{"id":"https://openalex.org/W4200320691","doi":"https://doi.org/10.1093/noajnl/vdab159.071","title":"NI-8 Molecular diagnostic prediction combining T2-FLAIR mismatch sign, calcification, and methionine PET in grade II and III gliomas","display_name":"NI-8 Molecular diagnostic prediction combining T2-FLAIR mismatch sign, calcification, and methionine PET in grade II and III gliomas","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200320691","doi":"https://doi.org/10.1093/noajnl/vdab159.071","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8648179"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdab159.071","doi":"https://doi.org/10.1093/noajnl/vdab159.071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.071","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537189/vdab159.071.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537189/vdab159.071.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083011984","display_name":"Yusuke Ebiko","orcid":"https://orcid.org/0000-0001-7861-0202","observed_orcids":["https://orcid.org/0000-0001-7861-0202"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210153859","display_name":"Soka Municipal Hospital","ror":"https://ror.org/0540c8n94","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153859"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Ebiko","raw_affiliation_strings":["Department of Neurosurgery, Soka Municipal Hospital","Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Soka Municipal Hospital","institution_ids":["https://openalex.org/I4210153859"]},{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011930120","display_name":"Kaoru Tamura","orcid":"https://orcid.org/0000-0002-7943-5458","observed_orcids":["https://orcid.org/0000-0002-7943-5458"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Tamura","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039440545","display_name":"Shoko Hara","orcid":"https://orcid.org/0000-0003-1097-2738","observed_orcids":["https://orcid.org/0000-0003-1097-2738"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoko Hara","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045738456","display_name":"Motoki Inaji","orcid":"https://orcid.org/0000-0002-6759-5729","observed_orcids":["https://orcid.org/0000-0002-6759-5729"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoki Inaji","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036336235","display_name":"Yoji Tanaka","orcid":"https://orcid.org/0000-0002-2433-924X","observed_orcids":["https://orcid.org/0000-0002-2433-924X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Tanaka","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045616103","display_name":"Tadashi Nariai","orcid":"https://orcid.org/0000-0001-8819-4855","observed_orcids":["https://orcid.org/0000-0001-8819-4855"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nariai","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074027917","display_name":"Kenji Ishii","orcid":"https://orcid.org/0000-0002-2928-0072","observed_orcids":["https://orcid.org/0000-0002-2928-0072"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Ishii","raw_affiliation_strings":["Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041515292","display_name":"Taketoshi Maehara","orcid":"https://orcid.org/0000-0001-6804-4665","observed_orcids":["https://orcid.org/0000-0001-6804-4665"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketoshi Maehara","raw_affiliation_strings":["Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2142,"currency":"USD","value_usd":2142},"apc_paid":{"value":2142,"currency":"USD","value_usd":2142},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"Supplement_6","first_page":"vi19","last_page":"vi19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oma","display_name":"OMA","score":0.6729999780654907},{"id":"https://openalex.org/keywords/t2-flair-mismatch-sign","display_name":"T2-FLAIR mismatch sign","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-calcification","display_name":"tumor calcification","score":0.9739999771118164},{"id":"https://openalex.org/keywords/methionine-pet","display_name":"methionine PET","score":0.9860000014305115},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9739999771118164},{"id":"https://openalex.org/keywords/2016-who-classification","display_name":"WHO 2016 classification","score":0.7739999890327454},{"id":"https://openalex.org/keywords/grade-ii-glioma","display_name":"grade II glioma","score":0.6460000276565552},{"id":"https://openalex.org/keywords/grade-iii-glioma","display_name":"grade III glioma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/astrocytic-tumors","display_name":"astrocytic tumors","score":0.6880000233650208},{"id":"https://openalex.org/keywords/oligodendroglial-tumors","display_name":"oligodendroglial tumors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diagnostic-prediction-model","display_name":"diagnostic