{"id":"https://openalex.org/W4200285253","doi":"https://doi.org/10.1016/j.ejpb.2021.11.010","title":"Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size","display_name":"Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size","publication_year":2021,"publication_date":"2021-12-05","ids":{"openalex":"https://openalex.org/W4200285253","doi":"https://doi.org/10.1016/j.ejpb.2021.11.010","pmid":"https://pubmed.ncbi.nlm.nih.gov/34879228"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejpb.2021.11.010","doi":"https://doi.org/10.1016/j.ejpb.2021.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2021.11.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0939641121003428/pdf","source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0939641121003428/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087199847","display_name":"Katherine C. Fein","orcid":"https://orcid.org/0000-0002-3430-9191","observed_orcids":["https://orcid.org/0000-0002-3430-9191"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine C. Fein","raw_affiliation_strings":["Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024668315","display_name":"John P. Gleeson","orcid":"https://orcid.org/0000-0003-2917-6758","observed_orcids":["https://orcid.org/0000-0003-2917-6758"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Gleeson","raw_affiliation_strings":["Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080909957","display_name":"Alexandra N. Newby","orcid":"https://orcid.org/0000-0002-1812-4744","observed_orcids":["https://orcid.org/0000-0002-1812-4744"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra N. Newby","raw_affiliation_strings":["Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010666650","display_name":"Kathryn A. Whitehead","orcid":"https://orcid.org/0000-0002-0100-7824","observed_orcids":["https://orcid.org/0000-0002-0100-7824"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathryn A. Whitehead","raw_affiliation_strings":["Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States; Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States. Electronic address: kawhite@cmu.edu","Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States; Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States. Electronic address: kawhite@cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010666650"],"corresponding_institution_ids":["https://openalex.org/I74973139"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":{"value":3950,"currency":"USD","value_usd":3950},"fwci":2.0261,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.85134553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"170","issue":null,"first_page":"70","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macromolecule-absorption","display_name":"macromolecule absorption","score":0.8320000171661377},{"id":"https://openalex.org/keywords/1-phenylpiperazine","display_name":"1-phenylpiperazine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sodium-deoxycholate","display_name":"sodium deoxycholate","score":1.0},{"id":"https://openalex.org/keywords/fitc-dextran","display_name":"FITC-dextran","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dextran-molecular-weight","display_name":"dextran molecular weight","score":0.949999988079071},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9240000247955322},{"id":"https://openalex.org/keywords/caco-2-cell-monolayers","display_name":"Caco-2 cell monolayers","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-drug-delivery","display_name":"protein drug delivery","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.9059462547302246},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7178080677986145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6890069246292114},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5815446972846985},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5310454964637756},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.4994983673095703},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49929285049438477},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.48448941111564636},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4722280502319336},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4502588212490082},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4287920594215393},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4148416817188263},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3895370066165924},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36466532945632935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30496832728385925},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.22065699100494385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12896525859832764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1098686158657074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10563865303993225},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1054885983467102},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000277","descriptor_name":"Adjuvants, Pharmaceutic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejpb.2021.11.010","doi":"https://doi.org/10.1016/j.ejpb.2021.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2021.11.