{"id":"https://openalex.org/W4200370722","doi":"https://doi.org/10.3389/fcell.2021.737809","title":"Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-\u03baB Pathway","display_name":"Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-\u03baB Pathway","publication_year":2021,"publication_date":"2021-12-03","ids":{"openalex":"https://openalex.org/W4200370722","doi":"https://doi.org/10.3389/fcell.2021.737809","pmid":"https://pubmed.ncbi.nlm.nih.gov/34926442","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8679914"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.737809","doi":"https://doi.org/10.3389/fcell.2021.737809","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.737809","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2021.737809","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100654161","display_name":"Fudong Li","orcid":"https://orcid.org/0000-0002-3407-0715","observed_orcids":["https://orcid.org/0000-0002-3407-0715"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fudong Li","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004397382","display_name":"Xiaofei Sun","orcid":"https://orcid.org/0000-0002-7724-6063","observed_orcids":["https://orcid.org/0000-0002-7724-6063"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Sun","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016396867","display_name":"Bing Zheng","orcid":"https://orcid.org/0000-0002-6098-7092","observed_orcids":["https://orcid.org/0000-0002-6098-7092","https://orcid.org/0000-0003-3299-4065"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Zheng","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083160122","display_name":"Kaiqiang Sun","orcid":"https://orcid.org/0000-0002-0272-8383","observed_orcids":["https://orcid.org/0000-0002-0272-8383"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiqiang Sun","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048899548","display_name":"Jian Zhu","orcid":"https://orcid.org/0000-0002-4629-9883","observed_orcids":["https://orcid.org/0000-0002-4629-9883"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhu","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chenglong Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenglong Ji","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113361005","display_name":"Feng Lin","orcid":"https://orcid.org/0000-0002-3226-6503","observed_orcids":["https://orcid.org/0000-0002-3226-6503"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Lin","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084697876","display_name":"Le Huan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Huan","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101628948","display_name":"Xi Luo","orcid":"https://orcid.org/0000-0002-5051-2659","observed_orcids":["https://orcid.org/0000-0002-5051-2659"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Luo","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714645","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0001-9302-3962","observed_orcids":["https://orcid.org/0000-0001-9302-3962"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Yan","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006953253","display_name":"Jiashun Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiashun Xu","raw_affiliation_strings":["The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004798515","display_name":"Yun Kyoung Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Hong","raw_affiliation_strings":["The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344905","display_name":"Yuan Wang","orcid":"https://orcid.org/0000-0003-3112-3831","observed_orcids":["https://orcid.org/0000-0003-3112-3831"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Wang","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009369904","display_name":"Ximing Xu","orcid":"https://orcid.org/0000-0002-6133-9660","observed_orcids":["https://orcid.org/0000-0002-6133-9660"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ximing Xu","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085787450","display_name":"Jingchuan Sun","orcid":"https://orcid.org/0000-0002-8956-9409","observed_orcids":["https://orcid.org/0000-0002-8956-9409"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingchuan Sun","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102203900","display_name":"Zheming Song","orcid":"https://orcid.org/0009-0002-8770-9671","observed_orcids":["https://orcid.org/0009-0002-8770-9671"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheming Song","raw_affiliation_strings":["The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 905th Hospital of the People's Liberation Army Navy of China, Shanghai, China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018751623","display_name":"Fanqi Kong","orcid":"https://orcid.org/0000-0001-9286-4962","observed_orcids":["https://orcid.org/0000-0001-9286-4962"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fanqi Kong","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088492383","display_name":"Jiangang Shi","orcid":"https://orcid.org/0000-0003-2133-0108","observed_orcids":["https://orcid.org/0000-0003-2133-0108","https://orcid.org/0000-0001-8034-5751"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiangang Shi","raw_affiliation_strings":["Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018751623","https://openalex.org/A5088492383","https://openalex.org/A5102203900"],"corresponding_institution_ids":["https://openalex.org/I4210099558","https://openalex.org/I4210160531"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.9267,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.96387335,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"737809","last_page":"737809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arginase-2","display_name":"arginase II","score":0.972000002861023},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleus-pulposus-cells","display_name":"nucleus pulposus cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/jsh-23","display_name":"JSH-23","score":0.9169999957084656},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8230000138282776},{"id":"https://openalex.org/keywords/low-back-pain","display_name":"low back