{"id":"https://openalex.org/W4200322352","doi":"https://doi.org/10.1002/14651858.cd006466.pub7","title":"Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation","display_name":"Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W4200322352","doi":"https://doi.org/10.1002/14651858.cd006466.pub7"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd006466.pub7","doi":"https://doi.org/10.1002/14651858.cd006466.pub7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd006466.pub7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013491140","display_name":"Lara A Kahale","orcid":"https://orcid.org/0000-0003-4466-0556","observed_orcids":["https://orcid.org/0000-0003-4466-0556"]},"institutions":[{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Lara A Kahale","raw_affiliation_strings":["Faculty of Medicine; American University of Beirut; Beirut Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine; American University of Beirut; Beirut Lebanon","institution_ids":["https://openalex.org/I98635879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024459640","display_name":"Charbel Fadi Matar","orcid":"https://orcid.org/0000-0001-7105-7408","observed_orcids":["https://orcid.org/0000-0001-7105-7408"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charbel F Matar","raw_affiliation_strings":["Department of Internal Medicine; University of Connecticut School of Medicine; Farmington Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine; University of Connecticut School of Medicine; Farmington Connecticut USA","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026324699","display_name":"Ibrahim G Tsolakian","orcid":"https://orcid.org/0000-0002-6761-8986","observed_orcids":["https://orcid.org/0000-0002-6761-8986"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim G Tsolakian","raw_affiliation_strings":["Department of Obstetrics and Gynaecology; Univeristy of Toledo; Toledo Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology; Univeristy of Toledo; Toledo Ohio USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090182271","display_name":"Maram B Hakoum","orcid":"https://orcid.org/0000-0003-0105-1937","observed_orcids":["https://orcid.org/0000-0003-0105-1937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maram B Hakoum","raw_affiliation_strings":["Department of Family Medicine; Cornerstone Care Teaching Health Center; Mt. Morris Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine; Cornerstone Care Teaching Health Center; Mt. Morris Pennsylvania USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065403219","display_name":"Maddalena Barba","orcid":"https://orcid.org/0000-0001-9050-2917","observed_orcids":["https://orcid.org/0000-0001-9050-2917"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maddalena Barba","raw_affiliation_strings":["Division of Medical Oncology 2 - Scientific Direction; IRCCS Regina Elena National Cancer Institute; Rome Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology 2 - Scientific Direction; IRCCS Regina Elena National Cancer Institute; Rome Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087847130","display_name":"Victor E D Yosuico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108581","display_name":"Buffalo Medical Group","ror":"https://ror.org/01w5s1t11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210108581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor ED Yosuico","raw_affiliation_strings":["Buffalo Medical Group; Buffalo New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Medical Group; Buffalo New York USA","institution_ids":["https://openalex.org/I4210108581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084919462","display_name":"Irene Terrenato","orcid":"https://orcid.org/0000-0002-0187-9323","observed_orcids":["https://orcid.org/0000-0002-0187-9323"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Terrenato","raw_affiliation_strings":["Biostatistics and Bioinformatic Unit; IRCCS Regina Elena National Cancer Institute; Rome Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatic Unit; IRCCS Regina Elena National Cancer Institute; Rome Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082149678","display_name":"Francesca Sperati","orcid":"https://orcid.org/0000-0002-6038-2798","observed_orcids":["https://orcid.org/0000-0002-6038-2798"]},"institutions":[{"id":"https://openalex.org/I4210141574","display_name":"San Gallicano Hospital","ror":"https://ror.org/03zhmy467","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210137471","https://openalex.org/I4210141574","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Sperati","raw_affiliation_strings":["Biostatistics and Bioinformatic Unit; San\u00a0Gallicano Dermatological Institute