{"id":"https://openalex.org/W4200324431","doi":"https://doi.org/10.1016/j.jmoldx.2021.10.012","title":"Evaluating the Clinical Performance of a Dual-Target Stool DNA Test for Colorectal Cancer Detection","display_name":"Evaluating the Clinical Performance of a Dual-Target Stool DNA Test for Colorectal Cancer Detection","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200324431","doi":"https://doi.org/10.1016/j.jmoldx.2021.10.012","pmid":"https://pubmed.ncbi.nlm.nih.gov/34890778"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmoldx.2021.10.012","doi":"https://doi.org/10.1016/j.jmoldx.2021.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2021.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jmoldx.2021.10.012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079292792","display_name":"Kangkang Wan","orcid":"https://orcid.org/0000-0002-9139-0707","observed_orcids":["https://orcid.org/0000-0002-9139-0707"]},"institutions":[{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongxin Wang","raw_affiliation_strings":["Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China","institution_ids":["https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Shang","raw_affiliation_strings":["Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China","Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]},{"raw_affiliation_string":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]},{"raw_affiliation_string":"Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101715956","display_name":"Guannan Zhang","orcid":"https://orcid.org/0000-0001-7733-826X","observed_orcids":["https://orcid.org/0000-0001-7733-826X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guannan Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lingjun Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjun Kong","raw_affiliation_strings":["Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582451","display_name":"Feng Zhang","orcid":"https://orcid.org/0000-0003-4902-8955","observed_orcids":["https://orcid.org/0000-0003-4902-8955"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026009881","display_name":"Ye Guo","orcid":"https://orcid.org/0000-0002-1813-9815","observed_orcids":["https://orcid.org/0000-0002-1813-9815"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Guo","raw_affiliation_strings":["Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090791245","display_name":"Yaling Dou","orcid":"https://orcid.org/0000-0001-5240-2384","observed_orcids":["https://orcid.org/0000-0001-5240-2384"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yaling Dou","raw_affiliation_strings":["Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: pumchdyl67@163.com","Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-5240-2384","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: pumchdyl67@163.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100684205","display_name":"Jun Lin","orcid":"https://orcid.org/0000-0002-5152-6518","observed_orcids":["https://orcid.org/0000-0002-5152-6518"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Lin","raw_affiliation_strings":["Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: linjun5478@163.com","Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: linjun5478@163.com","institution_ids":["https://openalex.org/I4210120234"]},{"raw_affiliation_string":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090791245","https://openalex.org/A5100684205"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662","https://openalex.org/I4210120234"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.7007,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88057875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"131","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer-detection","display_name":"colorectal cancer detection","score":0.9649999737739563},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.6069999933242798},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/fecal-dna-testing","display_name":"fecal DNA testing","score":0.49799999594688416},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.722000002861023},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cancer-surveillance","display_name":"cancer surveillance","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7832747101783752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7190517783164978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6904644966125488},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.6866657733917236},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.5219489932060242},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5164015889167786},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4441242218017578},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4225681722164154},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.19298571348190308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1379472315311432},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.109781414270401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06360208988189697}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jmoldx.2021.10.012","doi":"https://doi.org/10.1016/j.jmoldx.2021.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2021.