{"id":"https://openalex.org/W4200399212","doi":"https://doi.org/10.1128/spectrum.01736-21","title":"Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study","display_name":"Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4200399212","doi":"https://doi.org/10.1128/spectrum.01736-21","pmid":"https://pubmed.ncbi.nlm.nih.gov/34908439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8672900"},"language":"en","primary_location":{"id":"doi:10.1128/spectrum.01736-21","doi":"https://doi.org/10.1128/spectrum.01736-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/spectrum.01736-21","pdf_url":null,"source":{"id":"https://openalex.org/S2764766708","display_name":"Microbiology Spectrum","issn_l":"2165-0497","issn":["2165-0497"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology Spectrum","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/spectrum.01736-21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029018891","display_name":"Jolien Onsea","orcid":"https://orcid.org/0000-0002-5096-5789","observed_orcids":["https://orcid.org/0000-0002-5096-5789"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jolien Onsea","raw_affiliation_strings":["Department of Development and Regeneration, KU Leuven, Leuven, Belgium","Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-5096-5789","affiliations":[{"raw_affiliation_string":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052448096","display_name":"Virginia Post","orcid":"https://orcid.org/0000-0003-4104-0044","observed_orcids":["https://orcid.org/0000-0003-4104-0044"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Virginia Post","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032691462","display_name":"Tim Buchholz","orcid":"https://orcid.org/0000-0002-8470-8959","observed_orcids":["https://orcid.org/0000-0002-8470-8959"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tim Buchholz","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070281002","display_name":"Hella Schwegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hella Schwegler","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080025256","display_name":"Stephan Zeiter","orcid":"https://orcid.org/0000-0002-8155-4202","observed_orcids":["https://orcid.org/0000-0002-8155-4202"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephan Zeiter","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8155-4202","affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081074810","display_name":"Jeroen Wagemans","orcid":"https://orcid.org/0000-0002-2185-5724","observed_orcids":["https://orcid.org/0000-0002-2185-5724"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Wagemans","raw_affiliation_strings":["Laboratory of Gene Technology, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2185-5724","affiliations":[{"raw_affiliation_string":"Laboratory of Gene Technology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079179476","display_name":"Jean\u2010Paul Pirnay","orcid":"https://orcid.org/0000-0002-6863-5219","observed_orcids":["https://orcid.org/0000-0002-6863-5219"]},"institutions":[{"id":"https://openalex.org/I4210113471","display_name":"Queen Astrid Military Hospital","ror":"https://ror.org/0243t3259","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210113471"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Paul Pirnay","raw_affiliation_strings":["Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6863-5219","affiliations":[{"raw_affiliation_string":"Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I4210113471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112641420","display_name":"Maya Merabishvili","orcid":"https://orcid.org/0000-0002-2566-0772","observed_orcids":["https://orcid.org/0000-0002-2566-0772"]},"institutions":[{"id":"https://openalex.org/I4210113471","display_name":"Queen Astrid Military Hospital","ror":"https://ror.org/0243t3259","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210113471"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maya Merabishvili","raw_affiliation_strings":["Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I4210113471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055489989","display_name":"Matteo D\u2019Este","orcid":"https://orcid.org/0000-0002-0424-8172","observed_orcids":["https://orcid.org/0000-0002-0424-8172"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matteo D\u2019Este","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0424-8172","affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049743531","display_name":"Stijn G. Rotman","orcid":"https://orcid.org/0000-0002-6685-8312","observed_orcids":["https://orcid.org/0000-0002-6685-8312"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stijn G. Rotman","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6685-8312","affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068817061","display_name":"Andrej Trampu\u017e","orcid":"https://orcid.org/0000-0002-5219-2521","observed_orcids":["https://orcid.org/0000-0002-5219-2521"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrej Trampuz","raw_affiliation_strings":["Center for Musculoskeletal Surgery, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5219-2521","affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Surgery, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017571246","display_name":"M.H.J. Verhofstad","orcid":"https://orcid.org/0000-0001-8448-5903","observed_orcids":["https://orcid.org/0000-0001-8448-5903","https://orcid.org/0000-0002-7254-4950"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michael H. J. Verhofstad","raw_affiliation_strings":["Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8448-5903","affiliations":[{"raw_affiliation_string":"Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047172891","display_name":"William Todd Obremskey","orcid":"https://orcid.org/0000-0002-8942-1842","observed_orcids":["https://orcid.org/0000-0002-8942-1842"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Obremskey","raw_affiliation_strings":["Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-8942-1842","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056568447","display_name":"Rob