{"id":"https://openalex.org/W4200306752","doi":"https://doi.org/10.1093/ofid/ofab466.1050","title":"855. Persistence on F/TAF versus F/TDF for HIV Pre-Exposure Prophylaxis: A Real-World Evidence Analysis in the United States","display_name":"855. Persistence on F/TAF versus F/TDF for HIV Pre-Exposure Prophylaxis: A Real-World Evidence Analysis in the United States","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200306752","doi":"https://doi.org/10.1093/ofid/ofab466.1050"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofab466.1050","doi":"https://doi.org/10.1093/ofid/ofab466.1050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.1050","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofab466.1050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101639720","display_name":"Tao Li","orcid":"https://orcid.org/0000-0002-6720-3545","observed_orcids":["https://orcid.org/0000-0002-6720-3545"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Tao","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030992141","display_name":"Valentina A. Shvachko","orcid":"https://orcid.org/0009-0004-3697-7080","observed_orcids":["https://orcid.org/0009-0004-3697-7080"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina Shvachko","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076529428","display_name":"Moupali Das","orcid":"https://orcid.org/0000-0001-5034-8185","observed_orcids":["https://orcid.org/0000-0001-5034-8185"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moupali Das","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073519594","display_name":"Christoph C Carter","orcid":"https://orcid.org/0000-0001-7793-8011","observed_orcids":["https://orcid.org/0000-0001-7793-8011"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph C Carter","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Baeten","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102190298","display_name":"David Magnuson","orcid":"https://orcid.org/0009-0006-9769-6068","observed_orcids":["https://orcid.org/0009-0006-9769-6068"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Magnuson","raw_affiliation_strings":["Gilead Science, Inc., Foster City, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Science, Inc., Foster City, California","institution_ids":["https://openalex.org/I4210140816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140816"],"apc_list":{"value":3465,"currency":"USD","value_usd":3465},"apc_paid":{"value":3465,"currency":"USD","value_usd":3465},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23093134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"Supplement_1","first_page":"S518","last_page":"S519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-pre-exposure-prophylaxis","display_name":"HIV pre-exposure prophylaxis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prep-persistence","display_name":"PrEP persistence","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tenofovir-alafenamide","display_name":"tenofovir alafenamide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prep-discontinuation","display_name":"PrEP discontinuation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.4410000145435333},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8801008462905884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8430408239364624},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8024377822875977},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.6942319869995117},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6882022619247437},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5271658301353455},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5263251662254333},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5109728574752808},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4999570846557617},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.47309044003486633},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4607468843460083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4319274425506592},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.24056753516197205},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.1323564052581787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.072124183177948},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofab466.1050","doi":"https://doi.org/10.1093/ofid/ofab466.1050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.1050","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8644189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8644189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofab466.1050","doi":"https://doi.org/10.1093