{"id":"https://openalex.org/W4200328429","doi":"https://doi.org/10.1016/j.xhgg.2021.100077","title":"Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes","display_name":"Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes","publication_year":2021,"publication_date":"2021-12-10","ids":{"openalex":"https://openalex.org/W4200328429","doi":"https://doi.org/10.1016/j.xhgg.2021.100077","pmid":"https://pubmed.ncbi.nlm.nih.gov/35047862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8756518"},"language":"en","primary_location":{"id":"doi:10.1016/j.xhgg.2021.100077","doi":"https://doi.org/10.1016/j.xhgg.2021.100077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2021.100077","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666247721000580/pdf","source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2666247721000580/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jungyoon Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungyoon Choi","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026156414","display_name":"Guochong Jia","orcid":"https://orcid.org/0000-0002-8455-1832","observed_orcids":["https://orcid.org/0000-0002-8455-1832"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guochong Jia","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086118402","display_name":"Wanqing Wen","orcid":"https://orcid.org/0000-0002-3004-5168","observed_orcids":["https://orcid.org/0000-0002-3004-5168"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanqing Wen","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087325326","display_name":"Ran Tao","orcid":"https://orcid.org/0000-0002-1106-2923","observed_orcids":["https://orcid.org/0000-0002-1106-2923"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Tao","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101592761","display_name":"Jirong Long","orcid":"https://orcid.org/0000-0002-7433-9766","observed_orcids":["https://orcid.org/0000-0002-7433-9766"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jirong Long","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085657415","display_name":"Xiao\u2010Ou Shu","orcid":"https://orcid.org/0000-0002-0711-8314","observed_orcids":["https://orcid.org/0000-0002-0711-8314"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Ou Shu","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401143","display_name":"Wei Zheng","orcid":"https://orcid.org/0000-0003-1226-070X","observed_orcids":["https://orcid.org/0000-0003-1226-070X","https://orcid.org/0000-0003-1034-0757","https://orcid.org/0009-0008-5993-0647"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Zheng","raw_affiliation_strings":["Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA"],"raw_orcid":"https://orcid.org/0000-0003-1226-070X","affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100401143"],"corresponding_institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.4235,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58669189,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"1","first_page":"100077","last_page":"100077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.4350999891757965,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7049999833106995},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9210000038146973},{"id":"https://openalex.org/keywords/shared-genetic-risk","display_name":"shared genetic risk","score":0.7279999852180481},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cancer-risk-variants","display_name":"cancer risk variants","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8131002187728882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6546869277954102},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6454979181289673},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6220006942749023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5603541731834412},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5573707818984985},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5070497989654541},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49265819787979126},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4546712636947632},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3401387929916382},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.27303647994995117},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.24712321162223816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15837189555168152},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14574724435806274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08466282486915588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xhgg.2021.100077","doi":"https://doi.org/10.1016/j.xhgg.2021.100077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2021.100077","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666247721000580/pdf","source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8756518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8756518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HGG Adv","raw_type":"Text"},{"id":"pmid:35047862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35047862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HGG advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6eb47e8a05144aa5b328e682a70e852d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6eb47e8a05144aa5b328e682a70e852d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HGG Advances, Vol 3, Iss 1, Pp 100077- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xhgg.2021.100077","doi":"https://doi.org/10.1016/j.xhgg.2021.100077","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xhgg.2021.100077","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666247721000580/pdf","source":{"id":"https://openalex.org/S4210200806","display_name":"Human