{"id":"https://openalex.org/W4200345128","doi":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109","title":"Metabolic pathway analysis in HepG2 cells exposed to organoclorines using null diffusion-based enrichment","display_name":"Metabolic pathway analysis in HepG2 cells exposed to organoclorines using null diffusion-based enrichment","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W4200345128","doi":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109"},"language":"en","primary_location":{"id":"doi:10.1109/ci-ibbi54220.2021.9626109","doi":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109","pdf_url":null,"source":{"id":"https://openalex.org/S7407105444","display_name":"IEEE International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&amp;BI)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053686173","display_name":"Jorge Alejandro Lopera-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-2824-4678","observed_orcids":["https://orcid.org/0000-0002-2824-4678"]},"institutions":[{"id":"https://openalex.org/I4210141572","display_name":"Instituci\u00f3n Universitaria ITM","ror":"https://ror.org/03zb5p722","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210141572"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Jorge Alejandro Lopera-Rodriguez","raw_affiliation_strings":["Grupo de Investigaci\u00f3n GI2B, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n GI2B, Instituto Tecnol\u00f3gico Metropolitano, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I4210141572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085239964","display_name":"Martha Zuluaga","orcid":"https://orcid.org/0000-0003-1720-8476","observed_orcids":["https://orcid.org/0000-0003-1720-8476"]},"institutions":[{"id":"https://openalex.org/I4210145466","display_name":"Universidad Nacional Abierta y a Distancia","ror":"https://ror.org/047179s14","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210145466"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Martha Zuluaga","raw_affiliation_strings":["Grupo de Investigaci\u00f3n GIEPRONAL, Universidad Nacional Abierta y a Distancia, Dosquebradas, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n GIEPRONAL, Universidad Nacional Abierta y a Distancia, Dosquebradas, Colombia","institution_ids":["https://openalex.org/I4210145466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023202274","display_name":"Sergio Picart\u2010Armada","orcid":"https://orcid.org/0000-0002-6426-8204","observed_orcids":["https://orcid.org/0000-0002-6426-8204"]},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4388446393","display_name":"Institut de Recerca Sant Joan de D\u00e9u","ror":"https://ror.org/00gy2ar74","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4388446393"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Picart-Armada","raw_affiliation_strings":["B2SLab, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Espa\u00f1a","CIBER-BBN, Madrid, Espa\u00f1a","IRSJD, Esplugues de Llobregat, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B2SLab, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Espa\u00f1a","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"CIBER-BBN, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210105141","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"IRSJD, Esplugues de Llobregat, Espa\u00f1a","institution_ids":["https://openalex.org/I4388446393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041616492","display_name":"Alexandre Perera-Lluna","orcid":"https://orcid.org/0000-0001-6427-851X","observed_orcids":["https://orcid.org/0000-0001-6427-851X"]},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4388446393","display_name":"Institut de Recerca Sant Joan de D\u00e9u","ror":"https://ror.org/00gy2ar74","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4388446393"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexandre Perera Lluna","raw_affiliation_strings":["B2SLab, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Espa\u00f1a","CIBER-BBN, Madrid, Espa\u00f1a","IRSJD, Esplugues de Llobregat, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B2SLab, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Espa\u00f1a","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"CIBER-BBN, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210105141","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"IRSJD, Esplugues de Llobregat, Espa\u00f1a","institution_ids":["https://openalex.org/I4388446393"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4175,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.75945017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.43970000743865967,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.43970000743865967,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4302000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organochlorine-pesticides","display_name":"organochlorine pesticides","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metabolic-pathway-analysis","display_name":"metabolic pathway analysis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/svm-rfe","display_name":"SVM-RFE","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.6990000009536743},{"id":"https://openalex.org/keywords/aldrin","display_name":"aldrin","score":0.878000020980835},{"id":"https://openalex.org/keywords/ddt","display_name":"DDT","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endosulfan","display_name":"endosulfan","score":1.0},{"id":"https://openalex.org/keywords/lindane","display_name":"lindane","score":1.0},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9620000123977661},{"id":"https://openalex.org/keywords/alanine-aspartate-and-glutamate-metabolism","display_name":"alanine, aspartate and glutamate metabolism","score":0.8569999933242798},{"id":"https://openalex.org/keywords/taurine-and-hypotaurine-metabolism","display_name":"taurine and hypotaurine metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.996999979019165},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.656000018119812},{"id":"https://openalex.org/keywords/cell-components","display_name":"cellular component","score":0.3709999918937683},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene Ontology","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.7470647096633911},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.704663097858429},{"id":"https://openalex.org/C2781032171","wikidata":"https://www.wikidata.org/wiki/Q409054","display_name":"Aldrin","level":4,"score":0.6925491690635681},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.632684051990509},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4886167645454407},{"id":"https://openalex.org/C2780120631","wikidata":"https://www.wikidata.org/wiki/Q282003","display_name":"Lindane","level":3,"score":0.4884702265262604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4536537230014801},{"id":"https://openalex.org/C2776853492","wikidata":"https://www.wikidata.org/wiki/Q3138539","display_name":"Hypotaurine","level":4,"score":0.4520135819911957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43526825308799744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4133134186267853},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.4049355089664459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38380300998687744},{"id":"https://openalex.org/C2776640376","wikidata":"https://www.wikidata.org/wiki/Q423992","display_name":"Dieldrin","level":3,"score":0.3596751093864441},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35447603464126587},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.3315049409866333},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2371150255203247},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.23550152778625488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1869232952594757},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11953455209732056},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0959475040435791},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ci-ibbi54220.2021.9626109","doi":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ci-ibbi54220.2021.9626109","pdf_url":null,"source":{"id":"https://openalex.org/S7407105444","display_name":"IEEE International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&amp;BI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W97648961","https://openalex.org/W1527927437","https://openalex.org/W1603489731","https://openalex.org/W1810387001","https://openalex.org/W2015564297","https://openalex.org/W2077050339","https://openalex.org/W2082081674","https://openalex.org/W2096977864","https://openalex.org/W2108517723","https://openalex.org/W2132485204","https://openalex.org/W2134926220","https://openalex.org/W2154972152","https://openalex.org/W2155158051","https://openalex.org/W2199408341","https://openalex.org/W2253511220","https://openalex.org/W2273771970","https://openalex.org/W2462360576","https://openalex.org/W2582743722","https://openalex.org/W2772875656","https://openalex.org/W2906622050","https://openalex.org/W2974361058","https://openalex.org/W2977999434","https://openalex.org/W4206674535","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2253511220","https://openalex.org/W4200131253","https://openalex.org/W7152611898","https://openalex.org/W2606806978","https://openalex.org/W7204558389","https://openalex.org/W4394740190","https://openalex.org/W6997036438","https://openalex.org/W4393137174","https://openalex.org/W2108188071","https://openalex.org/W3145825492"],"abstract_inverted_index":{"Introduction:":[0],"organochlorines":[1,24,37,67,160,268],"are":[2],"a":[3,15,57,103,126],"group":[4,109],"of":[5,92,105],"organic":[6],"pesticides":[7],"developed":[8],"to":[9,33,49,60,97,133,152,159,234],"control":[10,108],"insect":[11],"plagues,":[12],"but":[13],"with":[14,76,87,110,173,251],"relevant":[16,135],"impact":[17,255],"for":[18,181,202,213,222,227],"human":[19],"health.":[20],"Intoxication":[21],"caused":[22],"by":[23,82,123,143,197,266],"can":[25,31],"cause":[26],"serious":[27],"health":[28],"compromises":[29],"that":[30],"lead":[32],"death.":[34],"However,":[35],"the":[36,62,174,177,189,228,239,243,248,267],"molecular":[38],"mechanism":[39],"remains":[40],"unclear.":[41],"Therefore,":[42],"researching":[43],"about":[44],"this":[45],"topic":[46],"is":[47],"necessary":[48],"propose":[50],"new":[51],"therapeutic":[52],"strategies.":[53],"This":[54],"study":[55],"presents":[56],"bioinformatics":[58],"approach":[59],"elucidate":[61],"metabolic":[63,138],"pathways":[64,139,201,210,244,264],"involved":[65],"in":[66,72,131,147,167,193,256],"exposure":[68],"using":[69,120,129],"strategies":[70],"based":[71],"support":[73],"vector":[74],"machines":[75],"recursive":[77],"feature":[78],"elimination":[79],"(SVM\u2014RFE)":[80],"followed":[81,122],"an":[83,254],"enrichment":[84],"pathway":[85,127,249],"analysis":[86,117,128,232,250],"null-diffusion.":[88],"Methods:":[89],"five":[90],"groups":[91],"HepG2":[93],"cells":[94],"were":[95,145,165,184,195,211],"exposed":[96],"aldrin,":[98,214],"DDT,":[99,215],"endosulfan,":[100],"lindane,":[101,223],"and":[102,125,137,176,188,207,216,219,224,236,259],"mixture":[104],"them.":[106],"A":[107,115],"dimethyl":[111],"sulfoxide":[112],"was":[113,118,171],"included.":[114],"metabolomic":[116,168],"done":[119],"GC/MS-TOF,":[121],"SVM-RFE":[124,170],"FELLA":[130,144,198,252],"order":[132],"identify":[134],"metabolites":[136,164,180],"affected.":[140],"Genes":[141],"reported":[142],"introduced":[146],"gene":[148],"ontology":[149],"platform":[150],"(GO)":[151],"estimate":[153],"cellular":[154,240],"components":[155,241],"where":[156,242],"reactions":[157],"associated":[158],"occur.":[161],"Results:":[162],"153":[163],"identified":[166,196],"analysis.":[169],"trained":[172],"datasets":[175],"top":[178],"ten":[179],"each":[182],"organochlorine":[183],"determined.":[185],"Pentose":[186],"phosphate":[187],"central":[190],"carbon":[191],"metabolism":[192,209,221],"cancer":[194],"as":[199,238],"common":[200],"all":[203],"organochlorines.":[204],"Alanine,":[205],"aspartate,":[206],"glutamate":[208],"suggested":[212],"endosulfan.":[217],"Taurine":[218],"hypotaurine":[220],"citrate":[225],"cycle":[226],"organochlorine\u2019s":[229],"mixture.":[230],"GO":[231],"proposed":[233],"cytosol":[235],"exosomes":[237],"take":[245],"place.":[246],"Conclusions:":[247],"suggests":[253],"energy":[257],"production":[258],"some":[260],"amino":[261],"acid":[262],"synthesis":[263],"occasioned":[265],"exposure.":[269]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-12-31T00:00:00"}
