{"id":"https://openalex.org/W4200375201","doi":"https://doi.org/10.2174/2666958702101010216","title":"The Role of Molecular Modeling and Bioinformatics in Treating a Pandemic Disease: The Case of COVID-19","display_name":"The Role of Molecular Modeling and Bioinformatics in Treating a Pandemic Disease: The Case of COVID-19","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4200375201","doi":"https://doi.org/10.2174/2666958702101010216"},"language":"en","primary_location":{"id":"doi:10.2174/2666958702101010216","doi":"https://doi.org/10.2174/2666958702101010216","is_oa":true,"landing_page_url":"https://doi.org/10.2174/2666958702101010216","pdf_url":null,"source":{"id":"https://openalex.org/S4210230109","display_name":"The Open COVID Journal","issn_l":"2666-9587","issn":["2666-9587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open COVID Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2174/2666958702101010216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086679426","display_name":"Abdallah S. Abdelsattar","orcid":"https://orcid.org/0000-0002-2902-3551","observed_orcids":["https://orcid.org/0000-0002-2902-3551"]},"institutions":[{"id":"https://openalex.org/I4210150948","display_name":"Zewail City of Science and Technology","ror":"https://ror.org/04w5f4y88","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210150948"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdallah S. Abdelsattar","raw_affiliation_strings":["Center for Microbiology and Phage Therapy, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, 12578, Egypt","Center for X-Ray and Determination of Structure of Matter, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiology and Phage Therapy, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, 12578, Egypt","institution_ids":["https://openalex.org/I4210150948"]},{"raw_affiliation_string":"Center for X-Ray and Determination of Structure of Matter, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt","institution_ids":["https://openalex.org/I4210150948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032091183","display_name":"Zahraa M. El-Awadly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150948","display_name":"Zewail City of Science and Technology","ror":"https://ror.org/04w5f4y88","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210150948"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Zahraa M. El-Awadly","raw_affiliation_strings":["Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt","institution_ids":["https://openalex.org/I4210150948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051654316","display_name":"Mai Abdelgawad","orcid":"https://orcid.org/0000-0003-0884-4235","observed_orcids":["https://orcid.org/0000-0003-0884-4235"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mai Abdelgawad","raw_affiliation_strings":["Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, 62511, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, 62511, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059959171","display_name":"Fayrouz Mahmoud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150948","display_name":"Zewail City of Science and Technology","ror":"https://ror.org/04w5f4y88","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210150948"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fayrouz Mahmoud","raw_affiliation_strings":["Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt","institution_ids":["https://openalex.org/I4210150948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051194124","display_name":"Sahar A. Allam","orcid":"https://orcid.org/0000-0002-1038-0444","observed_orcids":["https://orcid.org/0000-0002-1038-0444"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar A. Allam","raw_affiliation_strings":["Faculty of Medicine, Tanta University, Tanta, 31512, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Tanta University, Tanta, 31512, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003045933","display_name":"Mohamed A. Helal","orcid":"https://orcid.org/0000-0002-6304-8285","observed_orcids":["https://orcid.org/0000-0002-6304-8285"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]},{"id":"https://openalex.org/I4210150948","display_name":"Zewail City of Science and Technology","ror":"https://ror.org/04w5f4y88","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210150948"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed A. Helal","raw_affiliation_strings":["Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt","Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, 