{"id":"https://openalex.org/W4200241237","doi":"https://doi.org/10.29057/icbi.v9iespecial2.7968","title":"Evaluaci\u00f3n genot\u00f3xica de un novedoso nanoh\u00edbrido para la liberaci\u00f3n de mol\u00e9culas bioactivas","display_name":"Evaluaci\u00f3n genot\u00f3xica de un novedoso nanoh\u00edbrido para la liberaci\u00f3n de mol\u00e9culas bioactivas","publication_year":2021,"publication_date":"2021-12-12","ids":{"openalex":"https://openalex.org/W4200241237","doi":"https://doi.org/10.29057/icbi.v9iespecial2.7968"},"language":"es","primary_location":{"id":"doi:10.29057/icbi.v9iespecial2.7968","doi":"https://doi.org/10.29057/icbi.v9iespecial2.7968","is_oa":true,"landing_page_url":"https://doi.org/10.29057/icbi.v9iespecial2.7968","pdf_url":"https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/download/7968/8668","source":{"id":"https://openalex.org/S4210218234","display_name":"P\u00c4DI Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","issn_l":"2007-6363","issn":["2007-6363"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex"],"host_organization":"https://openalex.org/P4404662901","host_organization_name":"Universidad Aut\u00f3noma del Estado de Hidalgo","host_organization_lineage":["https://openalex.org/P4404662901"],"host_organization_lineage_names":["Universidad Aut\u00f3noma del Estado de Hidalgo"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P\u00e4di Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/download/7968/8668","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050543380","display_name":"Jenny Arratia-Quijada","orcid":"https://orcid.org/0000-0001-8264-9310","observed_orcids":["https://orcid.org/0000-0001-8264-9310"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jenny Arratia-Quijada","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":"https://orcid.org/0000-0001-8264-9310","affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027067557","display_name":"Beatriz Adriana Andrade-Espinoza","orcid":"https://orcid.org/0000-0003-3833-2230","observed_orcids":["https://orcid.org/0000-0003-3833-2230"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Beatriz Adriana Andrade-Espinoza","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":"https://orcid.org/0000-0003-3833-2230","affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041940619","display_name":"Karla Nu\u00f1o","orcid":"https://orcid.org/0000-0001-6437-7446","observed_orcids":["https://orcid.org/0000-0001-6437-7446"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Karla Nu\u00f1o-Anguiano","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":"https://orcid.org/0000-0001-6437-7446","affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422284","display_name":"Gualberto Iglesias-Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Gualberto Iglesias-Gonz\u00e1lez","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007456490","display_name":"Alberto Daniel Rocha-Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-1173-1736","observed_orcids":["https://orcid.org/0000-0002-1173-1736"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alberto Daniel Rocha-Mu\u00f1oz","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":"https://orcid.org/0000-0002-1173-1736","affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013280600","display_name":"Jes\u00fas Eduardo V\u00e1zquez-Zerme\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Eduardo V\u00e1zquez-Zerme\u00f1o","raw_affiliation_strings":["Universidad de Guadalajara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Guadalajara","institution_ids":["https://openalex.org/I193181351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193181351"],"apc_list":null,"apc_paid":null,"fwci":0.0859,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27413747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"9","issue":"Especial2","first_page":"29","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/organic-inorganic-hybrid-nanomaterials","display_name":"organic-inorganic hybrid nanomaterials","score":0.8550000190734863},{"id":"https://openalex.org/keywords/beta-hydroxy-beta-methylbutyrate","display_name":"beta-hydroxy-beta-methylbutyrate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nanohybrids","display_name":"hybrid nanostructures","score":0.5130000114440918},{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.6700000166893005},{"id":"https://openalex.org/keywords/acute-oral-exposure","display_name":"acute oral exposure","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bioactive-compound-delivery","display_name":"bioactive compound delivery","score":0.6079999804496765},{"id":"https://openalex.org/keywords/nanomaterial-toxicity","display_name":"nanomaterial