{"id":"https://openalex.org/W4200367381","doi":"https://doi.org/10.1021/acschembio.1c00932","title":"In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer\u2019s Disease (AD) Patients","display_name":"In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer\u2019s Disease (AD) Patients","publication_year":2021,"publication_date":"2021-12-29","ids":{"openalex":"https://openalex.org/W4200367381","doi":"https://doi.org/10.1021/acschembio.1c00932","pmid":"https://pubmed.ncbi.nlm.nih.gov/34964596","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240109"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.1c00932","doi":"https://doi.org/10.1021/acschembio.1c00932","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.1c00932","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101873017","display_name":"Zhengwei Chen","orcid":"https://orcid.org/0000-0002-5900-3359","observed_orcids":["https://orcid.org/0000-0002-5900-3359"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengwei Chen","raw_affiliation_strings":["Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Danqing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danqing Wang","raw_affiliation_strings":["Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040242042","display_name":"Qing Yu","orcid":"https://orcid.org/0000-0003-0468-5353","observed_orcids":["https://orcid.org/0000-0003-0468-5353"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Yu","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":"https://orcid.org/0000-0003-0468-5353","affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076959420","display_name":"Jillian Johnson","orcid":"https://orcid.org/0000-0002-1559-3377","observed_orcids":["https://orcid.org/0000-0002-1559-3377"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian Johnson","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050673366","display_name":"Richard David Shipman","orcid":"https://orcid.org/0000-0003-4731-5563","observed_orcids":["https://orcid.org/0000-0003-4731-5563"]},"institutions":[{"id":"https://openalex.org/I1921588","display_name":"University of Wisconsin\u2013Stout","ror":"https://ror.org/01gb8pc70","country_code":"US","type":"education","lineage":["https://openalex.org/I1921588"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Shipman","raw_affiliation_strings":["Applied Science Program, University of Wisconsin-Stout, Menomonie, Wisconsin 54751, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Science Program, University of Wisconsin-Stout, Menomonie, Wisconsin 54751, United States","institution_ids":["https://openalex.org/I1921588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103261052","display_name":"Xiaofang Zhong","orcid":"https://orcid.org/0000-0002-6843-0256","observed_orcids":["https://orcid.org/0000-0002-6843-0256"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofang Zhong","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047143972","display_name":"Junfeng Huang","orcid":"https://orcid.org/0000-0002-1672-3751","observed_orcids":["https://orcid.org/0000-0002-1672-3751"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Huang","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037364866","display_name":"Qinying Yu","orcid":"https://orcid.org/0000-0001-9483-1478","observed_orcids":["https://orcid.org/0000-0001-9483-1478"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinying Yu","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079766290","display_name":"Henrik Zetterberg","orcid":"https://orcid.org/0000-0003-3930-4354","observed_orcids":["https://orcid.org/0000-0003-3930-4354","https://orcid.org/0000-0002-4671-6763"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Henrik Zetterberg","raw_affiliation_strings":["Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 43180 M\u00f6lndal, Sweden","Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom","Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 43180 M\u00f6lndal, Sweden","UK Dementia Research Institute at UCL, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 43180 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 43180 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"UK Dementia Research Institute at UCL, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103911623","display_name":"Sanjay Asthana","orcid":"https://orcid.org/0000-0002-3298-6324","observed_orcids":["https://orcid.org/0000-0002-3298-6324","https://orcid.org/0000-0002-3998-4479"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Asthana","raw_affiliation_strings":["School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090940361","display_name":"Cynthia M. Carlsson","orcid":"https://orcid.org/0000-0001-5743-1563","observed_orcids":["https://orcid.org/0000-0001-5743-1563"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Carlsson","raw_affiliation_strings":["School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102750078","display_name":"Ozioma