prediction model","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C101070640","wikidata":"https://www.wikidata.org/wiki/Q3737215","display_name":"Fluid-attenuated inversion recovery","level":3,"score":0.8065718412399292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6656659245491028},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6409699320793152},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.5782730579376221},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.48236721754074097},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4290356934070587},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4048125743865967},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.32036495208740234},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08233523368835449}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/noajnl/vdab159.071","doi":"https://doi.org/10.1093/noajnl/vdab159.071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.071","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537189/vdab159.071.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8648179","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8648179/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdab159.071","doi":"https://doi.org/10.1093/noajnl/vdab159.071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdab159.071","pdf_url":"https://academic.oup.com/noa/article-pdf/3/Supplement_6/vi19/41537189/vdab159.071.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200320691.pdf","grobid_xml":"https://content.openalex.org/works/W4200320691.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3106987776","https://openalex.org/W4375956182","https://openalex.org/W3026813010","https://openalex.org/W4385897481","https://openalex.org/W4389522455","https://openalex.org/W4281383900","https://openalex.org/W2989238685","https://openalex.org/W4221017282","https://openalex.org/W2741009225","https://openalex.org/W2999549459"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,126],"2016":[3],"WHO":[4],"Classification":[5],"classified":[6],"grade":[7,47,287],"II":[8,48,288],"and":[9,23,33,49,57,95,104,120,171,194,212,220,228,245,254,264,276,289],"III":[10,50,290],"gliomas":[11],"into":[12],"three":[13],"molecular":[14,40,284],"subtypes":[15],"depending":[16],"on":[17],"the":[18,74,123,137,144,147,151,157,202,225,235,242],"presence":[19],"of":[20,73,116,130,150,156,272,286],"IDH":[21,96],"mutation":[22],"1p/19q":[24],"codeletion.":[25],"We":[26],"combined":[27],"T2-FLAIR":[28,117,160,203,226,243,273],"mismatch":[29,118,161],"sign,":[30],"tumor":[31,145,180],"calcification,":[32,275],"methionine":[34,131],"PET":[35],"uptake":[36,132,140],"to":[37,113],"examine":[38],"whether":[39],"diagnosis":[41,285],"could":[42],"be":[43,280],"predicted.":[44],"Methods:":[45],"53":[46,75,158],"glioma":[51],"patients":[52],"with":[53],"preoperative":[54,283],"MRI,":[55],"CT,":[56],"MET-PET":[58,207,249,277],"who":[59],"underwent":[60],"surgical":[61],"resection":[62],"or":[63,259],"biopsy":[64],"during":[65],"2000\u20132019":[66],"were":[67,84,93,101,107],"included":[68],"in":[69,122,165,168,174,179,183,186,191,197],"this":[70],"study.":[71],"Out":[72,155],"cases,":[76,159,205,230,247],"astrocytic":[77],"tumors":[78,87,98],"(A":[79],"group:":[80,89],"IDH-mutant,":[81,90],"1p19q":[82,91],"non-codeleted)":[83],"17,":[85],"oligodendroglial":[86],"(O":[88],"codeleted)":[92],"15,":[94],"wild":[97],"(W":[99],"group)":[100],"21.":[102],"MR":[103],"CT":[105],"scans":[106],"evaluated":[108],"by":[109,135,146],"3":[110,195],"independent":[111],"reviewers":[112],"assess":[114],"presence/absence":[115],"sign":[119,162],"calcification":[121],"tumor,":[124],"respectively.":[125],"tumor-to-normal":[127],"(T/N)":[128],"ratio":[129],"was":[133,163,181,209,214,218,222,239,251,256,262,266],"calculated":[134],"dividing":[136],"maximum":[138],"standardized":[139],"value":[141,238],"(SUV)":[142],"for":[143,282],"mean":[148],"SUV":[149],"normal":[152],"brain.":[153],"Results:":[154],"present":[164,182],"6":[166],"cases":[167,173,185,190,196],"group":[169,175,187,192,198,210,215,233,252,257],"A":[170,258],"9":[172],"W":[176,199,211,253],"(p=0.008).":[177],"Calcification":[178],"2":[184],"A,":[188,216],"7":[189],"O,":[193,234,260],"(p=0.046).":[200],"In":[201,224,241],"mismatch-positive":[204],"assuming":[206,231,248],"T/N>1.401":[208],"<1.401":[213],"sensitivity":[217,261],"100%":[219],"specificity":[221,265],"67%.":[223],"mismatch-negative":[227,244],"calcification-positive":[229],"those":[232],"diagnostic":[236,270],"predictive":[237],"70%.":[240],"calcification-negative":[246],"T/N>2.349":[250],"<2.349":[255],"60%":[263],"94%.":[267],"Conclusions:":[268],"Combined":[269],"prediction":[271],"mismatch,":[274],"T/N":[278],"may":[279],"useful":[281],"gliomas.":[291]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-12-31T00:00:00"}