Lavigne","orcid":"https://orcid.org/0000-0001-7377-1314","observed_orcids":["https://orcid.org/0000-0001-7377-1314"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rob Lavigne","raw_affiliation_strings":["Laboratory of Gene Technology, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-7377-1314","affiliations":[{"raw_affiliation_string":"Laboratory of Gene Technology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082211352","display_name":"Robert Geoff Richards","orcid":"https://orcid.org/0000-0002-7778-2480","observed_orcids":["https://orcid.org/0000-0002-7778-2480"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Geoff Richards","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7778-2480","affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007475990","display_name":"T. Fintan Moriarty","orcid":"https://orcid.org/0000-0003-2307-0397","observed_orcids":["https://orcid.org/0000-0003-2307-0397"]},"institutions":[{"id":"https://openalex.org/I24616306","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I24616306"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"T. Fintan Moriarty","raw_affiliation_strings":["AO Research Institute Davos, Davos, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2307-0397","affiliations":[{"raw_affiliation_string":"AO Research Institute Davos, Davos, Switzerland","institution_ids":["https://openalex.org/I24616306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080647333","display_name":"Willem\u2010Jan Metsemakers","orcid":"https://orcid.org/0000-0002-4114-9093","observed_orcids":["https://orcid.org/0000-0002-4114-9093"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Willem-Jan Metsemakers","raw_affiliation_strings":["Department of Development and Regeneration, KU Leuven, Leuven, Belgium","Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-4114-9093","affiliations":[{"raw_affiliation_string":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5007475990"],"corresponding_institution_ids":["https://openalex.org/I24616306"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":3.2958,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.93723597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"e0173621","last_page":"e0173621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fracture-related-infection","display_name":"fracture-related infection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/orthopedic-device-related-infection","display_name":"orthopedic device-related infection","score":0.9359999895095825},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9330000281333923},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7420047521591187},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.6587039828300476},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.6453093886375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5926893949508667},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.588934600353241},{"id":"https://openalex.org/C2779617845","wikidata":"https://www.wikidata.org/wiki/Q1563808","display_name":"Superinfection","level":3,"score":0.5475708842277527},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.492525190114975},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4746823012828827},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.43225646018981934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42693209648132324},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.42580530047416687},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3924948573112488},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3853839337825775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2644401490688324},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.26247912645339966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.255689799785614},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19619062542915344},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1204603910446167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071059","descriptor_name":"Phage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016459","descriptor_name":"Prosthesis-Related Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016459","descriptor_name":"Prosthesis-Related Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1128/spectrum.01736-21","doi":"https://doi.org/10.1128/spectrum.01736-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/spectrum.01736-21","pdf_url":null,"source":{"id":"https://openalex.org/S2764766708","display_name":"Microbiology Spectrum","issn_l":"2165-0497","issn":["2165-0497"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology Spectrum","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8672900","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8672900","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiol Spectr","raw_type":"Text"},{"id":"pmid:34908439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34908439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology spectrum","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.eur.nl:openaire/b0834223-6bb3-40e1-95cd-030d8c0bd44d","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b0834223-6bb3-40e1-95cd-030d8c0bd44d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onsea, J, Post, V, Buchholz, T, Schwegler, H, Zeiter, S, Wagemans, J, Pirnay, J P, Merabishvili, M, D'Este, M, Rotman, S G, Trampuz, A, Verhofstad, M H J, Obremskey, W T, Lavigne, R, Richards, R G, Moriarty, T F & Metsemakers, W J 2021, 'Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus : A Preclinical Study', Microbiology spectrum, vol. 9, no. 3, e01736-21. https://doi.org/10.1128/spectrum.01736-21","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/685904","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/685904","pdf_url":"https://lirias.kuleuven.be/retrieve/8f3e1916-f1fe-4b3a-96a9-96602bc6504f","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology