{"id":"https://openalex.org/W4200310641","doi":"https://doi.org/10.1016/j.molstruc.2021.132215","title":"Sulfonylbis(acylhydrazones) as anticholinesterase inhibitors: Synthesis, in vitro biological evaluation and computational studies","display_name":"Sulfonylbis(acylhydrazones) as anticholinesterase inhibitors: Synthesis, in vitro biological evaluation and computational studies","publication_year":2021,"publication_date":"2021-12-18","ids":{"openalex":"https://openalex.org/W4200310641","doi":"https://doi.org/10.1016/j.molstruc.2021.132215"},"language":"en","primary_location":{"id":"doi:10.1016/j.molstruc.2021.132215","doi":"https://doi.org/10.1016/j.molstruc.2021.132215","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2021.132215","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111103925","display_name":"M. N. IBRAHIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68649149","display_name":"University of Malakand","ror":"https://ror.org/012xdha97","country_code":"PK","type":"education","lineage":["https://openalex.org/I68649149"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhamad Ibrahim","raw_affiliation_strings":["Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan","institution_ids":["https://openalex.org/I68649149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066633544","display_name":"Abdul Latif","orcid":"https://orcid.org/0000-0002-9047-7747","observed_orcids":["https://orcid.org/0000-0002-9047-7747"]},"institutions":[{"id":"https://openalex.org/I68649149","display_name":"University of Malakand","ror":"https://ror.org/012xdha97","country_code":"PK","type":"education","lineage":["https://openalex.org/I68649149"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdul Latif","raw_affiliation_strings":["Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan","institution_ids":["https://openalex.org/I68649149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044856027","display_name":"Manzoor Ahmad","orcid":"https://orcid.org/0000-0001-9736-5900","observed_orcids":["https://orcid.org/0000-0001-9736-5900"]},"institutions":[{"id":"https://openalex.org/I68649149","display_name":"University of Malakand","ror":"https://ror.org/012xdha97","country_code":"PK","type":"education","lineage":["https://openalex.org/I68649149"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Manzoor Ahmad","raw_affiliation_strings":["Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan","institution_ids":["https://openalex.org/I68649149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045550052","display_name":"Sajjad Ahmad","orcid":"https://orcid.org/0000-0003-0754-1742","observed_orcids":["https://orcid.org/0000-0003-0754-1742"]},"institutions":[{"id":"https://openalex.org/I53831458","display_name":"Abasyn University","ror":"https://ror.org/05ws11813","country_code":"PK","type":"education","lineage":["https://openalex.org/I53831458"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Sajjad Ahmad","raw_affiliation_strings":["Department of Health and Biological Sciences, Abasyn University, Peshawar 25000, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Biological Sciences, Abasyn University, Peshawar 25000, Pakistan","institution_ids":["https://openalex.org/I53831458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083054946","display_name":"Akbar Ali","orcid":"https://orcid.org/0000-0002-2914-0934","observed_orcids":["https://orcid.org/0000-0002-2914-0934"]},"institutions":[{"id":"https://openalex.org/I194348271","display_name":"Government College University, Faisalabad","ror":"https://ror.org/051zgra59","country_code":"PK","type":"education","lineage":["https://openalex.org/I194348271"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Akbar Ali","raw_affiliation_strings":["Department of Chemistry, Government College University Faisalabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Government College University Faisalabad, Pakistan","institution_ids":["https://openalex.org/I194348271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046830308","display_name":"Abu Bakar Siddique","orcid":"https://orcid.org/0000-0003-2834-5708","observed_orcids":["https://orcid.org/0000-0003-2834-5708"]},"institutions":[{"id":"https://openalex.org/I160968435","display_name":"University of Sargodha","ror":"https://ror.org/0086rpr26","country_code":"PK","type":"education","lineage":["https://openalex.org/I160968435"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abu Bakar Siddique","raw_affiliation_strings":["Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan","institution_ids":["https://openalex.org/I160968435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005292762","display_name":"Mohammad Saadiq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305695959","display_name":"Bacha Khan University","ror":"https://ror.org/02an6vg71","country_code":"PK","type":"education","lineage":["https://openalex.org/I1305695959"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mohammad Saadiq","raw_affiliation_strings":["Department of Chemistry, Bacha Khan University, Charsadda, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bacha Khan University, Charsadda, Pakistan","institution_ids":["https://openalex.org/I1305695959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091742823","display_name":"Nazia Akbar","orcid":"https://orcid.org/0000-0003-2203-4933","observed_orcids":["https://orcid.org/0000-0003-2203-4933"]},"institutions":[{"id":"https://openalex.org/I263208278","display_name":"Hazara University","ror":"https://ror.org/018y22094","country_code":"PK","type":"education","lineage":["https://openalex.org/I263208278"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nazia Akbar","raw_affiliation_strings":["Department of Genetics, Hazzara University, Mansehra, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Hazzara University, Mansehra, Pakistan","institution_ids":["https://openalex.org/I263208278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049137960","display_name":"Umar Farooq","orcid":"https://orcid.org/0000-0001-5557-2776","observed_orcids":["https://orcid.org/0000-0001-5557-2776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umar farooq","raw_affiliation_strings":["Department of Chemistry University, COMSATS University, Abbotabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University, COMSATS University, Abbotabad, Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091778180","display_name":"Ajmal