12587, Egypt","institution_ids":["https://openalex.org/I4210150948"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt","institution_ids":["https://openalex.org/I114794399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003045933"],"corresponding_institution_ids":["https://openalex.org/I114794399","https://openalex.org/I4210150948"],"apc_list":null,"apc_paid":null,"fwci":0.0793,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47908543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1","issue":"1","first_page":"216","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.996999979019165},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":1.0},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7979999780654907},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.949999988079071},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/convalescent-plasma","display_name":"convalescent plasma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/il-6-inhibitors","display_name":"IL-6 inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8550000190734863},{"id":"https://openalex.org/keywords/viral-protein-structure","display_name":"viral protein structure","score":0.5239999890327454},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/main-protease","display_name":"main protease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7440000176429749},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.8999999761581421},{"id":"https://openalex.org/keywords/viral-genotyping","display_name":"viral genotyping","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7677599191665649},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6495493054389954},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6202901005744934},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.592580258846283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5132424831390381},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4411095976829529},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.43022966384887695},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41865652799606323},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.41256552934646606},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4109785854816437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4086880683898926},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36816340684890747},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3564035892486572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30127331614494324},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.2619543671607971},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2565659284591675},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23701393604278564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2188657522201538},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17922073602676392},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.17219603061676025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2174/2666958702101010216","doi":"https://doi.org/10.2174/2666958702101010216","is_oa":true,"landing_page_url":"https://doi.org/10.2174/2666958702101010216","pdf_url":null,"source":{"id":"https://openalex.org/S4210230109","display_name":"The Open COVID Journal","issn_l":"2666-9587","issn":["2666-9587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open COVID Journal","raw_type":"journal-article"},{"id":"doi:10.60692/8h5k9-chs52","doi":"https://doi.org/10.60692/8h5k9-chs52","is_oa":true,"landing_page_url":"https://doi.org/10.60692/8h5k9-chs52","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/ybx1v-5gt62","doi":"https://doi.org/10.60692/ybx1v-5gt62","is_oa":true,"landing_page_url":"https://doi.org/10.60692/ybx1v-5gt62","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.2174/2666958702101010216","doi":"https://doi.org/10.2174/2666958702101010216","is_oa":true,"landing_page_url":"https://doi.org/10.2174/2666958702101010216","pdf_url":null,"source":{"id":"https://openalex.org/S4210230109","display_name":"The Open COVID Journal","issn_l":"2666-9587","issn":["2666-9587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open