Spectrum, vol. 9 (3), Art.No. ARTN e01736-21","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/b0834223-6bb3-40e1-95cd-030d8c0bd44d","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b0834223-6bb3-40e1-95cd-030d8c0bd44d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology spectrum, 9(3):e01736-21. American Society for Microbiology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1fc940c4ca9847e2af0dd525c6251d01","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1fc940c4ca9847e2af0dd525c6251d01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology Spectrum, Vol 9, Iss 3 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/spectrum.01736-21","doi":"https://doi.org/10.1128/spectrum.01736-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/spectrum.01736-21","pdf_url":null,"source":{"id":"https://openalex.org/S2764766708","display_name":"Microbiology Spectrum","issn_l":"2165-0497","issn":["2165-0497"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology Spectrum","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2439619780","display_name":null,"funder_award_id":"IDN/20/024","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G3773423168","display_name":"Bacteriophage therapy for difficult-to-treat infections: the implementation of&nbsp;a multidisciplinary phage task force (PHAGEFORCE)","funder_award_id":"IDN/20/024","funder_id":"https://openalex.org/F4320327336","funder_display_name":"Vlaamse regering"},{"id":"https://openalex.org/G6945349459","display_name":null,"funder_award_id":"IDN/20/024","funder_id":"https://openalex.org/F4320322681","funder_display_name":"Onderzoeksraad, KU Leuven"}],"funders":[{"id":"https://openalex.org/F4320320914","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320322681","display_name":"Onderzoeksraad, KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200399212.pdf","grobid_xml":"https://content.openalex.org/works/W4200399212.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W8431785","https://openalex.org/W1902380478","https://openalex.org/W1978934923","https://openalex.org/W2019059930","https://openalex.org/W2019197162","https://openalex.org/W2070373460","https://openalex.org/W2090693472","https://openalex.org/W2118896207","https://openalex.org/W2145448735","https://openalex.org/W2159445822","https://openalex.org/W2203563127","https://openalex.org/W2298767300","https://openalex.org/W2318901692","https://openalex.org/W2468566089","https://openalex.org/W2519128930","https://openalex.org/W2521651902","https://openalex.org/W2613205665","https://openalex.org/W2652466501","https://openalex.org/W2739514884","https://openalex.org/W2767598597","https://openalex.org/W2770356305","https://openalex.org/W2789070437","https://openalex.org/W2795661478","https://openalex.org/W2796428137","https://openalex.org/W2883285900","https://openalex.org/W2889689336","https://openalex.org/W2898384637","https://openalex.org/W2922107828","https://openalex.org/W2922139929","https://openalex.org/W2924332698","https://openalex.org/W2939638736","https://openalex.org/W2943878465","https://openalex.org/W2953305767","https://openalex.org/W2969375211","https://openalex.org/W2969908381","https://openalex.org/W2974451646","https://openalex.org/W2974467838","https://openalex.org/W2982325569","https://openalex.org/W2990398323","https://openalex.org/W3022646801","https://openalex.org/W3038470858","https://openalex.org/W3046196685","https://openalex.org/W3046551743","https://openalex.org/W3047234466","https://openalex.org/W3087364625","https://openalex.org/W3099046230","https://openalex.org/W3103398320","https://openalex.org/W3116914735","https://openalex.org/W3161336598","https://openalex.org/W3179503823","https://openalex.org/W3190977796","https://openalex.org/W4214926690"],"related_works":["https://openalex.org/W4391918247","https://openalex.org/W2108483943","https://openalex.org/W4405446853","https://openalex.org/W4409166810","https://openalex.org/W2750687446","https://openalex.org/W4283023479","https://openalex.org/W3134506164","https://openalex.org/W7167151868","https://openalex.org/W6941109212","https://openalex.org/W2008046969"],"abstract_inverted_index":{"Because":[0],"of":[1,5,10,23,31,59,70,79,99,109,141],"the":[2,8,20,37,45,57,116],"growing":[3],"spread":[4],"antimicrobial":[6],"resistance,":[7],"use":[9],"alternative":[11],"prevention":[12],"and":[13,34,96,139],"treatment":[14,98,117],"strategies":[15],"is":[16,56],"gaining":[17],"interest.":[18],"Although":[19],"therapeutic":[21],"potential":[22],"bacteriophages":[24],"has":[25],"been":[26],"demonstrated":[27],"in":[28,73,92,103,115,128],"a":[29,50,68,74,93,104],"number":[30],"case":[32],"reports":[33],"series":[35],"over":[36],"past":[38],"decade,":[39],"many":[40],"unanswered":[41],"questions":[42],"remain":[43],"regarding":[44],"optimal":[46],"application":[47,143],"protocol.":[48],"Furthermore,":[49],"major":[51],"concern":[52],"during":[53],"phage":[54,60,71,110,123],"therapy":[55,72,87,124],"induction":[58],"neutralizing":[61,111],"antibodies.":[62],"This":[63,119],"study":[64,120],"aimed":[65],"at":[66],"providing":[67],"proof-of-concept":[69],"clinically":[75],"relevant":[76],"rabbit":[77],"model":[78],"fracture-related":[80],"infection":[81,102],"caused":[82],"by":[83],"Staphylococcus":[84],"aureus.":[85],"Phage":[86],"was":[88,113],"applied":[89],"as":[90,97,134],"prophylaxis":[91],"first":[94],"phase,":[95],"an":[100],"established":[101],"second":[105],"phase.":[106],"The":[107],"development":[108],"antibodies":[112],"evaluated":[114],"study.":[118],"demonstrates":[121],"that":[122],"can":[125],"be":[126],"useful":[127],"targeting":[129],"orthopedic":[130],"device-related":[131],"infection,":[132],"especially":[133],"prophylaxis;":[135],"however,":[136],"further":[137],"research":[138],"improvements":[140],"these":[142],"methods":[144],"are":[145],"required.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-12-31T00:00:00"}
