{"id":"https://openalex.org/W4200323231","doi":"https://doi.org/10.1039/d1fo02216d","title":"Neuroprotection of chicoric acid in a mouse model of Parkinson's disease involves gut microbiota and TLR4 signaling pathway","display_name":"Neuroprotection of chicoric acid in a mouse model of Parkinson's disease involves gut microbiota and TLR4 signaling pathway","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4200323231","doi":"https://doi.org/10.1039/d1fo02216d","pmid":"https://pubmed.ncbi.nlm.nih.gov/35103734"},"language":"en","primary_location":{"id":"doi:10.1039/d1fo02216d","doi":"https://doi.org/10.1039/d1fo02216d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1fo02216d","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Function","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100678969","display_name":"Ning Wang","orcid":"https://orcid.org/0000-0001-5287-5755","observed_orcids":["https://orcid.org/0000-0001-5287-5755"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109428704","display_name":"Bainian Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bai-Nian Feng","raw_affiliation_strings":["School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Hu","raw_affiliation_strings":["School of Biotechnology, Jiangnan University, Wuxi 214122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012496376","display_name":"Yuliang Cheng","orcid":"https://orcid.org/0000-0002-9616-7133","observed_orcids":["https://orcid.org/0000-0002-9616-7133","https://orcid.org/0000-0002-4510-882X"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Liang Cheng","raw_affiliation_strings":["School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"],"raw_orcid":"https://orcid.org/0000-0002-4510-882X","affiliations":[{"raw_affiliation_string":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001096197","display_name":"Yahui Guo","orcid":"https://orcid.org/0000-0002-6512-355X","observed_orcids":["https://orcid.org/0000-0002-6512-355X"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ya-Hui Guo","raw_affiliation_strings":["School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"],"raw_orcid":"https://orcid.org/0000-0002-6512-355X","affiliations":[{"raw_affiliation_string":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100746959","display_name":"He Qian","orcid":"https://orcid.org/0000-0003-1447-3776","observed_orcids":["https://orcid.org/0000-0003-1447-3776"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"He Qian","raw_affiliation_strings":["School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"],"raw_orcid":"https://orcid.org/0000-0003-1447-3776","affiliations":[{"raw_affiliation_string":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001096197","https://openalex.org/A5100746959"],"corresponding_institution_ids":["https://openalex.org/I111599522"],"apc_list":null,"apc_paid":null,"fwci":4.1156,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.95744646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"4","first_page":"2019","last_page":"2032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chicoric-acid","display_name":"chicoric acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":1.0},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/echinacea-purpurea","display_name":"Echinacea purpurea","score":0.8169999718666077},{"id":"https://openalex.org/keywords/chicory","display_name":"chicory","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7062675952911377},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6801282167434692},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.6745261549949646},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6264930963516235},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.5823502540588379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5343778133392334},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5239080190658569},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4911329448223114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3938778340816498},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3729765713214874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2549315392971039},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.25146782398223877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22025513648986816},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1985900104045868},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.15719833970069885}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020900","descriptor_name":"Echinacea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d1fo02216d","doi":"https://doi.org/10.1039/d1fo02216d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1fo02216d","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Function","raw_type":"journal-article"},{"id":"pmid:35103734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35103734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & function","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1149904523","display_name":null,"funder_award_id":"2017YFC1601704","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1582832380","https://openalex.org/W1953875876","https://openalex.org/W1979237351","https://openalex.org/W1988825846","https://openalex.org/W2008121559","https://openalex.org/W2015851283","https://openalex.org/W2019419945","https://openalex.org/W2022911097","https://openalex.org/W2030093136","https://openalex.org/W2062118842","https://openalex.org/W2062607366","https://openalex.org/W2079183971","https://openalex.org/W2083851628","https://openalex.org/W2088350637","https://openalex.org/W2094486011","https://openalex.org/W2103108588","https://openalex.org/W2109113634","https://openalex.org/W2112663559","https://openalex.org/W2148546434","https://openalex.org/W2155058651","https://openalex.org/W2155134319","https://openalex.org/W2156179625","https://openalex.org/W2336585584","https://openalex.org/W2342778169","https://openalex.org/W2558041282","https://openalex.org/W2563999700","https://openalex.org/W2582783317","https://openalex.org/W2599142662","https://openalex.org/W2603444149","https://openalex.org/W2695618445","https://openalex.org/W2737588504","https://openalex.org/W2739158355","https://openalex.org/W2754204730","https://openalex.org/W2761210275","https://openalex.org/W2780486569","https://openalex.org/W2790781105","https://openalex.org/W2791832333","https://openalex.org/W2800577687","https://openalex.org/W2890721699","https://openalex.org/W2904412904","https://openalex.org/W2906111512","https://openalex.org/W2906418973","https://openalex.org/W2922659213","https://openalex.org/W2946372752","https://openalex.org/W2951518977","https://openalex.org/W2965437143","https://openalex.org/W2968189861","https://openalex.org/W2994997584","https://openalex.org/W2998789609","https://openalex.org/W3002021571","https://openalex.org/W3008574333","https://openalex.org/W3088079880","https://openalex.org/W3093492766","https://openalex.org/W3111683082","https://openalex.org/W3116658172"],"related_works":["https://openalex.org/W3159262492","https://openalex.org/W4213149094","https://openalex.org/W2563999700","https://openalex.org/W2566109786","https://openalex.org/W4392858756","https://openalex.org/W7125816780","https://openalex.org/W4367059357","https://openalex.org/W4408780173","https://openalex.org/W7170415595","https://openalex.org/W2739158355"],"abstract_inverted_index":{"Chicoric":[0],"acid":[1,5],"(CA),":[2],"a":[3,20],"polyphenolic":[4],"obtained":[6],"from":[7],"chicory":[8],"and":[9,26],"purple":[10],"coneflower":[11],"(":[12],"Echinacea":[13],"purpurea":[14],"),":[15],"has":[16],"been":[17],"regarded":[18],"as":[19],"nutraceutical":[21],"to":[22],"combat":[23],"inflammation,":[24],"viruses":[25],"obesity.":[27]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}