COVID Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":196,"referenced_works":["https://openalex.org/W1761925601","https://openalex.org/W1968453663","https://openalex.org/W1971062326","https://openalex.org/W1985761301","https://openalex.org/W2015772507","https://openalex.org/W2021210077","https://openalex.org/W2031930066","https://openalex.org/W2033125750","https://openalex.org/W2053027085","https://openalex.org/W2057439500","https://openalex.org/W2062119339","https://openalex.org/W2067673704","https://openalex.org/W2085978024","https://openalex.org/W2096238447","https://openalex.org/W2111155300","https://openalex.org/W2124198028","https://openalex.org/W2146015083","https://openalex.org/W2161428851","https://openalex.org/W2177407033","https://openalex.org/W2306794997","https://openalex.org/W2341574236","https://openalex.org/W2509449660","https://openalex.org/W2611314002","https://openalex.org/W2808754971","https://openalex.org/W2896002881","https://openalex.org/W2898389621","https://openalex.org/W2999044305","https://openalex.org/W2999318660","https://openalex.org/W3001118548","https://openalex.org/W3002108456","https://openalex.org/W3002539152","https://openalex.org/W3002812395","https://openalex.org/W3003668884","https://openalex.org/W3003790823","https://openalex.org/W3004280078","https://openalex.org/W3004348779","https://openalex.org/W3004620471","https://openalex.org/W3004894342","https://openalex.org/W3004896487","https://openalex.org/W3005079553","https://openalex.org/W3005212621","https://openalex.org/W3005838342","https://openalex.org/W3006355661","https://openalex.org/W3006839750","https://openalex.org/W3007092620","https://openalex.org/W3007227604","https://openalex.org/W3007407747","https://openalex.org/W3007814559","https://openalex.org/W3007886991","https://openalex.org/W3008028633","https://openalex.org/W3008047170","https://openalex.org/W3008090866","https://openalex.org/W3008122393","https://openalex.org/W3008142620","https://openalex.org/W3008827533","https://openalex.org/W3009314935","https://openalex.org/W3009335299","https://openalex.org/W3009885589","https://openalex.org/W3009970748","https://openalex.org/W3010020071","https://openalex.org/W3010238729","https://openalex.org/W3010611713","https://openalex.org/W3010667412","https://openalex.org/W3010848803","https://openalex.org/W3010880616","https://openalex.org/W3010930696","https://openalex.org/W3011072970","https://openalex.org/W3011127849","https://openalex.org/W3011398105","https://openalex.org/W3011488280","https://openalex.org/W3011610993","https://openalex.org/W3011660632","https://openalex.org/W3011701533","https://openalex.org/W3011848620","https://openalex.org/W3011885014","https://openalex.org/W3012195391","https://openalex.org/W3012232836","https://openalex.org/W3012379316","https://openalex.org/W3012455685","https://openalex.org/W3013282133","https://openalex.org/W3013283620","https://openalex.org/W3013395653","https://openalex.org/W3013460037","https://openalex.org/W3013463737","https://openalex.org/W3013486442","https://openalex.org/W3013533831","https://openalex.org/W3013800395","https://openalex.org/W3013855790","https://openalex.org/W3014067025","https://openalex.org/W3014128886","https://openalex.org/W3014203610","https://openalex.org/W3014330788","https://openalex.org/W3014450743","https://openalex.org/W3014656992","https://openalex.org/W3014708904","https://openalex.org/W3014735311","https://openalex.org/W3014751348","https://openalex.org/W3014850166","https://openalex.org/W3014852814","https://openalex.org/W3015016176","https://openalex.org/W3015190630","https://openalex.org/W3015353977","https://openalex.org/W3015429854","https://openalex.org/W3015490759","https://openalex.org/W3015608194","https://openalex.org/W3015769528","https://openalex.org/W3015807479","https://openalex.org/W3016263512","https://openalex.org/W3016441544","https://openalex.org/W3016553966","https://openalex.org/W3016591679","https://openalex.org/W3016657634","https://openalex.org/W3016788022","https://openalex.org/W3016961971","https://openalex.org/W3017291089","https://openalex.org/W3017633633","https://openalex.org/W3017703988","https://openalex.org/W3018023298","https://openalex.org/W3018056400","https://openalex.org/W3019876900","https://openalex.org/W3020188044","https://openalex.org/W3020247120","https://openalex.org/W3020300207","https://openalex.org/W3021223986","https://openalex.org/W3021311677","https://openalex.org/W3021439445","https://openalex.org/W3022381041","https://openalex.org/W3022734398","https://openalex.org/W3022778162","https://openalex.org/W3023006972","https://openalex.org/W3023215109","https://openalex.org/W3023464695","https://openalex.org/W3023915741","https://openalex.org/W3024269707","https://openalex.org/W3025110834","https://openalex.org/W3025790227","https://openalex.org/W3025987322","https://openalex.org/W3026045751","https://openalex.org/W3027488591","https://openalex.org/W3027630905","https://openalex.org/W3027858755","https://openalex.org/W3028423411","https://openalex.org/W3029393188","https://openalex.org/W3030593001","https://openalex.org/W3031553202","https://openalex.org/W3032133680","https://openalex.org/W3032546265","https://openalex.org/W3033301286","https://openalex.org/W3034111647","https://openalex.org/W3034130789","https://openalex.org/W3034202401","https://openalex.org/W3035394610","https://openalex.org/W3036355841","https://openalex.org/W3036952492","https://openalex.org/W3041477809","https://openalex.org/W3042332408","https://openalex.org/W3043736252","https://openalex.org/W3045876280","https://openalex.org/W3046069898","https://openalex.org/W3046218112","https://openalex.org/W3046229683","https://openalex.org/W3046382549","https://openalex.org/W3046665888","https://openalex.org/W3081270060","https://openalex.org/W3087127729","https://openalex.org/W3087629585","https://openalex.org/W3092183638","https://openalex.org/W3093973000","https://openalex.org/W3095284495","https://openalex.org/W3096717940","https://openalex.org/W3096745495","https://openalex.org/W3096808252","https://openalex.org/W3098911933","https://openalex.org/W3102600701","https://openalex.org/W3111589685","https://openalex.org/W3114706264","https://openalex.org/W3117074222","https://openalex.org/W3118810627","https://openalex.org/W3123161910","https://openalex.org/W3125070192","https://openalex.org/W3125594406","https://openalex.org/W3130686756","https://openalex.org/W3132999071","https://openalex.org/W3133850195","https://openalex.org/W3134475481","https://openalex.org/W3139126471","https://openalex.org/W3140188894","https://openalex.org/W3148115595","https://openalex.org/W3152563552","https://openalex.org/W3159775614","https://openalex.org/W3161299338","https://openalex.org/W3197627421","https://openalex.org/W3216844600","https://openalex.org/W4205552948","https://openalex.org/W4232359574","https://openalex.org/W4318982013"],"related_works":["https://openalex.org/W4296945951","https://openalex.org/W4206638436","https://openalex.org/W3113095018","https://openalex.org/W3046913327","https://openalex.org/W3124941158","https://openalex.org/W6931455282","https://openalex.org/W3197693216","https://openalex.org/W3161183896","https://openalex.org/W3138683846","https://openalex.org/W4210854563"],"abstract_inverted_index":{"The":[0,17,104],"COVID-19":[1,45],"pandemic":[2],"first":[3],"appeared":[4],"in":[5,8,11,112,132,189,206,215],"Wuhan,":[6],"China,":[7],"December":[9],"2019":[10],"a":[12,129,150],"cluster":[13],"of":[14,36,59,101,136,157,171],"pneumonia":[15],"patients.":[16],"causative":[18],"agent":[19],"was":[20],"found":[21],"to":[22,92,167],"be":[23],"SARS-CoV-2.":[24],"Here,":[25],"we":[26],"are":[27,48,75,90],"summarizing":[28],"current":[29],"treatment":[30,58],"strategies":[31],"and":[32,40,70,85,99,117,125,146,153,178,193,205,221,223],"highlighting":[33],"the":[34,44,57,96,102,121,134,155,169,196],"role":[35,131,152,212],"bioinformatics,":[37],"molecular":[38],"modeling,":[39],"structural":[41],"biology":[42],"during":[43,213],"pandemic.":[46],"There":[47],"different":[49,114,186],"pharmacological":[50],"treatments,":[51],"mostly":[52],"repurposed":[53],"drugs,":[54,63,66],"employed":[55],"for":[56,107],"COVID-19,":[60],"including":[61,79],"antiviral":[62],"corticosteroids,":[64],"biologic":[65],"antibiotics,":[67],"antifungal":[68],"agents,":[69],"anticoagulants.":[71],"Some":[72],"immune-based":[73],"therapies":[74],"also":[76,110],"under":[77],"evaluation,":[78],"convalescent":[80],"plasma,":[81],"IL-1,":[82],"IL-6":[83],"inhibitors,":[84],"interferons.":[86],"Different":[87],"bioinformatics":[88,204],"networks":[89],"established":[91],"provide":[93],"information":[94,217],"about":[95,218],"structure,":[97],"transcriptome,":[98],"pathogenicity":[100],"virus.":[103],"genotyping":[105],"analysis":[106],"SARS-CoV-2":[108],"is":[109],"useful":[111],"identifying":[113],"mutations,":[115],"SNPs,":[116],"conservative":[118],"domains":[119],"along":[120],"viral":[122,137,219],"genome.":[123],"Cryo-EM":[124],"X-ray":[126],"diffraction":[127],"had":[128,149],"crucial":[130],"determining":[133,154],"structure":[135,156,220],"proteins":[138],"such":[139],"as":[140],"spike":[141],"(S)":[142],"protein,":[143],"main":[144],"protease,":[145],"RdRp.":[147],"NMR":[148],"minor":[151],"nucleocapsid":[158],"(N)":[159],"protein":[160],"only.":[161],"Several":[162],"docking":[163],"studies":[164,208],"were":[165],"performed":[166],"predict":[168],"interaction":[170],"certain":[172],"FDA-approved":[173],"drugs":[174],"with":[175,199],"known":[176],"efficacy":[177],"toxicity,":[179],"while":[180],"others":[181],"used":[182],"natural":[183],"products.":[184],"Among":[185],"study":[187],"types,":[188],"silico":[190,207],"drug":[191],"prediction":[192],"repurposing":[194],"have":[195,209],"lowest":[197],"risk":[198],"less":[200],"off-target":[201],"results.":[202],"Therefore,":[203],"an":[210],"important":[211],"pandemics":[214],"providing":[216],"function":[222],"predicting":[224],"potential":[225],"treatments.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-31T00:00:00"}
