{"id":"https://openalex.org/W4200375351","doi":"https://doi.org/10.1093/brain/awab353","title":"Forecasting stroke-like episodes and outcomes in mitochondrial disease","display_name":"Forecasting stroke-like episodes and outcomes in mitochondrial disease","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W4200375351","doi":"https://doi.org/10.1093/brain/awab353","pmid":"https://pubmed.ncbi.nlm.nih.gov/34927673","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9014738"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awab353","doi":"https://doi.org/10.1093/brain/awab353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awab353","pdf_url":"https://academic.oup.com/brain/article-pdf/145/2/542/43390555/awab353.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/brain/article-pdf/145/2/542/43390555/awab353.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044816818","display_name":"Yi Shiau Ng","orcid":"https://orcid.org/0000-0002-7591-2034","observed_orcids":["https://orcid.org/0000-0002-7591-2034"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yi Shiau Ng","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":"https://orcid.org/0000-0002-7591-2034","affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032780805","display_name":"Nichola Zoe Lax","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nichola Z Lax","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102797504","display_name":"Alasdair P. Blain","orcid":"https://orcid.org/0000-0002-3712-5283","observed_orcids":["https://orcid.org/0000-0002-3712-5283"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair P Blain","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047103736","display_name":"Daniel Erskine","orcid":"https://orcid.org/0000-0002-1752-5343","observed_orcids":["https://orcid.org/0000-0002-1752-5343"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Erskine","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":"https://orcid.org/0000-0002-1752-5343","affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078896471","display_name":"Mark R. Baker","orcid":"https://orcid.org/0000-0001-6916-1329","observed_orcids":["https://orcid.org/0000-0001-6916-1329"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark R Baker","raw_affiliation_strings":["Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043388402","display_name":"Tuomo M. Polvikoski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tuomo Polvikoski","raw_affiliation_strings":["Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062253540","display_name":"Rhys Huw Thomas","orcid":"https://orcid.org/0000-0003-2062-8623","observed_orcids":["https://orcid.org/0000-0003-2062-8623","https://orcid.org/0000-0002-7915-8075"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhys H Thomas","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079660167","display_name":"Christopher M. Morris","orcid":"https://orcid.org/0000-0002-3749-0993","observed_orcids":["https://orcid.org/0000-0002-3749-0993"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher M Morris","raw_affiliation_strings":["Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campus for Ageing and Vitality, Newcastle Brain Tissue Resource, Newcastle University, Edwardson Building, Newcastle upon Tyne NE4 5PL, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071630870","display_name":"Ming Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ming Lai","raw_affiliation_strings":["Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061231092","display_name":"Roger G. Whittaker","orcid":"https://orcid.org/0000-0002-3403-0182","observed_orcids":["https://orcid.org/0000-0002-3403-0182"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger G Whittaker","raw_affiliation_strings":["Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060022106","display_name":"Alasdair Gebbels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair Gebbels","raw_affiliation_strings":["Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030127002","display_name":"Amy Winder","orcid":"https://orcid.org/0000-0002-0945-2738","observed_orcids":["https://orcid.org/0000-0002-0945-2738"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amy Winder","raw_affiliation_strings":["Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103796455","display_name":"Julie Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Hall","raw_affiliation_strings":["Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049732192","display_name":"Catherine L Feeney","orcid":"https://orcid.org/0000-0003-3189-3991","observed_orcids":["https://orcid.org/0000-0003-3189-3991"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Feeney","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108883911","display_name":"Maria Elena Farrugia","orcid":"https://orcid.org/0000-0002-3776-1220","observed_orcids":["https://orcid.org/0000-0002-3776-1220"]},"institutions":[{"id":"https://openalex.org/I4210158502","display_name":"Queen Elizabeth University Hospital","ror":"https://ror.org/04y0x0x35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I4210158502"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Elena Farrugia","raw_affiliation_strings":["Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK","institution_ids":["https://openalex.org/I4210158502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067167651","display_name":"Claire