{"id":"https://openalex.org/W4200364879","doi":"https://doi.org/10.1080/1354750x.2021.2020903","title":"Apoptotic and anti-angiogenic effects of propolis against human bladder cancer: molecular docking and in vitro screening","display_name":"Apoptotic and anti-angiogenic effects of propolis against human bladder cancer: molecular docking and in vitro screening","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200364879","doi":"https://doi.org/10.1080/1354750x.2021.2020903","pmid":"https://pubmed.ncbi.nlm.nih.gov/34927500"},"language":"en","primary_location":{"id":"doi:10.1080/1354750x.2021.2020903","doi":"https://doi.org/10.1080/1354750x.2021.2020903","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1354750x.2021.2020903","pdf_url":null,"source":{"id":"https://openalex.org/S7166883","display_name":"Biomarkers","issn_l":"1354-750X","issn":["1354-750X","1366-5804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044030554","display_name":"Ahmed B. M. Mehany","orcid":"https://orcid.org/0000-0002-9913-5380","observed_orcids":["https://orcid.org/0000-0002-9913-5380"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed B. M. Mehany","raw_affiliation_strings":["Genetic Engineering, Department of Zoology, Faculty of Science Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering, Department of Zoology, Faculty of Science Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016921887","display_name":"Amany Belal","orcid":"https://orcid.org/0000-0003-1045-0163","observed_orcids":["https://orcid.org/0000-0003-1045-0163"]},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Amany Belal","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-1045-0163","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002458709","display_name":"Aly Fahmy Mohamed","orcid":"https://orcid.org/0000-0003-3629-3514","observed_orcids":["https://orcid.org/0000-0003-3629-3514"]},"institutions":[{"id":"https://openalex.org/I4210134127","display_name":"Vacsera (Egypt)","ror":"https://ror.org/03nh6bz87","country_code":"EG","type":"company","lineage":["https://openalex.org/I4210134127"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aly Fahmy Mohamed","raw_affiliation_strings":["Holding Company for Production of Vaccines and Biological Products (VACSERA), Agouza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holding Company for Production of Vaccines and Biological Products (VACSERA), Agouza, Egypt","institution_ids":["https://openalex.org/I4210134127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066805181","display_name":"Salwa Shaaban","orcid":"https://orcid.org/0000-0001-6269-806X","observed_orcids":["https://orcid.org/0000-0001-6269-806X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]},{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Salwa Shaaban","raw_affiliation_strings":["Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia","Department of Microbiology& Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]},{"raw_affiliation_string":"Department of Microbiology& Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ghada Abdelhamid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ghada Abdelhamid","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Egypt","institution_ids":["https://openalex.org/I84058292"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016921887","https://openalex.org/A5044030554"],"corresponding_institution_ids":["https://openalex.org/I179331831","https://openalex.org/I184834183"],"apc_list":null,"apc_paid":null,"fwci":2.1563,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85552926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"2","first_page":"138","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/t24-cells","display_name":"T24 cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-receptor","display_name":"vascular endothelial growth factor receptor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.9233781099319458},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8219832181930542},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7301857471466064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.585708737373352},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48580360412597656},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.47976669669151306},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4332856237888336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4246734082698822},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.415203332901001},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4145222306251526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3351096212863922