C. Okonkwo","orcid":"https://orcid.org/0009-0009-8764-811X","observed_orcids":["https://orcid.org/0009-0009-8764-811X","https://orcid.org/0000-0001-5803-6055"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozioma Okonkwo","raw_affiliation_strings":["School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53726, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100746152","display_name":"Lingjun Li","orcid":"https://orcid.org/0000-0003-0056-3869","observed_orcids":["https://orcid.org/0000-0003-0056-3869"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lingjun Li","raw_affiliation_strings":["Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States"],"raw_orcid":"https://orcid.org/0000-0003-0056-3869","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100746152"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.334,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.80700265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"11","first_page":"3059","last_page":"3068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/o-glycopeptides","display_name":"O-glycopeptides","score":0.765999972820282},{"id":"https://openalex.org/keywords/endogenous-peptides","display_name":"endogenous peptides","score":0.8029999732971191},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8199999928474426},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/fucosylation","display_name":"fucosylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/peptidomics","display_name":"peptidomics","score":0.75},{"id":"https://openalex.org/keywords/glycosylation-patterns","display_name":"glycosylation patterns","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.842807948589325},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.7574385404586792},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.7561295032501221},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6806617975234985},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6515375971794128},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6344420313835144},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5238064527511597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4411117136478424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28313910961151123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26670295000076294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.246211439371109}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acschembio.1c00932","doi":"https://doi.org/10.1021/acschembio.1c00932","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.1c00932","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:34964596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34964596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9240109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10143514","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10143514/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Chemical Biology , 17 (11) pp. 2059-3068. (2022)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9240109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9240109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.5099999904632568}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1603679598","display_name":"Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical Research","funder_award_id":"S10RR029531","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6174201662","display_name":null,"funder_award_id":"U01 CA231081","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6789993942","display_name":"Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's disease","funder_award_id":"RF1AG052324","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G822836364","display_name":null,"funder_award_id":"R01DK071801","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907065","display_name":"Wisconsin Alzheimer's Disease Research Center","funder_award_id":"P30AG062715","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G990633214","display_name":"Probing Protein Structural Changes in Alzheimers Disease","funder_award_id":"R21AG065728","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306555","display_name":"Wisconsin Alumni Research