{"id":"https://openalex.org/W4200401093","doi":"https://doi.org/10.4049/jimmunol.2100452","title":"Prosurvival IL-7\u2013Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1\u2013TCF1\u2013Id3 and Metabolic AMPK\u03b11\u2013ULK1\u2013ATG7 Pathways","display_name":"Prosurvival IL-7\u2013Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1\u2013TCF1\u2013Id3 and Metabolic AMPK\u03b11\u2013ULK1\u2013ATG7 Pathways","publication_year":2021,"publication_date":"2021-12-06","ids":{"openalex":"https://openalex.org/W4200401093","doi":"https://doi.org/10.4049/jimmunol.2100452","pmid":"https://pubmed.ncbi.nlm.nih.gov/34872976"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.2100452","doi":"https://doi.org/10.4049/jimmunol.2100452","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2100452","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064698550","display_name":"Aizhang Xu","orcid":"https://orcid.org/0000-0002-1843-1912","observed_orcids":["https://orcid.org/0000-0002-1843-1912"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Aizhang Xu","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048383846","display_name":"Scot C. Leary","orcid":"https://orcid.org/0000-0001-8488-7822","observed_orcids":["https://orcid.org/0000-0001-8488-7822"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Scot C Leary","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","\u2021Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":"https://orcid.org/0000-0001-8488-7822","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"\u2021Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084796027","display_name":"Md. Fahmid Islam","orcid":"https://orcid.org/0000-0002-7519-2049","observed_orcids":["https://orcid.org/0000-0002-7519-2049"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Md Fahmid Islam","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":"https://orcid.org/0000-0002-7519-2049","affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052500626","display_name":"Zhaojia Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Zhaojia Wu","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053958805","display_name":"Kalpana Kalyanasundaram Bhanumathy","orcid":"https://orcid.org/0000-0002-3499-6219","observed_orcids":["https://orcid.org/0000-0002-3499-6219"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kalpana Kalyanasundaram Bhanumathy","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080901552","display_name":"Anjuman Ara","orcid":"https://orcid.org/0000-0002-6302-4849","observed_orcids":["https://orcid.org/0000-0002-6302-4849"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Anjuman Ara","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":"https://orcid.org/0000-0002-6302-4849","affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052184366","display_name":"Rajni Chibbar","orcid":"https://orcid.org/0000-0003-2378-113X","observed_orcids":["https://orcid.org/0000-0003-2378-113X"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rajni Chibbar","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","\u00a7Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"\u00a7Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083130623","display_name":"Andrew Fleywald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Fleywald","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","\u00a7Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"\u00a7Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; and","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040460490","display_name":"Khawaja Ashfaque Ahmed","orcid":"https://orcid.org/0000-0001-6376-6036","observed_orcids":["https://orcid.org/0000-0001-6376-6036"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Khawaja Ashfaque Ahmed","raw_affiliation_strings":["Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","\u00b6Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6376-6036","affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"\u00b6Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109106555","display_name":"Jim Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210091762","display_name":"Saskatchewan Cancer Agency","ror":"https://ror.org/00e1nmf62","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210091762"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jim Xiang","raw_affiliation_strings":["Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research, Saskatchewan Cancer Agency , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"Division of Oncology, College of Medicine, University of Saskatchewan , Saskatoon, Saskatchewan,","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"*Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I4210091762"]},{"raw_affiliation_string":"\u2020Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052500626","https://openalex.org/A5064698550","https://openalex.org/A5080901552","https://openalex.org/A5109106555"],"corresponding_institution_ids":["https://openalex.org/I32625721","https://openalex.org/I4210091762"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.1878,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.75014622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"208","issue":"1","first_page":"155","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.8059999942779541},{"id":"https://openalex.org/keywords/il-7-receptor","display_name":"IL-7 