IRCCS\u00a0; Rome Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatic Unit; San\u00a0Gallicano Dermatological Institute IRCCS\u00a0; Rome Italy","institution_ids":["https://openalex.org/I4210141574","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071868716","display_name":"Holger Jens Sch\u00fcnemann","orcid":"https://orcid.org/0000-0003-3211-8479","observed_orcids":["https://orcid.org/0000-0003-3211-8479"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Holger Sch\u00fcnemann","raw_affiliation_strings":["Department of Health Research Methods, Evidence, and Impact; McMaster University; Hamilton Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Research Methods, Evidence, and Impact; McMaster University; Hamilton Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041615321","display_name":"Elie A. Akl","orcid":"https://orcid.org/0000-0002-3444-8618","observed_orcids":["https://orcid.org/0000-0002-3444-8618"]},"institutions":[{"id":"https://openalex.org/I4210104580","display_name":"American University of Beirut Medical Center","ror":"https://ror.org/00wmm6v75","country_code":"LB","type":"healthcare","lineage":["https://openalex.org/I4210104580"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Elie A Akl","raw_affiliation_strings":["Department of Internal Medicine; American University of Beirut Medical Center; Beirut Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine; American University of Beirut Medical Center; Beirut Lebanon","institution_ids":["https://openalex.org/I4210104580"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.1151,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.16864608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2023","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.699999988079071},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.9639999866485596},{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apixaban","display_name":"apixaban","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":1.0},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.7770000100135803},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.9049999713897705},{"id":"https://openalex.org/keywords/minor-bleeding","display_name":"minor bleeding","score":0.75},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.718999981880188},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9340506196022034},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4804094135761261},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48024943470954895},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.46935635805130005},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4468221068382263},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4433210492134094},{"id":"https://openalex.org/C2780638905","wikidata":"https://www.wikidata.org/wiki/Q414462","display_name":"Apixaban","level":5,"score":0.43279367685317993},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.42212122678756714},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4190976023674011},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41629162430763245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3800221383571625},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.3317086696624756},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.2621120810508728},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.1074070930480957},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/14651858.cd006466.pub7","doi":"https://doi.org/10.1002/14651858.cd006466.pub7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd006466.pub7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W179182397","https://openalex.org/W1516783539","https://openalex.org/W1784175517","https://openalex.org/W1847026520","https://openalex.org/W1863488026","https://openalex.org/W1895600627","https://openalex.org/W1963654054","https://openalex.org/W1968399105","https://openalex.org/W1977149417","https://openalex.org/W1980358129","https://openalex.org/W1990154448","https://openalex.org/W1992661527","https://openalex.org/W1995391277","https://openalex.org/W2000287607","https://openalex.org/W2002938738","https://openalex.org/W2012934272","https://openalex.org/W2013945874","https://openalex.org/W2019336592","https://openalex.org/W2028608222","https://openalex.org/W2030512823","https://openalex.org/W2052685518","https://openalex.org/W2059459105","https://openalex.org/W2065378584","https://openalex.org/W2068476516","https://openalex.org/W2071682406","https://openalex.org/W2076903503","https://openalex.org/W2083815143","https://openalex.org/W2085354161","https://openalex.org/W2100184560","https://openalex.org/W2102537088","https://openalex.org/W2103969621","https://openalex.org/W2107328434","https://openalex