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},{"id":"doi:10.1101/2021.03.10.21252951","doi":"https://doi.org/10.1101/2021.03.10.21252951","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.03.10.21252951","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/03/24/2021.03.10.21252951.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:34890778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34890778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of molecular diagnostics : JMD","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jmoldx.2021.10.012","doi":"https://doi.org/10.1016/j.jmoldx.2021.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2021.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200324431.pdf","grobid_xml":"https://content.openalex.org/works/W4200324431.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1934094702","https://openalex.org/W1984646383","https://openalex.org/W1990118688","https://openalex.org/W2020150058","https://openalex.org/W2023611112","https://openalex.org/W2030464212","https://openalex.org/W2032563963","https://openalex.org/W2038400317","https://openalex.org/W2065434214","https://openalex.org/W2084914098","https://openalex.org/W2087178629","https://openalex.org/W2095707035","https://openalex.org/W2099828433","https://openalex.org/W2103461959","https://openalex.org/W2111853146","https://openalex.org/W2113029107","https://openalex.org/W2141671690","https://openalex.org/W2147072570","https://openalex.org/W2159078264","https://openalex.org/W2164791558","https://openalex.org/W2339833938","https://openalex.org/W2341881865","https://openalex.org/W2484161709","https://openalex.org/W2542519792","https://openalex.org/W2557371741","https://openalex.org/W2578240158","https://openalex.org/W2584928759","https://openalex.org/W2604095865","https://openalex.org/W2624746969","https://openalex.org/W2756213969","https://openalex.org/W2766519221","https://openalex.org/W2772386530","https://openalex.org/W2800289222","https://openalex.org/W2800890282","https://openalex.org/W2803014819","https://openalex.org/W2805885226","https://openalex.org/W2883190858","https://openalex.org/W2887029183","https://openalex.org/W2899262668","https://openalex.org/W2909571268","https://openalex.org/W2911667253","https://openalex.org/W2940062333","https://openalex.org/W2943606118","https://openalex.org/W2948807690","https://openalex.org/W2958805177","https://openalex.org/W2983668961","https://openalex.org/W3004424038","https://openalex.org/W3020992444","https://openalex.org/W3047666369","https://openalex.org/W3095421680","https://openalex.org/W3126974743","https://openalex.org/W3173908225","https://openalex.org/W4220766329","https://openalex.org/W6681082847"],"related_works":["https://openalex.org/W3095421680","https://openalex.org/W3082164030","https://openalex.org/W7165166350","https://openalex.org/W4223924299","https://openalex.org/W2940062333","https://openalex.org/W4401749635","https://openalex.org/W4313827152","https://openalex.org/W3118686608","https://openalex.org/W2137888576","https://openalex.org/W3158347011"],"abstract_inverted_index":{"The":[0,63,84,98,163,191],"dual-target":[1],"stool":[2],"DNA":[3],"test,":[4],"iColocomf,":[5],"has":[6,18],"potential":[7,205],"utility":[8],"for":[9,102,134,168,181,197],"colorectal":[10,202],"cancer":[11,203],"(CRC)":[12],"detection,":[13],"but":[14],"its":[15],"clinical":[16,35,140,209],"accuracy":[17,70,112,165],"not":[19],"been":[20],"validated":[21],"on":[22],"larger":[23],"groups.":[24],"We":[25],"therefore":[26],"evaluated":[27],"the":[28,82,117,120,135,156,169,186,198],"performance":[29,196],"of":[30,66,75,95,113,128,172,201],"iColocomf":[31,192],"in":[32,137,208],"a":[33],"multicenter":[34],"trial.":[36],"In":[37],"this":[38],"double-blinded":[39],"case-control":[40],"study,":[41],"1164":[42],"participants":[43,76,183],"from":[44],"three":[45],"independent":[46],"hospitals,":[47],"including":[48],"320":[49],"CRC":[50,103],"patients,":[51],"148":[52],"adenomas,":[53],"396":[54],"interfering":[55,118],"diseases,":[56,119],"and":[57,69,79,93,100,107,149,160,179,204],"300":[58],"healthy":[59],"controls":[60],"were":[61,71,77,87,105,132,158],"enrolled.":[62],"primary":[64],"indicators":[65],"sensitivity,":[67],"specificity,":[68],"estimated.":[72],"Stool":[73],"samples":[74,174],"collected":[78],"tested":[80],"by":[81,90,176],"assay.":[83],"test":[85,136,187,193],"results":[86],"then":[88],"verified":[89,175],"Sanger":[91,177],"sequencing":[92],"retesting":[94],"resected":[96],"participants.":[97],"sensitivity":[99],"specificity":[101,121],"detection":[104,130,200],"95.31%":[106],"96.67%,":[108],"respectively,":[109],"with":[110],"an":[111],"90.29%.":[114],"When":[115],"combining":[116],"was":[122,166],"88.39%.":[123],"No":[124],"statistically":[125],"significant":[126],"variations":[127],"positive":[129],"rates":[131],"observed":[133],"different":[138],"patients'":[139],"features.":[141],"For":[142],"advanced":[143],"adenomas":[144,151],"(":[145,152],"n":[146,153],"=":[147,154],"38)":[148],"nonadvanced":[150],"110),":[155],"sensitivities":[157],"63.16%":[159],"33.64%,":[161],"respectively.":[162],"average":[164],"99.62%":[167],"methylation":[170],"status":[171],"375":[173],"sequencing,":[178],"94.12%":[180],"34":[182],"who":[184],"received":[185],"after":[188],"surgical":[189],"resection.":[190],"showed":[194],"robust":[195],"early":[199],"monitoring":[206],"ability":[207],"practice.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-12-31T00:00:00"}