/ofid/ofab466.1050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofab466.1050","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3119591941","https://openalex.org/W4311745473","https://openalex.org/W2915183816","https://openalex.org/W4200450685","https://openalex.org/W2768710193","https://openalex.org/W4388500049","https://openalex.org/W4400451537","https://openalex.org/W7171327029","https://openalex.org/W4404148097","https://openalex.org/W4410281961"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Persistence":[2,269],"to":[3,25,89,93,99,104,115,151,188,259],"preexposure":[4],"prophylaxis":[5],"(PrEP)":[6],"is":[7,19],"an":[8],"important":[9],"determinant":[10],"of":[11,34,81,110,120,222,224,271,279,291,297,303,344,353],"its":[12],"efficacy,":[13],"but":[14],"evidence":[15],"on":[16],"real-world":[17,320,349],"persistence":[18,144,166,331,359],"lacking.":[20],"This":[21],"study":[22],"assesses":[23],"adherence":[24],"F/TDF":[26,50,70,88,162,178,181,225,257,274,306,335],"and":[27,36,58,112,141,156,169,210,273,285,293,305,332,350,360],"F/TAF":[28,52,90,92,126,175,191,227,249,272,304,323],"for":[29,53,161,206,275,301,307,324,336],"PrEP":[30,54,132,143,165,229,276,280,308,325,345,358],"both":[31],"in":[32,44,197,202,309,347,362],"terms":[33],"discontinuation":[35,84,209,223,300],"re-initiation":[37,121,298,333,361],"patterns.":[38],"Methods":[39],"We":[40,95,216],"identified":[41],"HIV-negative":[42],"individuals":[43],"the":[45,106,117,262,310,322,341,348,351],"United":[46],"States":[47],"who":[48,364],"initiated":[49],"or":[51,91,235],"between":[55,208],"October":[56],"2019":[57,313],"December":[59],"2020":[60,316],"from":[61,87,367],"a":[62,77,219],"de-identified":[63],"prescription":[64,78],"claims":[65],"database;":[66],"users":[67,127,163,176,179,182,199,204,250,258,302],"taking":[68],"generic":[69],"were":[71,183,251],"excluded.":[72],"Non-persistence":[73],"was":[74,134,145,172,230,264,327],"defined":[75],"as":[76],"fill":[79],"gap":[80],">30":[82],"days;":[83],"included":[85],"switch":[86],"F/TDF.":[94],"used":[96],"survival":[97],"analyses":[98],"estimate":[100],"persistence,":[101],"Cox":[102],"regressions":[103],"compare":[105,116],"hazard":[107],"ratios":[108,119,283,295],"(HR)":[109,284],"discontinuation,":[111,248],"logistic":[113],"regression":[114],"odds":[118,294],"after":[122,299],"discontinuation.":[123],"Results":[124],"Among":[125],"(N=82,402)":[128],"median":[129,142],"age":[130,211],"at":[131,167,356],"initiation":[133,281],"35":[135],"years":[136,153],"(interquartile":[137],"range":[138],"[IQR]":[139],"28\u221247)":[140],"4":[146],"months":[147,158],"(IQR":[148,154,159],"1.8-8.9),":[149],"compared":[150],"31":[152],"25\u221240)":[155],"2":[157],"1.0-3.8)":[160],"(N=48,501).":[164],"60":[168],"90":[170],"days":[171],"higher":[173,220,330],"among":[174],"than":[177,190,200,239,256,334],"(Figure).":[180],"2.5":[184],"times":[185,253],"more":[186,194,254],"likely":[187,255],"discontinue":[189],"users,":[192],"with":[193,329],"marked":[195],"differences":[196],"older":[198],"that":[201],"younger":[203],"(p":[205],"interaction":[207],"group":[212],"<":[213],"0.01,":[214],"Table).":[215],"also":[217],"observed":[218],"rate":[221],"versus":[226],"if":[228],"prescribed":[231],"by":[232,240,267,277],"internal":[233],"medicine":[234,242],"infectious":[236],"disease":[237],"physicians":[238,243],"family":[241],"(data":[244],"not":[245,265],"shown).":[246],"After":[247],"1.7":[252],"re-initiate":[260],"PrEP;":[261],"association":[263],"different":[266],"age.":[268],"rates":[270],"time":[278],"Hazard":[282],"corresponding":[286],"95%":[287],"confidence":[288],"intervals":[289],"(CI)":[290],"non-persistence":[292],"(OR)":[296],"US,":[311],"Oct":[312],"\u2013":[314],"Dec":[315],"Conclusion":[317],"In":[318],"this":[319],"analysis,":[321],"regimen":[326],"associated":[328],"PrEP.":[337,368],"These":[338],"findings":[339],"underscore":[340],"dynamic":[342],"nature":[343],"utilization":[346],"importance":[352],"interventions":[354],"aimed":[355],"improving":[357],"people":[363],"would":[365],"benefit":[366],"Disclosures":[369],"Li":[370],"Tao,":[371],"MD,":[372,389,398,406],"PhD,":[373],"Gilead":[374,382,390,399,408,416],"Sciences":[375,383,391,400,409,417],"Inc":[376,384,418],"(Employee,":[377,385,393,402,411,419],"Shareholder)":[378,386,394,403,412,420],"Valentina":[379],"Shvachko,":[380],"MS,":[381],"Moupali":[387],"Das,":[388],"Inc.":[392,401,410],"Christoph":[395],"C.":[396],"Carter,":[397],"Jared":[404],"Baeten,":[405],"PHD,":[407],"David":[413],"Magnuson,":[414],"PharmD,":[415]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-12-31T00:00:00"}