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2597863972187042},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19614610075950623},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.17678788304328918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1505570113658905},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.04920467734336853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/1354750x.2021.2020903","doi":"https://doi.org/10.1080/1354750x.2021.2020903","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1354750x.2021.2020903","pdf_url":null,"source":{"id":"https://openalex.org/S7166883","display_name":"Biomarkers","issn_l":"1354-750X","issn":["1354-750X","1366-5804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers","raw_type":"journal-article"},{"id":"pmid:34927500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34927500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1976466885","https://openalex.org/W1977621221","https://openalex.org/W1983201985","https://openalex.org/W1995316103","https://openalex.org/W1998695957","https://openalex.org/W2000613531","https://openalex.org/W2008757142","https://openalex.org/W2030437798","https://openalex.org/W2040270316","https://openalex.org/W2067216473","https://openalex.org/W2069361214","https://openalex.org/W2070134611","https://openalex.org/W2088533523","https://openalex.org/W2092577537","https://openalex.org/W2098160574","https://openalex.org/W2137475138","https://openalex.org/W2137740444","https://openalex.org/W2152630148","https://openalex.org/W2161829332","https://openalex.org/W2163689980","https://openalex.org/W2170098987","https://openalex.org/W2256970336","https://openalex.org/W2274704822","https://openalex.org/W2497111153","https://openalex.org/W2570618306","https://openalex.org/W2591966157","https://openalex.org/W2607934365","https://openalex.org/W2749526150","https://openalex.org/W2793964572","https://openalex.org/W2929690593","https://openalex.org/W2947420633","https://openalex.org/W2955392144","https://openalex.org/W2971801381","https://openalex.org/W2973979210","https://openalex.org/W2981823807","https://openalex.org/W3044082277"],"related_works":["https://openalex.org/W2041351646","https://openalex.org/W7099103401","https://openalex.org/W2007436085","https://openalex.org/W4280547562","https://openalex.org/W2009145137","https://openalex.org/W4406422714","https://openalex.org/W1799139420","https://openalex.org/W1970370302","https://openalex.org/W2800779113","https://openalex.org/W2152166662"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Bladder":[1],"cancer":[2,19,37,182],"is":[3,11],"still":[4],"of":[5,80,104,122,139],"unknown":[6],"initiation":[7],"and":[8,46,51,60,85,98,100,111,128,155,184],"progression,":[9],"it":[10,146],"difficult":[12],"to":[13,89,93,107,141,168],"treat":[14],"the":[15,28,76,94,102,137],"patient":[16],"once":[17],"bladder":[18,36,181],"have":[20],"a":[21,175],"distant":[22],"metastasis.":[23],"MATERIALS":[24],"AND":[25],"METHODS:":[26],"In":[27],"present":[29],"study,":[30],"propolis":[31,82,105,123,140,171],"extract":[32,172],"was":[33,116],"evaluated":[34],"against":[35],"cells":[38],"(T24).":[39],"Two":[40],"independent":[41],"pathways":[42],"were":[43,130],"investigated,":[44],"apoptosis":[45],"angiogenesis,":[47],"Bax,":[48,125],"Bcl-2,":[49,126],"P53,":[50,127],"caspase-3":[52,129],"for":[53,75],"apoptosis,":[54],"vascular":[55,156],"endothelial":[56,157],"growth":[57,158],"factor":[58,159],"receptor":[59],"protein":[61,87,152],"kinase":[62,153],"A":[63,154],"as":[64],"angiogenesis":[65],"potential":[66],"targets.":[67],"OBJECTIVES:":[68],"Molecular":[69],"docking":[70],"studies":[71],"will":[72],"be":[73],"conducted":[74],"major":[77],"known":[78],"constituents":[79,106],"Egyptian":[81],"into":[83],"apoptotic":[84,110],"angiogenic":[86,112],"targets,":[88],"give":[90],"better":[91],"insights":[92],"possible":[95],"binding":[96],"mode":[97],"interactions":[99],"investigate":[101],"ability":[103,138],"target":[108],"both":[109],"pathways.":[113],"RESULTS:":[114],"value":[115],"6.36":[117],"\u00b5g/ml.":[118],"Also":[119,145],"significant":[120],"effects":[121,150],"on":[124,151],"observed.":[131],"DISCUSSION:":[132],"These":[133],"obtained":[134,163],"results":[135,164],"proved":[136],"induce":[142,174],"cell":[143,177],"death.":[144],"has":[147],"revealed":[148],"noticeable":[149],"receptor.":[160],"CONCLUSION:":[161],"The":[162],"can":[165,173],"encourage":[166],"us":[167],"say":[169],"that":[170],"programmed":[176],"death":[178],"in":[179],"human":[180],"cells,":[183],"also":[185],"affect":[186],"angiogenesis.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
