{"id":"https://openalex.org/W4200364387","doi":"https://doi.org/10.3389/fmicb.2021.750662","title":"Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection","display_name":"Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection","publication_year":2021,"publication_date":"2021-12-21","ids":{"openalex":"https://openalex.org/W4200364387","doi":"https://doi.org/10.3389/fmicb.2021.750662","pmid":"https://pubmed.ncbi.nlm.nih.gov/34992583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8724557"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2021.750662","doi":"https://doi.org/10.3389/fmicb.2021.750662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2021.750662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2021.750662/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2021.750662/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077894708","display_name":"De Chang","orcid":"https://orcid.org/0000-0001-9767-6901","observed_orcids":["https://orcid.org/0000-0001-9767-6901","https://orcid.org/0009-0001-0266-2345"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"De Chang","raw_affiliation_strings":["College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China","Department of Pulmonary and Critical Care Medicine, The Third Medical Center of Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Third Medical Center of Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003399137","display_name":"Lokesh Sharma","orcid":"https://orcid.org/0000-0003-3040-9029","observed_orcids":["https://orcid.org/0000-0003-3040-9029"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lokesh Sharma","raw_affiliation_strings":["Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016891336","display_name":"Charles S. Dela Cruz","orcid":"https://orcid.org/0000-0002-5258-1797","observed_orcids":["https://orcid.org/0000-0002-5258-1797"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles S. Dela Cruz","raw_affiliation_strings":["Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":null,"display_name":"Dong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Zhang","raw_affiliation_strings":["College of Tuberculosis Medicine, Chinese PLA General Hospital, Beijing, China","Department of Oncology, The Second Medical Center of Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Tuberculosis Medicine, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Department of Oncology, The Second Medical Center of Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003399137","https://openalex.org/A5016891336","https://openalex.org/A5077894708"],"corresponding_institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I32971472","https://openalex.org/I4210160531"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.2965,"has_fulltext":true,"cited_by_count":353,"citation_normalized_percentile":{"value":0.95728643,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"12","issue":null,"first_page":"750662","last_page":"750662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13849","display_name":"Enterobacteriaceae and Cronobacter Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/klebsiella-infections","display_name":"Klebsiella infections","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hypervirulent-klebsiella-pneumoniae","display_name":"hypervirulent Klebsiella pneumoniae","score":0.8040000200271606},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.996999979019165},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.7170000076293945},{"id":"https://openalex.org/keywords/epidemiology","display_name":"epidemiology","score":0.6330000162124634},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.5400000214576721},{"id":"https://openalex.org/keywords/bloodstream-infection","display_name":"bloodstream infection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/brain-infection","display_name":"brain infection","score":0.5839999914169312},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.49300000071525574},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.903490424156189},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6666300892829895},{"id":"https://openalex.org/C2779116282","wikidata":"https://www.wikidata.org/wiki/Q131854","display_name":"Klebsiella","level":4,"score":0.625701904296875},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5499876141548157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4512469172477722},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4264083504676819},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42539167404174805},{"id":"https://openalex.org/C166888038","wikidata":"https://www.wikidata.org/wiki/Q4118322","display_name":"Infection control","level":2,"score":0.4216923117637634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3781886100769043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14969033002853394},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2021.750662","doi":"https://doi.org/10.3389/fmicb.2021.750662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2021.750662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2021.750662/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8724557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8724557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:34992583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34992583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2c8e39188cbf477c9ceb5a6ffebbaf46","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2c8e39188cbf477c9ceb5a6ffebbaf46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2021.750662","doi":"https://doi.org/10.3389/fmicb.2021.750662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2021.750662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2021.750662/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2830222033","display_name":null,"funder_award_id":"Z191100001119021","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"}],"funders":[{"id":"https://openalex.org/F4320325891","display_name":"General Hospital of People\u2019s Liberation Army","ror":"https://ror.org/04gw3ra78"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200364387.pdf","grobid_xml":"https://content.openalex.org/works/W4200364387.