L. Hirst","orcid":"https://orcid.org/0000-0001-7832-5030","observed_orcids":["https://orcid.org/0000-0001-7832-5030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Hirst","raw_affiliation_strings":["Trust Headquarters, One Talbot Gateway, Baglan Energy Park, Baglan, Port Talbot SA12 7BR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trust Headquarters, One Talbot Gateway, Baglan Energy Park, Baglan, Port Talbot SA12 7BR, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109214473","display_name":"Mark Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Roberts","raw_affiliation_strings":["Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford M6 8HD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford M6 8HD, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I2801120809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082059814","display_name":"Charlotte Lawthom","orcid":"https://orcid.org/0000-0003-1774-6506","observed_orcids":["https://orcid.org/0000-0003-1774-6506"]},"institutions":[{"id":"https://openalex.org/I2802109268","display_name":"Aneurin Bevan University Health Board","ror":"https://ror.org/045gxp391","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802109268","https://openalex.org/I4210144625"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte Lawthom","raw_affiliation_strings":["Aneurin Bevan Epilepsy Specialist Team, Aneurin Bevan University Health Board, Newport, NP20 2UB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aneurin Bevan Epilepsy Specialist Team, Aneurin Bevan University Health Board, Newport, NP20 2UB, UK","institution_ids":["https://openalex.org/I2802109268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007867805","display_name":"Alexia Chrysostomou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexia Chrysostomou","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799680125","display_name":"Sligo University Hospital","ror":"https://ror.org/03ke5zk82","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799680125","https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kevin Murphy","raw_affiliation_strings":["Department of Neurology, Sligo University Hospital, Sligo F91 H684, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sligo University Hospital, Sligo F91 H684, Ireland","institution_ids":["https://openalex.org/I2799680125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015281358","display_name":"Tracey Anne Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158502","display_name":"Queen Elizabeth University Hospital","ror":"https://ror.org/04y0x0x35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I4210158502"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tracey Baird","raw_affiliation_strings":["Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK","institution_ids":["https://openalex.org/I4210158502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010743628","display_name":"Paul Maddison","orcid":"https://orcid.org/0000-0003-4437-7697","observed_orcids":["https://orcid.org/0000-0003-4437-7697"]},"institutions":[{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Maddison","raw_affiliation_strings":["Department of Neurology, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Queen\u2019s Medical Centre, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084794976","display_name":"Callum W. Duncan","orcid":"https://orcid.org/0000-0003-3625-9842","observed_orcids":["https://orcid.org/0000-0003-3625-9842"]},"institutions":[{"id":"https://openalex.org/I2800600548","display_name":"Aberdeen Royal Infirmary","ror":"https://ror.org/02q49af68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800600548","https://openalex.org/I4210093322"]},{"id":"https://openalex.org/I4210093322","display_name":"NHS Grampian","ror":"https://ror.org/00ma0mg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210093322"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Callum Duncan","raw_affiliation_strings":["Department of Neurology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen AB25 2ZN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen AB25 2ZN, UK","institution_ids":["https://openalex.org/I2800600548","https://openalex.org/I4210093322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077356959","display_name":"Joanna Poulton","orcid":"https://orcid.org/0000-0002-2460-5587","observed_orcids":["https://orcid.org/0000-0002-2460-5587","https://orcid.org/0000-0002-6427-1294"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna Poulton","raw_affiliation_strings":["Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford OX3 9DU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford OX3 9DU, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015877662","display_name":"Victoria Nesbitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Nesbitt","raw_affiliation_strings":["Department of Paediatrics, Medical Sciences Division, Oxford University, Oxford OX3 9DU, UK","Department of Paediatrics, The Children's Hospital, Oxford, OX3 9DU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Medical Sciences Division, Oxford University, Oxford OX3 9DU, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Paediatrics, The Children's Hospital, Oxford, OX3 9DU, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076782995","display_name":"Michael