Genetics and Genomics Advances","issn_l":"2666-2477","issn":["2666-2477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics and Genomics Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5026206600","display_name":null,"funder_award_id":"40685","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5331993534","display_name":"UK Biobank (core renewal)","funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7398219695","display_name":null,"funder_award_id":"40685","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8610864312","display_name":"Integrating genomic and transcriptomic data to identify breast cancer susceptibility genes","funder_award_id":"R01CA235553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000892074","display_name":"African-ancestry Breast Cancer Genetic Consortium","funder_award_id":"R01CA202981","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200328429.pdf","grobid_xml":"https://content.openalex.org/works/W4200328429.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1985550131","https://openalex.org/W1986230778","https://openalex.org/W1994664175","https://openalex.org/W2002715948","https://openalex.org/W2012379047","https://openalex.org/W2033151532","https://openalex.org/W2036145275","https://openalex.org/W2036307272","https://openalex.org/W2039310245","https://openalex.org/W2047200356","https://openalex.org/W2048352123","https://openalex.org/W2057621960","https://openalex.org/W2079712106","https://openalex.org/W2082190322","https://openalex.org/W2082326948","https://openalex.org/W2082704080","https://openalex.org/W2100518774","https://openalex.org/W2100989310","https://openalex.org/W2102213696","https://openalex.org/W2104549677","https://openalex.org/W2109887283","https://openalex.org/W2120232187","https://openalex.org/W2135665336","https://openalex.org/W2149473690","https://openalex.org/W2155533563","https://openalex.org/W2157043398","https://openalex.org/W2166702788","https://openalex.org/W2169248969","https://openalex.org/W2170137499","https://openalex.org/W2175278559","https://openalex.org/W2195783463","https://openalex.org/W2224210111","https://openalex.org/W2305720507","https://openalex.org/W2325363292","https://openalex.org/W2337707425","https://openalex.org/W2593940628","https://openalex.org/W2596634574","https://openalex.org/W2615555239","https://openalex.org/W2644301481","https://openalex.org/W2765253743","https://openalex.org/W2884572044","https://openalex.org/W2885684012","https://openalex.org/W2898585601","https://openalex.org/W2973641376","https://openalex.org/W2991007563","https://openalex.org/W3012141744","https://openalex.org/W3024294833","https://openalex.org/W3037682888","https://openalex.org/W3083488708","https://openalex.org/W3100475287","https://openalex.org/W3124119591","https://openalex.org/W3128061434","https://openalex.org/W3136202812","https://openalex.org/W4253754191","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W3128061434","https://openalex.org/W3037682888","https://openalex.org/W2398153610","https://openalex.org/W4403999043","https://openalex.org/W2901952863","https://openalex.org/W3012141744","https://openalex.org/W4411441806","https://openalex.org/W2593642799","https://openalex.org/W4391652229","https://openalex.org/W7135431641"],"abstract_inverted_index":{"Certain":[0],"genetic":[1,17,219,235],"variants":[2,36],"are":[3],"associated":[4,120,166,177],"with":[5,15,49,89,121,167,178,200,224],"risks":[6],"of":[7,21,46,69,86,115,125,132,195,206,221],"multiple":[8,249],"cancers.":[9,24,227,250],"We":[10,25,42],"investigated":[11],"breast":[12,50,90,117,170,180,197,222,238],"cancer":[13,51,91,118,149,158,174,181,198,223],"risk":[14,28,35,52,114,199,247],"overall":[16,116,196],"susceptibility":[18,220],"to":[19,82,106],"each":[20,87],"16":[22,32],"other":[23,226,240],"constructed":[26],"polygenic":[27],"scores":[29],"(PRS)":[30],"for":[31,128,146,202,217,237,248],"cancers":[33,131,205,241],"using":[34,57],"identified":[37],"by":[38,55,140],"genome-wide":[39],"association":[40,85],"studies.":[41],"evaluated":[43],"the":[44,84,95,108,126,133,144,192,207,234],"associations":[45,194],"these":[47],"PRSs":[48],"(overall":[53],"and":[54,66,75,101,130,156,204,210,239,242],"subtypes)":[56],"Breast":[58],"Cancer":[59],"Association":[60],"Consortium":[61],"data,":[62],"including":[63,98],"106,278":[64],"cases":[65,100],"91,477":[67],"controls":[68],"European":[70],"ancestry.":[71],"Odds":[72],"ratios":[73],"(OR)":[74],"95%":[76,153,162,185],"confidence":[77],"intervals":[78],"(CIs)":[79],"were":[80,104,165],"estimated":[81],"measure":[83],"PRS":[88,127,145,175,201],"risk.":[92],"Data":[93],"from":[94,229],"UK":[96,188],"Biobank,":[97],"4,337":[99],"209,983":[102],"non-cases,":[103],"used":[105],"replicate":[107],"findings.":[109],"A":[110],"5%-8%":[111],"significantly":[112],"elevated":[113],"was":[119,176],"per":[122],"unit":[123],"increase":[124],"glioma":[129],"corpus":[134,147],"uteri,":[135],"stomach,":[136,208],"or":[137],"colorectum.":[138],"Analyses":[139],"subtype":[141],"revealed":[142],"that":[143],"uteri":[148],"(OR":[150,159,182],"=":[151,160,183],"1.09;":[152],"CI,":[154,163,186],"1.03-1.15)":[155],"stomach":[157],"1.07;":[161],"1.03-1.12)":[164],"estrogen":[168],"receptor-positive":[169],"cancer,":[171],"while":[172],"ovarian":[173],"triple-negative":[179],"1.25;":[184],"1.01-1.55).":[187],"Biobank":[189],"data":[190],"supported":[191],"positive":[193],"melanoma":[203],"colorectum,":[209],"ovary.":[211],"Our":[212],"study":[213,231],"provides":[214],"strong":[215],"evidence":[216],"shared":[218],"several":[225],"Results":[228],"our":[230],"help":[232],"uncover":[233],"basis":[236],"identify":[243],"individuals":[244],"at":[245],"high":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-12-31T00:00:00"}