Foundation","ror":"https://ror.org/00hwxbz16"},{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W115204164","https://openalex.org/W304117529","https://openalex.org/W1494626566","https://openalex.org/W1531375840","https://openalex.org/W1578270753","https://openalex.org/W1781098768","https://openalex.org/W1820870565","https://openalex.org/W1870828328","https://openalex.org/W1919351059","https://openalex.org/W1969477781","https://openalex.org/W1974384968","https://openalex.org/W1978393830","https://openalex.org/W1985310505","https://openalex.org/W1986816633","https://openalex.org/W1990618795","https://openalex.org/W1996778982","https://openalex.org/W1997504014","https://openalex.org/W1998765654","https://openalex.org/W2004160810","https://openalex.org/W2018094089","https://openalex.org/W2022452100","https://openalex.org/W2024191848","https://openalex.org/W2048136147","https://openalex.org/W2051893774","https://openalex.org/W2058936782","https://openalex.org/W2073679731","https://openalex.org/W2074235202","https://openalex.org/W2085536531","https://openalex.org/W2086804420","https://openalex.org/W2091212732","https://openalex.org/W2095535715","https://openalex.org/W2097714831","https://openalex.org/W2098157576","https://openalex.org/W2110438218","https://openalex.org/W2115577515","https://openalex.org/W2116901594","https://openalex.org/W2124880597","https://openalex.org/W2140125568","https://openalex.org/W2147134028","https://openalex.org/W2156451718","https://openalex.org/W2169636187","https://openalex.org/W2175111362","https://openalex.org/W2321570512","https://openalex.org/W2328001827","https://openalex.org/W2335247296","https://openalex.org/W2342689418","https://openalex.org/W2346578990","https://openalex.org/W2347067222","https://openalex.org/W2406942791","https://openalex.org/W2526628093","https://openalex.org/W2549952127","https://openalex.org/W2566477670","https://openalex.org/W2613539552","https://openalex.org/W2619124219","https://openalex.org/W2738682266","https://openalex.org/W2766783676","https://openalex.org/W2792518984","https://openalex.org/W2897052519","https://openalex.org/W2925571658","https://openalex.org/W2968628755","https://openalex.org/W2980885964","https://openalex.org/W2998500331","https://openalex.org/W3090668577","https://openalex.org/W3153855105","https://openalex.org/W3155210079","https://openalex.org/W3180733182"],"related_works":["https://openalex.org/W3155210079","https://openalex.org/W7166045158","https://openalex.org/W2107032754","https://openalex.org/W2328001827","https://openalex.org/W2169142034","https://openalex.org/W2549952127","https://openalex.org/W7221639735","https://openalex.org/W4386158195","https://openalex.org/W2519577659","https://openalex.org/W2757225757"],"abstract_inverted_index":{"Site-specific":[0],"O-glycoproteome":[1,27,83,179],"mapping":[2],"in":[3,21,29,84,87,187,202,212,228],"complex":[4],"biological":[5],"systems":[6],"provides":[7],"a":[8,123,131,197,209],"molecular":[9],"basis":[10],"for":[11,71,116,136],"understanding":[12],"the":[13,82,88,107,128,153,178,188],"structure-function":[14],"relationships":[15],"of":[16,90,111,140,177,190,199,218],"glycoproteins":[17],"and":[18,23,64,66,99,113,130,146,161,180,192,214],"their":[19],"roles":[20],"physiological":[22],"pathological":[24],"processes.":[25],"Previous":[26],"analysis":[28,139],"cerebrospinal":[30],"fluid":[31],"(CSF)":[32],"focused":[33],"on":[34,40],"sialylated":[35,98],"glycoforms,":[36],"while":[37],"missing":[38],"information":[39],"other":[41,147],"glycosylation":[42,200],"types.":[43],"In":[44],"order":[45],"to":[46,80,118,195],"achieve":[47],"an":[48,54,215,225],"unbiased":[49],"O-glycosylation":[50],"profile,":[51],"we":[52],"developed":[53,122],"integrated":[55],"strategy":[56,79,135],"combining":[57],"universal":[58],"boronic":[59],"acid":[60],"enrichment,":[61],"high-pH":[62],"fractionation,":[63],"electron-transfer":[65],"higher-energy":[67],"collision":[68],"dissociation":[69],"(EThcD)":[70],"enhanced":[72],"intact":[73],"O-glycopeptide":[74],"analysis.":[75],"We":[76,120],"applied":[77],"this":[78,105],"analyze":[81],"CSF,":[85],"resulting":[86],"identification":[89],"308":[91],"O-glycopeptides":[92],"from":[93],"110":[94],"O-glycoproteins,":[95],"covering":[96],"both":[97],"nonsialylated":[100],"glycoforms.":[101],"To":[102],"our":[103],"knowledge,":[104],"is":[106],"largest":[108],"data":[109],"set":[110],"O-glycoproteins":[112],"O-glycosites":[114],"reported":[115],"CSF":[117,170,189],"date.":[119],"also":[121,185],"peptidomics":[124],"workflow":[125],"that":[126,169],"utilized":[127],"EThcD":[129],"three-step":[132],"database":[133],"searching":[134],"comprehensive":[137],"PTM":[138],"endogenous":[141,155,171,181,219],"peptides,":[142],"including":[143],"N-glycosylation,":[144],"O-glycosylation,":[145,221],"common":[148],"peptide":[149,165,220],"PTMs.":[150],"Interestingly,":[151],"among":[152],"1411":[154],"peptides":[156,172],"identified,":[157],"89":[158],"were":[159,173,184],"O-glycosylated,":[160],"only":[162],"one":[163],"N-glycosylated":[164],"was":[166],"found,":[167],"indicating":[168],"predominantly":[174],"O-glycosylated.":[175],"Analyses":[176],"peptidome":[182],"PTMs":[183],"conducted":[186],"MCI":[191],"AD":[193,229],"patients":[194],"provide":[196],"landscape":[198],"patterns":[201],"different":[203],"disease":[204],"states.":[205],"Our":[206],"results":[207],"showed":[208],"decreasing":[210],"trend":[211,217],"fucosylation":[213],"increasing":[216],"which":[222],"may":[223],"play":[224],"important":[226],"role":[227],"progression.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-12-31T00:00:00"}