G. Hanna","orcid":"https://orcid.org/0000-0003-0825-4075","observed_orcids":["https://orcid.org/0000-0003-0825-4075","https://orcid.org/0000-0002-1975-0501"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael G Hanna","raw_affiliation_strings":["Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005856741","display_name":"Robert D. S. Pitceathly","orcid":"https://orcid.org/0000-0002-6123-4551","observed_orcids":["https://orcid.org/0000-0002-6123-4551"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert D S Pitceathly","raw_affiliation_strings":["Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK"],"raw_orcid":"https://orcid.org/0000-0002-6123-4551","affiliations":[{"raw_affiliation_string":"Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636153","display_name":"Robert William Taylor","orcid":"https://orcid.org/0000-0002-7768-8873","observed_orcids":["https://orcid.org/0000-0002-7768-8873"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert W Taylor","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082587332","display_name":"Emma L. Blakely","orcid":"https://orcid.org/0000-0001-8247-4194","observed_orcids":["https://orcid.org/0000-0001-8247-4194"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma L Blakely","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067436636","display_name":"Andrew M. Schaefer","orcid":"https://orcid.org/0000-0001-8212-7635","observed_orcids":["https://orcid.org/0000-0001-8212-7635"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M Schaefer","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050697713","display_name":"Douglass M. Turnbull","orcid":"https://orcid.org/0000-0002-8878-9901","observed_orcids":["https://orcid.org/0000-0002-8878-9901"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Doug M Turnbull","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053767923","display_name":"Robert McFarland","orcid":"https://orcid.org/0000-0002-8833-2688","observed_orcids":["https://orcid.org/0000-0002-8833-2688"]},"institutions":[{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert McFarland","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006400472","display_name":"Gr\u00e1inne S. Gorman","orcid":"https://orcid.org/0000-0002-7585-3409","observed_orcids":["https://orcid.org/0000-0002-7585-3409"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210133722","display_name":"NIHR Newcastle Biomedical Research Centre","ror":"https://ror.org/044m9mw93","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210133722"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gr\u00e1inne S Gorman","raw_affiliation_strings":["Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne NE2 4HH, UK","institution_ids":[]},{"raw_affiliation_string":"Directorate of Neurosciences, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute; NIHR Newcastle Biomedical Research Centre and Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute","institution_ids":["https://openalex.org/I4210138563"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5006400472"],"corresponding_institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869","https://openalex.org/I4210133722","https://openalex.org/I4210138563","https://openalex.org/I84884186"],"apc_list":{"value":3383,"currency":"GBP","value_usd":4510},"apc_paid":{"value":3383,"currency":"GBP","value_usd":4510},"fwci":2.803,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.93468363,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"145","issue":"2","first_page":"542","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke-like-episodes","display_name":"stroke-like episodes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/melas","display_name":"MELAS","score":0.968999981880188},{"id":"https://openalex.org/keywords/mitochondrial-encephalomyopathy","display_name":"mitochondrial encephalomyopathy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mitochondrial-heteroplasmy","display_name":"mitochondrial heteroplasmy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.7279999852180481},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.6840000152587891},{"id":"https://openalex.org/keywords/serum-lactate","display_name":"serum lactate","score":0.843999981880188},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7020000219345093},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.8182170391082764},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.704175591468811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6797205805778503},{"id":"https://openalex.org/C2779799828","wikidata":"https://www.wikidata.org/wiki/Q6881866","display_name":"Mitochondrial encephalomyopathy","level":4,"score":0.6782863736152649},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.650190532207489},{"id":"https://openalex.org/C2780317664","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Lactic acidosis","level":2,"score":0.5858702659606934},{"id":"https://openalex.org/C2776287708","wikidata":"https://www.wikidata.org/wiki/Q2666433","display_name":"MELAS syndrome","level":5,"score":0.48334524035453796},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4605054557323456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44212764501571655},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43476197123527527},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43471860885620117},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43151798844337463},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.3004867434501648},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2661623954772949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13570785522460938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07737347483634949},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017241","descriptor_name":"MELAS Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/brain/awab353","doi":"https://doi.org/10.1093/brain/awab353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awab353","pdf_url":"https://academic.oup.com/brain/article-pdf/145/2/542/43390555/awab353.