://orcid.org/0000-0001-8062-0864"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hanne-Dorthe Emborg","raw_affiliation_strings":["Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-8062-0864","affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048360841"],"corresponding_institution_ids":["https://openalex.org/I101527212"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":3.8275,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95093848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"18","issue":"12","first_page":"e1003874","last_page":"e1003874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.6140000224113464},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8849999904632568},{"id":"https://openalex.org/keywords/covid-19-hospitalization","display_name":"COVID-19 hospitalization","score":0.9599999785423279},{"id":"https://openalex.org/keywords/covid-19-mortality","display_name":"COVID-19 mortality","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vaccine-effectiveness","display_name":"vaccine effectiveness","score":0.9850000143051147},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.4020000100135803},{"id":"https://openalex.org/keywords/denmark","display_name":"Denmark","score":0.49399998784065247},{"id":"https://openalex.org/keywords/population-based-cohort-study","display_name":"population-based cohort","score":0.6290000081062317},{"id":"https://openalex.org/keywords/covid-19-vaccination-program","display_name":"COVID-19 vaccination program","score":0.5019999742507935},{"id":"https://openalex.org/keywords/vaccine-hesitancy","display_name":"vaccine hesitancy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/sars-cov-2-breakthrough-infection","display_name":"SARS-CoV-2 breakthrough infection","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8355344533920288},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5872095823287964},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5518577098846436},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.4869557321071625},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.4801423251628876},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4757247269153595},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.47244197130203247},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3942547142505646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3683227300643921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2771851420402527},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09948751330375671}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090982","descriptor_name":"BNT162 Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000090985","descriptor_name":"ChAdOx1 nCoV-19","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pmed.1003874","doi":"https://doi.org/10.1371/journal.pmed.1003874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1003874","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003874&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Medicine","raw_type":"journal-article"},{"id":"doi:10.1101/2021.07.26.21261130","doi":"https://doi.org/10.1101/2021.07.26.21261130","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.07.26.21261130","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/07/28/2021.07.26.21261130.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:34919548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34919548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8726493","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8726493/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:23b2d9c09ef74834a97ca73c20321864","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/23b2d9c09ef74834a97ca73c20321864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 18, Iss 12, p e1003874 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.1003874","doi":"https://doi.org/10.1371/journal.pmed.1003874","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1003874","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003874&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335404","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200401272.pdf","grobid_xml":"https://content.openalex.org/works/W4200401272.