{"id":"https://openalex.org/W4200320681","doi":"https://doi.org/10.3390/app112412033","title":"Nanoscale Imaging and Analysis of Bone Pathologies","display_name":"Nanoscale Imaging and Analysis of Bone Pathologies","publication_year":2021,"publication_date":"2021-12-17","ids":{"openalex":"https://openalex.org/W4200320681","doi":"https://doi.org/10.3390/app112412033"},"language":"en","primary_location":{"id":"doi:10.3390/app112412033","doi":"https://doi.org/10.3390/app112412033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app112412033","pdf_url":"https://www.mdpi.com/2076-3417/11/24/12033/pdf?version=1639733205","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3417/11/24/12033/pdf?version=1639733205","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034188445","display_name":"Victoria Garcia-Giner","orcid":"https://orcid.org/0000-0001-9046-9336","observed_orcids":["https://orcid.org/0000-0001-9046-9336"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Garcia-Giner","raw_affiliation_strings":["Department of Materials, Imperial College London, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials, Imperial College London, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039314460","display_name":"Zexiang Han","orcid":"https://orcid.org/0000-0002-8968-0860","observed_orcids":["https://orcid.org/0000-0002-8968-0860"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zexiang Han","raw_affiliation_strings":["Department of Materials, Imperial College London, London SW7 2AZ, UK"],"raw_orcid":"https://orcid.org/0000-0002-8968-0860","affiliations":[{"raw_affiliation_string":"Department of Materials, Imperial College London, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029802531","display_name":"Finn Giuliani","orcid":"https://orcid.org/0000-0002-0259-934X","observed_orcids":["https://orcid.org/0000-0002-0259-934X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Finn Giuliani","raw_affiliation_strings":["Department of Materials, Imperial College London, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials, Imperial College London, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069007121","display_name":"Alexandra E. Porter","orcid":"https://orcid.org/0000-0003-1295-105X","observed_orcids":["https://orcid.org/0000-0003-1295-105X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexandra E. Porter","raw_affiliation_strings":["Department of Materials, Imperial College London, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials, Imperial College London, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069007121"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.9337,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68559759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"24","first_page":"12033","last_page":"12033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-pathology","display_name":"bone pathology","score":0.8399999737739563},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/paget-s-disease","display_name":"Paget's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-ultrastructure","display_name":"bone ultrastructure","score":0.8399999737739563},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.8080000281333923},{"id":"https://openalex.org/keywords/bone-mineral","display_name":"bone mineral","score":0.47200000286102295},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.8949999809265137},{"id":"https://openalex.org/keywords/knockout-mouse-models","display_name":"knockout mouse models","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5343806743621826},{"id":"https://openalex.org/C2993697008","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Bone matrix","level":3,"score":0.4804401099681854},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4740797281265259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41339969635009766},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.41305166482925415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33785372972488403},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.216543048620224},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/app112412033","doi":"https://doi.org/10.3390/app112412033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app112412033","pdf_url":"https://www.mdpi.com/2076-3417/11/24/12033/pdf?version=1639733205","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b340600be97448b98065a04c2e9c732d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b340600be97448b98065a04c2e9c732d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Sciences, Vol 11, Iss 24, p 12033 (2021)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/93751","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/93751","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"32","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/app112412033","doi":"https://doi.org/10.3390/app112412033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app112412033","pdf_url":"https://www.mdpi.com/2076-3417/11/24/12033/pdf?version=1639733205","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1959076559","display_name":null,"funder_award_id":"EP/S023259/1","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G3167905487","display_name":"EPSRC and SFI Centre for Doctoral Training in the Advanced Characterisation of Materials (CDT-ACM)","funder_award_id":"EP/S023259/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200320681.pdf","grobid_xml":"https://content.openalex.org/works/W4200320681.