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W11223535","https://openalex.org/W167245840","https://openalex.org/W1443061133","https://openalex.org/W1699311850","https://openalex.org/W1803007042","https://openalex.org/W1826616185","https://openalex.org/W1828953816","https://openalex.org/W1969064619","https://openalex.org/W1972211076","https://openalex.org/W1975107777","https://openalex.org/W1977209773","https://openalex.org/W1989910901","https://openalex.org/W1992681989","https://openalex.org/W1996973702","https://openalex.org/W1998453329","https://openalex.org/W1999949810","https://openalex.org/W2000902780","https://openalex.org/W2004441004","https://openalex.org/W2006137057","https://openalex.org/W2007331931","https://openalex.org/W2009933778","https://openalex.org/W2013332542","https://openalex.org/W2037231060","https://openalex.org/W2038279595","https://openalex.org/W2039853978","https://openalex.org/W2046447873","https://openalex.org/W2049148518","https://openalex.org/W2051855929","https://openalex.org/W2056957102","https://openalex.org/W2059372590","https://openalex.org/W2060550135","https://openalex.org/W2060935540","https://openalex.org/W2061729558","https://openalex.org/W2061974546","https://openalex.org/W2065337857","https://openalex.org/W2065805684","https://openalex.org/W2072172107","https://openalex.org/W2081323043","https://openalex.org/W2083974217","https://openalex.org/W2085237946","https://openalex.org/W2096143286","https://openalex.org/W2098765273","https://openalex.org/W2099140790","https://openalex.org/W2103338644","https://openalex.org/W2109578375","https://openalex.org/W2111117400","https://openalex.org/W2111538183","https://openalex.org/W2113089787","https://openalex.org/W2115566146","https://openalex.org/W2121022328","https://openalex.org/W2126377642","https://openalex.org/W2135845345","https://openalex.org/W2136653513","https://openalex.org/W2138935819","https://openalex.org/W2142073962","https://openalex.org/W2145069900","https://openalex.org/W2154556219","https://openalex.org/W2155802702","https://openalex.org/W2159449898","https://openalex.org/W2165094125","https://openalex.org/W2166097152","https://openalex.org/W2166269739","https://openalex.org/W2231991559","https://openalex.org/W2316914238","https://openalex.org/W2416884466","https://openalex.org/W2418535258","https://openalex.org/W2440181962","https://openalex.org/W2443415468","https://openalex.org/W2513238037","https://openalex.org/W2538058458","https://openalex.org/W2543439881","https://openalex.org/W2571679872","https://openalex.org/W2603039590","https://openalex.org/W2603910952","https://openalex.org/W2607102324","https://openalex.org/W2610758029","https://openalex.org/W2621632999","https://openalex.org/W2751994003","https://openalex.org/W2759724134","https://openalex.org/W2766009727","https://openalex.org/W2770310499","https://openalex.org/W2793582850","https://openalex.org/W2795477248","https://openalex.org/W2795694182","https://openalex.org/W2808824345","https://openalex.org/W2834599026","https://openalex.org/W2889991839","https://openalex.org/W2901222459","https://openalex.org/W2914581422","https://openalex.org/W2944443127","https://openalex.org/W2945505394","https://openalex.org/W2946693395","https://openalex.org/W2951121463","https://openalex.org/W2977322360","https://openalex.org/W2996440981","https://openalex.org/W3091052478"],"related_works":["https://openalex.org/W2915061496","https://openalex.org/W4410838369","https://openalex.org/W2498846178","https://openalex.org/W7203650877","https://openalex.org/W4408836681","https://openalex.org/W7150966728","https://openalex.org/W7156220383","https://openalex.org/W4409253255","https://openalex.org/W2759724134","https://openalex.org/W2443415468"],"abstract_inverted_index":{"Klebsiella":[0,31,69],"species":[1],"cause":[2],"infections":[3,19,84],"at":[4],"multiple":[5],"sites,":[6],"including":[7],"lung,":[8],"urinary":[9],"tract,":[10],"bloodstream,":[11],"wound":[12],"or":[13],"surgical":[14],"site,":[15],"and":[16,51,63,78,94],"brain.":[17],"These":[18],"are":[20],"more":[21],"likely":[22],"to":[23,45,57,66,85,98],"occur":[24],"in":[25],"people":[26],"with":[27],"preexisting":[28],"health":[29],"conditions.":[30],"pneumoniae":[32,83],"(K.":[33],"pneumoniae)":[34],"has":[35],"emerged":[36],"as":[37],"a":[38],"major":[39],"pathogen":[40,93],"of":[41,49],"international":[42],"concern":[43],"due":[44],"the":[46,74,87],"increasing":[47],"incidences":[48],"hypervirulent":[50],"carbapenem-resistant":[52],"strains.":[53],"It":[54],"is":[55],"imperative":[56],"understand":[58],"risk":[59,76,89],"factors,":[60,77],"prevention":[61],"strategies,":[62],"therapeutic":[64],"avenues":[65],"treat":[67,99],"multidrug-resistant":[68],"infections.":[70],"Here,":[71],"we":[72],"highlight":[73,86],"epidemiology,":[75],"control":[79],"strategies":[80],"against":[81],"K.":[82],"grave":[88],"posed":[90],"by":[91],"this":[92],"currently":[95],"available":[96],"options":[97],"Klebsiella-associated":[100],"diseases.":[101]},"counts_by_year":[{"year":2026,"cited_by_count":76},{"year":2025,"cited_by_count":109},{"year":2024,"cited_by_count":101},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-12-31T00:00:00"}