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmid:34927673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34927673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9014738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9014738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10141365","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10141365/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain , Article awab353. (2021) (In press).","raw_type":"Article"},{"id":"doi:10.25405/ncl.34447173","doi":"https://doi.org/10.25405/ncl.34447173","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34447173","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34447173.v1","doi":"https://doi.org/10.25405/ncl.34447173.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34447173.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1093/brain/awab353","doi":"https://doi.org/10.1093/brain/awab353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awab353","pdf_url":"https://academic.oup.com/brain/article-pdf/145/2/542/43390555/awab353.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1683062455","display_name":"MICA: MRC Centre for Neuromuscular Diseases","funder_award_id":"MR/K000608/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G23484813","display_name":"Investigating the role of cardiolipin metabolism in mitochondrial DNA replication and mitochondrial division","funder_award_id":"MR/S002065/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3918585456","display_name":null,"funder_award_id":"CL\u20102016\u201001\u2010003","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6151764808","display_name":"MRC Strategic Award to establish an International Centre for Genomic Medicine in Neuromuscular Diseases","funder_award_id":"MR/S005021/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8065043414","display_name":null,"funder_award_id":"L016354","funder_id":"https://openalex.org/F4320320295","funder_display_name":"Newcastle University"},{"id":"https://openalex.org/G8827204909","display_name":null,"funder_award_id":"L016354","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320295","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70"},{"id":"https://openalex.org/F4320331599","display_name":"Lily Foundation","ror":"https://ror.org/00daznq87"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200375351.pdf","grobid_xml":"https://content.openalex.org/works/W4200375351.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1007659581","https://openalex.org/W1484678674","https://openalex.org/W1521947818","https://openalex.org/W1542506335","https://openalex.org/W1554609063","https://openalex.org/W1924726292","https://openalex.org/W1964507575","https://openalex.org/W1965319690","https://openalex.org/W1972438679","https://openalex.org/W1977174816","https://openalex.org/W1986705681","https://openalex.org/W1996496566","https://openalex.org/W2000875498","https://openalex.org/W2003931544","https://openalex.org/W2013255748","https://openalex.org/W2013740936","https://openalex.org/W2022060312","https://openalex.org/W2026785969","https://openalex.org/W2045409504","https://openalex.org/W2052140157","https://openalex.org/W2052285428","https://openalex.org/W2057299803","https://openalex.org/W2060279210","https://openalex.org/W2065789205","https://openalex.org/W2068121714","https://openalex.org/W2072945343","https://openalex.org/W2074661552","https://openalex.org/W2078271269","https://openalex.org/W2086018537","https://openalex.org/W2087080349","https://openalex.org/W2095251357","https://openalex.org/W2100120774","https://openalex.org/W2105911051","https://openalex.org/W2108197952","https://openalex.org/W2110065044","https://openalex.org/W2110230480","https://openalex.org/W2131943911","https://openalex.org/W2139692864","https://openalex.org/W2162466020","https://openalex.org/W2166182038","https://openalex.org/W2166664098","https://openalex.org/W2167007161","https://openalex.org/W2168517980","https://openalex.org/W2189475194","https://openalex.org/W2285631572","https://openalex.org/W2317018432","https://openalex.org/W2339420972","https://openalex.org/W2512232080","https://openalex.org/W2513852964","https://openalex.org/W2517701649","https://openalex.org/W2597317991","https://openalex.org/W2605668131","https://openalex.org/W2744012576","https://openalex.org/W2762417172","https://openalex.org/W2771466468","https://openalex.org/W2774413115","https://openalex.org/W2783592187","https://openalex.org/W2790024787","https://openalex.org/W2791762984","https://openalex.org/W2801946129","https://openalex.org/W2888027905","https://openalex.org/W2894699074","https://openalex.org/W2900457101","https://openalex.org/W2901285886","https://openalex.org/W2911824951","https://openalex.org/W2913705661","https://openalex.org/W2965309542","https://openalex.org/W2998196885","https://openalex.org/W3000315473","https://openalex.org/W4210476933","https://openalex.org/W4232978019"],"related_works":["https://openalex.org/W4321380789","https://openalex.org/W4411657478","https://openalex.org/W4417101463","https://openalex.org/W4405323120","https://openalex.org/W3029786405","https://openalex.org/W3215471419","https://openalex.org/W3005191087","https://openalex.org/W4409226933","https://openalex.org/W4320011684","https://openalex.org/W2173668472"],"abstract_inverted_index":{"In":[0,251],"this":[1],"retrospective,":[2],"multicentre,":[3],"observational":[4],"cohort":[5],"study,":[6],"we":[7,35],"sought":[8],"to":[9,24,67,94,100,293],"determine":[10],"the":[11,69,114,210,239,281,287,295,308,367,404],"clinical,":[12,370],"radiological,":[13],"EEG,":[14],"genetics":[15],"and":[16,23,32,72,85,131,181,201,230,248,267,320,348,372,383,395,414],"neuropathological":[17,202],"characteristics":[18,374],"of":[19,50,75,110,144,160,172,190,204,212,228,238,241,246,256,275,289,297,323,375,381,386],"mitochondrial":[20,42,51,81,136,232,376],"stroke-like":[21,46,76,86,102,111,146,168,183,194,205,219,276,299,377],"episodes":[22,87,112,184,195,206,220,277,300],"identify":[25],"associated":[26,272],"risk":[27,274,296],"predictors.":[28],"Between":[29],"January":[30],"1998":[31],"June":[33],"2018,":[34],"identified":[36,57],"111":[37],"patients":[38,79,152,162,191,279,329],"with":[39,80,165,209,217,273,280,335],"genetically":[40],"determined":[41],"disease":[43,52,224,398],"who":[44],"developed":[45,192],"episodes.":[47,378],"Post-mortem":[48],"cases":[49,227],"(n":[53,119,128,139],"=":[54,120,129,140,310,316,362],"26)":[55],"were":[56,207,270,325],"from":[58],"Newcastle":[59],"Brain":[60],"Tissue":[61],"Resource.":[62],"The":[63,90,105,142,174,400],"primary":[64],"outcome":[65],"was":[66,93,113,148,185],"interrogate":[68],"clinico-radiopathological":[70],"correlates":[71],"prognostic":[73],"indicators":[74],"episode":[77,103,147,169],"in":[78,117,236,278,328,416],"encephalomyopathy,":[82],"lactic":[83],"acidosis":[84],"syndrome":[88],"(MELAS).":[89],"secondary":[91],"objective":[92],"develop":[95],"a":[96,158,290],"multivariable":[97],"prediction":[98,291],"model":[99,292,402],"forecast":[101],"risk.":[104],"most":[106],"common":[107],"genetic":[108,412],"cause":[109],"m.3243A>G":[115,229,262,282,405],"variant":[116,406],"MT-TL1":[118],"66),":[121],"followed":[122],"by":[123],"recessive":[124],"pathogenic":[125,135,234,331],"POLG":[126],"variants":[127,138,333],"22),":[130],"11":[132],"other":[133,231],"rarer":[134],"DNA":[137,233],"23).":[141],"age":[143],"first":[145,167,180],"available":[149],"for":[150,403],"105":[151],"[mean":[153],"(SD)":[154,353],"age:":[155],"31.8":[156],"(16.1)];":[157],"total":[159],"35":[161],"(32%)":[163],"presented":[164],"their":[166],"\u226540":[170],"years":[171],"age.":[173],"median":[175],"interval":[176],"(interquartile":[177],"range)":[178],"between":[179],"second":[182],"1.33":[186],"(2.86)":[187],"years;":[188],"43%":[189],"recurrent":[193],"within":[196],"12":[197],"months.":[198],"Clinico-radiological,":[199],"electrophysiological":[200],"findings":[203,365],"consistent":[208],"hallmarks":[211],"medically":[213],"refractory":[214,242],"epilepsy.":[215],"Patients":[216],"POLG-related":[218],"demonstrated":[221,302],"more":[222,326,410],"fulminant":[223],"trajectories":[225],"than":[226],"variants,":[235],"terms":[237],"frequency":[240],"status":[243],"epilepticus,":[244],"rapidity":[245],"progression":[247],"overall":[249,304],"mortality.":[250],"multivariate":[252],"analysis,":[253],"baseline":[254],"factors":[255,285],"body":[257],"mass":[258],"index,":[259],"age-adjusted":[260],"blood":[261],"heteroplasmy,":[263],"sensorineural":[264],"hearing":[265],"loss":[266,394],"serum":[268],"lactate":[269],"significantly":[271],"variant.":[283],"These":[284],"informed":[286],"development":[288],"assess":[294],"developing":[298],"that":[301],"good":[303],"discrimination":[305],"(area":[306],"under":[307],"curve":[309],"0.87,":[311],"95%":[312],"CI":[313],"0.82-0.93;":[314],"c-statistic":[315],"0.89).":[317],"Significant":[318],"radiological":[319,371],"pathological":[321],"features":[322],"neurodegeneration":[324],"evident":[327],"harbouring":[330],"mtDNA":[332],"compared":[334],"POLG:":[336],"brain":[337,351],"atrophy":[338],"on":[339],"cranial":[340],"MRI":[341],"(90%":[342],"versus":[343,357],"44%,":[344],"P":[345,361],"<":[346],"0.001)":[347],"reduced":[349],"mean":[350],"weight":[352],"[1044":[354],"g":[355,359],"(148)":[356],"1304":[358],"(142),":[360],"0.005].":[363],"Our":[364],"highlight":[366],"often":[368],"idiosyncratic":[369],"EEG":[373],"Early":[379],"recognition":[380],"seizures":[382],"aggressive":[384],"instigation":[385],"treatment":[387],"may":[388],"help":[389,408],"circumvent":[390],"or":[391],"slow":[392],"neuronal":[393],"abate":[396],"increasing":[397],"burden.":[399],"risk-prediction":[401],"can":[407],"inform":[409],"tailored":[411],"counselling":[413],"prognostication":[415],"routine":[417],"clinical":[418],"practice.":[419]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}