.org/W2109042377","https://openalex.org/W2112878705","https://openalex.org/W2116435978","https://openalex.org/W2120130633","https://openalex.org/W2124101267","https://openalex.org/W2125435699","https://openalex.org/W2129670822","https://openalex.org/W2133172137","https://openalex.org/W2134683286","https://openalex.org/W2137283681","https://openalex.org/W2139335996","https://openalex.org/W2140155526","https://openalex.org/W2141713306","https://openalex.org/W2158961472","https://openalex.org/W2196970594","https://openalex.org/W2288516595","https://openalex.org/W2314203153","https://openalex.org/W2337548499","https://openalex.org/W2419072237","https://openalex.org/W2512998317","https://openalex.org/W2579916850","https://openalex.org/W2615921597","https://openalex.org/W2619694921","https://openalex.org/W2754128910","https://openalex.org/W2755158184","https://openalex.org/W2767140416","https://openalex.org/W2791748396","https://openalex.org/W2795600571","https://openalex.org/W2802130786","https://openalex.org/W2883411530","https://openalex.org/W2902078827","https://openalex.org/W2917722773","https://openalex.org/W2945618666","https://openalex.org/W2954042561","https://openalex.org/W2955623082","https://openalex.org/W2959374711","https://openalex.org/W2964249631","https://openalex.org/W2968482725","https://openalex.org/W2980266010","https://openalex.org/W2983079501","https://openalex.org/W3080748956","https://openalex.org/W3095655536","https://openalex.org/W3113132170","https://openalex.org/W3139398038","https://openalex.org/W4230312308","https://openalex.org/W4241106625","https://openalex.org/W4245126545","https://openalex.org/W4245308645","https://openalex.org/W4246868134","https://openalex.org/W4251308593","https://openalex.org/W4322697128"],"related_works":["https://openalex.org/W4241106625","https://openalex.org/W1516783539","https://openalex.org/W4205166577","https://openalex.org/W2146022474","https://openalex.org/W2968482725","https://openalex.org/W4285493442","https://openalex.org/W2898577441","https://openalex.org/W3003234659","https://openalex.org/W2745607314","https://openalex.org/W2411090823"],"abstract_inverted_index":{"Background":[0],"Oral":[1],"anticoagulants":[2,30,148,528],"may":[3,642],"improve":[4],"the":[5,17,24,68,82,107,136,160,244,252,264,288,381,392,398,557,686,694,701,710,719,744,760,765,772],"survival":[6],"of":[7,19,28,96,106,140,162,214,218,221,240,246,278,383,400,559,696,703,712,721,768,775],"people":[8,33,152,168,671],"with":[9,34,48,153,672],"cancer":[10,35,154,673],"through":[11],"an":[12],"antithrombotic":[13],"effect,":[14],"yet":[15],"increase":[16,460,617,643],"risk":[18,217,333,558,720],"bleeding.":[20,723],"Objectives":[21],"To":[22],"evaluate":[23],"efficacy":[25],"and":[26,99,117,138,196,216,237,281,349,409,462,492,641],"safety":[27],"oral":[29,147,268,284,527],"in":[31,46,73,150,165,276,287,684,705,714,742,764],"ambulatory":[32,151,670],"undergoing":[36,171,674],"chemotherapy,":[37,177,675],"targeted":[38,178,676],"therapy,":[39,174,179,677],"immunotherapy,":[40,180,678],"or":[41,45,52,145,181,189,304,679,683],"radiotherapy":[42,680],"(either":[43,681],"alone":[44,682],"combination),":[47,685],"no":[49,186,305,309,388,404,519,565],"standard":[50,187],"therapeutic":[51,188],"prophylactic":[53,190],"indication":[54,191],"for":[55,101,192,248,489,514,771],"anticoagulation.":[56,193],"Search":[57],"methods":[58],"We":[59,79,129,242],"conducted":[60],"comprehensive":[61],"searches":[62,71,116],"on":[63,208,390,406,689],"14":[64],"June":[65],"2021,":[66],"following":[67,83],"original":[69],"electronic":[70],"performed":[72],"February":[74],"2016":[75],"(last":[76],"major":[77,233,461,490,618,697,722],"search).":[78],"electronically":[80],"searched":[81,100],"databases:":[84],"CENTRAL,":[85],"MEDLINE,":[86],"Embase.":[87],"In":[88,669],"addition,":[89],"we":[90,112],"handsearched":[91],"conference":[92],"proceedings,":[93],"checked":[94],"references":[95],"included":[97,130,223],"studies,":[98],"ongoing":[102],"studies.":[103],"As":[104],"part":[105],"living":[108,729],"systematic":[109,730,733],"review":[110,203,740,745],"approach,":[111],"are":[113,169],"running":[114],"continual":[115],"will":[118],"incorporate":[119],"new":[120,737,751],"evidence":[121,247,393,488,513,688],"rapidly":[122],"after":[123],"it":[124,754],"is":[125,727,746],"identified.":[126],"Selection":[127],"criteria":[128],"randomised":[131],"controlled":[132],"trials":[133],"(RCTs)":[134],"assessing":[135],"benefits":[137],"harms":[139],"vitamin":[141,272,311],"K":[142,273,312],"antagonists":[143,313],"(VKAs)":[144,314],"direct":[146,283,526],"(DOACs)":[149,529],"(i.e.,":[155],"not":[156,616],"hospital":[157],"inpatients":[158],"during":[159],"time":[161],"their