receptor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/memory-cd8-t-cells","display_name":"memory CD8+ T cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tcf1","display_name":"TCF1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/id3-algorithm","display_name":"ID3","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ampkalpha1","display_name":"AMPK\u03b11","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atg7","display_name":"ATG7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.6710000038146973},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.6470000147819519},{"id":"https://openalex.org/keywords/recall-response","display_name":"recall response","score":0.6700000166893005},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8173881769180298},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7487505674362183},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5152135491371155},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5024218559265137},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.4985826015472412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.494792640209198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39703238010406494},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3186878561973572},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.30370378494262695},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2791857123374939},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.24617955088615417},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24047398567199707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16865575313568115},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.06785735487937927}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071193","descriptor_name":"Autophagy-Related Protein 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000087506","descriptor_name":"Vaccine Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091246","descriptor_name":"Memory T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020395","descriptor_name":"Receptors, Interleukin-7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038744","descriptor_name":"Ribosomal Protein S6 Kinases, 90-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051796","descriptor_name":"Inhibitor of Differentiation Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051796","descriptor_name":"Inhibitor of Differentiation Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.2100452","doi":"https://doi.org/10.4049/jimmunol.2100452","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2100452","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:34872976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34872976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2336895484","display_name":null,"funder_award_id":"419228","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G314023415","display_name":null,"funder_award_id":"419228","funder_id":"https://openalex.org/F4320319880","funder_display_name":"Government of Canada"}],"funders":[{"id":"https://openalex.org/F4320319880","display_name":"Government of Canada","ror":"https://ror.org/010q4q527"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W1491399868","https://openalex.org/W1512247569","https://openalex.org/W1563775926","https://openalex.org/W1568778024","https://openalex.org/W1601504908","https://openalex.org/W1664430667","https://openalex.org/W1882193637","https://openalex.org/W1942948392","https://openalex.org/W1964598084","https://openalex.org/W1964876127","https://openalex.org/W1970041220","https://openalex.org/W1970637701","https://openalex.org/W1974433492","https://openalex.org/W1974842026","https://openalex.org/W1975398457","https://openalex.org/W1975783419","https://openalex.org/W1976355501","https://openalex.org/W1976714959","https://openalex.org/W1976785514","https://openalex.org/W1981480494","https://openalex.org/W1981597823","https://openalex.org/W1981629491","https://openalex.org/W1985294654","https://openalex.org/W1988557862","https://openalex.org/W1990555844","https://openalex.org/W1991800973","https://openalex.org/W1994162431","https://openalex.org/W1997130093","https://openalex.org/W1999324987","https://openalex.org/W2000633182","https://openalex.org/W2005176113","https://openalex.org/W2005853038","https://openalex.org/W2007505836","https://openalex.org/W2017176455","https://openalex.org/W2018476626","https://openalex.org/W2020604513","https://openalex.org/W2027132663","https://openalex.org/W2030375564","https://openalex.org/W2042301242","https://openalex.org/W2059423024","https://openalex.org/W2061318708","https://openalex.org/W2064876347","https://openalex.org/W2074425485","https://openalex.org/W2075052419","https://openalex.org/W2076866673","https://openalex.org/W2077884399","https://openalex.org/W2078262203","https://openalex.org/W2079167667","https://openalex.org/W2081920342","https://openalex.org/W2085887337","https://openalex.org/W2088801927","https://openalex.org/W2091218020","https://openalex.org/W2093644658","https://openalex.org/W2096682152","https://openalex.org/W2097016524","https://openalex.org/W2098563852","https://openalex.org/W2101099764","https://openalex.org/W2102906934","https://openalex.org/W2104156406","https://openalex.org/W2105344440","https://openalex.org/W2130746744","https://openalex.org/W2139356874","https://openalex.org/W2140286004","https://openalex.org/W2141182631