toxicity","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6907235383987427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3239767849445343},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.17942297458648682}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29057/icbi.v9iespecial2.7968","doi":"https://doi.org/10.29057/icbi.v9iespecial2.7968","is_oa":true,"landing_page_url":"https://doi.org/10.29057/icbi.v9iespecial2.7968","pdf_url":"https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/download/7968/8668","source":{"id":"https://openalex.org/S4210218234","display_name":"P\u00c4DI Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","issn_l":"2007-6363","issn":["2007-6363"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex"],"host_organization":"https://openalex.org/P4404662901","host_organization_name":"Universidad Aut\u00f3noma del Estado de Hidalgo","host_organization_lineage":["https://openalex.org/P4404662901"],"host_organization_lineage_names":["Universidad Aut\u00f3noma del Estado de Hidalgo"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P\u00e4di Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29057/icbi.v9iespecial2.7968","doi":"https://doi.org/10.29057/icbi.v9iespecial2.7968","is_oa":true,"landing_page_url":"https://doi.org/10.29057/icbi.v9iespecial2.7968","pdf_url":"https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/download/7968/8668","source":{"id":"https://openalex.org/S4210218234","display_name":"P\u00c4DI Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","issn_l":"2007-6363","issn":["2007-6363"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex"],"host_organization":"https://openalex.org/P4404662901","host_organization_name":"Universidad Aut\u00f3noma del Estado de Hidalgo","host_organization_lineage":["https://openalex.org/P4404662901"],"host_organization_lineage_names":["Universidad Aut\u00f3noma del Estado de Hidalgo"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P\u00e4di Bolet\u00edn Cient\u00edfico de Ciencias B\u00e1sicas e Ingenier\u00edas del ICBI","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200241237.pdf","grobid_xml":"https://content.openalex.org/works/W4200241237.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1982969924","https://openalex.org/W2004071118","https://openalex.org/W2039759758","https://openalex.org/W2044592220","https://openalex.org/W2054834723","https://openalex.org/W2144240074","https://openalex.org/W2153288575","https://openalex.org/W2477760436","https://openalex.org/W2572682966","https://openalex.org/W2766804255","https://openalex.org/W2800266378","https://openalex.org/W2810111102","https://openalex.org/W2946144116","https://openalex.org/W2990138690","https://openalex.org/W2998601003","https://openalex.org/W3002967539","https://openalex.org/W3015019499","https://openalex.org/W3088203978","https://openalex.org/W3128640398","https://openalex.org/W3130930727","https://openalex.org/W3155756718"],"related_works":["https://openalex.org/W1069048230","https://openalex.org/W109617282","https://openalex.org/W1503670958","https://openalex.org/W67406555","https://openalex.org/W191625260","https://openalex.org/W2784354129","https://openalex.org/W3006294727","https://openalex.org/W4376143408","https://openalex.org/W2035140275","https://openalex.org/W4401258147"],"abstract_inverted_index":{"En":[0],"las":[1],"\u00faltimas":[2],"dos":[3],"d\u00e9cadas,":[4],"los":[5,38,97,122,125],"nanomateriales":[6],"h\u00edbridos":[7],"org\u00e1nicos-inorg\u00e1nicos":[8],"han":[9],"alcanzado":[10],"un":[11],"desarrollo":[12],"intensivo.":[13],"Sin":[14],"embargo,":[15],"antes":[16],"de":[17,23,30,37,48,58,63,84,87,93,102,115,121],"su":[18],"posible":[19],"aplicaci\u00f3n,":[20],"se":[21,106],"requiere":[22],"una":[24,70,100,108],"evaluaci\u00f3n":[25],"completa":[26],"y":[27,34,118],"adecuada":[28],"tanto":[29],"sus":[31],"propiedades":[32],"fisicoqu\u00edmicas":[33],"beneficios,":[35],"como":[36],"potenciales":[39],"efectos":[40],"t\u00f3xicos":[41],"para":[42],"la":[43,119],"salud":[44],"humana.":[45],"El":[46,74],"objetivo":[47],"este":[49],"estudio":[50],"fue":[51,77],"determinar":[52],"el":[53,113],"potencial":[54,75],"genot\u00f3xico":[55,76],"in":[56],"vivo":[57],"nanoh\u00edbridos":[59],"dise\u00f1ados":[60],"a":[61,96,99],"base":[62],"hidr\u00f3xidos":[64],"dobles":[65],"laminares/\u00df-hidroxi-\u00df-metil":[66],"butirato/col\u00e1geno":[67],"(ZnAl/HMB/Col)":[68],"tras":[69,89],"exposici\u00f3n":[71,94],"oral":[72,95],"aguda.":[73],"evaluado":[78],"en":[79],"ratas":[80],"macho":[81],"Sprague-Dawley":[82],"(SD)":[83],"9":[85],"semanas":[86],"edad":[88],"7":[90],"d\u00edas":[91],"continuos":[92],"nanoh\u00edbridos,":[98],"dosis":[101],"2,000":[103],"mg/kg.":[104],"No":[105],"observ\u00f3":[107],"diferencia":[109],"estad\u00edsticamente":[110],"significativa":[111],"entre":[112],"n\u00famero":[114],"micron\u00facleos":[116],"(MN)":[117],"administraci\u00f3n":[120],"tratamientos":[123],"sobre":[124],"valores":[126],"del":[127],"grupo":[128],"control.":[129]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}