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W591971653","https://openalex.org/W1491950503","https://openalex.org/W1534731743","https://openalex.org/W1560412092","https://openalex.org/W1572175163","https://openalex.org/W1748044177","https://openalex.org/W1964377751","https://openalex.org/W1965987628","https://openalex.org/W1967086499","https://openalex.org/W1967275513","https://openalex.org/W1971044432","https://openalex.org/W1971119405","https://openalex.org/W1974149309","https://openalex.org/W1975450754","https://openalex.org/W1978122265","https://openalex.org/W1979878249","https://openalex.org/W1982018212","https://openalex.org/W1984305504","https://openalex.org/W1986024893","https://openalex.org/W1987576187","https://openalex.org/W1989496290","https://openalex.org/W1990019150","https://openalex.org/W1990158585","https://openalex.org/W1994731124","https://openalex.org/W1997212291","https://openalex.org/W1999038459","https://openalex.org/W2000280753","https://openalex.org/W2000621061","https://openalex.org/W2001018521","https://openalex.org/W2001576085","https://openalex.org/W2001847056","https://openalex.org/W2001923641","https://openalex.org/W2001957914","https://openalex.org/W2002225015","https://openalex.org/W2007684074","https://openalex.org/W2009756491","https://openalex.org/W2012944102","https://openalex.org/W2013130318","https://openalex.org/W2016752237","https://openalex.org/W2018287740","https://openalex.org/W2018475826","https://openalex.org/W2022024894","https://openalex.org/W2024152221","https://openalex.org/W2024608325","https://openalex.org/W2025198598","https://openalex.org/W2025464883","https://openalex.org/W2027886242","https://openalex.org/W2029064643","https://openalex.org/W2030345505","https://openalex.org/W2033275398","https://openalex.org/W2033677211","https://openalex.org/W2034210974","https://openalex.org/W2034569221","https://openalex.org/W2036512532","https://openalex.org/W2036599571","https://openalex.org/W2037090606","https://openalex.org/W2037504501","https://openalex.org/W2038989154","https://openalex.org/W2039833863","https://openalex.org/W2041125186","https://openalex.org/W2047704323","https://openalex.org/W2049980919","https://openalex.org/W2050765870","https://openalex.org/W2051314952","https://openalex.org/W2051959338","https://openalex.org/W2052801322","https://openalex.org/W2055637287","https://openalex.org/W2057235634","https://openalex.org/W2058628090","https://openalex.org/W2058711534","https://openalex.org/W2059726106","https://openalex.org/W2061417581","https://openalex.org/W2062972212","https://openalex.org/W2063474880","https://openalex.org/W2065675161","https://openalex.org/W2069223770","https://openalex.org/W2069641334","https://openalex.org/W2074161420","https://openalex.org/W2075350836","https://openalex.org/W2076440836","https://openalex.org/W2076850919","https://openalex.org/W2077455087","https://openalex.org/W2078641185","https://openalex.org/W2078998158","https://openalex.org/W2082170725","https://openalex.org/W2082466238","https://openalex.org/W2087134025","https://openalex.org/W2088798468","https://openalex.org/W2090042055","https://openalex.org/W2090553875","https://openalex.org/W2090867212","https://openalex.org/W2091174247","https://openalex.org/W2091186643","https://openalex.org/W2092024735","https://openalex.org/W2092362745","https://openalex.org/W2099885273","https://openalex.org/W2102719653","https://openalex.org/W2104779362","https://openalex.org/W2106704887","https://openalex.org/W2106842759","https://openalex.org/W2106846778","https://openalex.org/W2114528551","https://openalex.org/W2117729857","https://openalex.org/W2119509302","https://openalex.org/W2121194306","https://openalex.org/W2121780717","https://openalex.org/W2124890195","https://openalex.org/W2127754825","https://openalex.org/W2128172133","https://openalex.org/W2128778774","https://openalex.org/W2141225628","https://openalex.org/W2143302001","https://openalex.org/W2150101668","https://openalex.org/W2150329721","https://openalex.org/W2153483480","https://openalex.org/W2154877916","https://openalex.org/W2170248783","https://openalex.org/W2170442655","https://openalex.org/W2172461241","https://openalex.org/W2185891113","https://openalex.org/W2255910123","https://openalex.org/W2280357815","https://openalex.org/W2294261717","https://openalex.org/W2314123985","https://openalex.org/W2323403215","https://openalex.org/W2333257493","https://openalex.org/W2338193302","https://openalex.org/W2341