","https://openalex.org/W2143344012","https://openalex.org/W2144796561","https://openalex.org/W2145727904","https://openalex.org/W2149734790","https://openalex.org/W2152624886","https://openalex.org/W2153405301","https://openalex.org/W2153511402","https://openalex.org/W2157598971","https://openalex.org/W2168858092","https://openalex.org/W2190766406","https://openalex.org/W2192215274","https://openalex.org/W2252585899","https://openalex.org/W2259021796","https://openalex.org/W2295841223","https://openalex.org/W2312282875","https://openalex.org/W2345624579","https://openalex.org/W2360063079","https://openalex.org/W2411687688","https://openalex.org/W2415427537","https://openalex.org/W2554003937","https://openalex.org/W2578751200","https://openalex.org/W2593795304","https://openalex.org/W2609830515","https://openalex.org/W2625887862","https://openalex.org/W2644751370","https://openalex.org/W2747383311","https://openalex.org/W2750401294","https://openalex.org/W2752540906","https://openalex.org/W2755712391","https://openalex.org/W2764256140","https://openalex.org/W2766994089","https://openalex.org/W2776311197","https://openalex.org/W2793603553","https://openalex.org/W2804661053","https://openalex.org/W2886274086","https://openalex.org/W2888909823","https://openalex.org/W2900562404","https://openalex.org/W2901981894","https://openalex.org/W2906634874","https://openalex.org/W2921445913","https://openalex.org/W2936243442","https://openalex.org/W2967050212","https://openalex.org/W3011367360","https://openalex.org/W3011706914","https://openalex.org/W3027187303","https://openalex.org/W3047047153","https://openalex.org/W6683500024"],"related_works":["https://openalex.org/W4320061633","https://openalex.org/W4293169084","https://openalex.org/W4200507033","https://openalex.org/W7133843384","https://openalex.org/W2011177711","https://openalex.org/W2252585899","https://openalex.org/W4313404881","https://openalex.org/W2148328088","https://openalex.org/W990724472","https://openalex.org/W2104156406"],"abstract_inverted_index":{"Abstract":[0],"CD8+":[1],"memory":[2,79,239,268],"T":[3,32,77,84,237,266],"(TM)":[4],"cells":[5,34,85,166],"play":[6],"a":[7,201,256,260],"critical":[8],"role":[9],"in":[10,81,162,210,265],"immune":[11],"defense":[12],"against":[13],"infection.":[14,90],"Two":[15],"common":[16],"\u03b3-chain":[17],"family":[18],"cytokines,":[19],"IL-2":[20],"and":[21,35,57,72,75,92,95,99,106,126,136,153,155,159,169,174,179,184,199,221,245,269],"IL-7,":[22],"although":[23],"triggering":[24],"the":[25,40,132,137,146,192,196],"same":[26],"mTORC1\u2013S6K":[27,234],"pathway,":[28],"distinctly":[29],"induce":[30],"effector":[31],"(TE)":[33],"TM":[36,109,134],"cells,":[37,214],"respectively,":[38],"but":[39,194],"underlying":[41,115],"mechanism(s)":[42],"remains":[43],"elusive.":[44],"In":[45],"this":[46],"study,":[47],"we":[48,60,118],"generated":[49],"IL-7R-/and":[50],"AMPK\u03b11-knockout":[51],"(KO)/OTI":[52],"mice.":[53],"By":[54],"using":[55,131],"genetic":[56],"pharmaceutical":[58],"tools,":[59],"demonstrate":[61,228],"that":[62,145,229],"IL-7":[63],"deficiency":[64,190],"represses":[65],"expression":[66],"of":[67,218,233,242],"FOXO1,":[68,151],"TCF1,":[69,152],"p-AMPK\u03b11":[70],"(T172),":[71],"p-ULK1":[73],"(S555)":[74],"abolishes":[76,191],"cell":[78,110,182,219,238,267],"differentiation":[80],"IL-7R":[82,168],"KO":[83,212],"after":[86],"Listeria":[87],"monocytogenesis":[88],"rLmOVA":[89],"IL-2\u2013":[91],"IL-7\u2013stimulated":[93,230],"strong":[94],"weak":[96,231],"S6K":[97],"(IL-2/S6Kstrong":[98],"IL-7/S6Kweak)":[100],"signals":[101],"control":[102,138],"short-lived":[103],"IL-7R\u2212CD62L\u2212KLRG1+":[104],"TE":[105,140],"long-term":[107,181],"IL-7R+CD62L+KLRG1\u2212":[108],"formations,":[111],"respectively.":[112],"To":[113],"assess":[114],"molecular":[116],"pathway(s),":[117],"performed":[119],"flow":[120],"cytometry,":[121],"Western":[122],"blotting,":[123],"confocal":[124],"microscopy,":[125],"Seahorse":[127],"assay":[128],"analyses":[129],"by":[130],"IL-7/S6Kweak\u2013stimulated":[133],"(IL-7/TM)":[135],"IL-2/S6Kstrong\u2013stimulated":[139],"(IL-2/TE)":[141],"cells.":[142,164],"We":[143],"determine":[144],"IL-7/S6Kweak":[147],"signal":[148],"activates":[149],"transcriptional":[150,243],"Id3":[154],"metabolic":[156,202,246],"p-AMPK\u03b11,":[157],"p-ULK1,":[158],"ATG7":[160],"molecules":[161],"IL-7/TM":[163,165,213],"upregulate":[167],"CD62L,":[170],"promote":[171],"mitochondria":[172],"biogenesis":[173],"fatty":[175,205],"acid":[176,206],"oxidation":[177,207],"metabolism,":[178],"show":[180],"survival":[183,220],"functional":[185],"recall":[186,222],"responses.":[187,223],"Interestingly,":[188],"AMPK\u03b11":[189,193,211],"maintains":[195],"FOXO1":[197],"pathway":[198],"induces":[200],"switch":[203],"from":[204],"to":[208,216],"glycolysis":[209],"leading":[215],"loss":[217],"Taken":[224],"together,":[225],"our":[226,251],"data":[227],"strength":[232],"signaling":[235],"controls":[236],"via":[240],"activation":[241],"FOXO1\u2013TCF1\u2013Id3":[244],"AMPK\u03b11\u2013ULK1\u2013ATG7":[247],"pathways.":[248],"This":[249],"(to":[250],"knowledge)":[252],"novel":[253],"finding":[254],"provides":[255],"new":[257],"mechanism":[258],"for":[259],"distinct":[261],"IL-2/IL-7":[262],"stimulation":[263],"model":[264],"greatly":[270],"impacts":[271],"vaccine":[272],"development.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}