":[163],"participation":[164],"trials)":[166],"These":[167],"typically":[170],"systemic":[172],"anticancer":[173],"possibly":[175],"including":[176],"radiotherapy,":[182],"but":[183],"otherwise":[184],"have":[185],"Data":[194],"collection":[195],"analysis":[197],"Using":[198],"a":[199,271,282,384,728,736],"standardised":[200],"form,":[201],"two":[202],"authors":[204],"independently":[205],"extracted":[206],"data":[207],"study":[209,379],"design,":[210],"participants,":[211],"intervention":[212],"outcomes":[213],"interest,":[215],"bias.":[219],"Outcomes":[220],"interest":[222],"all\u2010cause":[224],"mortality,":[225],"pulmonary":[226,407,560],"embolism,":[227],"symptomatic":[228,410,590],"deep":[229],"vein":[230],"thrombosis":[231],"(DVT),":[232],"bleeding,":[234,491],"minor":[235,463,515,644],"bleeding":[236,464,619,645,698],"health\u2010related":[238],"quality":[239],"life.":[241],"assessed":[243,380],"certainty":[245],"each":[249],"outcome":[250],"using":[251],"GRADE":[253],"approach.":[254],"Main":[255],"results":[256],"Of":[257],"12,620":[258],"identified":[259],"citations,":[260],"10":[261,660],"RCTs":[262,291],"fulfilled":[263],"inclusion":[265],"criteria.":[266],"The":[267,299],"anticoagulant":[269,285],"was":[270,301,394],"antagonist":[274],"(VKA)":[275],"six":[277,319,524],"these":[279],"RCTs,":[280],"(DOAC)":[286],"remaining":[289],"four":[290],"(three":[292],"studies":[293],"used":[294,297],"apixaban;":[295],"one":[296],"rivaroxaban).":[298],"comparator":[300],"either":[302],"placebo":[303],"prophylaxis.":[306],"Compared":[307,517],"to":[308,331,344,362,373,387,403,417,428,439,450,473,484,498,509,518,523,539,550,564,572,583,598,609,625,636,651,662,739,759],"prophylaxis,":[310,520],"probably":[315,350,459,530,555,588,614],"reduce":[316,351,531,556,589],"mortality":[317,352,532],"at":[318,353,465,521],"months":[320,355,467],"slightly":[321,356,533,562,592],"(risk":[322],"ratio":[323],"(RR)":[324],"0.93,":[325],"95%":[326,340,359,369,414,424,436,446,470,480,495,505,536,546,569,579,595,605,622,632,648,658],"confidence":[327],"interval":[328],"(CI)":[329],"0.77":[330],"1.13;":[332],"difference":[334],"(RD)":[335],"22":[336],"fewer":[337,343,366,372,421,427,443,449,543,549,576,582,602,608,635,661],"per":[338,367,422,444,478,503,544,577,603,630,656],"1000,":[339,368,423,445,479,504,545,578,604,631,657],"CI":[341,360,370,415,425,437,447,471,481,496,506,537,547,570,580,596,606,623,633,649,659],"72":[342],"41":[345],"more;":[346,375,430,452,486,511,552,611,638,664],"moderate\u2010certainty":[347,376,487,512,553,586,612,639],"evidence),":[348,554,587,613,640],"12":[354,466],"(RR":[357,412,468,534,567,593,620,646],"0.95,":[358],"0.87":[361],"1.03;":[363],"RD":[364,419,441,475,500,541,574,600,627,653],"29":[365],"75":[371],"17":[374],"evidence).":[377,666],"One":[378],"effect":[382,399],"VKA":[385,401,405,690],"compared":[386,402,563],"prophylaxis":[389,566],"thrombosis;":[391],"very":[395,431,453],"uncertain":[396],"about":[397],"embolism":[408,561],"DVT":[411,591],"1.05,":[413],"0.07":[416],"16.58;":[418],"0":[420],"6":[426],"98":[429],"low\u2010certainty":[432,454,665],"evidence;":[433],"RR":[434,493],"0.08,":[435],"0.01":[438],"1.42;":[440],"35":[442,581,607],"37":[448],"16":[451],"evidence,":[455,752],"respectively).":[456],"Also,":[457],"VKAs":[458],"2.93,":[469],"1.86":[472],"4.62;":[474],"107":[476],"more":[477,483,502,508,629,655],"48":[482],"201":[485],"3.14,":[494],"1.85":[497],"5.32;":[499],"167":[501],"66":[507],"337":[510],"bleeding).":[516],"three":[522],"months,":[525],"0.94,":[535],"0.64":[538],"1.38,":[540],"11":[542],"67":[548],"70":[551],"0.48,":[568],"0.24":[571],"0.98;":[573],"24":[575],"1":[584],"fewer;":[585],"0.58,":[594],"0.30":[597],"1.15;":[599],"21":[601],"8":[610],"do":[615],"1.65,":[621],"0.72":[624],"3.80;":[626],"9":[628],"4":[634],"40":[637],"3.58,":[647],"0.55":[650],"23.44;":[652],"55":[654],"482":[663],"Authors'":[667],"conclusions":[668],"current":[687,773],"thromboprophylaxis":[691],"suggests":[692],"that":[693],"harm":[695],"might":[699],"outweigh":[700],"benefit":[702,711],"reduction":[704,713],"venous":[706,715],"thromboembolism.":[707],"With":[708],"DOACs,":[709],"thromboembolic":[716],"events":[717],"outweighs":[718],"Editorial":[724],"note:":[725],"this":[726,776],"review.":[731,777],"Living":[732],"reviews":[734],"offer":[735],"approach":[738],"updating":[741],"which":[743],"continually":[747],"updated,":[748],"incorporating":[749],"relevant":[750],"as":[753],"becomes":[755],"available.":[756],"Please":[757],"refer":[758],"'What's":[761],"new'":[762],"section":[763],"Cochrane":[766],"Database":[767],"Systematic":[769],"Reviews":[770],"status":[774]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-12-31T00:00:00"}