Khan","orcid":"https://orcid.org/0000-0001-7851-6080","observed_orcids":["https://orcid.org/0000-0001-7851-6080"]},"institutions":[{"id":"https://openalex.org/I209803261","display_name":"University of Nizwa","ror":"https://ror.org/01pxe3r04","country_code":"OM","type":"education","lineage":["https://openalex.org/I209803261"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Ajmal Khan","raw_affiliation_strings":["Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa, Oman","institution_ids":["https://openalex.org/I209803261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076140757","display_name":"Ahmed Al\u2010Harrasi","orcid":"https://orcid.org/0000-0002-0815-5942","observed_orcids":["https://orcid.org/0000-0002-0815-5942"]},"institutions":[{"id":"https://openalex.org/I209803261","display_name":"University of Nizwa","ror":"https://ror.org/01pxe3r04","country_code":"OM","type":"education","lineage":["https://openalex.org/I209803261"]}],"countries":["OM"],"is_corresponding":true,"raw_author_name":"Ahmed Al-Harrasi","raw_affiliation_strings":["Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa, Oman","institution_ids":["https://openalex.org/I209803261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078925950","display_name":"Mumtaz Ali","orcid":"https://orcid.org/0000-0001-7573-7953","observed_orcids":["https://orcid.org/0000-0001-7573-7953"]},"institutions":[{"id":"https://openalex.org/I68649149","display_name":"University of Malakand","ror":"https://ror.org/012xdha97","country_code":"PK","type":"education","lineage":["https://openalex.org/I68649149"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Mumtaz Ali","raw_affiliation_strings":["Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malakand, Lower Dir, Chakdara, Pakistan","institution_ids":["https://openalex.org/I68649149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045550052","https://openalex.org/A5076140757","https://openalex.org/A5078925950"],"corresponding_institution_ids":["https://openalex.org/I209803261","https://openalex.org/I53831458","https://openalex.org/I68649149"],"apc_list":{"value":2760,"currency":"USD","value_usd":2760},"apc_paid":null,"fwci":1.5474,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.79124195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"1252","issue":null,"first_page":"132215","last_page":"132215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibition","display_name":"butyrylcholinesterase inhibition","score":1.0},{"id":"https://openalex.org/keywords/hydrazone-synthesis","display_name":"hydrazone synthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9409999847412109},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/binding-free-energy","display_name":"binding free energy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/alzheimer-s-disease-drug-candidates","display_name":"Alzheimer's disease drug candidates","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9418691396713257},{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.8669309616088867},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7127959728240967},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.6880757808685303},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5831996202468872},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.497653990983963},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.47035789489746094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4349440634250641},{"id":"https://openalex.org/C126061179","wikidata":"https://www.wikidata.org/wiki/Q189627","display_name":"van der Waals force","level":3,"score":0.43344253301620483},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.4286801815032959},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3879031538963318},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36973080039024353},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.32800033688545227},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2698901295661926},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.2481517791748047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17392122745513916},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.14858239889144897},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07384321093559265},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molstruc.2021.132215","doi":"https://doi.org/10.1016/j.molstruc.2021.132215","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2021.132215","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8913089857","display_name":null,"funder_award_id":"20\u20134029","funder_id":"https://openalex.org/F4320322799","funder_display_name":"Higher Education Commission, Pakistan"}],"funders":[{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"},{"id":"https://openalex.org/F4320326275","display_name":"Higher Education Commision, Pakistan","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1721196610","https://openalex.org/W1968984443","https://openalex.org/W1971048984","https://openalex.org/W1977776931","https://openalex.org/W1979915001","https://openalex.org/W2011601475","https://openalex.org/W2028180822","https://openalex.org/W2030472841","https://openalex.org/W2035175790","https://openalex.org/W2035331491","https://openalex.org/W2043666236","https://openalex.org/W2050456292","https://openalex.org/W2052030759","https://openalex.org/W2053599146","https://openalex.org/W2091687624","https://openalex.org/W2093221728","https://openalex.org/W2095719702","https://openalex.org/W2100561975","https://openalex.org/W2104797123","https://openalex.org/W2131288855","https://openalex.org/W2132629607","https://openalex.org/W2139064886","https://openalex.org/W2142868265","https://openalex.org/W2147993766","https://openalex.org/W2153954155","https://openalex.org/W2186024249","https://openalex.org/W2252707248","https://openalex.org/W2332712348","https://openalex.org/W2343588350","https://openalex.org/W2376591453","https://openalex.org/W2408399550","https://openalex.org/W2553292796","https://openalex.org/W2604263066","https://openalex.org/W2949638220","https://openalex.org/W3014614371","https://openalex.org/W6729921790"],"related_works":["https://openalex.org/W4407685789","https://openalex.org/W4285083674","https://openalex.org/W4391115741","https://openalex.org/W4400772422","https://openalex.org/W4410088707","https://openalex.org/W4385496935","https://openalex.org/W3012423878","https://openalex.org/W4362659427","https://openalex.org/W4388952087","https://openalex.org/W4386726835"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-31T00:00:00"}