pain","score":0.9459999799728394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8262538909912109},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7953523397445679},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7751448750495911},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7120155692100525},{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.6776527762413025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5138126015663147},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4996466636657715},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4604099690914154},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4467162787914276},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.4395969808101654},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4209628999233246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40019845962524414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36504697799682617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3388199806213379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31792736053466797},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18668106198310852},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1436253786087036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14265522360801697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12012544274330139},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10121902823448181},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2021.737809","doi":"https://doi.org/10.3389/fcell.2021.737809","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.737809","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8679914","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8679914/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8679914/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:34926442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34926442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7e04b2bd64bd4cf8b79e34906b8da1e9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e04b2bd64bd4cf8b79e34906b8da1e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.737809","doi":"https://doi.org/10.3389/fcell.2021.737809","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.737809","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2642261714","display_name":null,"funder_award_id":"81871828","funder_id":"https://openalex.org/F4320327720","funder_display_name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China"},{"id":"https://openalex.org/G4253135752","display_name":null,"funder_award_id":"8210091000","funder_id":"https://openalex.org/F4320327720","funder_display_name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China"},{"id":"https://openalex.org/G4822903453","display_name":null,"funder_award_id":"8180218","funder_id":"https://openalex.org/F4320327720","funder_display_name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327720","display_name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200370722.pdf","grobid_xml":"https://content.openalex.org/works/W4200370722.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1480515510","https://openalex.org/W1487824903","https://openalex.org/W1930477314","https://openalex.org/W1985738247","https://openalex.org/W2052078816","https://openalex.org/W2061456864","https://openalex.org/W2067510355","https://openalex.org/W2071774163","https://openalex.org/W2086897399","https://openalex.org/W2150115576","https://openalex.org/W2345313069","https://openalex.org/W2589016670","https://openalex.org/W2753263415","https://openalex.org/W2756951902","https://openalex.org/W2788764162","https://openalex.org/W2792862715","https://openalex.org/W2793993491","https://openalex.org/W2798059234","https://openalex.org/W2890376302","https://openalex.org/W2908321945","https://openalex.org/W2916745611","https://openalex.org/W2949229203","https://openalex.org/W2954937777","https://openalex.org/W2961082130","https://openalex.org/W2961862844","https://openalex.org/W2963715560","https://openalex.org/W2963755831","https://openalex.org/W2972861106","https://openalex.org/W2989876701","https://openalex.org/W2990095623","https://openalex.org/W2998516815","https://openalex.org/W3009257298","https://openalex.org/W3011028005","https://openalex.org/W3013635252","https://openalex.org/W3034057323","https://openalex.org/W3080193067","https://openalex.org/W3081378029","https://openalex.org/W3109141891","https://openalex.org/W3109445174","https://openalex.org/W3164835730","https://openalex.org/W3177438337"],"related_works":["https://openalex.org/W4299963090","https://openalex.org/W4413401864","https://openalex.org/W2792517651","https://openalex.org/W2984067051","https://openalex.org/W4401931078","https://openalex.org/W3024177876","https://openalex.org/W4320007586","https://openalex.org/W2974938421","https://openalex.org/W3109445174","https://openalex.org/W7166663134"],"abstract_inverted_index":{"Intervertebral":[0],"disc":[1],"degeneration":[2,74,135],"(IDD)":[3],"has":[4,69],"been":[5,70],"generally":[6],"accepted":[7],"as":[8],"the":[9,42,95,101,104,109,137,144,152,164],"major":[10],"cause":[11,47],"of":[12,36,58,97,103,132,136,161],"low":[13],"back":[14],"pain":[15],"(LBP),":[16],"which":[17],"imposes":[18],"massive":[19],"clinical":[20],"and":[21,31,34,67,108,112,116,130,134,143,179],"socioeconomic":[22],"burdens.":[23],"Previous":[24],"studies":[25],"have":[26],"demonstrated":[27],"that":[28,46,88,125,172],"oxidative":[29,65,110,141],"stress":[30,111,142],"inflammation-induced":[32],"senescence":[33,115,129],"apoptosis":[35,117,131],"nucleus":[37],"pulposus":[38],"cells":[39],"(NPCs)":[40],"are":[41],"main":[43],"cellular":[44,62],"processes":[45],"IDD.":[48,188],"Arginase":[49],"II":[50],"(ARG2),":[51],"an":[52],"enzyme":[53],"involved":[54],"in":[55,75],"a":[56,183],"variety":[57],"pathological":[59],"processes,":[60],"including":[61,79],"senescence,":[63],"apoptosis,":[64],"stress,":[66],"inflammation,":[68],"shown":[71],"to":[72,94],"promote":[73],"several":[76],"degenerative":[77],"diseases,":[78],"osteoarticular":[80],"diseases.":[81],"Based":[82],"on":[83],"previous":[84],"studies,":[85],"we":[86,123],"hypothesized":[87],"ARG2":[89,126,162,173],"deficiency":[90,127,174],"might":[91],"be":[92,182],"conducive":[93],"treatment":[96],"IDD":[98,176],"by":[99,140],"inhibiting":[100],"dyshomeostasis":[102],"extracellular":[105],"matrix":[106],"(ECM),":[107],"inflammatory":[113,145],"response-induced":[114],"via":[118,177],"NF-\u03baB.":[119],"In":[120,158],"this":[121],"study,":[122],"found":[124,150],"inhibited":[128],"NPCs,":[133],"ECM":[138],"induced":[139],"response.":[146],"Similar":[147],"results":[148,170],"were":[149],"with":[151],"selective":[153],"NF-\u03baB":[154],"pathway":[155],"inhibitor":[156],"JSH-23.":[157],"contrast,":[159],"overexpression":[160],"had":[163],"opposite":[165],"effect.":[166],"Taken":[167],"together,":[168],"our":[169],"suggest":[171],"prevents":[175],"NF-\u03baB,":[178],"may":[180],"therefore,":[181],"potential":[184],"therapeutic":[185],"strategy":[186],"for":[187]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-12-31T00:00:00"}