962741","https://openalex.org/W2415137979","https://openalex.org/W2434381113","https://openalex.org/W2469856186","https://openalex.org/W2473166483","https://openalex.org/W2516248496","https://openalex.org/W2517380036","https://openalex.org/W2520790269","https://openalex.org/W2521269685","https://openalex.org/W2525042272","https://openalex.org/W2559809466","https://openalex.org/W2569380175","https://openalex.org/W2612164042","https://openalex.org/W2736893036","https://openalex.org/W2737103102","https://openalex.org/W2740936167","https://openalex.org/W2755562215","https://openalex.org/W2765365236","https://openalex.org/W2766775316","https://openalex.org/W2769845850","https://openalex.org/W2780597973","https://openalex.org/W2784148496","https://openalex.org/W2786572354","https://openalex.org/W2787614952","https://openalex.org/W2800184149","https://openalex.org/W2807794824","https://openalex.org/W2811189142","https://openalex.org/W2890385125","https://openalex.org/W2902932924","https://openalex.org/W2904039649","https://openalex.org/W2907719236","https://openalex.org/W2910191031","https://openalex.org/W2926367219","https://openalex.org/W2944994424","https://openalex.org/W2946408387","https://openalex.org/W2952081998","https://openalex.org/W2969183756","https://openalex.org/W2969409571","https://openalex.org/W2972965845","https://openalex.org/W3017928579","https://openalex.org/W3020154434","https://openalex.org/W3024020179","https://openalex.org/W3024105172","https://openalex.org/W3037449578","https://openalex.org/W3049329130","https://openalex.org/W3084616969","https://openalex.org/W3089464856","https://openalex.org/W3090414745","https://openalex.org/W3091188794","https://openalex.org/W3091986402","https://openalex.org/W3101524305","https://openalex.org/W3107208023","https://openalex.org/W3110970993","https://openalex.org/W3114114365","https://openalex.org/W3129574894","https://openalex.org/W3133607419","https://openalex.org/W3136459518","https://openalex.org/W3145605951","https://openalex.org/W3152299454","https://openalex.org/W3164242868","https://openalex.org/W3182643927","https://openalex.org/W3195195170","https://openalex.org/W3197887074","https://openalex.org/W4211060251","https://openalex.org/W4211221406"],"related_works":["https://openalex.org/W3088386448","https://openalex.org/W2361419783","https://openalex.org/W2103525058","https://openalex.org/W2804713657","https://openalex.org/W3197887074","https://openalex.org/W2601463542","https://openalex.org/W4401503317","https://openalex.org/W2807165335","https://openalex.org/W2093733577","https://openalex.org/W6927023385"],"abstract_inverted_index":{"Understanding":[0],"the":[1,41,58,79,104,177],"properties":[2],"of":[3,6,14,61,84,92,106,146,179],"bone":[4,47,85,109,122,125,148,173],"is":[5,49,55,102],"both":[7],"fundamental":[8],"and":[9,17,31,33,64,82,128,175],"clinical":[10],"relevance.":[11],"The":[12,150],"basis":[13],"bone\u2019s":[15],"quality":[16,127],"mechanical":[18,144],"resilience":[19],"lies":[20],"in":[21,45,68,78,87,121],"its":[22],"nanoscale":[23],"building":[24],"blocks":[25],"(i.e.,":[26],"mineral,":[27],"collagen,":[28],"non-collagenous":[29,108],"proteins,":[30,111],"water)":[32],"their":[34],"complex":[35],"interactions":[36],"across":[37],"length":[38],"scales.":[39],"Although":[40],"structure\u2013mechanical":[42],"property":[43],"relationship":[44],"healthy":[46],"tissue":[48,86],"relatively":[50],"well":[51],"characterized,":[52],"not":[53],"much":[54],"known":[56],"about":[57],"molecular-level":[59],"origin":[60],"impaired":[62],"mechanics":[63],"higher":[65],"fracture":[66],"risks":[67],"skeletal":[69],"disorders":[70],"such":[71,88],"as":[72],"osteoporosis":[73],"or":[74,114],"Paget\u2019s":[75],"disease.":[76],"Alterations":[77],"ultrastructure,":[80],"chemistry,":[81],"nano-/micromechanics":[83],"a":[89,138],"diverse":[90],"group":[91],"diseased":[93],"states":[94],"have":[95],"only":[96],"been":[97],"briefly":[98],"explored.":[99],"Recent":[100],"research":[101],"uncovering":[103],"effects":[105],"several":[107],"matrix":[110,126],"whose":[112],"deficiencies":[113],"mutations":[115],"are,":[116],"to":[117,162],"some":[118],"extent,":[119],"implicated":[120],"diseases,":[123],"on":[124,135,140],"mechanics.":[129],"Herein,":[130],"we":[131],"review":[132],"existing":[133],"studies":[134],"ultrastructural":[136],"imaging\u2014with":[137],"focus":[139],"electron":[141],"microscopy\u2014and":[142],"chemical,":[143],"analysis":[145],"pathological":[147],"tissues.":[149],"nanometric":[151],"details":[152],"offered":[153],"by":[154],"these":[155],"reports,":[156],"from":[157],"studying":[158],"knockout":[159],"mice":[160],"models":[161],"characterizing":[163],"exact":[164],"disease":[165],"phenotypes,":[166],"can":[167],"provide":[168],"key":[169],"insights":[170],"into":[171],"various":[172],"pathologies":[174],"facilitate":[176],"development":[178],"new":[180],"treatments.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-12-31T00:00:00"}