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W11414727","https://openalex.org/W1978670003","https://openalex.org/W2102420102","https://openalex.org/W2219591537","https://openalex.org/W2407815780","https://openalex.org/W3049027736","https://openalex.org/W3093877663","https://openalex.org/W3103811749","https://openalex.org/W3132313785","https://openalex.org/W3134660507","https://openalex.org/W3137307037","https://openalex.org/W3138777155","https://openalex.org/W3157488589","https://openalex.org/W3158005252","https://openalex.org/W3158123254","https://openalex.org/W3160138987","https://openalex.org/W3161183609","https://openalex.org/W3163988408","https://openalex.org/W3172599793","https://openalex.org/W3174534250","https://openalex.org/W3175995708","https://openalex.org/W3177819637","https://openalex.org/W3192494915","https://openalex.org/W4200433348"],"related_works":["https://openalex.org/W4226124668","https://openalex.org/W4292171922","https://openalex.org/W4210301583","https://openalex.org/W4294043822","https://openalex.org/W4210528838","https://openalex.org/W4293194778","https://openalex.org/W3206891011","https://openalex.org/W4200226333","https://openalex.org/W4320021165","https://openalex.org/W4319461286"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,36,152,174,224,243,266],"recommendations":[2],"in":[3,86,101,327,353],"several":[4],"countries":[5],"to":[6,14,47,89,95,126,336],"stop":[7],"using":[8],"the":[9,49,66,70,74,77,102,181,193,197,210,228,232,273,288,301,305,310,328,342,354,361],"ChAdOx1":[10,71,194,233,274,362],"vaccine":[11,15,23,29,34,72,195,208,234,278,307,325],"has":[12],"led":[13],"programs":[16],"combining":[17,272,360],"different":[18],"Coronavirus":[19,56],"Disease":[20],"2019":[21],"(COVID-19)":[22],"types,":[24],"which":[25],"necessitates":[26],"knowledge":[27],"on":[28,108],"effectiveness":[30],"(VE)":[31],"of":[32,38,69,76,169,180,187,201,215,231,240,252,356],"heterologous":[33],"schedules.":[35],"aim":[37],"this":[39,346],"Danish":[40,103,116,183],"nationwide":[41],"population-based":[42],"cohort":[43],"study":[44,244,311],"was":[45,113,246,279],"therefore":[46],"estimate":[48],"VE":[50,153,267],"against":[51,139,268],"Severe":[52],"Acute":[53],"Respiratory":[54],"Syndrome":[55],"2":[57],"(SARS-CoV-2)":[58],"infection":[59,141,270,358],"and":[60,63,73,111,120,129,142,163,171,200,218,254,257,262,275,291,322,363],"COVID-19-related":[61,143,296],"hospitalization":[62,144],"death":[64,146],"following":[65],"first":[67,198,229],"dose":[68,230,235,290],"combination":[75],"ChAdOx1/mRNA":[78],"vaccines.":[79],"METHODS":[80],"AND":[81],"FINDINGS:":[82],"All":[83],"individuals":[84,178,189,204,225,302],"alive":[85],"or":[87,145,298],"immigrating":[88],"Denmark":[90],"from":[91,115,260],"9":[92],"February":[93],"2021":[94,98],"23":[96],"June":[97],"were":[99,124,155,190,222,294],"identified":[100],"Civil":[104],"Registration":[105],"System.":[106],"Information":[107],"exposure,":[109],"outcomes,":[110],"covariates":[112],"obtained":[114],"national":[117],"registries.":[118],"Poisson":[119],"Cox":[121],"regression":[122],"models":[123],"used":[125],"calculate":[127],"crude":[128],"adjusted":[130,156],"VE,":[131],"respectively,":[132],"along":[133],"with":[134,192,227,304,368],"95%":[135],"confidence":[136],"intervals":[137],"(CIs)":[138],"SARS-CoV-2":[140,220,269,357],"comparing":[147],"vaccinated":[148,191,226,303],"versus":[149],"unvaccinated":[150,369],"individuals.":[151,370],"estimates":[154],"for":[157,164],"calendar":[158],"time":[159,162],"as":[160,196,209,319],"underlying":[161],"sex,":[165],"age,":[166],"comorbidity,":[167],"country":[168],"origin,":[170],"hospital":[172],"admission.":[173],"analyses":[175],"included":[176],"5,542,079":[177],"(97.6%":[179],"total":[182,186,214],"population).":[184],"A":[185,213],"144,360":[188],"dose,":[199],"these,":[202],"136,551":[203],"received":[205],"an":[206,249,276,364],"mRNA":[207,277,365],"second":[211,289],"dose.":[212],"1,691,464":[216],"person-years":[217],"83,034":[219],"infections":[221],"included.":[223],"had":[236],"a":[237,350],"median":[238],"age":[239],"45":[241],"years.":[242],"population":[245,330],"characterized":[247],"by":[248],"equal":[250],"distribution":[251],"males":[253],"females;":[255],"6.7%":[256],"9.2%":[258],"originated":[259],"high-income":[261],"other":[263],"countries,":[264],"respectively.":[265],"when":[271,340,359],"88%":[280],"(95%":[281],"CI:":[282],"83;":[283],"92)":[284],"14":[285],"days":[286],"after":[287],"onwards.":[292],"There":[293],"no":[295],"hospitalizations":[297],"deaths":[299],"among":[300],"combined":[306],"schedule":[308],"during":[309],"period.":[312],"Study":[313],"limitations":[314],"including":[315],"unmeasured":[316],"confounders":[317],"such":[318],"risk":[320,355],"behavior":[321],"increasing":[323],"overall":[324],"coverage":[326],"general":[329],"creating":[331],"herd":[332],"immunity":[333],"are":[334],"important":[335],"take":[337],"into":[338],"consideration":[339],"interpreting":[341],"results.":[343],"CONCLUSIONS:":[344],"In":[345],"study,":[347],"we":[348],"observed":[349],"large":[351],"reduction":[352],"vaccine,":[366],"compared":[367]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}