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0939641121003428/pdf","source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},{"id":"pmid:34879228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34879228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ejpb.2021.11.010","doi":"https://doi.org/10.1016/j.ejpb.2021.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2021.11.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0939641121003428/pdf","source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.4099999964237213,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1645948808","display_name":"Protein-Piperazine Polymer Conjugates as a New Platform for Oral Protein Therapy","funder_award_id":"1807983","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4271287996","display_name":null,"funder_award_id":"DP2-HD098860","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8635716485","display_name":"Fate, Function and Genetic Engineering of Breast Milk Cells for Infant Therapy","funder_award_id":"DP2HD098860","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310207","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200285253.pdf","grobid_xml":"https://content.openalex.org/works/W4200285253.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1976980511","https://openalex.org/W1987708381","https://openalex.org/W2004312574","https://openalex.org/W2028273867","https://openalex.org/W2052157194","https://openalex.org/W2062853793","https://openalex.org/W2068704289","https://openalex.org/W2073909305","https://openalex.org/W2087505851","https://openalex.org/W2108042351","https://openalex.org/W2115555666","https://openalex.org/W2134716171","https://openalex.org/W2146292237","https://openalex.org/W2153192347","https://openalex.org/W2153392360","https://openalex.org/W2159097441","https://openalex.org/W2228716042","https://openalex.org/W2256219273","https://openalex.org/W2288554561","https://openalex.org/W2337192313","https://openalex.org/W2433570839","https://openalex.org/W2463479819","https://openalex.org/W2604190474","https://openalex.org/W2616818052","https://openalex.org/W2724823461","https://openalex.org/W2755638713","https://openalex.org/W2888357119","https://openalex.org/W2901306081","https://openalex.org/W2957371100","https://openalex.org/W2969106555","https://openalex.org/W2982322219","https://openalex.org/W2991107049","https://openalex.org/W2998069424","https://openalex.org/W3000171350","https://openalex.org/W3003818063","https://openalex.org/W3087369767","https://openalex.org/W3107076968","https://openalex.org/W3128271517","https://openalex.org/W4297977229","https://openalex.org/W6756295121"],"related_works":["https://openalex.org/W6903485948","https://openalex.org/W2089594946","https://openalex.org/W3002303692","https://openalex.org/W4313432427","https://openalex.org/W3087369767","https://openalex.org/W2012286726","https://openalex.org/W4281615977","https://openalex.org/W2531306910","https://openalex.org/W4280622504","https://openalex.org/W4313472620"],"abstract_inverted_index":{"The":[0],"decades-long":[1],"effort":[2],"to":[3,41,84,192],"deliver":[4],"peptide":[5,36],"drugs":[6,37],"orally":[7],"has":[8],"resulted":[9],"in":[10,116,118,121,144,182],"several":[11],"clinically":[12],"successful":[13],"formulations.":[14],"These":[15],"formulations":[16],"are":[17],"enabled":[18],"by":[19],"the":[20,27,100,125,136,154,173,187,194],"inclusion":[21],"of":[22,30,57,88,96,102,107,124,138,156,160,176,189,196,202],"permeation":[23,65,73,180,190],"enhancers":[24,191],"that":[25,60],"facilitate":[26],"intestinal":[28,86],"absorption":[29,155,195],"peptides.":[31],"Thus":[32],"far,":[33],"these":[34],"oral":[35],"have":[38],"been":[39],"limited":[40],"peptides":[42],"less":[43],"than":[44],"5":[45],"kDa,":[46],"and":[47,77,111,120,132,141,147,168,184],"it":[48,185],"is":[49,53,172],"unclear":[50],"whether":[51],"there":[52],"an":[54,117],"upper":[55],"bound":[56],"protein":[58,206],"size":[59],"can":[61],"be":[62],"delivered":[63],"with":[64,104],"enhancers.":[66],"In":[67,127],"this":[68],"work,":[69],"we":[70],"examined":[71],"two":[72],"enhancers,":[74],"1-phenylpiperazine":[75],"(PPZ)":[76],"sodium":[78],"deoxycholate":[79],"(SDC),":[80],"for":[81,166,205],"their":[82],"ability":[83,188],"increase":[85],"transport":[87],"a":[89,94,179,199],"model":[90,123],"macromolecule":[91],"(FITC-Dextran)":[92],"as":[93,178],"function":[95],"its":[97],"size.":[98],"Specifically,":[99],"permeability":[101,137],"dextrans":[103],"molecular":[105],"weights":[106],"4,":[108],"10,":[109],"40,":[110],"70":[112],"kDa":[113],"was":[114,163],"assessed":[115],"vitro":[119],"vivo":[122],"intestine.":[126],"Caco-2":[128],"monolayers,":[129],"both":[130],"PPZ":[131,146,162,177],"SDC":[133,148,152],"significantly":[134],"increased":[135],"only":[139,165],"FD4":[140,167],"FD10.":[142,169],"However,":[143],"mice,":[145],"behaved":[149],"differently.":[150],"While":[151],"improved":[153],"all":[157],"tested":[158],"sizes":[159,203],"dextrans,":[161],"effective":[164],"This":[170],"work":[171],"first":[174],"report":[175],"enhancer":[181],"vivo,":[183],"highlights":[186],"improve":[193],"macromolecules":[197],"across":[198],"broad":[200],"range":[201],"relevant":[204],"drugs.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}
