{"id":"https://openalex.org/W4200312888","doi":"https://doi.org/10.21518/2079-701x-2021-20-25-34","title":"Role of pre-metastatic niche in organ specificity of breast cancer metastasis. Influence on metastatic potential as a basis for CDK4/6-inhibition efficacy in early therapy of disseminated hormone-receptor-positive disease","display_name":"Role of pre-metastatic niche in organ specificity of breast cancer metastasis. Influence on metastatic potential as a basis for CDK4/6-inhibition efficacy in early therapy of disseminated hormone-receptor-positive disease","publication_year":2021,"publication_date":"2021-12-08","ids":{"openalex":"https://openalex.org/W4200312888","doi":"https://doi.org/10.21518/2079-701x-2021-20-25-34"},"language":"en","primary_location":{"id":"doi:10.21518/2079-701x-2021-20-25-34","doi":"https://doi.org/10.21518/2079-701x-2021-20-25-34","is_oa":true,"landing_page_url":"https://doi.org/10.21518/2079-701x-2021-20-25-34","pdf_url":"https://www.med-sovet.pro/jour/article/download/6576/5960","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.med-sovet.pro/jour/article/download/6576/5960","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081086608","display_name":"\u0410. I. Stukan","orcid":"https://orcid.org/0000-0002-0698-7710","observed_orcids":["https://orcid.org/0000-0002-0698-7710","https://orcid.org/0009-0005-6153-3059"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. I. Stukan","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-0698-7710","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082375361","display_name":"\u0410. Yu. Goryainova","orcid":"https://orcid.org/0000-0001-7127-7945","observed_orcids":["https://orcid.org/0000-0001-7127-7945"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Yu. Goryainova","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University"],"raw_orcid":"https://orcid.org/0000-0001-7127-7945","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023418983","display_name":"\u0415. V. Lymar","orcid":"https://orcid.org/0000-0002-6866-1425","observed_orcids":["https://orcid.org/0000-0002-6866-1425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. V. Lymar","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1"],"raw_orcid":"https://orcid.org/0000-0002-6866-1425","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009647183","display_name":"\u0428\u0430\u0440\u043e\u0432 \u0421\u0435\u0440\u0433\u0435\u0439 \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-8715-2992","observed_orcids":["https://orcid.org/0000-0002-8715-2992"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. V. Sharov","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1;\r\nKuban State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-8715-2992","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1;\r\nKuban State Medical University","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057914979","display_name":"D. V. Andreev","orcid":"https://orcid.org/0000-0003-3041-520X","observed_orcids":["https://orcid.org/0000-0003-3041-520X"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. V. Andreev","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1;\r\nKuban State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-3041-520X","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1;\r\nKuban State Medical University","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082827399","display_name":"V. V. Antipova","orcid":"https://orcid.org/0000-0002-0006-3306","observed_orcids":["https://orcid.org/0000-0002-0006-3306"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. V. Antipova","raw_affiliation_strings":["Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-0006-3306","affiliations":[{"raw_affiliation_string":"Clinical Oncologic Dispensary No.1; \r\nKuban State Medical University","institution_ids":["https://openalex.org/I168528297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"20","first_page":"25","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/organ-specificity","display_name":"organ specificity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":0.9629999995231628},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bone-marrow-derived-progenitor-cells","display_name":"bone marrow progenitor cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7099999785423279},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tumor-cell-microenvironment-interactions","display_name":"tumor cell-microenvironment interactions","score":0.5440000295639038},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cdk4-6","display_name":"CDK4/6","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6834485530853271},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5832849144935608},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5075350999832153},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4608018696308136},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4585722088813782},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4491708278656006},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4464603066444397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4435714781284332},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.4400452971458435},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4243055284023285},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.42065468430519104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34064602851867676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2848667800426483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25332653522491455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21296367049217224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21268874406814575}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21518/2079-701x-2021-20-25-34","doi":"https://doi.org/10.21518/2079-701x-2021-20-25-34","is_oa":true,"landing_page_url":"https://doi.org/10.21518/2079-701x-2021-20-25-34","pdf_url":"https://www.med-sovet.pro/jour/article/download/6576/5960","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:244ee19ad8b84ee6901795ba2aa7c743","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/244ee19ad8b84ee6901795ba2aa7c743","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0441\u043e\u0432\u0435\u0442, Vol 0, Iss 20, Pp 25-34 (2021)","raw_type":"article"},{"id":"pmh:oai:oai.medsovet.elpub.ru:article/6576","doi":null,"is_oa":true,"landing_page_url":"https://www.med-sovet.pro/jour/article/view/6576","pdf_url":null,"source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Meditsinskiy sovet = Medical Council; \u2116 20 (2021); 25-34","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21518/2079-701x-2021-20-25-34","doi":"https://doi.org/10.21518/2079-701x-2021-20-25-34","is_oa":true,"landing_page_url":"https://doi.org/10.21518/2079-701x-2021-20-25-34","pdf_url":"https://www.med-sovet.pro/jour/article/download/6576/5960","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200312888.pdf","grobid_xml":"https://content.openalex.org/works/W4200312888.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966535852","https://openalex.org/W2041003905","https://openalex.org/W2044748328","https://openalex.org/W2048657818","https://openalex.org/W2050650884","https://openalex.org/W2062265555","https://openalex.org/W2071732560","https://openalex.org/W2079032404","https://openalex.org/W2103324798","https://openalex.org/W2134287597","https://openalex.org/W2140948050","https://openalex.org/W2146530991","https://openalex.org/W2193074466","https://openalex.org/W2287802389","https://openalex.org/W2404884142","https://openalex.org/W2510836433","https://openalex.org/W2586679548","https://openalex.org/W2620993107","https://openalex.org/W2806699208","https://openalex.org/W2899330895","https://openalex.org/W2904980737","https://openalex.org/W2913469816","https://openalex.org/W2914591999","https://openalex.org/W2916822920","https://openalex.org/W2947163755","https://openalex.org/W2949106781","https://openalex.org/W2976415870","https://openalex.org/W2979002784","https://openalex.org/W3005893653","https://openalex.org/W3010011098","https://openalex.org/W3011823578","https://openalex.org/W3012416987","https://openalex.org/W3087501542","https://openalex.org/W3150548835","https://openalex.org/W3201975794","https://openalex.org/W4239051461"],"related_works":["https://openalex.org/W3182528945","https://openalex.org/W2157792277","https://openalex.org/W2938651901","https://openalex.org/W2570537891","https://openalex.org/W4409664824","https://openalex.org/W146285696","https://openalex.org/W2273510161","https://openalex.org/W2885486322","https://openalex.org/W2557222435","https://openalex.org/W2195885200"],"abstract_inverted_index":{"Influencing":[0],"the":[1,35,38,46,57,64,82,95,103,113,124,136,139,151,203,224,241,250,266,272,278,294,298,318,333,365],"pre-metastatic":[2,39,54,96],"niche":[3],"is":[4,90,109,144,354],"a":[5,196,246],"very":[6],"perspective":[7],"cancer":[8,165,183,238,257,285,308,350,378],"treatment":[9,351,361,379],"strategy":[10],"in":[11,34,53,181,184,187,236,249,302,312,323,332,344,348,360,375],"order":[12],"of":[13,37,49,66,106,111,138,163,198,226,230,252,260,268,274,283,297,305,320,328,381],"preventing":[14,179],"metastases":[15],"formation.":[16],"It":[17],"was":[18,130,221,262],"found":[19,131],"that":[20,102,171],"bone":[21,50],"marrow":[22,51],"progenitor":[23],"cells":[24,27,43,52,71,80,89,108],"and":[25,157,186,208,216,234,281,330,352],"tumor":[26,79,118,125],"secreting":[28],"biological":[29,289],"compounds":[30],"are":[31,45],"key":[32,247],"components":[33],"formation":[36,115],"niche.":[40],"Myeloid":[41],"suppressor":[42,75],"(MSCs)":[44],"main":[47],"type":[48],"niches.":[55],"At":[56,202],"same":[58],"time,":[59],"tumor-associated":[60],"chronic":[61],"inflammation":[62],"induces":[63],"expression":[65,225,267,273],"proinflammatory":[67],"cytokines":[68],"triggering":[69],"myeloid":[70,74],"differentiation":[72],"into":[73],"cells.":[76,119,166],"When":[77],"circulating":[78,117],"enter":[81],"circulatory":[83],"channel,":[84],"their":[85],"interaction":[86],"with":[87,123],"immune":[88,107],"observed,":[91],"which":[92,211],"additionally":[93],"influences":[94,213],"site":[97],"preparation.":[98],"Studies":[99],"have":[100],"shown":[101,263],"entire":[104],"spectrum":[105],"capable":[110],"influencing":[112],"metastasis":[114,180,251],"by":[116,146],"The":[120,368],"epithelialmesenchymal":[121],"transition":[122,162],"cell":[126,286],"transporting":[127],"form":[128],"appearence":[129],"to":[132,135,264,364],"be":[133],"related":[134],"function":[137],"ZEB1":[140,175,214,235],"protein.":[141],"Its":[142],"activity":[143],"regulated":[145],"numerous":[147],"signaling":[148],"mechanisms":[149],"at":[150,325],"transcriptional":[152],"level,":[153,205],"including":[154],"TGF\u03b2,":[155],"Wnt":[156],"Notch.":[158],"This":[159,288],"initiates":[160],"epithelial-mesenchymal":[161],"breast":[164,182,237,253,256,284,307,349,377],"Zhang":[167],"Z.et":[168],"al.":[169],"proved":[170],"CDK4/6":[172,206,231,261,299,347],"blocking":[173],"leads":[174],"protein":[176],"stability":[177],"decreasing,":[178],"vitro":[185],"vivo.":[188],"Moreover,":[189],"USP51":[190],"deubiquitinase":[191],"has":[192],"been":[193],"identified":[194],"as":[195,309,311],"target":[197],"cyclin-dependent":[199],"4/6":[200],"kinases.":[201],"molecular":[204],"phosphorylate":[207],"activates":[209],"USP51,":[210],"then":[212],"deubiquitination":[215],"stabilization.":[217],"A":[218],"positive":[219],"correlation":[220],"demonstrated":[222],"between":[223],"p-RB":[227],"(an":[228],"indicator":[229],"activity),":[232],"p-USP51":[233],"samples.":[239],"Thus,":[240],"CDK4/6-USP51-ZEB1":[242],"axis":[243],"may":[244,291],"play":[245],"role":[248],"cancer.":[254],"In":[255],"cells,":[258],"inhibition":[259],"increase":[265],"E-cadherin":[269],"but":[270],"decrease":[271],"mesenchymal":[275],"markers,":[276],"reducing":[277],"migratory":[279],"ability":[280],"invasiveness":[282],"lines.":[287],"effect":[290],"also":[292],"explain":[293],"clinical":[295,369,373],"efficacy":[296,374],"inhibitor":[300],"Abemaciclib":[301],"early-line":[303],"therapy":[304,316],"metastatic":[306,321,366,376,382],"well":[310],"adjuvant":[313],"combination":[314],"hormone":[315],"for":[317],"prevention":[319],"lesions":[322],"patients":[324],"high":[326],"risk":[327],"recurrence":[329],"progression":[331],"MONARCH":[334],"E":[335],"study.":[336],"Besides,":[337],"there":[338,357],"were":[339],"no":[340],"response":[341,362],"predictors":[342],"evaluated":[343],"trials":[345],"investigating":[346],"it":[353],"unknown":[355],"if":[356],"any":[358],"differences":[359],"according":[363],"site.":[367,383],"cases":[370],"demonstrate":[371],"abemaciclib":[372],"regardless":[380]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-31T00:00:00"}
